NO880268D0 - Fremgangsmaate for fremstilling av anti-koagulerende peptider. - Google Patents

Fremgangsmaate for fremstilling av anti-koagulerende peptider.

Info

Publication number
NO880268D0
NO880268D0 NO880268A NO880268A NO880268D0 NO 880268 D0 NO880268 D0 NO 880268D0 NO 880268 A NO880268 A NO 880268A NO 880268 A NO880268 A NO 880268A NO 880268 D0 NO880268 D0 NO 880268D0
Authority
NO
Norway
Prior art keywords
coagulating
peptides
procedure
preparation
coagulating peptides
Prior art date
Application number
NO880268A
Other languages
English (en)
Other versions
NO880268L (no
NO174105C (no
NO174105B (no
Inventor
John L Krstenansky
Simon J T Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO880268D0 publication Critical patent/NO880268D0/no
Publication of NO880268L publication Critical patent/NO880268L/no
Publication of NO174105B publication Critical patent/NO174105B/no
Publication of NO174105C publication Critical patent/NO174105C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
NO880268A 1987-01-23 1988-01-22 Analogifremgangsmåte for fremstilling av antikoagulerende peptider NO174105C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US641787A 1987-01-23 1987-01-23
US5316287A 1987-05-21 1987-05-21

Publications (4)

Publication Number Publication Date
NO880268D0 true NO880268D0 (no) 1988-01-22
NO880268L NO880268L (no) 1988-07-25
NO174105B NO174105B (no) 1993-12-06
NO174105C NO174105C (no) 1994-03-16

Family

ID=26675603

Family Applications (1)

Application Number Title Priority Date Filing Date
NO880268A NO174105C (no) 1987-01-23 1988-01-22 Analogifremgangsmåte for fremstilling av antikoagulerende peptider

Country Status (19)

Country Link
EP (1) EP0276014B1 (no)
JP (1) JP2709817B2 (no)
KR (1) KR960014105B1 (no)
CN (1) CN88100260A (no)
AR (1) AR245140A1 (no)
AT (1) ATE110743T1 (no)
AU (1) AU601801B2 (no)
CA (1) CA1341032C (no)
DE (1) DE3851238T2 (no)
DK (1) DK173757B1 (no)
ES (1) ES2063740T3 (no)
FI (1) FI89060C (no)
HU (1) HU199159B (no)
IE (1) IE63547B1 (no)
IL (1) IL85159A (no)
NO (1) NO174105C (no)
NZ (1) NZ223236A (no)
PH (1) PH26263A (no)
PT (1) PT86600B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
JPH04503660A (ja) * 1988-12-05 1992-07-02 バイオジェン インコーポレイテッド 血小板凝集抑制の方法及び組成物
US5232912A (en) * 1988-12-07 1993-08-03 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
CA2026376C (en) * 1989-10-03 2002-01-01 John L. Krstenansky Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4005591A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
EP0540574B1 (en) * 1990-07-24 1996-09-11 Merrell Pharmaceuticals Inc. Anticoagulant peptides
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
CA2081305A1 (en) * 1991-03-05 1992-09-06 Japan Energy Corporation Hirudin variants or their salts, method for their production and anticoagulants having said compounds as active ingredients
US5767235A (en) * 1991-03-05 1998-06-16 Nippon Mining Company Limited Anticoagulant hirudin variants and methods for their production
IT1250689B (it) * 1991-07-22 1995-04-21 Marco Gerna Analoghi dell'irudina e procedimento per la loro preparazione
PT100757A (pt) * 1991-07-31 1993-10-29 Pasteur Institut Polipeptidos aptos para induzir "in vivo"anticorpos capazes de inibir a invasao de globulos vermelhos por merozoitos de "p.falciparum", produtos aparentados e sua aplicacao na producao de composicoes de vacinacao
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) * 1996-06-28 1998-11-03 Bayer Corporation Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) * 2002-04-23 2002-06-05 Evolutec Ltd Anticoagulants
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
CN102757479B (zh) * 2012-05-09 2014-04-30 北京林业大学 高活性降血压肽及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.

Also Published As

Publication number Publication date
FI89060B (fi) 1993-04-30
HUT46339A (en) 1988-10-28
ATE110743T1 (de) 1994-09-15
NO880268L (no) 1988-07-25
HU199159B (en) 1990-01-29
IL85159A0 (en) 1988-06-30
DK31088A (da) 1988-07-24
EP0276014A3 (en) 1990-05-16
KR880009045A (ko) 1988-09-13
DE3851238D1 (de) 1994-10-06
NO174105C (no) 1994-03-16
PT86600A (pt) 1988-02-01
ES2063740T3 (es) 1995-01-16
JP2709817B2 (ja) 1998-02-04
IL85159A (en) 1993-04-04
EP0276014A2 (en) 1988-07-27
NZ223236A (en) 1989-11-28
PH26263A (en) 1992-04-01
KR960014105B1 (ko) 1996-10-14
AR245140A1 (es) 1993-12-30
FI880286A (fi) 1988-07-24
DK31088D0 (da) 1988-01-22
DK173757B1 (da) 2001-09-10
CN88100260A (zh) 1988-11-09
PT86600B (pt) 1991-12-31
AU1072988A (en) 1988-07-28
JPS63215698A (ja) 1988-09-08
FI880286A0 (fi) 1988-01-22
DE3851238T2 (de) 1995-03-16
EP0276014B1 (en) 1994-08-31
NO174105B (no) 1993-12-06
AU601801B2 (en) 1990-09-20
IE880167L (en) 1988-07-23
CA1341032C (en) 2000-06-20
IE63547B1 (en) 1995-05-17
FI89060C (fi) 1993-08-10

Similar Documents

Publication Publication Date Title
NO880268D0 (no) Fremgangsmaate for fremstilling av anti-koagulerende peptider.
NO874530D0 (no) Fremgangsmaate for fremstilling av nor-statin- eller nor-cyklostatin-polypeptider.
NO882200D0 (no) Fremgangsmaate for fremstilling av kalsiumsulfat-alfa-halvhydrat.
NO880262L (no) Fremgangsmaate for fremstilling av b avermectiner.
NO885454D0 (no) Fremgangsmaate for fremstilling av triklormonosilan.
NO894210L (no) Fremgangsmaate for fremstilling av kinolyloxazol-2-oner.
NO894649L (no) Fremgangsmaate for fremstilling av (s)-alfa-ethyl-2-oxo-1-pyrrolidinacetamid.
NO895032D0 (no) Fremgangsmaate for fremstilling av 2-benzotiazoliner.
NO882893L (no) Fremgangsmaate for fremstilling av ureaformaldehydharpiks.
NO893794L (no) Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO882856L (no) Fremgangsmaate for fremstilling av immunoundertrykkende peptider.
NO890159D0 (no) Fremgangsmaate for fremstilling av 1-alkyl-5-nitroimidazoler.
NO882730D0 (no) Fremgangsmaate for fremstilling av aminocyklopentyletere.
NO885002D0 (no) FremgangsmŸte for fremstilling av sialocylglycerolipider.
NO895040D0 (no) Fremgangsmaate for fremstilling av polyhydroxybenzyloxypropanolaminer.
NO884792D0 (no) Fremgangsmaate for fremstilling av alfa-olefinpolymer.
NO885446D0 (no) Fremgangsmaate for fremstilling av kinolincarboxylsyrer.
NO880834L (no) Fremgangsmaate for fremstilling av heterocyclyl-2-propyn-1-aminer.
NO880106L (no) Fremgangsmaate til fremstilling av kalknitrogen.
NO893796D0 (no) Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO893795D0 (no) Fremgangsmaate for fremstilling av forbedret hydrolysert protein.
NO890375L (no) Fremgangsmaate for fremstilling av heksanitrostilben.
NO880844L (no) Fremgangsmaate for fremstilling av cytotoksiner.
NO890819D0 (no) Fremgangsmaate for fremstilling av hydroksybenzaldehyder.