DK128285A - Cyclosporinderivater - Google Patents

Cyclosporinderivater Download PDF

Info

Publication number
DK128285A
DK128285A DK128285A DK128285A DK128285A DK 128285 A DK128285 A DK 128285A DK 128285 A DK128285 A DK 128285A DK 128285 A DK128285 A DK 128285A DK 128285 A DK128285 A DK 128285A
Authority
DK
Denmark
Prior art keywords
cyclosporin derivatives
cyclosporin
derivatives
Prior art date
Application number
DK128285A
Other languages
Danish (da)
English (en)
Other versions
DK128285D0 (da
Inventor
Roland Wenger
Rene P Traber
Hans Kobel
Hans Hofmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK128285D0 publication Critical patent/DK128285D0/da
Publication of DK128285A publication Critical patent/DK128285A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK128285A 1984-03-23 1985-03-21 Cyclosporinderivater DK128285A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds

Publications (2)

Publication Number Publication Date
DK128285D0 DK128285D0 (da) 1985-03-21
DK128285A true DK128285A (da) 1985-09-24

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
DK128285A DK128285A (da) 1984-03-23 1985-03-21 Cyclosporinderivater

Country Status (24)

Country Link
US (1) US4639434A (de)
JP (1) JPH08838B2 (de)
AT (1) AT388737B (de)
BE (1) BE901980A (de)
CA (1) CA1247546A (de)
CH (1) CH667274A5 (de)
CS (1) CS249542B2 (de)
DE (1) DE3509809A1 (de)
DK (1) DK128285A (de)
ES (1) ES8702926A1 (de)
FI (1) FI851120L (de)
FR (1) FR2561651B1 (de)
GB (1) GB2155936B (de)
GR (1) GR850716B (de)
HU (1) HU200786B (de)
IL (1) IL74681A (de)
IT (1) IT1199962B (de)
LU (1) LU85819A1 (de)
NL (1) NL8500828A (de)
NO (1) NO851160L (de)
NZ (1) NZ211526A (de)
PH (2) PH23357A (de)
PT (1) PT80149B (de)
SE (1) SE461334B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314862A1 (de) 1984-10-04 1989-05-10 Sandoz Ag Immunogenische Konjugate, die Cyclosporine enthalten
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
EP0373260B1 (de) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
EP0391909B1 (de) * 1987-09-03 1994-08-17 The University Of Georgia Research Foundation, Inc. Cyclosporin-augenmittel
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
CH679119A5 (de) * 1988-05-13 1991-12-31 Sandoz Ag
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
DK0484281T4 (da) * 1990-11-02 2001-02-05 Novartis Ag Cyclosporiner
EP0487289B1 (de) * 1990-11-20 1996-09-04 BEHRINGWERKE Aktiengesellschaft Immunotest für Cyclosporin
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
JP4261049B2 (ja) 1997-10-08 2009-04-30 アイソテクニカ インコーポレイテッド 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
EP1714977B1 (de) 2001-10-19 2009-03-11 Isotechnika Inc. Synthese von Cyclosporinanalogen
PL206018B1 (pl) * 2001-10-19 2010-06-30 Isotechnika Inc Preparat farmaceutyczny, sposób jego wytwarzania, mikroemulsja i zastosowanie tego preparatu farmaceutycznego
EP1603512A2 (de) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
EP1804823A4 (de) * 2004-09-29 2010-06-09 Amr Technology Inc Neue cyclosporin-analoga und ihre pharmazeutischen anwendungen
WO2006041631A2 (en) * 2004-10-06 2006-04-20 Amr Technology, Inc. Novel cyclosporin alkynes and their utility as pharmaceutical agents
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
BR112013014890B1 (pt) 2010-12-15 2023-10-24 Contravir Pharmaceuticals, Inc Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
PT3556774T (pt) 2011-03-11 2024-02-29 Beth Israel Deaconess Medical Ct Inc Anticorpos anti-cd40 e suas utilizações
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
MX2018002708A (es) 2015-09-04 2018-08-01 Primatope Therapeutics Inc Anticuerpos anti-cd40 humanizados y usos de los mismos.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine
US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins

Also Published As

Publication number Publication date
BE901980A (fr) 1985-09-23
PH21868A (en) 1988-03-25
CS249542B2 (en) 1987-03-12
FR2561651A1 (fr) 1985-09-27
SE8501392D0 (sv) 1985-03-21
NL8500828A (nl) 1985-10-16
PH23357A (en) 1989-07-14
CH667274A5 (de) 1988-09-30
DE3509809A1 (de) 1986-01-09
US4639434A (en) 1987-01-27
FI851120L (fi) 1985-09-24
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
GB2155936A (en) 1985-10-02
ES541465A0 (es) 1987-01-16
JPS60215700A (ja) 1985-10-29
DK128285D0 (da) 1985-03-21
IL74681A0 (en) 1985-06-30
NO851160L (no) 1985-09-24
SE8501392L (sv) 1985-09-24
JPH08838B2 (ja) 1996-01-10
ES8702926A1 (es) 1987-01-16
FI851120A0 (fi) 1985-03-20
SE461334B (sv) 1990-02-05
GR850716B (de) 1985-07-19
HUT38370A (en) 1986-05-28
GB8507270D0 (en) 1985-04-24
HU200786B (en) 1990-08-28
GB2155936B (en) 1987-09-16
AT388737B (de) 1989-08-25
NZ211526A (en) 1988-08-30
IT8547852A0 (it) 1985-03-22
IT1199962B (it) 1989-01-05
IT8547852A1 (it) 1986-09-22
IL74681A (en) 1989-09-10
PT80149B (en) 1987-03-23
PT80149A (en) 1985-04-01
FR2561651B1 (fr) 1990-03-09
LU85819A1 (fr) 1985-12-12

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