NO922853L - Aminosubstituerte piperazinderivater - Google Patents
Aminosubstituerte piperazinderivaterInfo
- Publication number
- NO922853L NO922853L NO92922853A NO922853A NO922853L NO 922853 L NO922853 L NO 922853L NO 92922853 A NO92922853 A NO 92922853A NO 922853 A NO922853 A NO 922853A NO 922853 L NO922853 L NO 922853L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxy
- lower alkyl
- carboxy
- stands
- Prior art date
Links
- -1 AMINOSUBSTITUTED PIPERAZINE Chemical class 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 102000000589 Interleukin-1 Human genes 0.000 abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000003431 oxalo group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH216091 | 1991-07-19 | ||
| CH134092 | 1992-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO922853D0 NO922853D0 (no) | 1992-07-17 |
| NO922853L true NO922853L (no) | 1993-01-20 |
Family
ID=25687395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92922853A NO922853L (no) | 1991-07-19 | 1992-07-17 | Aminosubstituerte piperazinderivater |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5286728A (fi) |
| EP (1) | EP0524146A1 (fi) |
| JP (1) | JPH05202014A (fi) |
| KR (1) | KR930002330A (fi) |
| AU (1) | AU650989B2 (fi) |
| CA (1) | CA2074154A1 (fi) |
| CZ (1) | CZ222392A3 (fi) |
| FI (1) | FI923280A (fi) |
| HU (1) | HUT67047A (fi) |
| IE (1) | IE922336A1 (fi) |
| IL (1) | IL102533A0 (fi) |
| MX (1) | MX9204171A (fi) |
| NO (1) | NO922853L (fi) |
| NZ (1) | NZ243607A (fi) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0489690A1 (de) * | 1990-12-05 | 1992-06-10 | Ciba-Geigy Ag | Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine |
| US5384319A (en) * | 1993-01-06 | 1995-01-24 | Ciba-Geigy Corporation | Aminoalkylphenyl compounds |
| US5380726A (en) * | 1993-01-15 | 1995-01-10 | Ciba-Geigy Corporation | Substituted dialkylthio ethers |
| US5561212A (en) * | 1993-03-05 | 1996-10-01 | Baylor University | Poly(methylene oxalate), a new composition of matter |
| US5371171A (en) * | 1993-03-05 | 1994-12-06 | Baylor University | Poly(methylene oxalate) and precursors thereto |
| AU5321796A (en) * | 1995-03-23 | 1996-10-08 | Affymax Technologies N.V. | Novel piperazine derivatives as type il-1 receptor antagonists |
| FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| FR2744449B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| FR2744450A1 (fr) * | 1996-02-02 | 1997-08-08 | Pf Medicament | Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| JP3476203B2 (ja) * | 1997-02-24 | 2003-12-10 | ザイモジュネティックス インコーポレイテッド | カルシトニン擬似体 |
| NZ504465A (en) * | 1997-10-14 | 2001-11-30 | Welfide Corp | 1-Phenylacylamino substituted piperazine derivatives which are 4-substituted by a heteroaryl group |
| EP1146790A4 (en) * | 1999-01-25 | 2004-03-17 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| UY27003A1 (es) | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| PL212089B1 (pl) * | 2002-03-13 | 2012-08-31 | Janssen Pharmaceutica Nv | Związki heterocykliczne jako inhibitory deacetylazy histonowej, kompozycja farmaceutyczna je zawierająca, ich zastosowanie, sposób wytwarzania, sposób wykrywania lub identyfikacji HDAC oraz kompozycja |
| BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| JP4958786B2 (ja) | 2004-09-20 | 2012-06-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
| CA2580787A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AR051294A1 (es) * | 2004-09-20 | 2007-01-03 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
| EP1799668A1 (en) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| CN101597278B (zh) * | 2008-06-04 | 2013-04-17 | 中国中化股份有限公司 | 酰胺类化合物及其制备与应用 |
| CA3068254A1 (en) | 2017-06-20 | 2018-12-27 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL105768C (fi) * | 1959-02-25 | |||
| CH590261A5 (fi) * | 1973-07-10 | 1977-07-29 | Ciba Geigy Ag | |
| DE2365988B2 (de) * | 1973-07-12 | 1978-09-07 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | Verfahren zur Herstellung von N-Dialkylaminoäthyl-2-alkoxy-4-amino-5-chlor-benzoesäureamiden |
| EP0008072B1 (de) * | 1978-08-10 | 1984-02-22 | Ciba-Geigy Ag | Substituierte Anthranilsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Herstellung |
| MY102447A (en) * | 1986-06-16 | 1992-06-30 | Ciba Geigy Ag | Disubtituted piperazines |
| AU606808B2 (en) * | 1988-06-29 | 1991-02-14 | Otsuka Pharmaceutical Factory, Inc. | Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same |
| US5051423A (en) * | 1988-07-13 | 1991-09-24 | Schering Ag | Derivatized alkanolamines as cardiovascular agents |
| EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
| EP0489690A1 (de) * | 1990-12-05 | 1992-06-10 | Ciba-Geigy Ag | Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine |
-
1992
- 1992-07-10 EP EP92810525A patent/EP0524146A1/de not_active Withdrawn
- 1992-07-14 US US07/913,277 patent/US5286728A/en not_active Expired - Fee Related
- 1992-07-15 AU AU20317/92A patent/AU650989B2/en not_active Ceased
- 1992-07-16 MX MX9204171A patent/MX9204171A/es unknown
- 1992-07-16 CZ CS922223A patent/CZ222392A3/cs unknown
- 1992-07-17 NZ NZ243607A patent/NZ243607A/en unknown
- 1992-07-17 FI FI923280A patent/FI923280A/fi not_active Application Discontinuation
- 1992-07-17 CA CA002074154A patent/CA2074154A1/en not_active Abandoned
- 1992-07-17 HU HU9202359A patent/HUT67047A/hu unknown
- 1992-07-17 IL IL102533A patent/IL102533A0/xx unknown
- 1992-07-17 JP JP4190894A patent/JPH05202014A/ja active Pending
- 1992-07-17 IE IE233692A patent/IE922336A1/en not_active Application Discontinuation
- 1992-07-17 NO NO92922853A patent/NO922853L/no unknown
- 1992-07-18 KR KR1019920012804A patent/KR930002330A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO922853D0 (no) | 1992-07-17 |
| IE922336A1 (en) | 1993-01-27 |
| KR930002330A (ko) | 1993-02-23 |
| US5286728A (en) | 1994-02-15 |
| JPH05202014A (ja) | 1993-08-10 |
| FI923280A0 (fi) | 1992-07-17 |
| IL102533A0 (en) | 1993-01-14 |
| AU650989B2 (en) | 1994-07-07 |
| CA2074154A1 (en) | 1993-01-20 |
| FI923280A (fi) | 1993-01-20 |
| HUT67047A (en) | 1995-01-30 |
| NZ243607A (en) | 1995-02-24 |
| EP0524146A1 (de) | 1993-01-20 |
| HU9202359D0 (en) | 1992-10-28 |
| MX9204171A (es) | 1993-01-01 |
| AU2031792A (en) | 1993-01-21 |
| CZ222392A3 (en) | 1993-02-17 |
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