DK175885B1 - Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler - Google Patents

Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler Download PDF

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Publication number
DK175885B1
DK175885B1 DK199002230A DK223090A DK175885B1 DK 175885 B1 DK175885 B1 DK 175885B1 DK 199002230 A DK199002230 A DK 199002230A DK 223090 A DK223090 A DK 223090A DK 175885 B1 DK175885 B1 DK 175885B1
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DK
Denmark
Prior art keywords
hydrocarbyl
halogen
alkoxy
hydroxy
optionally
Prior art date
Application number
DK199002230A
Other languages
Danish (da)
English (en)
Other versions
DK223090A (da
DK223090D0 (da
Inventor
William W Lee
J Martin Brown
Edward W Grange
Abelardo P Martinez
Michael Tracy
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of DK223090D0 publication Critical patent/DK223090D0/da
Publication of DK223090A publication Critical patent/DK223090A/da
Application granted granted Critical
Publication of DK175885B1 publication Critical patent/DK175885B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
DK199002230A 1988-03-18 1990-09-17 Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler DK175885B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16987388A 1988-03-18 1988-03-18
US16987388 1988-03-18
US8901037 1989-03-15
PCT/US1989/001037 WO1989008647A1 (en) 1988-03-18 1989-03-15 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (3)

Publication Number Publication Date
DK223090D0 DK223090D0 (da) 1990-09-17
DK223090A DK223090A (da) 1990-11-15
DK175885B1 true DK175885B1 (da) 2005-05-23

Family

ID=22617563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002230A DK175885B1 (da) 1988-03-18 1990-09-17 Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler

Country Status (14)

Country Link
EP (1) EP0413706B1 (no)
JP (1) JP2793312B2 (no)
KR (1) KR0140894B1 (no)
AT (1) ATE170515T1 (no)
AU (1) AU637572B2 (no)
CA (1) CA1339217C (no)
DE (1) DE68928802T2 (no)
DK (1) DK175885B1 (no)
ES (1) ES2013123A6 (no)
IE (1) IE62911B1 (no)
NO (1) NO179005C (no)
NZ (1) NZ228323A (no)
PT (1) PT90039B (no)
WO (1) WO1989008647A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929050T2 (de) * 1989-09-18 2000-02-03 Sri International, Menlo Park 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel
US5110347A (en) * 1990-11-26 1992-05-05 E. I Du Pont De Nemours And Company Substituted fused heterocyclic herbicides
EP1723125A4 (en) * 2004-03-01 2009-11-18 Auckland Uniservices Ltd 1,2,4-benzotriazine-1,4-dioxides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (de) * 1963-10-22 1970-03-15 Siegfried Ag Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) * 1972-11-15 1978-03-30 Bayer Ag, 5090 Leverkusen Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IL44058A (en) * 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
SE7501624L (no) * 1974-03-15 1975-09-16 Ciba Geigy Ag
DE2538179C2 (de) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) * 1977-09-10 1979-03-22 Bayer Ag Mittel zur bekaempfung von pflanzenbakteriosen
JP2668232B2 (ja) * 1986-09-25 1997-10-27 エス・アール・アイ・インターナシヨナル 放射線増感剤及び選択性細胞毒性剤としての１，２，４―ベンゾトリアジンオキシド

Also Published As

Publication number Publication date
EP0413706A1 (en) 1991-02-27
ES2013123A6 (es) 1990-04-16
NO179005B (no) 1996-04-09
NO179005C (no) 1996-07-17
DE68928802D1 (de) 1998-10-08
ATE170515T1 (de) 1998-09-15
NO904003L (no) 1990-09-13
EP0413706B1 (en) 1998-09-02
DK223090A (da) 1990-11-15
KR0140894B1 (ko) 1998-06-01
NZ228323A (en) 1992-09-25
IE62911B1 (en) 1995-03-08
JP2793312B2 (ja) 1998-09-03
PT90039A (pt) 1989-11-10
CA1339217C (en) 1997-08-05
DE68928802T2 (de) 1999-04-01
PT90039B (pt) 1994-05-31
DK223090D0 (da) 1990-09-17
AU637572B2 (en) 1993-06-03
AU3433789A (en) 1989-10-05
NO904003D0 (no) 1990-09-13
IE890721L (en) 1989-09-18
KR900700466A (ko) 1990-08-13
WO1989008647A1 (en) 1989-09-21
JPH03505867A (ja) 1991-12-19

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