NO920600L - 5-(1-aminocykloheksyl)-2(1h)-pyridinon og beslektede forbindelser - Google Patents
5-(1-aminocykloheksyl)-2(1h)-pyridinon og beslektede forbindelserInfo
- Publication number
- NO920600L NO920600L NO92920600A NO920600A NO920600L NO 920600 L NO920600 L NO 920600L NO 92920600 A NO92920600 A NO 92920600A NO 920600 A NO920600 A NO 920600A NO 920600 L NO920600 L NO 920600L
- Authority
- NO
- Norway
- Prior art keywords
- image
- loweralkyl
- hydrogen
- pyridinon
- aminocyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/394,448 US4978663A (en) | 1989-08-16 | 1989-08-16 | 5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility |
PCT/US1990/004522 WO1991002721A1 (fr) | 1989-08-16 | 1990-08-16 | 5-(1-aminocyclohexyle)-2(1h)-pyridinone et composes apparentes |
Publications (2)
Publication Number | Publication Date |
---|---|
NO920600D0 NO920600D0 (no) | 1992-02-14 |
NO920600L true NO920600L (no) | 1992-04-14 |
Family
ID=23558997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92920600A NO920600L (no) | 1989-08-16 | 1992-02-14 | 5-(1-aminocykloheksyl)-2(1h)-pyridinon og beslektede forbindelser |
Country Status (14)
Country | Link |
---|---|
US (1) | US4978663A (fr) |
EP (1) | EP0487602B1 (fr) |
JP (3) | JP2557568B2 (fr) |
KR (1) | KR927003532A (fr) |
AT (1) | ATE155458T1 (fr) |
AU (1) | AU652126B2 (fr) |
CA (2) | CA2332188C (fr) |
DE (1) | DE69031075T2 (fr) |
DK (1) | DK0487602T3 (fr) |
ES (1) | ES2109239T3 (fr) |
FI (1) | FI920637A0 (fr) |
HU (2) | HUT67589A (fr) |
NO (1) | NO920600L (fr) |
WO (1) | WO1991002721A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW473479B (en) | 1997-12-19 | 2002-01-21 | Takeda Chemical Industries Ltd | Phosphonocephem derivatives, their production and use |
AR059898A1 (es) * | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CN103342695B (zh) | 2007-09-14 | 2015-04-22 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
ES2409215T3 (es) * | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 4-fenil-1H-piridin-2-onas 1-3-disustituidas |
AU2008297876B2 (en) | 2007-09-14 | 2011-07-07 | Addex Pharma S.A. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
JP5433582B2 (ja) * | 2007-11-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | イミダゾ[1,2−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
CN102186477B (zh) | 2008-10-16 | 2013-07-17 | 奥梅-杨森制药有限公司 | 作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物 |
MX2011005242A (es) | 2008-11-28 | 2011-09-06 | Ortho Mcneil Janssen Pharm | Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos. |
AR076859A1 (es) | 2009-05-12 | 2011-07-13 | Ortho Mcneil Janssen Pharm | Derivados de 1,2,4-triazolo[4,3-a]piridina moduladores alostericos positivos de receptores mglur2 , composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos neurologicos y siquiatricos. |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
ES2552879T3 (es) | 2010-11-08 | 2015-12-02 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
WO2012062750A1 (fr) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | Dérivés de 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
CN106061504B (zh) | 2014-01-21 | 2019-09-06 | 詹森药业有限公司 | 包括代谢型谷氨酸能受体亚型2的正别构调节物或正位激动剂的组合及其用途 |
KR20200126026A (ko) | 2014-01-21 | 2020-11-05 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
CN112409266A (zh) * | 2019-08-22 | 2021-02-26 | 江苏阿尔法药业有限公司 | 一种索菲布韦中间体及其制备方法 |
CN112409267A (zh) * | 2019-08-22 | 2021-02-26 | 江苏阿尔法药业有限公司 | 一种索菲布韦中间体的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA903224A (en) * | 1972-06-20 | F. Czaja Robert | Process for the production of pyridones | |
GB851577A (en) * | 1958-03-06 | 1960-10-19 | Parke Davis & Co | Pyridine compounds and methods for producing the same |
US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
JPS61165372A (ja) * | 1985-01-17 | 1986-07-26 | Daicel Chem Ind Ltd | 5−ハロピリジン−3−カルボキサミド化合物 |
DE3823991A1 (de) * | 1988-07-15 | 1990-02-15 | Basf Ag | Heterocyclisch substituierte (alpha)-aryl-acrylsaeureester und fungizide, die diese verbindungen enthalten |
-
1989
- 1989-08-16 US US07/394,448 patent/US4978663A/en not_active Expired - Lifetime
-
1990
- 1990-08-16 HU HU9200461A patent/HUT67589A/hu unknown
- 1990-08-16 CA CA002332188A patent/CA2332188C/fr not_active Expired - Lifetime
- 1990-08-16 ES ES90912876T patent/ES2109239T3/es not_active Expired - Lifetime
- 1990-08-16 EP EP90912876A patent/EP0487602B1/fr not_active Expired - Lifetime
- 1990-08-16 CA CA002063594A patent/CA2063594C/fr not_active Expired - Lifetime
- 1990-08-16 AT AT90912876T patent/ATE155458T1/de not_active IP Right Cessation
- 1990-08-16 JP JP2512071A patent/JP2557568B2/ja not_active Expired - Lifetime
- 1990-08-16 KR KR1019920700362A patent/KR927003532A/ko not_active Application Discontinuation
- 1990-08-16 AU AU62842/90A patent/AU652126B2/en not_active Ceased
- 1990-08-16 DK DK90912876.1T patent/DK0487602T3/da active
- 1990-08-16 DE DE69031075T patent/DE69031075T2/de not_active Expired - Lifetime
- 1990-08-16 WO PCT/US1990/004522 patent/WO1991002721A1/fr active IP Right Grant
- 1990-08-16 HU HU9200461A patent/HU9200461D0/hu unknown
-
1992
- 1992-02-14 NO NO92920600A patent/NO920600L/no unknown
- 1992-02-14 FI FI920637A patent/FI920637A0/fi unknown
-
1996
- 1996-05-14 JP JP8118929A patent/JP2708736B2/ja not_active Expired - Lifetime
- 1996-05-14 JP JP8118930A patent/JP2708737B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2109239T3 (es) | 1998-01-16 |
DK0487602T3 (da) | 1998-02-09 |
KR927003532A (ko) | 1992-12-18 |
JP2708736B2 (ja) | 1998-02-04 |
AU6284290A (en) | 1991-04-03 |
JPH09100288A (ja) | 1997-04-15 |
JPH04507421A (ja) | 1992-12-24 |
NO920600D0 (no) | 1992-02-14 |
WO1991002721A1 (fr) | 1991-03-07 |
DE69031075T2 (de) | 1998-02-26 |
HUT67589A (en) | 1995-04-28 |
AU652126B2 (en) | 1994-08-18 |
EP0487602A4 (en) | 1993-03-17 |
CA2332188A1 (fr) | 1991-02-17 |
CA2063594C (fr) | 2002-07-16 |
CA2063594A1 (fr) | 1991-02-17 |
US4978663A (en) | 1990-12-18 |
HU9200461D0 (en) | 1992-05-28 |
FI920637A0 (fi) | 1992-02-14 |
EP0487602A1 (fr) | 1992-06-03 |
DE69031075D1 (de) | 1997-08-21 |
ATE155458T1 (de) | 1997-08-15 |
JP2557568B2 (ja) | 1996-11-27 |
JPH09100287A (ja) | 1997-04-15 |
JP2708737B2 (ja) | 1998-02-04 |
EP0487602B1 (fr) | 1997-07-16 |
CA2332188C (fr) | 2007-01-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO920600L (no) | 5-(1-aminocykloheksyl)-2(1h)-pyridinon og beslektede forbindelser | |
DK0461079T3 (da) | Substituerede phthalider og heterocykliske phthalider | |
SE7906722L (sv) | Merkaptoacylderivat av substituerade proliner | |
SE7907121L (sv) | Ftalimidinderivat | |
DK0450812T3 (da) | Antihypercholesterolemika | |
ES2121761T3 (es) | Carbamatos sustituidos de 1-(piridinilamino sustituido)-1h-indol-5-ilo, un procedimiento para su preparacion y su uso como medicamentos. | |
ES2022342B3 (es) | Hidrazinas n-(opcinalmente sustituidas)-n'-sustituidas-n, n'-disustituidas, insecticidas. | |
ATE76405T1 (de) | 2-trifluormethyl-benzimidazole. | |
NO874872D0 (no) | Kondenderte heterocykliske tetrahydroaminokinolinoler og beslektede forbindelser samt fremgangsmaate for fremstilling derav. | |
HUT42277A (en) | Herbicides containing as active subtance derivatives of new 1-aryl-4-nitro-pirasole and process for production of the active substances | |
DK177783D0 (da) | Organosilylforbindelser og fungicider indeholdende sadanne forbindelser | |
NO913140L (no) | 1-(pyridinylalkyl)-1h-indoler, indoliner og beslektede analoger. | |
DK470287D0 (da) | 2-cyano-2-alkoximino-acetamider, deres fremstilling og anvendelse til bekaempelse af skadelige organismer | |
NO911998L (no) | Pyrido(3,4-b)(pyrrolo(1,2-e)(1,4,5)oksadiazepin og beslektede analoger og fremgangsmaate for fremstilling derav. | |
FI902851A0 (fi) | 4,5,5a,6-tetrahydro-3h-isoxazolo/5,4,3 -kl/akridinderivat, foerfarande foer deras framstaellande och deras anvaendning som laekemedel. | |
SE7704033L (sv) | Oxotiaforeningar | |
SE8203245L (sv) | Forfarande for enantioselektiv framstellning av n-substituerade prolinderivat | |
DK0485716T3 (da) | Fremgangsmåde til fremstilling af insekticide, nematicide og acaricide 4-substituerede 5-(trifluormethyl)pyrrol-3-carbonitril-forbindelser | |
ZA832824B (en) | New therapeutically useful dithiino (1,4)(2,3-c)pyrrole derivatives |