IL85159A - Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them - Google Patents

Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them

Info

Publication number
IL85159A
IL85159A IL85159A IL8515988A IL85159A IL 85159 A IL85159 A IL 85159A IL 85159 A IL85159 A IL 85159A IL 8515988 A IL8515988 A IL 8515988A IL 85159 A IL85159 A IL 85159A
Authority
IL
Israel
Prior art keywords
hirudin
region
pharmaceutical compositions
compositions containing
peptides corresponding
Prior art date
Application number
IL85159A
Other languages
English (en)
Other versions
IL85159A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL85159A0 publication Critical patent/IL85159A0/xx
Publication of IL85159A publication Critical patent/IL85159A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
IL85159A 1987-01-23 1988-01-21 Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them IL85159A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US641787A 1987-01-23 1987-01-23
US5316287A 1987-05-21 1987-05-21

Publications (2)

Publication Number Publication Date
IL85159A0 IL85159A0 (en) 1988-06-30
IL85159A true IL85159A (en) 1993-04-04

Family

ID=26675603

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85159A IL85159A (en) 1987-01-23 1988-01-21 Anticoagulant peptides corresponding to a region of hirudin and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP0276014B1 (xx)
JP (1) JP2709817B2 (xx)
KR (1) KR960014105B1 (xx)
CN (1) CN88100260A (xx)
AR (1) AR245140A1 (xx)
AT (1) ATE110743T1 (xx)
AU (1) AU601801B2 (xx)
CA (1) CA1341032C (xx)
DE (1) DE3851238T2 (xx)
DK (1) DK173757B1 (xx)
ES (1) ES2063740T3 (xx)
FI (1) FI89060C (xx)
HU (1) HU199159B (xx)
IE (1) IE63547B1 (xx)
IL (1) IL85159A (xx)
NO (1) NO174105C (xx)
NZ (1) NZ223236A (xx)
PH (1) PH26263A (xx)
PT (1) PT86600B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
JPH04503660A (ja) * 1988-12-05 1992-07-02 バイオジェン インコーポレイテッド 血小板凝集抑制の方法及び組成物
ZA899247B (en) * 1988-12-07 1990-09-26 Merrell Dow Pharma Anticoagulant peptides
US5232912A (en) * 1988-12-07 1993-08-03 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2026376C (en) * 1989-10-03 2002-01-01 John L. Krstenansky Anticoagulant peptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
AU641215B2 (en) * 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4005591A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
AU640502B2 (en) * 1990-07-24 1993-08-26 Merrell Dow Pharmaceuticals Inc. Analogs of hirudin having antiplatelet activity
WO1992001710A1 (en) * 1990-07-24 1992-02-06 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
US5767235A (en) * 1991-03-05 1998-06-16 Nippon Mining Company Limited Anticoagulant hirudin variants and methods for their production
ATE142642T1 (de) * 1991-03-05 1996-09-15 Japan Energy Corp Hirudinanalog oder dessen salz, dessen herstellung und das als aktiven bestandteil enthaltende antikoagulanz
IT1250689B (it) * 1991-07-22 1995-04-21 Marco Gerna Analoghi dell'irudina e procedimento per la loro preparazione
AU2442792A (en) * 1991-07-31 1993-03-02 Institut Pasteur Polypeptides capable of (in vivo) induction of antibodies themselves capable of inhibiting the invasion of red blood corpuscles by merozoites of (p.falciparum), related products and their use in producing vaccine compositions
CN1124964A (zh) * 1993-06-11 1996-06-19 默里尔药物公司 三功能抗凝血酶和抗血小板的肽
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
US5831003A (en) * 1996-06-28 1998-11-03 Bayer Corporation Peptides which bind to prothrombin and thrombin
GB0209249D0 (en) * 2002-04-23 2002-06-05 Evolutec Ltd Anticoagulants
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
CN102757479B (zh) * 2012-05-09 2014-04-30 北京林业大学 高活性降血压肽及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.

Also Published As

Publication number Publication date
IL85159A0 (en) 1988-06-30
IE880167L (en) 1988-07-23
CN88100260A (zh) 1988-11-09
KR880009045A (ko) 1988-09-13
EP0276014A3 (en) 1990-05-16
DE3851238T2 (de) 1995-03-16
CA1341032C (en) 2000-06-20
AU601801B2 (en) 1990-09-20
IE63547B1 (en) 1995-05-17
AR245140A1 (es) 1993-12-30
EP0276014A2 (en) 1988-07-27
DK173757B1 (da) 2001-09-10
DE3851238D1 (de) 1994-10-06
NO880268L (no) 1988-07-25
PH26263A (en) 1992-04-01
NO174105B (no) 1993-12-06
DK31088D0 (da) 1988-01-22
HUT46339A (en) 1988-10-28
JPS63215698A (ja) 1988-09-08
FI880286A0 (fi) 1988-01-22
PT86600B (pt) 1991-12-31
FI89060B (fi) 1993-04-30
PT86600A (pt) 1988-02-01
FI880286A (fi) 1988-07-24
ES2063740T3 (es) 1995-01-16
AU1072988A (en) 1988-07-28
FI89060C (fi) 1993-08-10
NO880268D0 (no) 1988-01-22
JP2709817B2 (ja) 1998-02-04
HU199159B (en) 1990-01-29
NO174105C (no) 1994-03-16
KR960014105B1 (ko) 1996-10-14
NZ223236A (en) 1989-11-28
ATE110743T1 (de) 1994-09-15
EP0276014B1 (en) 1994-08-31
DK31088A (da) 1988-07-24

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.