NO333369B1 - Fremgangsmate for a oke konsentrasjonen av en farmasoytisk aktiv bestanddel i forhold til fyllpreparat-viskositet for doseenheter og myk gelatinkapsel - Google Patents
Fremgangsmate for a oke konsentrasjonen av en farmasoytisk aktiv bestanddel i forhold til fyllpreparat-viskositet for doseenheter og myk gelatinkapsel Download PDFInfo
- Publication number
- NO333369B1 NO333369B1 NO20030897A NO20030897A NO333369B1 NO 333369 B1 NO333369 B1 NO 333369B1 NO 20030897 A NO20030897 A NO 20030897A NO 20030897 A NO20030897 A NO 20030897A NO 333369 B1 NO333369 B1 NO 333369B1
- Authority
- NO
- Norway
- Prior art keywords
- active ingredient
- pharmaceutically active
- ion source
- hydroxide ion
- approx
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 68
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 239000007903 gelatin capsule Substances 0.000 title claims abstract description 18
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229960001680 ibuprofen Drugs 0.000 claims abstract description 21
- 239000004615 ingredient Substances 0.000 claims abstract description 18
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims abstract description 10
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000945 filler Substances 0.000 claims abstract description 7
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960000905 indomethacin Drugs 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 229960002009 naproxen Drugs 0.000 claims abstract description 5
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims abstract description 5
- 229960005489 paracetamol Drugs 0.000 claims abstract description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 40
- 229920001223 polyethylene glycol Polymers 0.000 claims description 27
- 239000002202 Polyethylene glycol Substances 0.000 claims description 25
- 239000000725 suspension Substances 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 12
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000002552 dosage form Substances 0.000 abstract description 6
- 239000000470 constituent Substances 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 description 13
- 108010010803 Gelatin Proteins 0.000 description 11
- 239000008273 gelatin Substances 0.000 description 11
- 229920000159 gelatin Polymers 0.000 description 11
- 235000019322 gelatine Nutrition 0.000 description 11
- 235000011852 gelatine desserts Nutrition 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 239000002775 capsule Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007887 hard shell capsule Substances 0.000 description 1
- -1 hydroxide ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- RECVMTHOQWMYFX-UHFFFAOYSA-N oxygen(1+) dihydride Chemical compound [OH2+] RECVMTHOQWMYFX-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000008063 pharmaceutical solvent Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/649,947 US6387400B1 (en) | 2000-08-29 | 2000-08-29 | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
| PCT/US2001/026711 WO2002017855A2 (en) | 2000-08-29 | 2001-08-28 | Process for preparing pharmaceutical compositions for use with soft gelatin formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030897L NO20030897L (no) | 2003-02-26 |
| NO20030897D0 NO20030897D0 (no) | 2003-02-26 |
| NO333369B1 true NO333369B1 (no) | 2013-05-13 |
Family
ID=24606884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030897A NO333369B1 (no) | 2000-08-29 | 2003-02-26 | Fremgangsmate for a oke konsentrasjonen av en farmasoytisk aktiv bestanddel i forhold til fyllpreparat-viskositet for doseenheter og myk gelatinkapsel |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6387400B1 (el) |
| EP (1) | EP1365749B1 (el) |
| JP (1) | JP4990474B2 (el) |
| KR (1) | KR100634571B1 (el) |
| CN (1) | CN1237959C (el) |
| AT (1) | ATE353009T1 (el) |
| AU (2) | AU2002224317B2 (el) |
| BR (1) | BRPI0113539B8 (el) |
| CA (1) | CA2419993C (el) |
| CY (1) | CY1106542T1 (el) |
| CZ (1) | CZ299449B6 (el) |
| DE (2) | DE01984557T1 (el) |
| DK (1) | DK1365749T3 (el) |
| ES (1) | ES2206081T3 (el) |
| HK (1) | HK1056326A1 (el) |
| HU (1) | HU229381B1 (el) |
| MX (1) | MXPA03001762A (el) |
| NO (1) | NO333369B1 (el) |
| PL (1) | PL200398B1 (el) |
| PT (1) | PT1365749E (el) |
| SI (1) | SI1365749T1 (el) |
| TW (1) | TW589199B (el) |
| WO (1) | WO2002017855A2 (el) |
| ZA (1) | ZA200301007B (el) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4226846B2 (ja) * | 2002-06-07 | 2009-02-18 | キャタレント・ジャパン株式会社 | 口腔内で崩壊可能なソフトカプセル剤 |
| WO2005046727A2 (en) * | 2003-11-12 | 2005-05-26 | Ranbaxy Laboratories Limited | Ibuprofen-containing soft gelatin capsules |
| US9241902B2 (en) * | 2003-12-17 | 2016-01-26 | R.P. Scherer Technologies, Llc | Chewable soft capsules containing ungelatinized starch |
| US20050137262A1 (en) * | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
| WO2005063219A2 (en) * | 2003-12-23 | 2005-07-14 | Ranbaxy Laboratories Limited | Ibuprofen-containing soft gelatin capsules |
| EP1701710A1 (en) * | 2004-01-09 | 2006-09-20 | Wyeth | Microemulsions for pharmaceutical compositions |
| US20050249802A1 (en) * | 2004-05-06 | 2005-11-10 | The Procter & Gamble Company | Softgel encapsulated pharmaceutical compositions comprising concentrated active ingredients |
| WO2005123133A1 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | A process for preparing ibuprofen soft gelatin capsules |
| BRPI0512900A (pt) | 2004-06-30 | 2008-04-15 | Albemarle Corp | composição farmacêutica compreendendo de ibuprofeno, processo de preparação dos gránulos enriquecidos em ibuprofeno e os gránulos secos feitos por este processo |
| US20060088590A1 (en) * | 2004-10-22 | 2006-04-27 | Banner Pharmacaps, Inc. | Non-blooming gelatin and non-gelatin formulations |
| US8231896B2 (en) * | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
| US20070053868A1 (en) | 2005-03-08 | 2007-03-08 | Banner Pharmacaps, Inc. | Solvent system for enhancing the solubility of pharmaceutical agents |
| JP2009508951A (ja) * | 2005-09-19 | 2009-03-05 | アルベマール・コーポレーシヨン | カリウムイブプロフェンの極めて濃厚な注入可能な水溶液、その製造法および使用 |
| CN100404031C (zh) * | 2006-03-13 | 2008-07-23 | 浙江万联药业有限公司 | 含葡萄糖酸锌、布洛芬和马来酸氯苯那敏的软胶囊组合物 |
| US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
| WO2010011522A1 (en) | 2008-07-21 | 2010-01-28 | Albemarle Corporation | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
| ES2363964B1 (es) | 2009-11-20 | 2012-08-22 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados. |
| CA2690488C (en) | 2010-01-19 | 2013-06-11 | Accucaps Industries Limited | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof |
| CN104083339A (zh) * | 2014-08-04 | 2014-10-08 | 人福普克药业（武汉）有限公司 | 萘普生钠软胶囊及其制备方法 |
| CN107951857B (zh) * | 2017-11-29 | 2019-12-24 | 浙江安宝药业有限公司 | 布洛芬软胶囊 |
| US11911517B2 (en) | 2018-05-16 | 2024-02-27 | Bayer Healthcare Llc | High concentration suspension formulation for cold and flu soft gel capsule medications |
| WO2019224832A1 (en) * | 2018-05-25 | 2019-11-28 | Strides Shasun Limited | Process for preparing pharmaceutical compositions resulting in reduction in overall fill volume for use with soft gelatin formulations |
| CN108904465B (zh) * | 2018-10-17 | 2021-02-26 | 石药集团恩必普药业有限公司 | 一种布洛芬药物制剂组合物及其制备方法 |
| CN109820833B (zh) * | 2019-04-01 | 2022-02-01 | 人福普克药业（武汉）有限公司 | 一种快速溶出的布洛芬软胶囊及其制备方法 |
| KR20220004691A (ko) * | 2019-04-26 | 2022-01-11 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 미니 연질 겔 나프록센 조성물 |
| CA3155876A1 (en) * | 2019-10-09 | 2021-04-15 | R.P. Scherer Technologies, Llc | NON-ANIMAL SOFT GEL CAPSULE FORMULATIONS, METHODS OF PREPARATION AND METHODS OF USE |
| US20220233452A1 (en) * | 2021-01-25 | 2022-07-28 | R.P. Scherer Technologies, Llc | Mini softgel naproxen composition |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2118040A (en) | 1982-02-15 | 1983-10-26 | Hoechst Uk Ltd | Oral anti-diabetic preparation |
| HU195918B (en) | 1984-03-14 | 1988-08-29 | Jerome Corbiere | Process for producing pharmaceutical compositions containing non-steroide antiflogistic active components |
| DE3437599A1 (de) | 1984-10-13 | 1986-04-17 | Dolorgiet GmbH & Co KG, 5205 St Augustin | Ibuprofen enthaltende weichgelatinekapseln und verfahren zu ihrer herstellung |
| US5071643A (en) | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
| JP3121080B2 (ja) | 1991-12-19 | 2000-12-25 | アール・ピー・シーラー コーポレイション | カプセル封入用溶液 |
| US5376688A (en) | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
| BR9808136A (pt) * | 1997-03-03 | 2000-03-28 | Sanofi Synthelabo | Formulações farmacêuticas contendo substâncias medicamentosas fracamente solúveis. |
-
2000
- 2000-08-29 US US09/649,947 patent/US6387400B1/en not_active Expired - Lifetime
-
2001
- 2001-08-28 ES ES01984557T patent/ES2206081T3/es not_active Expired - Lifetime
- 2001-08-28 JP JP2002522830A patent/JP4990474B2/ja not_active Expired - Lifetime
- 2001-08-28 BR BRPI0113539A patent/BRPI0113539B8/pt not_active IP Right Cessation
- 2001-08-28 DE DE0001365749T patent/DE01984557T1/de active Pending
- 2001-08-28 PT PT01984557T patent/PT1365749E/pt unknown
- 2001-08-28 CZ CZ20030564A patent/CZ299449B6/cs not_active IP Right Cessation
- 2001-08-28 DE DE60126433T patent/DE60126433T2/de not_active Expired - Lifetime
- 2001-08-28 MX MXPA03001762A patent/MXPA03001762A/es active IP Right Grant
- 2001-08-28 CA CA002419993A patent/CA2419993C/en not_active Expired - Lifetime
- 2001-08-28 CN CNB01814778XA patent/CN1237959C/zh not_active Expired - Lifetime
- 2001-08-28 WO PCT/US2001/026711 patent/WO2002017855A2/en active IP Right Grant
- 2001-08-28 AT AT01984557T patent/ATE353009T1/de active
- 2001-08-28 DK DK01984557T patent/DK1365749T3/da active
- 2001-08-28 PL PL365752A patent/PL200398B1/pl unknown
- 2001-08-28 KR KR1020037002971A patent/KR100634571B1/ko active IP Right Grant
- 2001-08-28 SI SI200130688T patent/SI1365749T1/sl unknown
- 2001-08-28 HU HU0401224A patent/HU229381B1/hu unknown
- 2001-08-28 AU AU2002224317A patent/AU2002224317B2/en not_active Expired
- 2001-08-28 AU AU2431702A patent/AU2431702A/xx active Pending
- 2001-08-28 EP EP01984557A patent/EP1365749B1/en not_active Expired - Lifetime
-
2002
- 2002-01-17 TW TW091100669A patent/TW589199B/zh not_active IP Right Cessation
-
2003
- 2003-02-05 ZA ZA200301007A patent/ZA200301007B/xx unknown
- 2003-02-26 NO NO20030897A patent/NO333369B1/no not_active IP Right Cessation
- 2003-12-03 HK HK03108793A patent/HK1056326A1/xx not_active IP Right Cessation
-
2007
- 2007-04-26 CY CY20071100560T patent/CY1106542T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |