GB2185254A - Benzamide and nicotinamide radiosensitizers - Google Patents

Benzamide and nicotinamide radiosensitizers

Info

Publication number
GB2185254A
GB2185254A GB08630514A GB8630514A GB2185254A GB 2185254 A GB2185254 A GB 2185254A GB 08630514 A GB08630514 A GB 08630514A GB 8630514 A GB8630514 A GB 8630514A GB 2185254 A GB2185254 A GB 2185254A
Authority
GB
United Kingdom
Prior art keywords
nicotinamide
benzamide
radiosensitizers
dervatives
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08630514A
Other versions
GB8630514D0 (en
GB2185254B (en
Inventor
William W Lee
Martin J Brown
Edward W Grange
Abelardo P Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of GB8630514D0 publication Critical patent/GB8630514D0/en
Publication of GB2185254A publication Critical patent/GB2185254A/en
Application granted granted Critical
Publication of GB2185254B publication Critical patent/GB2185254B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method for sensitizing hypoxic tumor cells to radiation using dervatives of benzamide and nicotinamide. Some of the compounds useful in the method of the invention are novel.
GB8630514A 1985-05-03 1986-04-30 Benzamide and nicotinamide radiosensitizers Expired GB2185254B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73076185A 1985-05-03 1985-05-03
US78876285A 1985-10-18 1985-10-18
PCT/US1986/000976 WO1986006628A1 (en) 1985-05-03 1986-04-30 Benzamide and nicotinamide radiosensitizers

Publications (3)

Publication Number Publication Date
GB8630514D0 GB8630514D0 (en) 1987-01-28
GB2185254A true GB2185254A (en) 1987-07-15
GB2185254B GB2185254B (en) 1989-09-13

Family

ID=27112105

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8630514A Expired GB2185254B (en) 1985-05-03 1986-04-30 Benzamide and nicotinamide radiosensitizers

Country Status (3)

Country Link
DE (1) DE3690206T1 (en)
GB (1) GB2185254B (en)
WO (1) WO1986006628A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177075A (en) * 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence
WO1998027975A1 (en) * 1996-12-20 1998-07-02 Geron Corporation Poly(adp-ribose) polymerase inhibitors to treat diseases associated with cellular senescence

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2106509A1 (en) * 1970-02-13 1971-08-19 Recherches Pharmaceutiques et Seien tifiques, Paris, Omnium Chimique S A , Brüssel Aryloxy propanolamine
AU522049B2 (en) * 1978-01-13 1982-05-13 Van Scott, Eugene Joseph Treatment of psoriasis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584715A (en) * 1967-06-06 1970-01-02
IL45396A0 (en) * 1973-08-23 1974-11-29 Beecham Group Ltd Pharmaceutical compositions containing aryl aralkyl ether and thioether derivatives,certain such novel compounds and their preparation
DK149748C (en) * 1978-08-25 1987-04-06 Daiichi Seiyaku Co ANALOGY PROCEDURE FOR THE PREPARATION OF N-PHENETHYLACETAMIDE COMPOUNDS
JPS5874680A (en) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd Beta-lactam compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2106509A1 (en) * 1970-02-13 1971-08-19 Recherches Pharmaceutiques et Seien tifiques, Paris, Omnium Chimique S A , Brüssel Aryloxy propanolamine
AU522049B2 (en) * 1978-01-13 1982-05-13 Van Scott, Eugene Joseph Treatment of psoriasis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, VOL. 93, NO. 7, 18 AUGUST 1980 PAGE 112 *
JOURNAL OF MEDICINAL CHEMISTRY, VOL. 20, NO. 1, JANUARY 1977 PAGE 132 *

Also Published As

Publication number Publication date
GB8630514D0 (en) 1987-01-28
WO1986006628A1 (en) 1986-11-20
GB2185254B (en) 1989-09-13
DE3690206T1 (en) 1987-09-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940430