NO814240L - Analogifremgangsmaate for fremstilling av farmakologisk aktive cefalosporin-derivater - Google Patents
Analogifremgangsmaate for fremstilling av farmakologisk aktive cefalosporin-derivaterInfo
- Publication number
- NO814240L NO814240L NO814240A NO814240A NO814240L NO 814240 L NO814240 L NO 814240L NO 814240 A NO814240 A NO 814240A NO 814240 A NO814240 A NO 814240A NO 814240 L NO814240 L NO 814240L
- Authority
- NO
- Norway
- Prior art keywords
- group
- tetrazol
- general formula
- hydroxy
- pyrimidinyl
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title claims description 16
- 229940124587 cephalosporin Drugs 0.000 title claims description 16
- 150000001780 cephalosporins Chemical class 0.000 title claims description 14
- 238000000034 method Methods 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title claims description 13
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- 229910052708 sodium Inorganic materials 0.000 claims description 20
- 239000011734 sodium Substances 0.000 claims description 20
- AVWRKZWQTYIKIY-UHFFFAOYSA-N ureidocarboxylic acid Natural products NC(=O)NC(O)=O AVWRKZWQTYIKIY-UHFFFAOYSA-N 0.000 claims description 16
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- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
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- 239000008187 granular material Substances 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 125000005633 phthalidyl group Chemical group 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004262 preparative liquid chromatography Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803047082 DE3047082A1 (de) | 1980-12-13 | 1980-12-13 | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO814240L true NO814240L (no) | 1982-06-14 |
Family
ID=6119125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO814240A NO814240L (no) | 1980-12-13 | 1981-12-11 | Analogifremgangsmaate for fremstilling av farmakologisk aktive cefalosporin-derivater |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4401667A (cs) |
| EP (1) | EP0054677B1 (cs) |
| JP (1) | JPS57123192A (cs) |
| AR (1) | AR229804A1 (cs) |
| AT (1) | ATE13536T1 (cs) |
| AU (1) | AU7814881A (cs) |
| CA (1) | CA1170652A (cs) |
| CS (1) | CS224637B2 (cs) |
| DD (1) | DD201905A5 (cs) |
| DE (2) | DE3047082A1 (cs) |
| DK (1) | DK542081A (cs) |
| ES (3) | ES507829A0 (cs) |
| FI (1) | FI813992L (cs) |
| GB (1) | GB2089346B (cs) |
| GR (1) | GR76948B (cs) |
| HU (1) | HU186448B (cs) |
| IL (1) | IL64427A (cs) |
| NO (1) | NO814240L (cs) |
| NZ (1) | NZ199129A (cs) |
| PL (1) | PL129917B1 (cs) |
| PT (1) | PT74117B (cs) |
| SU (1) | SU1075977A3 (cs) |
| ZA (1) | ZA818317B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59104389A (ja) * | 1982-12-06 | 1984-06-16 | Shionogi & Co Ltd | オキサセファム誘導体 |
| FR2816309B1 (fr) * | 2000-11-09 | 2002-12-27 | Bioprojet Soc Civ | Procede de synthese de derives n-(mercaptoacyl)-amino-acides a partir d'acides acryliques alpha-substitues |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5344585A (en) * | 1976-10-02 | 1978-04-21 | Meiji Seika Kaisha Ltd | Cephalosporin derivatives and their preparation |
| US4311699A (en) * | 1979-03-12 | 1982-01-19 | Haskell Theodore H | Aminoacid derivatives of cephalosporin compounds |
| DE2924948A1 (de) * | 1979-06-21 | 1981-01-22 | Thomae Gmbh Dr K | Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2928344A1 (de) * | 1979-07-13 | 1981-02-05 | Thomae Gmbh Dr K | Neue lactame, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3007685A1 (de) * | 1980-02-29 | 1981-10-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue cephylosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0053276A3 (de) * | 1980-12-02 | 1983-08-03 | Dr. Karl Thomae GmbH | Neue Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
-
1980
- 1980-12-13 DE DE19803047082 patent/DE3047082A1/de not_active Withdrawn
-
1981
- 1981-10-23 EP EP81108768A patent/EP0054677B1/de not_active Expired
- 1981-10-23 DE DE8181108768T patent/DE3170755D1/de not_active Expired
- 1981-10-23 AT AT81108768T patent/ATE13536T1/de not_active IP Right Cessation
- 1981-11-20 US US06/323,432 patent/US4401667A/en not_active Expired - Fee Related
- 1981-12-01 GB GB8136205A patent/GB2089346B/en not_active Expired
- 1981-12-01 ZA ZA818317A patent/ZA818317B/xx unknown
- 1981-12-01 IL IL64427A patent/IL64427A/xx unknown
- 1981-12-01 CA CA000391309A patent/CA1170652A/en not_active Expired
- 1981-12-01 AU AU78148/81A patent/AU7814881A/en not_active Abandoned
- 1981-12-01 NZ NZ199129A patent/NZ199129A/en unknown
- 1981-12-07 SU SU813361699A patent/SU1075977A3/ru active
- 1981-12-08 DK DK542081A patent/DK542081A/da not_active Application Discontinuation
- 1981-12-09 DD DD81235589A patent/DD201905A5/de unknown
- 1981-12-10 GR GR66767A patent/GR76948B/el unknown
- 1981-12-10 ES ES507829A patent/ES507829A0/es active Granted
- 1981-12-10 CS CS819179A patent/CS224637B2/cs unknown
- 1981-12-11 PT PT74117A patent/PT74117B/pt unknown
- 1981-12-11 JP JP56199949A patent/JPS57123192A/ja active Pending
- 1981-12-11 NO NO814240A patent/NO814240L/no unknown
- 1981-12-11 AR AR287775A patent/AR229804A1/es active
- 1981-12-11 HU HU813746A patent/HU186448B/hu unknown
- 1981-12-11 FI FI813992A patent/FI813992L/fi not_active Application Discontinuation
- 1981-12-11 PL PL1981234192A patent/PL129917B1/pl unknown
-
1982
- 1982-06-11 ES ES513019A patent/ES8304995A1/es not_active Expired
- 1982-06-11 ES ES513020A patent/ES513020A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ES8302006A1 (es) | 1983-01-01 |
| PL129917B1 (en) | 1984-06-30 |
| GR76948B (cs) | 1984-09-04 |
| ES8304996A1 (es) | 1983-03-16 |
| EP0054677A3 (en) | 1983-07-06 |
| US4401667A (en) | 1983-08-30 |
| PT74117A (de) | 1982-01-01 |
| NZ199129A (en) | 1985-02-28 |
| ZA818317B (en) | 1983-08-31 |
| PT74117B (de) | 1983-12-19 |
| FI813992L (fi) | 1982-06-14 |
| DE3047082A1 (de) | 1982-07-29 |
| ES513020A0 (es) | 1983-03-16 |
| JPS57123192A (en) | 1982-07-31 |
| ATE13536T1 (de) | 1985-06-15 |
| HU186448B (en) | 1985-07-29 |
| AU7814881A (en) | 1982-06-24 |
| GB2089346B (en) | 1984-08-15 |
| DE3170755D1 (en) | 1985-07-04 |
| EP0054677A2 (de) | 1982-06-30 |
| DK542081A (da) | 1982-06-14 |
| DD201905A5 (de) | 1983-08-17 |
| CS224637B2 (en) | 1984-01-16 |
| EP0054677B1 (de) | 1985-05-29 |
| ES507829A0 (es) | 1983-01-01 |
| IL64427A0 (en) | 1982-03-31 |
| CA1170652A (en) | 1984-07-10 |
| ES513019A0 (es) | 1983-03-16 |
| SU1075977A3 (ru) | 1984-02-23 |
| PL234192A1 (en) | 1983-03-14 |
| GB2089346A (en) | 1982-06-23 |
| IL64427A (en) | 1984-10-31 |
| AR229804A1 (es) | 1983-11-30 |
| ES8304995A1 (es) | 1983-03-16 |
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