NO862825L - Polynukleotidprober. - Google Patents
Polynukleotidprober.Info
- Publication number
- NO862825L NO862825L NO86862825A NO862825A NO862825L NO 862825 L NO862825 L NO 862825L NO 86862825 A NO86862825 A NO 86862825A NO 862825 A NO862825 A NO 862825A NO 862825 L NO862825 L NO 862825L
- Authority
- NO
- Norway
- Prior art keywords
- dna
- sequence
- core
- polynucleotides
- fragments
- Prior art date
Links
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- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848428491A GB8428491D0 (en) | 1984-11-12 | 1984-11-12 | Polynucleotide probes |
GB858505744A GB8505744D0 (en) | 1985-03-06 | 1985-03-06 | Repeat sequence dna |
GB858518755A GB8518755D0 (en) | 1985-07-24 | 1985-07-24 | Repeat sequence dna |
GB858522135A GB8522135D0 (en) | 1985-09-06 | 1985-09-06 | Repeat sequence dna |
PCT/GB1985/000477 WO1986002948A1 (en) | 1984-11-12 | 1985-10-17 | Polynucleotide probes |
Publications (2)
Publication Number | Publication Date |
---|---|
NO862825D0 NO862825D0 (no) | 1986-07-11 |
NO862825L true NO862825L (no) | 1986-09-15 |
Family
ID=27449602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO86862825A NO862825L (no) | 1984-11-12 | 1986-07-11 | Polynukleotidprober. |
Country Status (28)
Country | Link |
---|---|
US (1) | US5413908A (is) |
EP (1) | EP0186271B1 (is) |
JP (1) | JP2750228B2 (is) |
KR (1) | KR880700078A (is) |
CN (1) | CN1014429B (is) |
AU (1) | AU581582B2 (is) |
BR (1) | BR8507049A (is) |
CY (1) | CY1427A (is) |
DE (2) | DE186271T1 (is) |
DK (1) | DK331886A (is) |
ES (1) | ES8800349A1 (is) |
FI (1) | FI862915A0 (is) |
GB (1) | GB2166445B (is) |
GR (1) | GR852708B (is) |
HK (1) | HK13989A (is) |
HU (1) | HU203795B (is) |
IE (1) | IE62864B1 (is) |
IL (1) | IL76668A0 (is) |
IS (1) | IS1355B6 (is) |
KE (1) | KE3800A (is) |
MY (1) | MY102570A (is) |
NO (1) | NO862825L (is) |
NZ (1) | NZ213762A (is) |
PL (1) | PL256209A1 (is) |
PT (1) | PT81468B (is) |
SG (1) | SG12688G (is) |
WO (1) | WO1986002948A1 (is) |
YU (1) | YU176985A (is) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635389A (en) * | 1985-05-02 | 1997-06-03 | Institut Pasteur | Antibodies which recognize and bind human villin |
GB8606719D0 (en) * | 1986-03-19 | 1986-04-23 | Lister Preventive Med | Genetic probes |
FR2603047B1 (fr) * | 1986-08-19 | 1990-03-02 | Vassart Gilbert | Sonde d'hybridation pour la detection de sequences nucleotidiques polymorphes contenues dans un echantillon d'adn humain ou animal, procede de detection de sequences d'adn polymorphes utilisant une telle sonde, ses applications biologiques |
US4987066A (en) * | 1986-11-07 | 1991-01-22 | Max Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Process for the detection of restriction fragment length polymorphisms in eukaryotic genomes |
EP0294098A1 (en) * | 1987-05-29 | 1988-12-07 | City Of Hope | Synthetic DNA probes |
US4880750A (en) * | 1987-07-09 | 1989-11-14 | Miragen, Inc. | Individual-specific antibody identification methods |
GB8716367D0 (en) * | 1987-07-10 | 1987-08-19 | Reeders S T | Genetic identification |
GB8720855D0 (en) * | 1987-09-04 | 1987-10-14 | Oxford University Of Chancello | Probe |
US5064948A (en) * | 1988-02-12 | 1991-11-12 | The United States Of America As Represented By The Department Of Energy | Chromosome specific repetitive dna sequences |
DE68929070T2 (de) * | 1988-02-18 | 2000-05-25 | The University Of Utah, Salt Lake City | Verwendung von dna-proben mit variabler anzahl von tandem-repetitiven stellen zur genetischen identifizierung |
EP0337625A3 (en) * | 1988-04-13 | 1991-07-24 | Imperial Chemical Industries Plc | Probes |
IT1230152B (it) * | 1988-06-10 | 1991-10-14 | Ici Plc | Sequenze di nucleotidi. |
NZ225513A (en) * | 1988-07-21 | 1990-11-27 | Nz Scientific & Ind Res Biotech Div | Polynucleotides useful for identifying polymorphism in animals by genetic fingerprinting |
WO1990002818A1 (en) * | 1988-09-08 | 1990-03-22 | Lifecodes Corporation | Probes for the detection of rflp in eucaryotic genomes |
US5766847A (en) * | 1988-10-11 | 1998-06-16 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Process for analyzing length polymorphisms in DNA regions |
DE3834636A1 (de) | 1988-10-11 | 1990-04-19 | Max Planck Gesellschaft | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
GB8824531D0 (en) * | 1988-10-20 | 1988-11-23 | Ici Plc | Polynucleotide probes |
FR2638464B1 (fr) * | 1988-10-28 | 1992-01-03 | Pasteur Institut | Fragments d'acide nucleique specifiques du gene de la villine humaine, leur utilisation aux fins de diagnostic |
GB2228086A (en) * | 1988-11-25 | 1990-08-15 | Ici Plc | Characterisation of genomic DNA |
FR2641792A1 (fr) * | 1988-12-28 | 1990-07-20 | Pasteur Institut | Sequences de nucleotides codant pour la calmoduline chez l'homme et leurs applications biologiques |
US5032501A (en) * | 1989-02-10 | 1991-07-16 | Virginia Mason Research Center | DNA probes to vntr loci |
FR2645877B1 (fr) * | 1989-04-12 | 1991-07-05 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un, ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum au niveau du stade sporozoite et dans les hepatocytes |
US5097024A (en) * | 1989-09-25 | 1992-03-17 | Hodes Marion E | DNA probes for fingerpint analysis without tandem repeats |
US5273878A (en) * | 1990-08-30 | 1993-12-28 | John Groffen | Nucleic acid probes that reveal hypervariable restriction fragment length polymorphisms within the ABR gene |
AU8953991A (en) * | 1990-11-06 | 1992-05-26 | Lubrizol Corporation, The | Compositions and methods for analyzing genomic variation |
US5364759B2 (en) * | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
FR2680520B1 (fr) * | 1991-08-22 | 1995-09-22 | France Etat Armement | Procede de detection de nouvelles regions hypervariables dans une sequence d'adn, sequences de nucleotides constituant des sondes d'hybridation et leur application biologique. |
AU4800693A (en) * | 1992-08-07 | 1994-03-03 | Battelle Memorial Institute | Low c0t dna as dna fingerprinting probe, and method of manufacture |
AU4174397A (en) | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Methods for identification and isolation of specific nucleotide sequences in cdna and genomic dna |
US6306588B1 (en) | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
US7099777B1 (en) | 1997-09-05 | 2006-08-29 | Affymetrix, Inc. | Techniques for identifying confirming mapping and categorizing nucleic acids |
CA2302193A1 (en) * | 1997-09-05 | 1999-03-25 | Affymetrix, Inc. | Techniques for identifying, confirming, mapping and categorizing polymers |
US6238863B1 (en) | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
AUPP421798A0 (en) * | 1998-06-18 | 1998-07-09 | Kazamias, Christian | Process of identification |
US6187540B1 (en) * | 1998-11-09 | 2001-02-13 | Identigene, Inc. | Method of newborn identification and tracking |
JP2002543795A (ja) * | 1999-05-12 | 2002-12-24 | インビトロゲン・コーポレーション | 核酸合成の感度および特異性の増大のための組成物および方法 |
GB9913556D0 (en) * | 1999-06-11 | 1999-08-11 | Zeneca Ltd | Assays |
WO2001068919A2 (en) | 2000-03-10 | 2001-09-20 | Ana-Gen Technologies, Inc. | Mutation detection using denaturing gradients |
EP2258172B1 (en) * | 2000-05-09 | 2017-04-19 | Xy, Llc | Flow cytometer for diffentiating x-chromosome bearing and y-chromosome bearing populations of spermatozoa |
US7957907B2 (en) * | 2001-03-30 | 2011-06-07 | Sorenson Molecular Genealogy Foundation | Method for molecular genealogical research |
US20050176025A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA) |
US20050196765A1 (en) * | 2001-05-18 | 2005-09-08 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
US20050196767A1 (en) * | 2001-05-18 | 2005-09-08 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA) |
US20050159381A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA) |
AU2002316135B9 (en) * | 2001-05-18 | 2009-05-28 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
US20050233997A1 (en) * | 2001-05-18 | 2005-10-20 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
US20050203040A1 (en) * | 2001-05-18 | 2005-09-15 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
US20050158735A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA) |
US20050159382A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
US20050124566A1 (en) * | 2001-05-18 | 2005-06-09 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
US20050288242A1 (en) * | 2001-05-18 | 2005-12-29 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA) |
US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
KR100459106B1 (ko) * | 2002-03-21 | 2004-12-03 | 한국해양연구원 | 시간 유전자 인트론의 염기서열을 dna 지문으로 이용한생물체 식별 방법 |
US8855935B2 (en) * | 2006-10-02 | 2014-10-07 | Ancestry.Com Dna, Llc | Method and system for displaying genetic and genealogical data |
RU2373842C2 (ru) * | 2003-12-02 | 2009-11-27 | Шрага РОТТЕМ | Искусственный интеллект и устройство для диагностики, скрининга, профилактики и лечения состояний системы матери и плода |
US20070266003A1 (en) * | 2006-05-09 | 2007-11-15 | 0752004 B.C. Ltd. | Method and system for constructing dynamic and interacive family trees based upon an online social network |
US20080189047A1 (en) * | 2006-11-01 | 2008-08-07 | 0752004 B.C. Ltd. | Method and system for genetic research using genetic sampling via an interactive online network |
US20080130778A1 (en) * | 2006-12-04 | 2008-06-05 | Samsung Electronics Co., Ltd. | System and method for wireless communication of uncompressed high definition video data using a transfer matrix for beamforming estimation |
ES2663009T3 (es) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic) |
CN105296473A (zh) * | 2015-08-27 | 2016-02-03 | 苏州新海生物科技股份有限公司 | 一种分子量内标及其应用 |
US11631477B2 (en) | 2017-09-07 | 2023-04-18 | Dmitry Shvartsman | System and method for authenticated exchange of biosamples |
WO2019193551A1 (en) | 2018-04-05 | 2019-10-10 | Ancestry.Com Dna, Llc | Community assignments in identity by descent networks and genetic variant origination |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57182650A (en) * | 1981-05-06 | 1982-11-10 | Mitsubishi Chem Ind Ltd | Detection method for gene by oligoliponucleotide |
DE3381518D1 (de) * | 1982-01-22 | 1990-06-07 | Cetus Corp | Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel. |
DK105582A (da) * | 1982-03-11 | 1983-09-12 | Nordisk Insulinlab | Fremgangsmaade til bestemmelse af humane hla-d(r) vaevstyper og gensonde til brug ved fremgangsmaaden |
US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
IL71064A (en) * | 1983-02-28 | 1989-10-31 | Lifecodes Corp | Paternity and forensic test involving analysis of dna polymorphic genetic regions |
EP0135108A3 (en) * | 1983-08-12 | 1988-07-13 | Rockefeller University | Nucleotide hybridization assay for protozoan parasites |
WO1985002862A1 (en) * | 1983-12-23 | 1985-07-04 | Monash University | PRODUCTION OF HUMAN INTERFERON-alpha |
GB8606719D0 (en) * | 1986-03-19 | 1986-04-23 | Lister Preventive Med | Genetic probes |
US4963663A (en) * | 1988-12-23 | 1990-10-16 | University Of Utah | Genetic identification employing DNA probes of variable number tandem repeat loci |
-
1985
- 1985-10-08 IS IS3047A patent/IS1355B6/is unknown
- 1985-10-09 NZ NZ213762A patent/NZ213762A/xx unknown
- 1985-10-11 IL IL76668A patent/IL76668A0/xx not_active IP Right Cessation
- 1985-10-14 DE DE198585307350T patent/DE186271T1/de active Pending
- 1985-10-14 GB GB08525252A patent/GB2166445B/en not_active Expired
- 1985-10-14 DE DE85307350T patent/DE3584957D1/de not_active Expired - Fee Related
- 1985-10-14 EP EP85307350A patent/EP0186271B1/en not_active Expired - Lifetime
- 1985-10-17 WO PCT/GB1985/000477 patent/WO1986002948A1/en active Application Filing
- 1985-10-17 BR BR8507049A patent/BR8507049A/pt unknown
- 1985-10-17 AU AU49626/85A patent/AU581582B2/en not_active Ceased
- 1985-10-17 HU HU855064A patent/HU203795B/hu unknown
- 1985-10-23 IE IE261985A patent/IE62864B1/en not_active IP Right Cessation
- 1985-11-08 CN CN85109013A patent/CN1014429B/zh not_active Expired
- 1985-11-08 GR GR852708A patent/GR852708B/el unknown
- 1985-11-11 ES ES548749A patent/ES8800349A1/es not_active Expired
- 1985-11-12 PL PL25620985A patent/PL256209A1/xx unknown
- 1985-11-12 PT PT81468A patent/PT81468B/pt not_active IP Right Cessation
- 1985-11-12 YU YU01769/85A patent/YU176985A/xx unknown
-
1986
- 1986-07-11 DK DK331886A patent/DK331886A/da not_active Application Discontinuation
- 1986-07-11 NO NO86862825A patent/NO862825L/no unknown
- 1986-07-11 FI FI862915A patent/FI862915A0/fi not_active Application Discontinuation
- 1986-07-12 KR KR1019860700460A patent/KR880700078A/ko not_active Application Discontinuation
-
1987
- 1987-10-01 MY MYPI87002825A patent/MY102570A/en unknown
-
1988
- 1988-02-16 KE KE3800A patent/KE3800A/xx unknown
- 1988-02-24 SG SG126/88A patent/SG12688G/en unknown
- 1988-09-02 CY CY1427A patent/CY1427A/xx unknown
-
1989
- 1989-02-16 HK HK139/89A patent/HK13989A/xx not_active IP Right Cessation
-
1991
- 1991-05-27 JP JP3149288A patent/JP2750228B2/ja not_active Expired - Lifetime
-
1992
- 1992-07-29 US US07/921,375 patent/US5413908A/en not_active Expired - Lifetime
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