NO894228L - Tienopyridiner, fremstilling, mellomprodukter og farmasoeytiske preparater. - Google Patents

Tienopyridiner, fremstilling, mellomprodukter og farmasoeytiske preparater.

Info

Publication number
NO894228L
NO894228L NO89894228A NO894228A NO894228L NO 894228 L NO894228 L NO 894228L NO 89894228 A NO89894228 A NO 89894228A NO 894228 A NO894228 A NO 894228A NO 894228 L NO894228 L NO 894228L
Authority
NO
Norway
Prior art keywords
alkyl
pyridine
thieno
group
ethyl
Prior art date
Application number
NO89894228A
Other languages
English (en)
Norwegian (no)
Other versions
NO894228D0 (no
Inventor
Robert John Ife
Thomas Henry Brown
Colin Andrew Leach
Original Assignee
Smithkline Beckman Intercredit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Intercredit filed Critical Smithkline Beckman Intercredit
Publication of NO894228D0 publication Critical patent/NO894228D0/no
Publication of NO894228L publication Critical patent/NO894228L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO89894228A 1988-02-25 1989-10-24 Tienopyridiner, fremstilling, mellomprodukter og farmasoeytiske preparater. NO894228L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888804448A GB8804448D0 (en) 1988-02-25 1988-02-25 Compounds
PCT/EP1989/000174 WO1989008112A1 (en) 1988-02-25 1989-02-20 Thienopyridines, preparation, intermediates and pharmaceutical compositions

Publications (2)

Publication Number Publication Date
NO894228D0 NO894228D0 (no) 1989-10-24
NO894228L true NO894228L (no) 1989-10-24

Family

ID=10632380

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89894228A NO894228L (no) 1988-02-25 1989-10-24 Tienopyridiner, fremstilling, mellomprodukter og farmasoeytiske preparater.

Country Status (16)

Country Link
US (1) US4935431A (de)
EP (1) EP0334491A1 (de)
JP (1) JPH02503317A (de)
KR (1) KR900700485A (de)
CN (1) CN1035508A (de)
AU (1) AU3181689A (de)
DK (1) DK528689D0 (de)
FI (1) FI895047A7 (de)
GB (1) GB8804448D0 (de)
HU (1) HU891461D0 (de)
IL (1) IL89347A0 (de)
NO (1) NO894228L (de)
PT (1) PT89793A (de)
WO (1) WO1989008112A1 (de)
ZA (1) ZA891440B (de)
ZW (1) ZW2089A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
NZ233641A (en) * 1989-05-16 1992-07-28 Merrell Dow Pharma Quinoline and thienopyridine derivatives and excitatory amino acid antagonistic pharmaceutical compositions
US5026700A (en) * 1989-05-16 1991-06-25 Merrell Dow Pharmaceuticals Certain quinolines and thienopyridines as excitatory amino acid antagonists
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
GB9010296D0 (en) * 1990-05-08 1990-06-27 Beecham Group Plc Novel compounds
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
KR0169813B1 (ko) * 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
WO1999043681A1 (en) 1998-02-26 1999-09-02 Neurogen Corporation 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
MX2007007026A (es) * 2004-12-17 2007-07-04 Hoffmann La Roche Derivados de tieno-piridina como intensificadores alostericos de gaba-b.
CN101189208A (zh) 2005-06-02 2008-05-28 弗·哈夫曼-拉罗切有限公司 作为gaba-b增强剂的3-甲磺酰基喹啉
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CA2696948C (en) 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
KR20100080597A (ko) 2007-09-14 2010-07-09 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된-４-페닐-1ｈ-피리딘-2-온
KR20100065191A (ko) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 １,３-이치환된 ４-(아릴-ｘ-페닐)-１ｈ-피리딘-２-온
EP2220083B1 (de) 2007-11-14 2017-07-19 Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]-pyridin-derivate und ihre verwendung als positive allosterische modulatoren von mglur2-rezeptoren
EP2574610A1 (de) * 2007-11-15 2013-04-03 Gilead Sciences, Inc. Hemmer der Replikation des menschlichen Immundefizienz-Virus
CA2735764C (en) 2008-09-02 2016-06-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
EP2643320B1 (de) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridinderivate und ihre verwendung als positiv allosterische modulatoren des mglur2 receptors
CA2815002C (en) 2010-11-08 2019-10-22 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR102414246B1 (ko) 2014-01-21 2022-06-27 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
LT3431106T (lt) 2014-01-21 2021-02-10 Janssen Pharmaceutica Nv Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652398A (en) * 1949-11-17 1953-09-15 Endo Products Inc N-substituted-2-amino (methyl) quinolines
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
EP0126970A3 (de) * 1983-04-27 1985-11-06 Beecham Group Plc Anxiolytische und anti-depressante Thienopyridinderivate
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
HU891461D0 (en) 1990-01-28
PT89793A (pt) 1989-10-04
DK528689A (da) 1989-10-24
DK528689D0 (da) 1989-10-24
FI895047A0 (fi) 1989-10-24
ZA891440B (en) 1990-10-31
WO1989008112A1 (en) 1989-09-08
NO894228D0 (no) 1989-10-24
AU3181689A (en) 1989-09-22
IL89347A0 (en) 1989-12-15
FI895047A7 (fi) 1989-10-24
ZW2089A1 (en) 1989-09-13
CN1035508A (zh) 1989-09-13
KR900700485A (ko) 1990-08-13
GB8804448D0 (en) 1988-03-23
EP0334491A1 (de) 1989-09-27
US4935431A (en) 1990-06-19
JPH02503317A (ja) 1990-10-11

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