DK223090A - Anvendelse af 1,2,4-benzotriazinoxider som straalingssensibiliserende midler og selektive cytotoksiske midler - Google Patents
Anvendelse af 1,2,4-benzotriazinoxider som straalingssensibiliserende midler og selektive cytotoksiske midler Download PDFInfo
- Publication number
- DK223090A DK223090A DK223090A DK223090A DK223090A DK 223090 A DK223090 A DK 223090A DK 223090 A DK223090 A DK 223090A DK 223090 A DK223090 A DK 223090A DK 223090 A DK223090 A DK 223090A
- Authority
- DK
- Denmark
- Prior art keywords
- cytotoxic agents
- benzotriazinoxides
- application
- selective cytotoxic
- radiation sensitizers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16987388A | 1988-03-18 | 1988-03-18 | |
US16987388 | 1988-03-18 | ||
US8901037 | 1989-03-15 | ||
PCT/US1989/001037 WO1989008647A1 (en) | 1988-03-18 | 1989-03-15 | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
Publications (3)
Publication Number | Publication Date |
---|---|
DK223090D0 DK223090D0 (da) | 1990-09-17 |
DK223090A true DK223090A (da) | 1990-11-15 |
DK175885B1 DK175885B1 (da) | 2005-05-23 |
Family
ID=22617563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK199002230A DK175885B1 (da) | 1988-03-18 | 1990-09-17 | Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0413706B1 (da) |
JP (1) | JP2793312B2 (da) |
KR (1) | KR0140894B1 (da) |
AT (1) | ATE170515T1 (da) |
AU (1) | AU637572B2 (da) |
CA (1) | CA1339217C (da) |
DE (1) | DE68928802T2 (da) |
DK (1) | DK175885B1 (da) |
ES (1) | ES2013123A6 (da) |
IE (1) | IE62911B1 (da) |
NO (1) | NO179005C (da) |
NZ (1) | NZ228323A (da) |
PT (1) | PT90039B (da) |
WO (1) | WO1989008647A1 (da) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68929050T2 (de) * | 1989-09-18 | 2000-02-03 | Sri International, Menlo Park | 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel |
US5110347A (en) * | 1990-11-26 | 1992-05-05 | E. I Du Pont De Nemours And Company | Substituted fused heterocyclic herbicides |
EP1723125A4 (en) * | 2004-03-01 | 2009-11-18 | Auckland Uniservices Ltd | 1,2,4-benzotriazine-1,4-dioxides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2489352A (en) * | 1946-04-10 | 1949-11-29 | Merck & Co Inc | Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1 |
US2489359A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
CH487171A (de) * | 1963-10-22 | 1970-03-15 | Siegfried Ag | Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine |
DE1809390A1 (de) * | 1968-11-16 | 1970-06-11 | Bayer Ag | Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung |
DE2255825C3 (de) * | 1972-11-15 | 1978-03-30 | Bayer Ag, 5090 Leverkusen | Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4) |
IL44058A (en) * | 1973-02-02 | 1978-10-31 | Ciba Geigy Ag | 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them |
SE7501624L (da) * | 1974-03-15 | 1975-09-16 | Ciba Geigy Ag | |
DE2538179C2 (de) * | 1975-08-27 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide |
US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
DE2740887A1 (de) * | 1977-09-10 | 1979-03-22 | Bayer Ag | Mittel zur bekaempfung von pflanzenbakteriosen |
JP2668232B2 (ja) * | 1986-09-25 | 1997-10-27 | エス・アール・アイ・インターナシヨナル | 放射線増感剤及び選択性細胞毒性剤としての1,2,4―ベンゾトリアジンオキシド |
-
1989
- 1989-03-06 IE IE72189A patent/IE62911B1/en not_active IP Right Cessation
- 1989-03-08 CA CA000593060A patent/CA1339217C/en not_active Expired - Fee Related
- 1989-03-14 NZ NZ228323A patent/NZ228323A/en unknown
- 1989-03-15 JP JP1504293A patent/JP2793312B2/ja not_active Expired - Fee Related
- 1989-03-15 DE DE68928802T patent/DE68928802T2/de not_active Expired - Fee Related
- 1989-03-15 AT AT89904704T patent/ATE170515T1/de not_active IP Right Cessation
- 1989-03-15 EP EP89904704A patent/EP0413706B1/en not_active Expired - Lifetime
- 1989-03-15 AU AU34337/89A patent/AU637572B2/en not_active Ceased
- 1989-03-15 WO PCT/US1989/001037 patent/WO1989008647A1/en active IP Right Grant
- 1989-03-15 KR KR1019890702141A patent/KR0140894B1/ko not_active IP Right Cessation
- 1989-03-17 PT PT90039A patent/PT90039B/pt not_active IP Right Cessation
- 1989-03-17 ES ES8900991A patent/ES2013123A6/es not_active Expired - Lifetime
-
1990
- 1990-09-13 NO NO904003A patent/NO179005C/no not_active IP Right Cessation
- 1990-09-17 DK DK199002230A patent/DK175885B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0413706A1 (en) | 1991-02-27 |
ES2013123A6 (es) | 1990-04-16 |
NO179005B (no) | 1996-04-09 |
NO179005C (no) | 1996-07-17 |
DE68928802D1 (de) | 1998-10-08 |
ATE170515T1 (de) | 1998-09-15 |
NO904003L (no) | 1990-09-13 |
EP0413706B1 (en) | 1998-09-02 |
KR0140894B1 (ko) | 1998-06-01 |
NZ228323A (en) | 1992-09-25 |
IE62911B1 (en) | 1995-03-08 |
JP2793312B2 (ja) | 1998-09-03 |
PT90039A (pt) | 1989-11-10 |
CA1339217C (en) | 1997-08-05 |
DE68928802T2 (de) | 1999-04-01 |
PT90039B (pt) | 1994-05-31 |
DK223090D0 (da) | 1990-09-17 |
AU637572B2 (en) | 1993-06-03 |
AU3433789A (en) | 1989-10-05 |
NO904003D0 (no) | 1990-09-13 |
IE890721L (en) | 1989-09-18 |
DK175885B1 (da) | 2005-05-23 |
KR900700466A (ko) | 1990-08-13 |
WO1989008647A1 (en) | 1989-09-21 |
JPH03505867A (ja) | 1991-12-19 |
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PBP | Patent lapsed |
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