KR900700466A - 방사선 감수성 증강물질 및 선택적인 세포장해제로서의 1,2,4- 벤조 트리아진 옥사이드 - Google Patents

방사선 감수성 증강물질 및 선택적인 세포장해제로서의 1,2,4- 벤조 트리아진 옥사이드

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Publication number
KR900700466A
KR900700466A KR1019890702141A KR890702141A KR900700466A KR 900700466 A KR900700466 A KR 900700466A KR 1019890702141 A KR1019890702141 A KR 1019890702141A KR 890702141 A KR890702141 A KR 890702141A KR 900700466 A KR900700466 A KR 900700466A
Authority
KR
South Korea
Prior art keywords
cytotoxic agent
radiation sensitive
selective cytotoxic
benzotriazine oxide
sensitive enhancer
Prior art date
Application number
KR1019890702141A
Other languages
English (en)
Other versions
KR0140894B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR900700466A publication Critical patent/KR900700466A/ko
Application granted granted Critical
Publication of KR0140894B1 publication Critical patent/KR0140894B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019890702141A 1988-03-18 1989-03-15 방사선감수성증강물질 및 선택적인 세포장해제로서의 1,2,4- 벤조트리아진 옥사이드 KR0140894B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16987388A 1988-03-18 1988-03-18
US169,873 1988-03-18
USPUS89/01037 1989-03-15
PCT/US1989/001037 WO1989008647A1 (en) 1988-03-18 1989-03-15 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (2)

Publication Number Publication Date
KR900700466A true KR900700466A (ko) 1990-08-13
KR0140894B1 KR0140894B1 (ko) 1998-06-01

Family

ID=22617563

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702141A KR0140894B1 (ko) 1988-03-18 1989-03-15 방사선감수성증강물질 및 선택적인 세포장해제로서의 1,2,4- 벤조트리아진 옥사이드

Country Status (14)

Country Link
EP (1) EP0413706B1 (ko)
JP (1) JP2793312B2 (ko)
KR (1) KR0140894B1 (ko)
AT (1) ATE170515T1 (ko)
AU (1) AU637572B2 (ko)
CA (1) CA1339217C (ko)
DE (1) DE68928802T2 (ko)
DK (1) DK175885B1 (ko)
ES (1) ES2013123A6 (ko)
IE (1) IE62911B1 (ko)
NO (1) NO179005C (ko)
NZ (1) NZ228323A (ko)
PT (1) PT90039B (ko)
WO (1) WO1989008647A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE183094T1 (de) 1989-09-18 1999-08-15 Stanford Res Inst Int 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel
US5110347A (en) * 1990-11-26 1992-05-05 E. I Du Pont De Nemours And Company Substituted fused heterocyclic herbicides
WO2005082867A1 (en) * 2004-03-01 2005-09-09 Auckland Uniservices Limited Novel 1,2,4-benzotriazine-1,4-dioxides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (de) * 1963-10-22 1970-03-15 Siegfried Ag Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) * 1972-11-15 1978-03-30 Bayer Ag, 5090 Leverkusen Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IE38778B1 (en) * 1973-02-02 1978-05-24 Ciba Geigy New 1,2,4-benzotriazine derivatives
SE7501624L (ko) * 1974-03-15 1975-09-16 Ciba Geigy Ag
DE2538179C2 (de) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) * 1977-09-10 1979-03-22 Bayer Ag Mittel zur bekaempfung von pflanzenbakteriosen
DE3790581T1 (ko) * 1986-09-25 1988-08-25

Also Published As

Publication number Publication date
DK223090D0 (da) 1990-09-17
NO179005C (no) 1996-07-17
NO179005B (no) 1996-04-09
PT90039B (pt) 1994-05-31
JPH03505867A (ja) 1991-12-19
NZ228323A (en) 1992-09-25
NO904003L (no) 1990-09-13
EP0413706B1 (en) 1998-09-02
WO1989008647A1 (en) 1989-09-21
EP0413706A1 (en) 1991-02-27
ATE170515T1 (de) 1998-09-15
DK223090A (da) 1990-11-15
PT90039A (pt) 1989-11-10
JP2793312B2 (ja) 1998-09-03
DK175885B1 (da) 2005-05-23
DE68928802D1 (de) 1998-10-08
NO904003D0 (no) 1990-09-13
AU3433789A (en) 1989-10-05
KR0140894B1 (ko) 1998-06-01
ES2013123A6 (es) 1990-04-16
IE890721L (en) 1989-09-18
AU637572B2 (en) 1993-06-03
DE68928802T2 (de) 1999-04-01
IE62911B1 (en) 1995-03-08
CA1339217C (en) 1997-08-05

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