GB1287431A - Improvements in pharmaceutical formulations - Google Patents
Improvements in pharmaceutical formulationsInfo
- Publication number
- GB1287431A GB1287431A GB1954869A GB1954869A GB1287431A GB 1287431 A GB1287431 A GB 1287431A GB 1954869 A GB1954869 A GB 1954869A GB 1954869 A GB1954869 A GB 1954869A GB 1287431 A GB1287431 A GB 1287431A
- Authority
- GB
- United Kingdom
- Prior art keywords
- particles
- paracetamol
- coated
- binding agent
- aqueous medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1287431 Paracetamol formulations ASPRONICHOLAS Ltd 16 June 1970 [16 April 1969] 19548/69 Heading A5B Discrete paracetamol particles coated with from 2 to 5% by weight (on a dry basis) of a binding agent selected from pharmaceutically acceptable substances capable of dispersing in an aqueous medium, of forming a film on the paracetamol particles, and of assisting adherence of the coated particles after their compression into tablets, for example a sugar (such as sucrose, molasses or lactose), a natural or synthetic gum (such as acacia, tragacanth, sodium alginate, carboxymethylcellulose, methylcellulose or polyvinylyrrolidone), gelatin or a derivative thereof (such as a cold-water-soluble protein material derived hydrolytically from gelatin, preferably that known under the trade name Byco-C or -D), are prepared by agitating particles of paracetamol and the binding agent in an aqueous medium to form a slurry and drying the slurry to obtain discrete particles of paracetamol coated with the binding agent, the ratio by weight of the particles of paracetamol prior to coating to the water in the aqueous medium being not greater than 5:1. The coated particles are dried in a manner such that the formation of large agglomerates is avoided, for example by fluid bed- or spray-drying. Preferably the paracetamol particles prior to coating are of such a size that all will pass through a 25 mesh B.S.S. screen and that at least 50% by weight will pass through a 350 mesh B.S.S. screen. Pharmaceutical compositions, especially tablets, optionally in effervescent form, comprise the coated paracetamol particles and a pharmaceutically acceptable carrier therefor and optionally one or more other pharmacologically active ingredient such as salicylamide, caffeine, codeine phosphate, butobarbitone, dexamphetamine, dextropropoxyphene, chloral hydrate, chlormezanone, aspirin, orphenadrine, phenyl butazone, meprobamate, phenylpropanolamine, phenyltoloxamine, mepyramine, homatropine and ethoheptazine. A preferred tablet contains the coated paracetamol particles salicylamide and caffeine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1954869A GB1287431A (en) | 1969-04-16 | 1969-04-16 | Improvements in pharmaceutical formulations |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1954869A GB1287431A (en) | 1969-04-16 | 1969-04-16 | Improvements in pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1287431A true GB1287431A (en) | 1972-08-31 |
Family
ID=10131225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1954869A Expired GB1287431A (en) | 1969-04-16 | 1969-04-16 | Improvements in pharmaceutical formulations |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1287431A (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2338234A1 (en) * | 1973-01-24 | 1974-07-25 | Sterwin Ag | TABLET COMPOUND CONTAINING PARACETAMOL AND THE METHOD OF MANUFACTURING IT |
US4016254A (en) | 1972-05-19 | 1977-04-05 | Beecham Group Limited | Pharmaceutical formulations |
EP0040472A2 (en) * | 1980-05-20 | 1981-11-25 | Mallinckrodt, Inc. (a Delaware corporation) | Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof |
EP0100168A2 (en) * | 1982-07-06 | 1984-02-08 | Alan George Rogerson | Processes for preparing tablets by a modified 'wet-granulation' technique |
US4562024A (en) * | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
US4631284A (en) * | 1984-11-19 | 1986-12-23 | Mallinckrodt, Inc. | Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom |
US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4940588A (en) * | 1984-10-30 | 1990-07-10 | Elan Corporation | Controlled release powder and process for its preparation |
WO1992000065A1 (en) * | 1990-06-28 | 1992-01-09 | The Upjohn Company | Gelatin coated medicament and process for making same |
US5716991A (en) * | 1993-03-12 | 1998-02-10 | British Technology Group Limited | Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof |
EP1518551A1 (en) * | 2003-09-23 | 2005-03-30 | McNEIL-PPC, INC. | Solid dosage form comprising caffeine |
WO2007071240A1 (en) * | 2005-12-23 | 2007-06-28 | Niro A/S | A plant and a process for production of tablets |
RU2578482C2 (en) * | 2010-05-06 | 2016-03-27 | Алколоид Ао | Combination tabletted form and method for manufacturing it |
-
1969
- 1969-04-16 GB GB1954869A patent/GB1287431A/en not_active Expired
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016254A (en) | 1972-05-19 | 1977-04-05 | Beecham Group Limited | Pharmaceutical formulations |
DE2338234A1 (en) * | 1973-01-24 | 1974-07-25 | Sterwin Ag | TABLET COMPOUND CONTAINING PARACETAMOL AND THE METHOD OF MANUFACTURING IT |
EP0040472A2 (en) * | 1980-05-20 | 1981-11-25 | Mallinckrodt, Inc. (a Delaware corporation) | Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof |
EP0040472A3 (en) * | 1980-05-20 | 1982-07-21 | Mallinckrodt, Inc. | Spray dried n-acetyl-p-aminophenol compositions and method for manufacture thereof |
EP0100168A2 (en) * | 1982-07-06 | 1984-02-08 | Alan George Rogerson | Processes for preparing tablets by a modified 'wet-granulation' technique |
EP0100168A3 (en) * | 1982-07-06 | 1984-11-28 | Sterwin Ag. | Processes for preparing tablets by a modified 'wet-granulation' technique |
US4562024A (en) * | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
AU574345B2 (en) * | 1982-07-06 | 1988-07-07 | Sterling Drug Inc. | Preparing compressed tablets by wet granulation and tablets therefrom |
US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
US4940588A (en) * | 1984-10-30 | 1990-07-10 | Elan Corporation | Controlled release powder and process for its preparation |
US4952402A (en) * | 1984-10-30 | 1990-08-28 | Elan Corporation, P.L.C. | Controlled release powder and process for its preparation |
US4631284A (en) * | 1984-11-19 | 1986-12-23 | Mallinckrodt, Inc. | Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom |
US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
WO1992000065A1 (en) * | 1990-06-28 | 1992-01-09 | The Upjohn Company | Gelatin coated medicament and process for making same |
US5716991A (en) * | 1993-03-12 | 1998-02-10 | British Technology Group Limited | Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof |
EP1518551A1 (en) * | 2003-09-23 | 2005-03-30 | McNEIL-PPC, INC. | Solid dosage form comprising caffeine |
WO2007071240A1 (en) * | 2005-12-23 | 2007-06-28 | Niro A/S | A plant and a process for production of tablets |
RU2578482C2 (en) * | 2010-05-06 | 2016-03-27 | Алколоид Ао | Combination tabletted form and method for manufacturing it |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |