GB1287431A - Improvements in pharmaceutical formulations - Google Patents

Improvements in pharmaceutical formulations

Info

Publication number
GB1287431A
GB1287431A GB1954869A GB1954869A GB1287431A GB 1287431 A GB1287431 A GB 1287431A GB 1954869 A GB1954869 A GB 1954869A GB 1954869 A GB1954869 A GB 1954869A GB 1287431 A GB1287431 A GB 1287431A
Authority
GB
United Kingdom
Prior art keywords
particles
paracetamol
coated
binding agent
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1954869A
Inventor
William Lakenorris
John Edward Slater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB1954869A priority Critical patent/GB1287431A/en
Publication of GB1287431A publication Critical patent/GB1287431A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1287431 Paracetamol formulations ASPRONICHOLAS Ltd 16 June 1970 [16 April 1969] 19548/69 Heading A5B Discrete paracetamol particles coated with from 2 to 5% by weight (on a dry basis) of a binding agent selected from pharmaceutically acceptable substances capable of dispersing in an aqueous medium, of forming a film on the paracetamol particles, and of assisting adherence of the coated particles after their compression into tablets, for example a sugar (such as sucrose, molasses or lactose), a natural or synthetic gum (such as acacia, tragacanth, sodium alginate, carboxymethylcellulose, methylcellulose or polyvinylyrrolidone), gelatin or a derivative thereof (such as a cold-water-soluble protein material derived hydrolytically from gelatin, preferably that known under the trade name Byco-C or -D), are prepared by agitating particles of paracetamol and the binding agent in an aqueous medium to form a slurry and drying the slurry to obtain discrete particles of paracetamol coated with the binding agent, the ratio by weight of the particles of paracetamol prior to coating to the water in the aqueous medium being not greater than 5:1. The coated particles are dried in a manner such that the formation of large agglomerates is avoided, for example by fluid bed- or spray-drying. Preferably the paracetamol particles prior to coating are of such a size that all will pass through a 25 mesh B.S.S. screen and that at least 50% by weight will pass through a 350 mesh B.S.S. screen. Pharmaceutical compositions, especially tablets, optionally in effervescent form, comprise the coated paracetamol particles and a pharmaceutically acceptable carrier therefor and optionally one or more other pharmacologically active ingredient such as salicylamide, caffeine, codeine phosphate, butobarbitone, dexamphetamine, dextropropoxyphene, chloral hydrate, chlormezanone, aspirin, orphenadrine, phenyl butazone, meprobamate, phenylpropanolamine, phenyltoloxamine, mepyramine, homatropine and ethoheptazine. A preferred tablet contains the coated paracetamol particles salicylamide and caffeine.
GB1954869A 1969-04-16 1969-04-16 Improvements in pharmaceutical formulations Expired GB1287431A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1954869A GB1287431A (en) 1969-04-16 1969-04-16 Improvements in pharmaceutical formulations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1954869A GB1287431A (en) 1969-04-16 1969-04-16 Improvements in pharmaceutical formulations

Publications (1)

Publication Number Publication Date
GB1287431A true GB1287431A (en) 1972-08-31

Family

ID=10131225

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1954869A Expired GB1287431A (en) 1969-04-16 1969-04-16 Improvements in pharmaceutical formulations

Country Status (1)

Country Link
GB (1) GB1287431A (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2338234A1 (en) * 1973-01-24 1974-07-25 Sterwin Ag TABLET COMPOUND CONTAINING PARACETAMOL AND THE METHOD OF MANUFACTURING IT
US4016254A (en) 1972-05-19 1977-04-05 Beecham Group Limited Pharmaceutical formulations
EP0040472A2 (en) * 1980-05-20 1981-11-25 Mallinckrodt, Inc. (a Delaware corporation) Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof
EP0100168A2 (en) * 1982-07-06 1984-02-08 Alan George Rogerson Processes for preparing tablets by a modified 'wet-granulation' technique
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
US4757090A (en) * 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4940588A (en) * 1984-10-30 1990-07-10 Elan Corporation Controlled release powder and process for its preparation
WO1992000065A1 (en) * 1990-06-28 1992-01-09 The Upjohn Company Gelatin coated medicament and process for making same
US5716991A (en) * 1993-03-12 1998-02-10 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
EP1518551A1 (en) * 2003-09-23 2005-03-30 McNEIL-PPC, INC. Solid dosage form comprising caffeine
WO2007071240A1 (en) * 2005-12-23 2007-06-28 Niro A/S A plant and a process for production of tablets
RU2578482C2 (en) * 2010-05-06 2016-03-27 Алколоид Ао Combination tabletted form and method for manufacturing it

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016254A (en) 1972-05-19 1977-04-05 Beecham Group Limited Pharmaceutical formulations
DE2338234A1 (en) * 1973-01-24 1974-07-25 Sterwin Ag TABLET COMPOUND CONTAINING PARACETAMOL AND THE METHOD OF MANUFACTURING IT
EP0040472A2 (en) * 1980-05-20 1981-11-25 Mallinckrodt, Inc. (a Delaware corporation) Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof
EP0040472A3 (en) * 1980-05-20 1982-07-21 Mallinckrodt, Inc. Spray dried n-acetyl-p-aminophenol compositions and method for manufacture thereof
EP0100168A2 (en) * 1982-07-06 1984-02-08 Alan George Rogerson Processes for preparing tablets by a modified 'wet-granulation' technique
EP0100168A3 (en) * 1982-07-06 1984-11-28 Sterwin Ag. Processes for preparing tablets by a modified 'wet-granulation' technique
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
AU574345B2 (en) * 1982-07-06 1988-07-07 Sterling Drug Inc. Preparing compressed tablets by wet granulation and tablets therefrom
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4940588A (en) * 1984-10-30 1990-07-10 Elan Corporation Controlled release powder and process for its preparation
US4952402A (en) * 1984-10-30 1990-08-28 Elan Corporation, P.L.C. Controlled release powder and process for its preparation
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4757090A (en) * 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
WO1992000065A1 (en) * 1990-06-28 1992-01-09 The Upjohn Company Gelatin coated medicament and process for making same
US5716991A (en) * 1993-03-12 1998-02-10 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
EP1518551A1 (en) * 2003-09-23 2005-03-30 McNEIL-PPC, INC. Solid dosage form comprising caffeine
WO2007071240A1 (en) * 2005-12-23 2007-06-28 Niro A/S A plant and a process for production of tablets
RU2578482C2 (en) * 2010-05-06 2016-03-27 Алколоид Ао Combination tabletted form and method for manufacturing it

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years