NO853255L - Fremgangsmaate for fremstilling av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-benzazepin. - Google Patents

Fremgangsmaate for fremstilling av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-benzazepin.

Info

Publication number
NO853255L
NO853255L NO853255A NO853255A NO853255L NO 853255 L NO853255 L NO 853255L NO 853255 A NO853255 A NO 853255A NO 853255 A NO853255 A NO 853255A NO 853255 L NO853255 L NO 853255L
Authority
NO
Norway
Prior art keywords
methyl
benzazepine
tetrahydro
approx
trichlorobenzene
Prior art date
Application number
NO853255A
Other languages
English (en)
Norwegian (no)
Inventor
Stanley John Borowski
Thomas Anthony Post
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of NO853255L publication Critical patent/NO853255L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO853255A 1984-09-05 1985-08-19 Fremgangsmaate for fremstilling av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-benzazepin. NO853255L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (1)

Publication Number Publication Date
NO853255L true NO853255L (no) 1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
NO853255A NO853255L (no) 1984-09-05 1985-08-19 Fremgangsmaate for fremstilling av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-benzazepin.

Country Status (19)

Country Link
US (1) US4541954A (instruction)
EP (1) EP0174118A3 (instruction)
JP (1) JPS6168469A (instruction)
KR (1) KR860002470A (instruction)
AU (1) AU581918B2 (instruction)
CA (1) CA1244017A (instruction)
DK (1) DK379985A (instruction)
EG (1) EG17149A (instruction)
ES (1) ES8609266A1 (instruction)
FI (1) FI853255L (instruction)
GR (1) GR852041B (instruction)
HU (1) HU194181B (instruction)
IL (1) IL76100A0 (instruction)
NO (1) NO853255L (instruction)
NZ (1) NZ213141A (instruction)
PH (1) PH20796A (instruction)
PT (1) PT81018B (instruction)
ZA (1) ZA856268B (instruction)
ZW (1) ZW13385A1 (instruction)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
DE69218587T2 (de) * 1991-12-06 1997-08-14 Yuasa Battery Co Ltd Dünne batterie und monolitische dünne batterie
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
CN1805939B (zh) 2003-06-17 2010-10-13 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
SI2332921T1 (sl) * 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
RS50996B (sr) 2004-12-21 2010-10-31 Arena Pharmaceuticals Inc. Kristalni oblici (r)-8-hloro-1-metil-2,3,4,5-tetrahidro-1h-benzazepin hlorhidrat
CA2588941A1 (en) 2004-12-23 2006-07-06 Arena Pharmaceuticals, Inc. 5ht2c receptor modulator compositions and methods of use
EP2518053A1 (en) 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
ES2522587T3 (es) * 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
CN102015591B (zh) * 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ, インコーポレイテッド 5−ht2cアゴニストの非吸湿性塩
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
JP6272695B2 (ja) 2010-09-01 2018-01-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 体重管理のために有用な5−ht2cアゴニストの改変放出剤形
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
DE3272044D1 (de) * 1981-11-27 1986-08-21 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists

Also Published As

Publication number Publication date
ZW13385A1 (en) 1985-11-20
NZ213141A (en) 1988-07-28
IL76100A0 (en) 1985-12-31
US4541954A (en) 1985-09-17
JPS6168469A (ja) 1986-04-08
HUT38617A (en) 1986-06-30
GR852041B (instruction) 1985-12-19
KR860002470A (ko) 1986-04-26
ZA856268B (en) 1986-07-30
EG17149A (en) 1989-06-30
PT81018A (en) 1985-09-01
FI853255A7 (fi) 1986-03-06
PH20796A (en) 1987-04-14
DK379985D0 (da) 1985-08-21
FI853255L (fi) 1986-03-06
AU581918B2 (en) 1989-03-09
FI853255A0 (fi) 1985-08-23
ES546285A0 (es) 1986-09-01
CA1244017A (en) 1988-11-01
EP0174118A2 (en) 1986-03-12
ES8609266A1 (es) 1986-09-01
DK379985A (da) 1986-03-06
EP0174118A3 (en) 1986-12-30
HU194181B (en) 1988-01-28
AU4648185A (en) 1986-03-13
PT81018B (en) 1987-06-24

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