NO832446L - Fremgangsmaate ved fremstilling av tabletter. - Google Patents
Fremgangsmaate ved fremstilling av tabletter.Info
- Publication number
- NO832446L NO832446L NO832446A NO832446A NO832446L NO 832446 L NO832446 L NO 832446L NO 832446 A NO832446 A NO 832446A NO 832446 A NO832446 A NO 832446A NO 832446 L NO832446 L NO 832446L
- Authority
- NO
- Norway
- Prior art keywords
- weight
- granulation
- slurry
- particulate
- tablets
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 74
- 239000008187 granular material Substances 0.000 claims abstract description 114
- 238000005469 granulation Methods 0.000 claims abstract description 80
- 230000003179 granulation Effects 0.000 claims abstract description 79
- 239000002002 slurry Substances 0.000 claims abstract description 76
- 238000004519 manufacturing process Methods 0.000 claims abstract description 49
- 239000011343 solid material Substances 0.000 claims abstract description 23
- 238000005550 wet granulation Methods 0.000 claims abstract description 23
- 239000007787 solid Substances 0.000 claims abstract description 20
- 230000006835 compression Effects 0.000 claims abstract description 19
- 238000007906 compression Methods 0.000 claims abstract description 19
- 230000008569 process Effects 0.000 claims abstract description 7
- 239000008247 solid mixture Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 68
- 239000000203 mixture Substances 0.000 claims description 63
- 239000011149 active material Substances 0.000 claims description 45
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 39
- 229960005489 paracetamol Drugs 0.000 claims description 38
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 238000000265 homogenisation Methods 0.000 claims description 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- FEJKLNWAOXSSNR-UHFFFAOYSA-N benorilate Chemical compound C1=CC(NC(=O)C)=CC=C1OC(=O)C1=CC=CC=C1OC(C)=O FEJKLNWAOXSSNR-UHFFFAOYSA-N 0.000 claims description 6
- 229930182817 methionine Natural products 0.000 claims description 6
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims description 6
- 229960004277 benorilate Drugs 0.000 claims description 5
- 229960000210 nalidixic acid Drugs 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 4
- 238000009736 wetting Methods 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- MFZCIDXOLLEMOO-GYSGTQPESA-N myo-inositol hexanicotinate Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](OC(=O)C=2C=NC=CC=2)[C@@H](OC(=O)C=2C=NC=CC=2)[C@@H]1OC(=O)C=1C=NC=CC=1)OC(=O)C=1C=NC=CC=1)OC(=O)C=1C=NC=CC=1)C(=O)C1=CC=CN=C1 MFZCIDXOLLEMOO-GYSGTQPESA-N 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 12
- 238000005056 compaction Methods 0.000 abstract description 5
- 230000001427 coherent effect Effects 0.000 abstract 2
- 235000011837 pasties Nutrition 0.000 abstract 2
- 239000011872 intimate mixture Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 122
- 238000002360 preparation method Methods 0.000 description 48
- 239000004615 ingredient Substances 0.000 description 27
- 239000006185 dispersion Substances 0.000 description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 19
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 19
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- 239000000126 substance Substances 0.000 description 15
- 229940079832 sodium starch glycolate Drugs 0.000 description 12
- 239000008109 sodium starch glycolate Substances 0.000 description 12
- 229920003109 sodium starch glycolate Polymers 0.000 description 12
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- 239000000314 lubricant Substances 0.000 description 9
- 235000019359 magnesium stearate Nutrition 0.000 description 9
- 239000002904 solvent Substances 0.000 description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 239000011230 binding agent Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000007796 conventional method Methods 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 239000004067 bulking agent Substances 0.000 description 5
- 239000007884 disintegrant Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229940032147 starch Drugs 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 229920002261 Corn starch Polymers 0.000 description 4
- 235000021355 Stearic acid Nutrition 0.000 description 4
- 239000007894 caplet Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 235000006109 methionine Nutrition 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
- 229940080313 sodium starch Drugs 0.000 description 4
- 239000008117 stearic acid Substances 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000005461 lubrication Methods 0.000 description 3
- 229960004452 methionine Drugs 0.000 description 3
- 238000009481 moist granulation Methods 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- MFZCIDXOLLEMOO-UHFFFAOYSA-N inositol hexanicotinate Chemical compound C=1C=CN=CC=1C(=O)OC(C(C(OC(=O)C=1C=NC=CC=1)C(OC(=O)C=1C=NC=CC=1)C1OC(=O)C=2C=NC=CC=2)OC(=O)C=2C=NC=CC=2)C1OC(=O)C1=CC=CN=C1 MFZCIDXOLLEMOO-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004470 DL Methionine Substances 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- YVIGPQSYEAOLAD-UHFFFAOYSA-L disodium;dodecyl phosphate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOP([O-])([O-])=O YVIGPQSYEAOLAD-UHFFFAOYSA-L 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Preparation (AREA)
- Formation And Processing Of Food Products (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Glanulating (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8219487 | 1982-07-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO832446L true NO832446L (no) | 1984-01-30 |
Family
ID=10531495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO832446A NO832446L (no) | 1982-07-06 | 1983-07-05 | Fremgangsmaate ved fremstilling av tabletter. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0100168B1 (it) |
| AT (1) | ATE39417T1 (it) |
| AU (1) | AU574345B2 (it) |
| CA (1) | CA1212331A (it) |
| DE (1) | DE3378741D1 (it) |
| DK (1) | DK312283A (it) |
| ES (1) | ES523904A0 (it) |
| FI (1) | FI832481L (it) |
| GB (1) | GB2124078B (it) |
| GR (1) | GR79340B (it) |
| IE (1) | IE55579B1 (it) |
| NO (1) | NO832446L (it) |
| PT (1) | PT76990B (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1235053B (it) * | 1989-04-07 | 1992-06-17 | Poli Ind Chimica Spa | Metodi per la preparazione di composizioni farmaceutiche a base di bromocriptina dotate di elevata stabilita' e prodotti derivanti. |
| HU206828B (en) * | 1989-08-10 | 1993-01-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing veterinary compositions containing benzimidazol derivatives as active components |
| US5037658A (en) * | 1989-09-14 | 1991-08-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Direct dry compressible acetaminophen composition |
| SK282071B6 (sk) * | 1991-01-30 | 2001-10-08 | The Wellcome Foundation Limited | Tableta dispergovateľná vo vode a spôsob jej prípravy |
| US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| HU206975B (en) * | 1991-03-14 | 1993-03-01 | Reanal Finomvegyszergyar | Process for producing granulation and veterinary composition comprising water-soluble flumequine complex |
| GB9305058D0 (en) * | 1993-03-12 | 1993-04-28 | Penn Pharm Ltd | Pharmaceutical compositions |
| US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
| AUPM460994A0 (en) * | 1994-03-21 | 1994-04-14 | Technological Resources Pty Limited | A process for producing agglomerates |
| AU5882298A (en) * | 1997-01-29 | 1998-08-18 | Chong Kun Dang Corporation | New analgesic composition |
| EP1177726A1 (en) * | 2000-08-04 | 2002-02-06 | Aventis Animal Nutrition S.A. | Process for the production of granules of methionine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1287431A (en) * | 1969-04-16 | 1972-08-31 | Aspro Nicholas Ltd | Improvements in pharmaceutical formulations |
| DE2057853B2 (de) * | 1970-11-25 | 1974-02-28 | Roehm Gmbh, 6100 Darmstadt | Verfahren zur Herstellung von Arzneimittelkugelchen |
| GB1390032A (en) * | 1971-08-27 | 1975-04-09 | Sterling Winthrop Group Ltd | Pharmaceutical compositions |
| GB1410909A (en) * | 1971-10-26 | 1975-10-22 | Sterling Winthrop Group Ltd | Pharmaceutical compositions |
| US3873694A (en) * | 1973-09-27 | 1975-03-25 | Cpc International Inc | Direct compression tabletting composition and pharmaceutical tablets produced therefrom |
-
1983
- 1983-07-05 GR GR71867A patent/GR79340B/el unknown
- 1983-07-05 NO NO832446A patent/NO832446L/no unknown
- 1983-07-05 IE IE1577/83A patent/IE55579B1/en not_active IP Right Cessation
- 1983-07-06 DE DE8383303935T patent/DE3378741D1/de not_active Expired
- 1983-07-06 AT AT83303935T patent/ATE39417T1/de not_active IP Right Cessation
- 1983-07-06 GB GB08318298A patent/GB2124078B/en not_active Expired
- 1983-07-06 PT PT76990A patent/PT76990B/pt unknown
- 1983-07-06 DK DK312283A patent/DK312283A/da not_active Application Discontinuation
- 1983-07-06 EP EP83303935A patent/EP0100168B1/en not_active Expired
- 1983-07-06 FI FI832481A patent/FI832481L/fi not_active Application Discontinuation
- 1983-07-06 ES ES523904A patent/ES523904A0/es active Granted
-
1984
- 1984-02-03 AU AU24084/84A patent/AU574345B2/en not_active Ceased
- 1984-03-30 CA CA000450935A patent/CA1212331A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2124078A (en) | 1984-02-15 |
| EP0100168B1 (en) | 1988-12-28 |
| DK312283D0 (da) | 1983-07-06 |
| DE3378741D1 (en) | 1989-02-02 |
| GR79340B (it) | 1984-10-22 |
| DK312283A (da) | 1984-01-07 |
| FI832481L (fi) | 1984-01-07 |
| EP0100168A3 (en) | 1984-11-28 |
| ATE39417T1 (de) | 1989-01-15 |
| IE831577L (en) | 1984-01-06 |
| ES8500760A1 (es) | 1984-11-01 |
| PT76990A (en) | 1983-08-01 |
| FI832481A0 (fi) | 1983-07-06 |
| GB2124078B (en) | 1985-11-27 |
| PT76990B (en) | 1986-01-09 |
| GB8318298D0 (en) | 1983-08-10 |
| EP0100168A2 (en) | 1984-02-08 |
| ES523904A0 (es) | 1984-11-01 |
| AU574345B2 (en) | 1988-07-07 |
| AU2408484A (en) | 1985-08-08 |
| CA1212331A (en) | 1986-10-07 |
| IE55579B1 (en) | 1990-11-07 |
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