NO874530D0 - Fremgangsmaate for fremstilling av nor-statin- eller nor-cyklostatin-polypeptider. - Google Patents

Fremgangsmaate for fremstilling av nor-statin- eller nor-cyklostatin-polypeptider.

Info

Publication number
NO874530D0
NO874530D0 NO874530A NO874530A NO874530D0 NO 874530 D0 NO874530 D0 NO 874530D0 NO 874530 A NO874530 A NO 874530A NO 874530 A NO874530 A NO 874530A NO 874530 D0 NO874530 D0 NO 874530D0
Authority
NO
Norway
Prior art keywords
cyclostatin
statin
polypeptides
procedure
preparation
Prior art date
Application number
NO874530A
Other languages
English (en)
Other versions
NO173017C (no
NO874530L (no
NO173017B (no
Inventor
Dennis Jay Hoover
Robert Louis Rosati
Ronald Thure Wester
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO874530D0 publication Critical patent/NO874530D0/no
Publication of NO874530L publication Critical patent/NO874530L/no
Publication of NO173017B publication Critical patent/NO173017B/no
Publication of NO173017C publication Critical patent/NO173017C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO874530A 1986-10-31 1987-10-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive nor-statin- eller nor-cyklostatinpolypeptider NO173017C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92544986A 1986-10-31 1986-10-31
US6898287A 1987-07-01 1987-07-01

Publications (4)

Publication Number Publication Date
NO874530D0 true NO874530D0 (no) 1987-10-30
NO874530L NO874530L (no) 1988-05-02
NO173017B NO173017B (no) 1993-07-05
NO173017C NO173017C (no) 1993-10-13

Family

ID=26749566

Family Applications (1)

Application Number Title Priority Date Filing Date
NO874530A NO173017C (no) 1986-10-31 1987-10-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive nor-statin- eller nor-cyklostatinpolypeptider

Country Status (22)

Country Link
EP (1) EP0266950B1 (no)
JP (1) JPH07108901B2 (no)
KR (1) KR910002544B1 (no)
CN (1) CN1027271C (no)
AR (1) AR245732A1 (no)
AU (1) AU585180B2 (no)
CA (1) CA1310793C (no)
DE (1) DE3788626T2 (no)
DK (1) DK568487A (no)
EG (1) EG18378A (no)
ES (1) ES2061512T3 (no)
FI (1) FI90346C (no)
HU (1) HU207869B (no)
IE (1) IE61087B1 (no)
IL (1) IL84270A0 (no)
MY (1) MY103189A (no)
NO (1) NO173017C (no)
NZ (1) NZ222373A (no)
PH (1) PH25231A (no)
PL (1) PL151679B1 (no)
PT (1) PT86024B (no)
YU (1) YU46819B (no)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214129A (en) * 1985-01-23 1993-05-25 Abbott Laboratories Peptidylaminodiols
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
WO1988003022A1 (en) * 1986-10-31 1988-05-05 Pfizer Inc. Relatively low molecular weight polypeptides as renin inhibitors
US4977141A (en) * 1987-10-01 1990-12-11 G. D. Searle & Co. Peptidyl α-aminoacyl aminodiol carbamates as anti-hypertensive agents
US4927807A (en) * 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
HUT52785A (en) * 1988-03-03 1990-08-28 Squibb & Sons Inc Process for producing 1,2-hydroxy-phosphonates and derivatives
US5217958A (en) * 1988-03-03 1993-06-08 E. R. Squibb & Sons, Inc. 1,2-hydroxy phosphonates and derivatives thereof
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
EP0376040A3 (en) * 1988-12-27 1990-09-12 American Cyanamid Company N-phosphinyl di-and tripeptides as renin inhibitors
US4965372A (en) * 1989-01-19 1990-10-23 Pfizer Inc. Process and intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US5223534A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5175170A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. β-amino acid derivatives
US5212175A (en) * 1989-12-04 1993-05-18 G. D. Searle & Co. Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives
US5179102A (en) * 1989-12-04 1993-01-12 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives
US5223514A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5223532A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives
US5223512A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5217989A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5147888A (en) * 1989-12-04 1992-09-15 G. D. Searle & Co. N-terminal indolyy indolylalkylaminodiol β-amino acid derivatives
US5215996A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5216013A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives
US5217991A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5180725A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy
DE69016760T2 (de) * 1989-12-04 1995-07-06 Searle & Co Heterozyklische Acylaminodiol-beta-aminosäure-Derivate.
US5217988A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyβ-amino acid derivatives
US5210095A (en) * 1989-12-04 1993-05-11 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal amino hydroxy
US5171751A (en) * 1989-12-04 1992-12-15 G. D. Searle & Co. Benzofuran/benzofuranalkyl-N-terminal amino hydroxy
US5180744A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Aralkyl-N-terminal amino hydroxy
US5175181A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy
US5231111A (en) * 1989-12-04 1993-07-27 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
TW209870B (no) * 1990-01-18 1993-07-21 Pfizer
US5023338A (en) * 1990-03-08 1991-06-11 American Home Products Corporation Renin inhibitors
US5095119A (en) * 1990-03-08 1992-03-10 American Home Products Corporation Renin inhibitors
US5064965A (en) * 1990-03-08 1991-11-12 American Home Products Corporation Renin inhibitors
US5075451A (en) * 1990-03-08 1991-12-24 American Home Products Corporation Pyrrolimidazolones useful as renin inhibitors
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
JPH04243835A (ja) * 1990-08-29 1992-08-31 Pfizer Inc 高眼圧症又は緑内障治療用薬剤組成物及び治療方法
US5442105A (en) * 1991-06-21 1995-08-15 Takasago International Corporation Process for producing cyclohexylbutyric acid derivative
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
WO1993011799A1 (en) * 1991-12-18 1993-06-24 Pfizer Inc. Soybean protein or hydrolyzates in pharmaceutical compositions to protect bioactive peptides from enzymatic inactivation
US6153592A (en) * 1992-11-09 2000-11-28 Port Systems, Llc Enhancing the bioavailability of proteolytically labile therapeutic agents
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
US7183278B1 (en) 1998-11-04 2007-02-27 Meiji Seika Kaisha, Ltd. Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
US6117870A (en) * 1998-11-12 2000-09-12 Fujirebio Kabushiki Kaisha Cyclic amide derivatives
US20020002152A1 (en) 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI850948A7 (fi) * 1984-03-12 1985-09-13 Pfizer Reniinin inhibitoreja, jotka sisältävät statiinia tai sen johdannaisia.
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
EP0190891A3 (en) * 1985-01-31 1988-04-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions

Also Published As

Publication number Publication date
PL268521A1 (en) 1988-09-01
JPH07108901B2 (ja) 1995-11-22
AU585180B2 (en) 1989-06-08
HU207869B (en) 1993-06-28
FI874787A7 (fi) 1988-05-01
CA1310793C (en) 1992-11-24
NO173017C (no) 1993-10-13
DK568487D0 (da) 1987-10-30
IE872929L (en) 1988-04-30
JPH07173134A (ja) 1995-07-11
KR880005152A (ko) 1988-06-28
PL151679B1 (en) 1990-09-28
HUT45270A (en) 1988-06-28
DK568487A (da) 1988-05-01
YU198087A (en) 1989-02-28
ES2061512T3 (es) 1994-12-16
PT86024A (en) 1987-11-01
NO874530L (no) 1988-05-02
PH25231A (en) 1991-03-27
FI90346B (fi) 1993-10-15
YU46819B (sh) 1994-06-10
FI90346C (fi) 1994-01-25
KR910002544B1 (ko) 1991-04-23
AR245732A1 (es) 1994-02-28
IL84270A0 (en) 1988-03-31
NO173017B (no) 1993-07-05
CN87101499A (zh) 1988-05-11
EG18378A (en) 1993-04-30
EP0266950A2 (en) 1988-05-11
PT86024B (pt) 1990-07-31
DE3788626D1 (de) 1994-02-10
NZ222373A (en) 1989-09-27
MY103189A (en) 1993-05-29
AU8054187A (en) 1988-05-05
CN1027271C (zh) 1995-01-04
FI874787A0 (fi) 1987-10-30
EP0266950A3 (en) 1990-04-11
EP0266950B1 (en) 1993-12-29
DE3788626T2 (de) 1994-04-28
IE61087B1 (en) 1994-09-21

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