NO904003L - 1,2,4-benzotriazinoksider som radiosensibiliseringsmidlerog selektive cytotoksiske midler. - Google Patents

1,2,4-benzotriazinoksider som radiosensibiliseringsmidlerog selektive cytotoksiske midler.

Info

Publication number
NO904003L
NO904003L NO90904003A NO904003A NO904003L NO 904003 L NO904003 L NO 904003L NO 90904003 A NO90904003 A NO 90904003A NO 904003 A NO904003 A NO 904003A NO 904003 L NO904003 L NO 904003L
Authority
NO
Norway
Prior art keywords
cytotoxic agents
radiosensibilizers
selective cytotoxic
benzotriazine oxides
disclosed
Prior art date
Application number
NO90904003A
Other languages
English (en)
Other versions
NO179005C (no
NO179005B (no
NO904003D0 (no
Inventor
William W Lee
Martin J Brown
Edward W Grange
Abelardo P Martinez
Michael Tracy
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of NO904003L publication Critical patent/NO904003L/no
Publication of NO904003D0 publication Critical patent/NO904003D0/no
Publication of NO179005B publication Critical patent/NO179005B/no
Publication of NO179005C publication Critical patent/NO179005C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
NO904003A 1988-03-18 1990-09-13 Analogifremgangsmåte for fremstilling av terapeutisk aktive 1,2,4-benzotriazinoksider NO179005C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16987388A 1988-03-18 1988-03-18
PCT/US1989/001037 WO1989008647A1 (en) 1988-03-18 1989-03-15 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (4)

Publication Number Publication Date
NO904003L true NO904003L (no) 1990-09-13
NO904003D0 NO904003D0 (no) 1990-09-13
NO179005B NO179005B (no) 1996-04-09
NO179005C NO179005C (no) 1996-07-17

Family

ID=22617563

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904003A NO179005C (no) 1988-03-18 1990-09-13 Analogifremgangsmåte for fremstilling av terapeutisk aktive 1,2,4-benzotriazinoksider

Country Status (14)

Country Link
EP (1) EP0413706B1 (no)
JP (1) JP2793312B2 (no)
KR (1) KR0140894B1 (no)
AT (1) ATE170515T1 (no)
AU (1) AU637572B2 (no)
CA (1) CA1339217C (no)
DE (1) DE68928802T2 (no)
DK (1) DK175885B1 (no)
ES (1) ES2013123A6 (no)
IE (1) IE62911B1 (no)
NO (1) NO179005C (no)
NZ (1) NZ228323A (no)
PT (1) PT90039B (no)
WO (1) WO1989008647A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3034541B2 (ja) * 1989-09-18 2000-04-17 エスアールアイ インターナショナル 放射線増感剤および選択的細胞毒性物質としての１，２，４―ベンゾトリアジンオキシド
US5110347A (en) * 1990-11-26 1992-05-05 E. I Du Pont De Nemours And Company Substituted fused heterocyclic herbicides
WO2005082867A1 (en) * 2004-03-01 2005-09-09 Auckland Uniservices Limited Novel 1,2,4-benzotriazine-1,4-dioxides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (de) * 1963-10-22 1970-03-15 Siegfried Ag Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) * 1972-11-15 1978-03-30 Bayer Ag, 5090 Leverkusen Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IL44058A (en) * 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
SE7501624L (no) * 1974-03-15 1975-09-16 Ciba Geigy Ag
DE2538179C2 (de) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) * 1977-09-10 1979-03-22 Bayer Ag Mittel zur bekaempfung von pflanzenbakteriosen
WO1988002366A1 (en) * 1986-09-25 1988-04-07 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Also Published As

Publication number Publication date
ES2013123A6 (es) 1990-04-16
ATE170515T1 (de) 1998-09-15
DK223090A (da) 1990-11-15
AU637572B2 (en) 1993-06-03
NO179005C (no) 1996-07-17
NO179005B (no) 1996-04-09
DE68928802T2 (de) 1999-04-01
DK223090D0 (da) 1990-09-17
JPH03505867A (ja) 1991-12-19
JP2793312B2 (ja) 1998-09-03
PT90039A (pt) 1989-11-10
WO1989008647A1 (en) 1989-09-21
CA1339217C (en) 1997-08-05
IE62911B1 (en) 1995-03-08
DK175885B1 (da) 2005-05-23
NO904003D0 (no) 1990-09-13
NZ228323A (en) 1992-09-25
EP0413706B1 (en) 1998-09-02
AU3433789A (en) 1989-10-05
KR0140894B1 (ko) 1998-06-01
PT90039B (pt) 1994-05-31
DE68928802D1 (de) 1998-10-08
EP0413706A1 (en) 1991-02-27
IE890721L (en) 1989-09-18
KR900700466A (ko) 1990-08-13

Similar Documents

Publication Publication Date Title
MX9200675A (es) Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral.
ES8606289A1 (es) Un procedimiento para la preparacion de piridazinaminas.
ATE81505T1 (de) Azacycloalkanderivate, absorptionspromotoren, die die derivate als effektiven inhaltsstoff enthalten und aeusserlich anzuwendende praeparate, die absorptionspromotoren enthalten.
SE8504720D0 (sv) New drug preparation
HN1998000143A (es) Tetrahidronaftalenos substituidos y compuestos analogos.
GB8824869D0 (en) Synthetic antibody
NO165922C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO166080C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6,8-trifluorkinoliner.
SE8700203D0 (sv) Pyroglutamide derivatives
ES2058343T3 (es) Piridinas disubstituidas.
NO163486C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oxy-4h-3,1-benzoxazin-4-on-derivater.
ATE80616T1 (de) Prostaglandin e1-derivate und ihre therapeutische anwendung.
FI902966A0 (fi) Stabil frystorkad polyhematoporfyrineter/esterkomposition.
NO904003L (no) 1,2,4-benzotriazinoksider som radiosensibiliseringsmidlerog selektive cytotoksiske midler.
ES2068714T3 (es) Derivados de pirimidina para aumentar la actividad antitumoral.
ES546701A0 (es) Procedimiento para preparar un agente terapeutico a base de celulas tumorales humanas y eventualmente, neuraminidasa.
ZA862484B (en) Peptides
ZA864610B (en) Use of benzamido-azabicyclo compounds in the treatment of migraine,nausea,vomiting and cardiac arrhythmia
EP0147707A3 (en) 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
ES2032797T3 (es) Agente terapeutico para el tratamiento de la enfermedad ulcera peptica.
NO854277L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 6-fenetylaminoalkyl-7-hydroksy-furo-(3,4-c)-pyridin-derivater.
GB2185254A (en) Benzamide and nicotinamide radiosensitizers
TR20690A (tr) Kirisler,raylar veya diger benzer profillerin olusturulmasina mahsus ueniversel bir haddeleme tesisinin bir haddeleme uenitesinin tek bir merdane takimina,bircok degisik haddeleme girintisinin,gecme suretiyle,yerlestirilmesine mahsus usul;merdaneler,haddeleme ueniteleri ve haddeleme tesisleri
GR1000941B (el) Μεθοδος παρασκευης οξειδιων 1,2,4,βενζοτριαζινης.
NO164973C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive gem-dihalo- og tetrahalo-1,2-diamino-4,9,-diaza-dodecaner.

Legal Events

Date Code Title Description
MK1K Patent expired