NO851160L - Fremgangsmaate for fremstilling av cyklosporiner - Google Patents
Fremgangsmaate for fremstilling av cyklosporinerInfo
- Publication number
- NO851160L NO851160L NO851160A NO851160A NO851160L NO 851160 L NO851160 L NO 851160L NO 851160 A NO851160 A NO 851160A NO 851160 A NO851160 A NO 851160A NO 851160 L NO851160 L NO 851160L
- Authority
- NO
- Norway
- Prior art keywords
- nva
- cyclosporine
- val
- mebmt
- ser
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 35
- 238000002360 preparation method Methods 0.000 title claims description 9
- 108010036941 Cyclosporins Proteins 0.000 title description 52
- 229960001265 ciclosporin Drugs 0.000 claims description 136
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 72
- 108010036949 Cyclosporine Proteins 0.000 claims description 70
- 229930105110 Cyclosporin A Natural products 0.000 claims description 29
- 125000000539 amino acid group Chemical group 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 11
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- 239000001257 hydrogen Substances 0.000 claims description 9
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848407618A GB8407618D0 (en) | 1984-03-23 | 1984-03-23 | Organic compounds |
| GB848411922A GB8411922D0 (en) | 1984-05-10 | 1984-05-10 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO851160L true NO851160L (no) | 1985-09-24 |
Family
ID=26287502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO851160A NO851160L (no) | 1984-03-23 | 1985-03-22 | Fremgangsmaate for fremstilling av cyklosporiner |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4639434A (de) |
| JP (1) | JPH08838B2 (de) |
| AT (1) | AT388737B (de) |
| BE (1) | BE901980A (de) |
| CA (1) | CA1247546A (de) |
| CH (1) | CH667274A5 (de) |
| CS (1) | CS249542B2 (de) |
| DE (1) | DE3509809A1 (de) |
| DK (1) | DK128285A (de) |
| ES (1) | ES8702926A1 (de) |
| FI (1) | FI851120L (de) |
| FR (1) | FR2561651B1 (de) |
| GB (1) | GB2155936B (de) |
| GR (1) | GR850716B (de) |
| HU (1) | HU200786B (de) |
| IL (1) | IL74681A (de) |
| IT (1) | IT1199962B (de) |
| LU (1) | LU85819A1 (de) |
| NL (1) | NL8500828A (de) |
| NO (1) | NO851160L (de) |
| NZ (1) | NZ211526A (de) |
| PH (2) | PH23357A (de) |
| PT (1) | PT80149B (de) |
| SE (1) | SE461334B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE92501T1 (de) | 1984-10-04 | 1993-08-15 | Sandoz Ag | Monoklonale antikoerper gegen zyklosporine. |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| ATE95193T1 (de) * | 1987-06-17 | 1993-10-15 | Sandoz Ag | Cyclosporine und deren benutzung als arzneimittel. |
| DE3888357T2 (de) * | 1987-06-22 | 1994-09-15 | Merck & Co Inc | Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. |
| US5227467A (en) * | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| WO1989001772A1 (en) * | 1987-09-03 | 1989-03-09 | University Of Georgia Research Foundation, Inc. | Ocular cyclosporin composition |
| US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| US5089390A (en) * | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
| US4914188A (en) * | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
| US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| CH679119A5 (de) * | 1988-05-13 | 1991-12-31 | Sandoz Ag | |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US5202310A (en) * | 1990-06-06 | 1993-04-13 | Levy Gary A | Cyclosporine metabolites |
| DK0484281T4 (da) * | 1990-11-02 | 2001-02-05 | Novartis Ag | Cyclosporiner |
| ES2091301T3 (es) | 1990-11-20 | 1996-11-01 | Behringwerke Ag | Inmunoensayo de ciclosporina. |
| US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| NZ502362A (en) | 1997-10-08 | 2001-05-25 | Isotechnika Inc | Deuterated cyclosporine A derivatives and their use as immunomodulating agents |
| US5990274A (en) | 1997-11-25 | 1999-11-23 | Dade Behring Inc. | Cyclosporine derivatives and uses thereof |
| US7449544B2 (en) * | 1999-11-30 | 2008-11-11 | Cyclacel Limited | p21 peptides |
| WO2003033526A2 (en) * | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
| AU2002333098B2 (en) * | 2001-10-19 | 2006-03-16 | Isotechnika Pharma Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| AU2004222306A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| US7378391B2 (en) * | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| JP2008514702A (ja) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| JP2008515886A (ja) * | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキンおよびそれらの医用薬剤としての有用性 |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| AU2011342284C1 (en) | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| CN106279401A (zh) | 2011-03-11 | 2017-01-04 | 贝丝以色列女执事医疗中心 | Cd40片段及其用途 |
| CN104877013B (zh) * | 2015-06-03 | 2018-04-20 | 兰州大学 | 环孢菌素t及其制备方法和应用 |
| AU2016315873B2 (en) | 2015-09-04 | 2022-08-18 | Primatope Therapeutics Inc. | Humanized anti-CD40 antibodies and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0056782B1 (de) * | 1981-01-09 | 1984-08-01 | Sandoz Ag | Cyclosporine |
| JPS57140753A (en) * | 1981-01-09 | 1982-08-31 | Sandoz Ag | Novel cyclosporine |
-
1985
- 1985-03-18 CH CH1194/85A patent/CH667274A5/de not_active IP Right Cessation
- 1985-03-19 FR FR858504172A patent/FR2561651B1/fr not_active Expired - Lifetime
- 1985-03-19 US US06/713,429 patent/US4639434A/en not_active Expired - Fee Related
- 1985-03-19 DE DE19853509809 patent/DE3509809A1/de not_active Ceased
- 1985-03-20 PH PH32014A patent/PH23357A/en unknown
- 1985-03-20 GB GB08507270A patent/GB2155936B/en not_active Expired
- 1985-03-20 PH PH32013A patent/PH21868A/en unknown
- 1985-03-20 FI FI851120A patent/FI851120L/fi not_active Application Discontinuation
- 1985-03-21 SE SE8501392A patent/SE461334B/sv not_active IP Right Cessation
- 1985-03-21 IL IL74681A patent/IL74681A/xx unknown
- 1985-03-21 CA CA000477127A patent/CA1247546A/en not_active Expired
- 1985-03-21 ES ES541465A patent/ES8702926A1/es not_active Expired
- 1985-03-21 NZ NZ211526A patent/NZ211526A/xx unknown
- 1985-03-21 GR GR850716A patent/GR850716B/el unknown
- 1985-03-21 NL NL8500828A patent/NL8500828A/nl not_active Application Discontinuation
- 1985-03-21 HU HU851045A patent/HU200786B/hu not_active IP Right Cessation
- 1985-03-21 DK DK128285A patent/DK128285A/da not_active Application Discontinuation
- 1985-03-21 LU LU85819A patent/LU85819A1/fr unknown
- 1985-03-21 BE BE1/011217A patent/BE901980A/fr not_active IP Right Cessation
- 1985-03-21 PT PT80149A patent/PT80149B/pt not_active IP Right Cessation
- 1985-03-22 IT IT47852/85A patent/IT1199962B/it active
- 1985-03-22 AT AT0086385A patent/AT388737B/de not_active IP Right Cessation
- 1985-03-22 JP JP60059339A patent/JPH08838B2/ja not_active Expired - Lifetime
- 1985-03-22 NO NO851160A patent/NO851160L/no unknown
- 1985-03-23 CS CS852132A patent/CS249542B2/cs unknown
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