NO940135L - Substituerte dialkyltioetere - Google Patents
Substituerte dialkyltioetereInfo
- Publication number
- NO940135L NO940135L NO940135A NO940135A NO940135L NO 940135 L NO940135 L NO 940135L NO 940135 A NO940135 A NO 940135A NO 940135 A NO940135 A NO 940135A NO 940135 L NO940135 L NO 940135L
- Authority
- NO
- Norway
- Prior art keywords
- alkoxy
- alkyl
- lower alkyl
- independently represent
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Det er beskrevet substituerte dialkyltioetere med formel (I) R, ¿ N ¿ Y O hvor R! kan ha flere betydninger og blant annet bety hydrogen, laveralkyl , hydroksy-laverealkyl , lavereal- koksy-laverealkyl eller laverealkoksy-laverealkoksy- laverealkyl; R2 betyr laverealkyl som eventuelt er substituert, for eksempel med amino, acylamino eller karboksy; R3 og R4 betyr uavhengig av hverandre hydrogen, laverealkyl, halogen, laverealkoksy eller laverealkyltio, R5 og R^, betyr uavhengig av hverandre hydrogen, laverealkyl, halogen-laverealkyl , lavereal- koksy, laverealkyltio, halogen, amino, laverealkylami- no, dilaverealkylamino eller laverealkanoylamino, alk betyr laverealkylen og X og Y betyr uavhengig av hverandre en direkte binding, laverealkylen eller laverealkenylen, samt salter derav. Disse forbindel- sene hemmer biosyntesen av interleukin-1 (IL-1) og oppviser videre analgetiske egenskaper. De kan derfor anvendes som virksomme stoffer i legemidler. Forbind- elsene fremstilles på i og for seg kjent måte.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH11593 | 1993-01-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940135D0 NO940135D0 (no) | 1994-01-14 |
NO940135L true NO940135L (no) | 1994-07-18 |
Family
ID=4179596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940135A NO940135L (no) | 1993-01-15 | 1994-01-14 | Substituerte dialkyltioetere |
Country Status (13)
Country | Link |
---|---|
US (1) | US5380726A (no) |
EP (1) | EP0606824A1 (no) |
JP (1) | JPH06247949A (no) |
KR (1) | KR940018370A (no) |
AU (1) | AU5261193A (no) |
CA (1) | CA2112786A1 (no) |
CZ (1) | CZ7794A3 (no) |
FI (1) | FI940154A (no) |
HU (1) | HUT70936A (no) |
IL (1) | IL108329A0 (no) |
NO (1) | NO940135L (no) |
SK (1) | SK4394A3 (no) |
ZA (1) | ZA94280B (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4441873A1 (de) * | 1994-11-24 | 1996-05-30 | Wella Ag | Mittel zur dauerhaften Haarverformung |
WO1996029088A1 (en) * | 1995-03-23 | 1996-09-26 | Affymax Technologies N.V. | Novel piperazine derivatives as type il-1 receptor antagonists |
FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
FR2744449B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
FR2744450A1 (fr) * | 1996-02-02 | 1997-08-08 | Pf Medicament | Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
GB0224917D0 (en) * | 2002-10-25 | 2002-12-04 | Novartis Ag | Organic compounds |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
CN101083993A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
CN101084207A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
AR051294A1 (es) * | 2004-09-20 | 2007-01-03 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
US8541457B2 (en) * | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
ES2919779T3 (es) | 2017-06-20 | 2022-07-28 | Imbria Pharmaceuticals Inc | Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL105768C (no) * | 1959-02-25 | |||
CH590261A5 (no) * | 1973-07-10 | 1977-07-29 | Ciba Geigy Ag | |
DE2365988B2 (de) * | 1973-07-12 | 1978-09-07 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | Verfahren zur Herstellung von N-Dialkylaminoäthyl-2-alkoxy-4-amino-5-chlor-benzoesäureamiden |
EP0008072B1 (de) * | 1978-08-10 | 1984-02-22 | Ciba-Geigy Ag | Substituierte Anthranilsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Herstellung |
MY102447A (en) * | 1986-06-16 | 1992-06-30 | Ciba Geigy Ag | Disubtituted piperazines |
AU606808B2 (en) * | 1988-06-29 | 1991-02-14 | Otsuka Pharmaceutical Factory, Inc. | Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same |
US5051423A (en) * | 1988-07-13 | 1991-09-24 | Schering Ag | Derivatized alkanolamines as cardiovascular agents |
EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
EP0489690A1 (de) * | 1990-12-05 | 1992-06-10 | Ciba-Geigy Ag | Substituierte N-Benzoyl-N'-(2-phenylethyl)-piperazine |
EP0524146A1 (de) * | 1991-07-19 | 1993-01-20 | Ciba-Geigy Ag | Aminosubstituierte Piperazinderivate |
-
1993
- 1993-12-20 US US08/170,110 patent/US5380726A/en not_active Expired - Fee Related
- 1993-12-21 AU AU52611/93A patent/AU5261193A/en not_active Abandoned
- 1993-12-24 EP EP93810906A patent/EP0606824A1/de not_active Withdrawn
- 1993-12-29 JP JP5351780A patent/JPH06247949A/ja active Pending
-
1994
- 1994-01-04 CA CA002112786A patent/CA2112786A1/en not_active Abandoned
- 1994-01-12 FI FI940154A patent/FI940154A/fi not_active Application Discontinuation
- 1994-01-13 CZ CZ9477A patent/CZ7794A3/cs unknown
- 1994-01-13 IL IL10832994A patent/IL108329A0/xx unknown
- 1994-01-13 SK SK43-94A patent/SK4394A3/sk unknown
- 1994-01-14 HU HU9400118A patent/HUT70936A/hu unknown
- 1994-01-14 ZA ZA94280A patent/ZA94280B/xx unknown
- 1994-01-14 NO NO940135A patent/NO940135L/no unknown
- 1994-01-14 KR KR1019940000557A patent/KR940018370A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA94280B (en) | 1994-07-05 |
HUT70936A (en) | 1995-11-28 |
US5380726A (en) | 1995-01-10 |
FI940154A0 (fi) | 1994-01-12 |
JPH06247949A (ja) | 1994-09-06 |
HU9400118D0 (en) | 1994-05-30 |
AU5261193A (en) | 1994-07-21 |
SK4394A3 (en) | 1994-12-07 |
FI940154A (fi) | 1994-07-16 |
IL108329A0 (en) | 1994-04-12 |
CA2112786A1 (en) | 1994-07-16 |
CZ7794A3 (en) | 1994-08-17 |
EP0606824A1 (de) | 1994-07-20 |
KR940018370A (ko) | 1994-08-16 |
NO940135D0 (no) | 1994-01-14 |
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