NO861302L - Rekombinant humant renin. - Google Patents
Rekombinant humant renin.Info
- Publication number
- NO861302L NO861302L NO861302A NO861302A NO861302L NO 861302 L NO861302 L NO 861302L NO 861302 A NO861302 A NO 861302A NO 861302 A NO861302 A NO 861302A NO 861302 L NO861302 L NO 861302L
- Authority
- NO
- Norway
- Prior art keywords
- renin
- cells
- prorenin
- recombinant
- preprorenin
- Prior art date
Links
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
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- 238000010348 incorporation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
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- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- 229940111202 pepsin Drugs 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
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- 238000009790 rate-determining step (RDS) Methods 0.000 description 1
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- 210000003660 reticulum Anatomy 0.000 description 1
- PFGWGEPQIUAZME-NXSMLHPHSA-N saralasin Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)C1=CC=C(O)C=C1 PFGWGEPQIUAZME-NXSMLHPHSA-N 0.000 description 1
- 229960004785 saralasin Drugs 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
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- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- DMRMZQATXPQOTP-GWTDSMLYSA-M sodium;(4ar,6r,7r,7as)-6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound [Na+].C([C@H]1O2)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br DMRMZQATXPQOTP-GWTDSMLYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000000352 storage cell Anatomy 0.000 description 1
- 210000001913 submandibular gland Anatomy 0.000 description 1
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6486—Renin (3.4.23.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23015—Renin (3.4.23.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71941485A | 1985-04-03 | 1985-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO861302L true NO861302L (no) | 1986-10-06 |
Family
ID=24889982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO861302A NO861302L (no) | 1985-04-03 | 1986-04-02 | Rekombinant humant renin. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0196921A3 (fr) |
| JP (1) | JPS62282A (fr) |
| KR (1) | KR860008282A (fr) |
| AU (1) | AU5559786A (fr) |
| DK (1) | DK152886A (fr) |
| ES (1) | ES8800723A1 (fr) |
| FI (1) | FI861428A (fr) |
| GR (1) | GR860847B (fr) |
| HU (1) | HUT40698A (fr) |
| IL (1) | IL78314A0 (fr) |
| NO (1) | NO861302L (fr) |
| PT (1) | PT82311B (fr) |
| ZA (1) | ZA862479B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586266T2 (de) * | 1984-05-03 | 1993-02-18 | Kazuo Murakami | Genomische dns menschlichen renins. |
| DE3438545A1 (de) * | 1984-10-20 | 1986-04-24 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
| AU7084787A (en) * | 1986-02-20 | 1987-09-09 | Karo Bio Ab | Eucaryotic expression of steroid receptor proteins |
| GB2200118A (en) * | 1987-01-23 | 1988-07-27 | Allelix Inc | Synthetic chymosin-and prochymosin-encoding DNA segments |
| CA2020720A1 (fr) * | 1989-07-13 | 1991-01-14 | Shigeko Yamazaki | Methode de purification d'un facteur de croissance de fibroblaste acide recombinant ayant une action therapeutique |
| DE4136443A1 (de) * | 1991-11-06 | 1993-05-13 | Boehringer Ingelheim Int | Expression der reifen proteinase 2a, ihre partielle reinigung und bereitstellung kompetitiv wirkender substrate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3280392D1 (de) * | 1981-11-23 | 1992-03-26 | University Patents Inc | Steuerung der dna-sequenzen-transkription. |
| JPH0683670B2 (ja) * | 1983-08-12 | 1994-10-26 | 第一製薬株式会社 | デオキシリボ核酸 |
| DE3586266T2 (de) * | 1984-05-03 | 1993-02-18 | Kazuo Murakami | Genomische dns menschlichen renins. |
| ATE89314T1 (de) * | 1985-02-13 | 1993-05-15 | Scios Nova Inc | Menschlicher metallothionein ii-promotor in saeugetierexpressionssystemen. |
-
1986
- 1986-03-28 IL IL78314A patent/IL78314A0/xx unknown
- 1986-03-31 GR GR860847A patent/GR860847B/el unknown
- 1986-04-01 PT PT82311A patent/PT82311B/pt unknown
- 1986-04-02 EP EP86302432A patent/EP0196921A3/fr not_active Withdrawn
- 1986-04-02 ES ES553644A patent/ES8800723A1/es not_active Expired
- 1986-04-02 NO NO861302A patent/NO861302L/no unknown
- 1986-04-02 HU HU861355A patent/HUT40698A/hu unknown
- 1986-04-02 FI FI861428A patent/FI861428A/fi not_active IP Right Cessation
- 1986-04-02 AU AU55597/86A patent/AU5559786A/en not_active Abandoned
- 1986-04-03 ZA ZA862479A patent/ZA862479B/xx unknown
- 1986-04-03 KR KR1019860002529A patent/KR860008282A/ko not_active Application Discontinuation
- 1986-04-03 DK DK152886A patent/DK152886A/da not_active IP Right Cessation
- 1986-04-03 JP JP61077502A patent/JPS62282A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0196921A2 (fr) | 1986-10-08 |
| EP0196921A3 (fr) | 1987-12-02 |
| GR860847B (en) | 1986-07-31 |
| FI861428A (fi) | 1986-10-04 |
| PT82311B (en) | 1987-09-08 |
| ZA862479B (en) | 1986-12-30 |
| JPS62282A (ja) | 1987-01-06 |
| ES8800723A1 (es) | 1987-11-16 |
| KR860008282A (ko) | 1986-11-14 |
| DK152886D0 (da) | 1986-04-03 |
| PT82311A (en) | 1986-05-01 |
| HUT40698A (en) | 1987-01-28 |
| AU5559786A (en) | 1986-10-09 |
| ES553644A0 (es) | 1987-11-16 |
| IL78314A0 (en) | 1986-07-31 |
| DK152886A (da) | 1986-10-04 |
| FI861428A0 (fi) | 1986-04-02 |
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