NO773225L - Fremgangsmaate for fremstilling av en polymorf form av cimetidin - Google Patents
Fremgangsmaate for fremstilling av en polymorf form av cimetidinInfo
- Publication number
- NO773225L NO773225L NO773225A NO773225A NO773225L NO 773225 L NO773225 L NO 773225L NO 773225 A NO773225 A NO 773225A NO 773225 A NO773225 A NO 773225A NO 773225 L NO773225 L NO 773225L
- Authority
- NO
- Norway
- Prior art keywords
- cimetidine
- suspension
- procedure
- stated
- solvent
- Prior art date
Links
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title claims description 45
- 229960001380 cimetidine Drugs 0.000 title claims description 44
- 238000000034 method Methods 0.000 title claims description 15
- 239000000725 suspension Substances 0.000 claims description 17
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 238000002329 infrared spectrum Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 238000005147 X-ray Weissenberg Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3906576A GB1543238A (en) | 1976-09-21 | 1976-09-21 | Polymorph of cimetidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO773225L true NO773225L (no) | 1978-03-22 |
Family
ID=10407431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO773225A NO773225L (no) | 1976-09-21 | 1977-09-20 | Fremgangsmaate for fremstilling av en polymorf form av cimetidin |
Country Status (18)
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| GB1531221A (en) * | 1974-09-02 | 1978-11-08 | Smith Kline French Lab | Process for preparing guanidine derivatives |
-
1977
- 1977-04-18 DD DD7700198451A patent/DD129906A5/xx unknown
- 1977-05-13 GR GR53452A patent/GR61173B/el unknown
- 1977-05-17 BG BG7736338A patent/BG28050A3/xx unknown
- 1977-08-11 ZA ZA00774857A patent/ZA774857B/xx unknown
- 1977-08-16 PT PT66927A patent/PT66927B/pt unknown
- 1977-08-26 FI FI772542A patent/FI772542A/fi unknown
- 1977-09-08 IT IT27402/77A patent/IT1086352B/it active
- 1977-09-12 ZM ZM7770A patent/ZM7077A1/xx unknown
- 1977-09-19 AR AR269254A patent/AR218267A1/es active
- 1977-09-20 PL PL1977200960A patent/PL103681B1/pl unknown
- 1977-09-20 NO NO773225A patent/NO773225L/no unknown
- 1977-09-20 SE SE7710518A patent/SE7710518L/xx not_active Application Discontinuation
- 1977-09-21 CS CS611677A patent/CS207482B1/cs unknown
- 1977-09-21 ES ES462517A patent/ES462517A1/es not_active Expired
- 1977-09-21 NL NL7710354A patent/NL7710354A/xx not_active Application Discontinuation
- 1977-09-21 DK DK417677A patent/DK417677A/da not_active Application Discontinuation
-
1984
- 1984-07-31 JP JP59162761A patent/JPS60185767A/ja active Granted
- 1984-12-30 MY MY26/84A patent/MY8400026A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL200960A1 (pl) | 1978-05-22 |
| ZM7077A1 (en) | 1978-08-21 |
| ES462517A1 (es) | 1978-07-01 |
| ZA774857B (en) | 1978-06-28 |
| JPS60185767A (ja) | 1985-09-21 |
| GR61173B (en) | 1978-10-03 |
| JPS6234759B2 (US20100056889A1-20100304-C00004.png) | 1987-07-28 |
| MY8400026A (en) | 1984-12-31 |
| IT1086352B (it) | 1985-05-28 |
| SE7710518L (sv) | 1978-03-22 |
| CS207482B1 (en) | 1981-07-31 |
| FI772542A (US20100056889A1-20100304-C00004.png) | 1977-08-29 |
| PL103681B1 (pl) | 1979-07-31 |
| PT66927A (en) | 1977-09-01 |
| DK417677A (da) | 1978-03-22 |
| BG28050A3 (en) | 1980-02-25 |
| AR218267A1 (es) | 1980-05-30 |
| PT66927B (en) | 1979-03-13 |
| DD129906A5 (de) | 1978-02-15 |
| NL7710354A (nl) | 1978-03-23 |
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