KR950703524A - 타목시펜-내성 종양 치료용 비대사성 클로미펜 유사체(Non-Metabolizable Clomiphene Analogs for Treatment of Tamoxifen-Resistant Tumors) - Google Patents

타목시펜-내성 종양 치료용 비대사성 클로미펜 유사체(Non-Metabolizable Clomiphene Analogs for Treatment of Tamoxifen-Resistant Tumors) Download PDF

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KR950703524A
KR950703524A KR1019950700991A KR19950700991A KR950703524A KR 950703524 A KR950703524 A KR 950703524A KR 1019950700991 A KR1019950700991 A KR 1019950700991A KR 19950700991 A KR19950700991 A KR 19950700991A KR 950703524 A KR950703524 A KR 950703524A
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tamoxifen
compound
treatment
resistant tumors
metabolizable
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KR1019950700991A
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KR100326962B1 (ko
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알란 제이. 비톤티
러쎌 제이. 바우만
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스티븐 엘. 네스비트
메렐 다우 파마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/48—N-alkylated amines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

하기 식의 화합물 및 그의 약학적으로 허용가능한 염은 타목시펜 내성 종양 치료에 효과적인 것을 나타났다:
상기식에서, R1및 R2는 각각 C1-C4저급 알킬군으로부터 선택되고, X는 NH 또는 S이고, n은 1과 4를 포함하여 그 사이에 있는 모든 수이고, n이 0일 때 X는(CH2)3이다.

Description

타목시펜-내성 종양 치료용 비대사성 클로미펜 유사체(Non-Metabolizable Clomiphene Analogs for Treatment of Tamoxifen-Resistant Tumors)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 식의 화합물 및 그의 약학적으로 허용가능한 염의 유효량을 타목시펜- 내성 종양의 치료를 필요로 하는 환자에게 투여하는 것을 특징으로 하는 타목시펜-내성 종양을 치료하는 방법:
    상기식에서, R1및 R2는 각각 C1-C4저급 알킬군으로부터 선택되고, X는 NH 또는 S이고, n은 1과 4를 포함하여 그 사이에 있는 모든 수이고, n이 0일 때 X는(CH2)3이다.
  2. 제1항에 있어서, 상기 화합물이 2-[p-(2-클로로-1, 2-디페닐비닐)-아닐리노]트리에틸아민인 것이 특징인 방법.
  3. 제1항에 있어서, 상기 화합물이 2-[p-(2-클로로-1, 2-디페닐비닐)-페닐티오]트리에틸아민인 것이 특징인 방법.
  4. 제1항에 있어서, 상기 화합물이 1-[p-γ-디에틸아미노프로필)-페닐]-1, 2-디페닐클로로에틸렌인 것이 특징인 방법.
  5. 2-[p-(2-클로로-1, 2-디페닐비닐)-페닐티오]트리에틸아민 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700991A 1992-09-15 1993-08-16 타목시펜-내성종양치료용비대사성클로미펜유사체 KR100326962B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94530592A 1992-09-15 1992-09-15
US945305 1992-09-15
PCT/US1993/007697 WO1994006762A1 (en) 1992-09-15 1993-08-16 Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors

Publications (2)

Publication Number Publication Date
KR950703524A true KR950703524A (ko) 1995-09-20
KR100326962B1 KR100326962B1 (ko) 2002-12-02

Family

ID=25482938

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950700991A KR100326962B1 (ko) 1992-09-15 1993-08-16 타목시펜-내성종양치료용비대사성클로미펜유사체

Country Status (16)

Country Link
US (2) US5410080A (ko)
EP (1) EP0660821B1 (ko)
JP (1) JPH09500863A (ko)
KR (1) KR100326962B1 (ko)
AT (1) ATE162516T1 (ko)
AU (1) AU672234B2 (ko)
CA (1) CA2143000C (ko)
DE (1) DE69316633T2 (ko)
DK (1) DK0660821T3 (ko)
ES (1) ES2112994T3 (ko)
FI (1) FI951193A0 (ko)
GR (1) GR3026236T3 (ko)
HU (1) HUT71244A (ko)
NO (1) NO950985L (ko)
NZ (1) NZ255785A (ko)
WO (1) WO1994006762A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR008155A1 (es) * 1996-09-06 1999-12-09 Smithkline Beecham Corp Uso de un compuesto de formula i para preparar un medicamento util para tratar y prevenir la enfermedad cardiovascular post menopausica en mujeres.
CA2301032C (en) 1997-08-15 2009-01-13 Duke University A method of preventing or treating estrogen-dependent diseases and disorders
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
JP2015535283A (ja) 2012-11-02 2015-12-10 レプロス セラピューティクス インコーポレイティド 癌療法における使用のためのトランス−クロミフェン
CN106068121A (zh) * 2014-03-11 2016-11-02 利普生物药剂公司 使用单一溶剂进行克罗米芬合成

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2750416A (en) * 1950-12-21 1956-06-12 Rohm & Haas Aminomethylphenols and method for their preparation
US3143568A (en) * 1961-01-25 1964-08-04 Vismara Francesco Spa Diarylamino-acetyl-aryl derivatives
US3244705A (en) * 1962-11-14 1966-04-05 Richardson Merrell Inc Triphenylhaloethylene derivatives
CH373975A (de) * 1963-07-20 1963-12-15 Heierle Werner Kronen-Verschluss für Flaschen
FR3575M (fr) * 1964-01-28 1965-10-04 Richardson Merrell Triphénylhalogénoéthylenes substitués.
US3631109A (en) * 1968-12-04 1971-12-28 Uniroyal Inc Beta beta'-bis(dialkylaminomethyl-4-hydroxy-benzylthio)dialkylethers
GB2126576B (en) * 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
US5114951A (en) * 1989-04-11 1992-05-19 Burroughs Wellcome Company Agents for combating multiple drug resistance
US5130424A (en) * 1990-08-01 1992-07-14 Merrell Dow Pharmaceuticals Inc. 4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Also Published As

Publication number Publication date
FI951193A (fi) 1995-03-14
NZ255785A (en) 1997-05-26
WO1994006762A1 (en) 1994-03-31
HUT71244A (en) 1995-11-28
DE69316633D1 (de) 1998-02-26
AU672234B2 (en) 1996-09-26
GR3026236T3 (en) 1998-05-29
DE69316633T2 (de) 1998-05-20
US5681863A (en) 1997-10-28
EP0660821B1 (en) 1998-01-21
AU5015093A (en) 1994-04-12
ES2112994T3 (es) 1998-04-16
JPH09500863A (ja) 1997-01-28
CA2143000A1 (en) 1994-03-31
FI951193A0 (fi) 1995-03-14
EP0660821A1 (en) 1995-07-05
US5410080A (en) 1995-04-25
DK0660821T3 (da) 1998-09-21
NO950985D0 (no) 1995-03-14
ATE162516T1 (de) 1998-02-15
KR100326962B1 (ko) 2002-12-02
HU9500775D0 (en) 1995-05-29
NO950985L (no) 1995-03-14
CA2143000C (en) 2000-03-28

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