NO333367B1 - Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat - Google Patents
Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat Download PDFInfo
- Publication number
- NO333367B1 NO333367B1 NO20024221A NO20024221A NO333367B1 NO 333367 B1 NO333367 B1 NO 333367B1 NO 20024221 A NO20024221 A NO 20024221A NO 20024221 A NO20024221 A NO 20024221A NO 333367 B1 NO333367 B1 NO 333367B1
- Authority
- NO
- Norway
- Prior art keywords
- component
- preparation
- tartrate
- solubility
- imidazolin
- Prior art date
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- QZHBYNSSDLTCRG-UHFFFAOYSA-N 5-bromo-n-(4,5-dihydro-1h-imidazol-2-yl)quinoxalin-6-amine;2,3-dihydroxybutanedioate;hydron Chemical compound OC(=O)C(O)C(O)C(O)=O.C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 QZHBYNSSDLTCRG-UHFFFAOYSA-N 0.000 title claims description 22
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21820000P | 2000-07-14 | 2000-07-14 | |
| PCT/US2001/021552 WO2002005853A2 (en) | 2000-07-14 | 2001-07-09 | Compositions containing alpha-2-adrenergic agonist components |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024221D0 NO20024221D0 (no) | 2002-09-04 |
| NO20024221L NO20024221L (no) | 2002-10-28 |
| NO333367B1 true NO333367B1 (no) | 2013-05-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024221A NO333367B1 (no) | 2000-07-14 | 2002-09-04 | Blandinger inneholdende et oftalmisk preparat omfattende 5- brom-6-(2-imidazolin-2-ylamino)kinoksalintartrat |
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| EP (1) | EP1365811A2 (pl) |
| JP (3) | JP4927298B2 (pl) |
| KR (1) | KR100757656B1 (pl) |
| CN (2) | CN100569291C (pl) |
| AR (1) | AR033539A1 (pl) |
| AU (2) | AU7326901A (pl) |
| BR (1) | BR0109317A (pl) |
| CA (1) | CA2402405C (pl) |
| HU (1) | HUP0303197A3 (pl) |
| IL (2) | IL151530A0 (pl) |
| MX (1) | MXPA02008930A (pl) |
| NO (1) | NO333367B1 (pl) |
| NZ (1) | NZ521185A (pl) |
| PL (1) | PL360707A1 (pl) |
| RU (1) | RU2311928C2 (pl) |
| TW (1) | TWI287998B (pl) |
| WO (1) | WO2002005853A2 (pl) |
| ZA (1) | ZA200207413B (pl) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8858961B2 (en) | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| CA2416169C (en) * | 2000-07-14 | 2008-09-23 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
| PL360707A1 (pl) * | 2000-07-14 | 2004-09-20 | Allergan Inc. | Kompozycje zawierające składniki o działaniu agonisty alfa-2-adrenergicznego |
| AU2011250793B2 (en) * | 2000-07-14 | 2012-11-29 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| CA2446705C (en) * | 2001-05-03 | 2012-03-06 | David F. Woodward | Compositions of quinoxaline-based therapeutic agents and fatty acids having enhanced pharmacokinetic characteristics |
| US20020198209A1 (en) * | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| US6753017B2 (en) * | 2001-11-07 | 2004-06-22 | Jrs Pharma Lp | Process for preparing dry extracts |
| US7642258B2 (en) * | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US6982079B2 (en) * | 2002-04-26 | 2006-01-03 | Allergan, Inc. | Compositions for treating hyperemia |
| US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| DE60327335D1 (de) * | 2002-10-08 | 2009-06-04 | Allergan Inc | Alpha 2b oder 2b/2c adrenozeptor-agonisten zur behandlung von morbus alzheimer und morbus parkinson |
| JP2006504741A (ja) * | 2002-10-08 | 2006-02-09 | アラーガン、インコーポレイテッド | 痴呆およびパーキンソン病の処置における(2−イミダゾリン−2−イルアミノ)キノキサリンの使用方法 |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| US20040191332A1 (en) * | 2003-03-27 | 2004-09-30 | Allergan, Inc. | Preserved ophthalmic compositions |
| US7439241B2 (en) | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| CA2534484A1 (en) * | 2003-08-07 | 2005-02-17 | Allergan, Inc. | Compositions for delivery of therapeutics into the eyes and methods for making and using same |
| WO2005041869A2 (en) * | 2003-10-24 | 2005-05-12 | Josef Rettenmaier & Soehne Gmbh & Co., Kg | Process for co-spray drying agents with dry silicified mcc |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
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| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
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| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| CA2505836C (en) * | 2004-05-06 | 2013-08-27 | Alcon Inc. | Topical brimonidine tartrate formulations that lack chlorine dioxide |
| JP4955543B2 (ja) * | 2004-05-25 | 2012-06-20 | サンズローザ ファーマシューティカル ディヴェロップメント インコーポレイテッド | 炎症性皮膚疾患を治療又は予防するための化合物、製剤及び方法 |
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| US20060228487A1 (en) * | 2005-04-11 | 2006-10-12 | J. Rettenmaier & Söehne GmbH + Co. KG | Methods of combining active agents with augmented microcrystalline cellulose |
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| BRPI0615307A2 (pt) * | 2005-08-25 | 2009-08-04 | Schering Corp | agonistas de adrenorreceptor alfa2c |
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| WO2007056457A2 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| US20070238732A1 (en) * | 2006-04-10 | 2007-10-11 | Allergan, Inc. | Brimonidine and timolol compositions |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
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| US9415036B2 (en) * | 2008-02-15 | 2016-08-16 | Bone Therapeutics | Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases |
| US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
| US9192571B2 (en) | 2008-03-03 | 2015-11-24 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
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| US20100028266A1 (en) * | 2008-08-01 | 2010-02-04 | Alpha Synergy Development. Inc. | Composition and methods for treating allergic response |
| US20120156244A1 (en) * | 2008-08-01 | 2012-06-21 | Alpha Synergy Development Inc. | Nasal Compositions and Uses Thereof |
| US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
| US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
| US12246013B2 (en) | 2008-08-01 | 2025-03-11 | Eye Therapies Llc | Vasoconstriction compositions and methods of use |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| EP2323734A1 (en) * | 2008-08-04 | 2011-05-25 | Schering Corporation | Cyclopropylchromene derivatives as modulators of the alpha-2c receptor |
| EP2356106A1 (en) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| PH12012500928A1 (en) | 2009-11-09 | 2012-11-26 | Allergan Inc | Compositions and methods for stimulating hair growth |
| US20110152271A1 (en) * | 2009-12-17 | 2011-06-23 | Gerald Horn | Compositions and methods for ophthalmic delivery of nasal decongestants |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| EP3085358B1 (en) | 2010-01-22 | 2017-11-01 | Allergan, Inc. | Intracameral sustained release therapeutic agent implants |
| US8513247B2 (en) | 2010-03-26 | 2013-08-20 | Galderma Laboratories, L.P. | Methods and compositions for safe and effective treatment of erythema |
| US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
| PH12014500783A1 (en) | 2011-10-19 | 2014-05-12 | Galderma Sa | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
| CN109602691A (zh) | 2013-02-15 | 2019-04-12 | 阿勒根公司 | 持续药物递送植入物 |
| US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
| CN105682645B (zh) | 2013-10-31 | 2019-09-06 | 阿勒根公司 | 含前列腺酰胺的眼内植入物及其使用方法 |
| ES2818073T3 (es) * | 2013-12-24 | 2021-04-09 | Sentiss Pharma Private Ltd | Solución oftálmica de tartrato de brimonidina tópica |
| KR20170129823A (ko) * | 2015-03-19 | 2017-11-27 | 알러간, 인코포레이티드 | 브리모니딘 및 티몰롤의 고정된 용량 조합 |
| MX2019001633A (es) | 2016-08-12 | 2019-09-18 | Silk Tech Ltd | Proteina derivada de la seda para el tratamiento de la inflamacion. |
| EP3962478A1 (en) | 2019-05-01 | 2022-03-09 | Clexio Biosciences Ltd. | Methods of treating pruritus |
| EP4057941A4 (en) | 2019-11-15 | 2024-05-29 | Silk Technologies Ltd. | Stable formulations of silk-derived protein |
| KR102678138B1 (ko) | 2022-09-29 | 2024-06-25 | 주식회사태준제약 | 브리모니딘을 포함하는 안과용 조성물 |
| KR20250049934A (ko) | 2023-10-05 | 2025-04-14 | 주식회사태준제약 | 브리모니딘을 포함하는 안과용 조성물 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1154119B (de) * | 1961-11-30 | 1963-09-12 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von 2-(2', 4', 6'-Trimethylbenzyl)-1, 3-diazacyclopenten-(2) und seinen Salzen |
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4530920A (en) | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5607698A (en) | 1988-08-04 | 1997-03-04 | Ciba-Geigy Corporation | Method of preserving ophthalmic solution and compositions therefor |
| US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
| CA2007181C (en) | 1989-01-06 | 1998-11-24 | Angelo Mario Morella | Sustained release pharmaceutical composition |
| JPH085779B2 (ja) * | 1989-09-22 | 1996-01-24 | 杏林製薬株式会社 | フレロキサシン点眼液 |
| US5352796A (en) | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| GB9017353D0 (en) | 1990-08-08 | 1990-09-19 | Merck Sharp & Dohme | Chemical process |
| IT1252692B (it) * | 1991-11-27 | 1995-06-23 | Zambon Spa | Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi |
| JPH05271053A (ja) * | 1992-03-27 | 1993-10-19 | Lion Corp | 安定な点眼剤 |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| AU6124494A (en) | 1993-01-28 | 1994-08-15 | University Of Iowa Research Foundation, The | Ophthalmic uses of signa agonists |
| GB9310965D0 (en) * | 1993-05-27 | 1993-07-14 | Ucb Sa | 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides |
| WO1995010280A1 (en) | 1993-10-13 | 1995-04-20 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
| SK77396A3 (en) * | 1993-12-17 | 1997-01-08 | Procter & Gamble | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| US5994110A (en) | 1995-02-10 | 1999-11-30 | Mosbach; Klaus | Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof |
| US6294563B1 (en) * | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| ZA965837B (en) | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
| EP0834308A1 (en) | 1996-09-30 | 1998-04-08 | LG Chemical Limited | Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin |
| EP0975607A1 (en) | 1997-04-18 | 2000-02-02 | Abbott Laboratories | A process for the preparation of highly pure 6,7-dichloro-5- nitro-2,3-dihydroquinoxaline-2,3-dione |
| MY116782A (en) * | 1997-12-22 | 2004-03-31 | Otsuka Pharma Co Ltd | Water-soluble eye drop |
| AU2870899A (en) | 1998-02-26 | 1999-09-15 | Abbott Laboratories | Oral formulation for hydrophilic drugs |
| EP1069913B1 (en) | 1998-04-07 | 2003-07-23 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| AU757896B2 (en) * | 1998-09-02 | 2003-03-13 | Allergan, Inc. | Preserved cyclodextrin-containing compositions |
| WO2000019981A1 (en) | 1998-10-08 | 2000-04-13 | Karagoezian Hampar L | Synergistic antimicrobial, dermatological and ophthalmic preparations containing chlorite and hydrogen peroxide |
| IN185228B (pl) * | 1999-02-03 | 2000-12-09 | Bakulesh Mafatlal Dr Khamar | |
| PL360707A1 (pl) * | 2000-07-14 | 2004-09-20 | Allergan Inc. | Kompozycje zawierające składniki o działaniu agonisty alfa-2-adrenergicznego |
| CA2416169C (en) * | 2000-07-14 | 2008-09-23 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
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- 2001-07-09 AU AU7326901A patent/AU7326901A/xx active Pending
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- 2001-07-09 KR KR1020027014270A patent/KR100757656B1/ko not_active Expired - Lifetime
- 2001-07-09 WO PCT/US2001/021552 patent/WO2002005853A2/en not_active Ceased
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- 2001-07-09 MX MXPA02008930A patent/MXPA02008930A/es active IP Right Grant
- 2001-07-09 BR BR0109317-7A patent/BR0109317A/pt not_active Application Discontinuation
- 2001-07-09 IL IL15153001A patent/IL151530A0/xx unknown
- 2001-07-09 JP JP2002511784A patent/JP4927298B2/ja not_active Expired - Lifetime
- 2001-07-09 RU RU2003101321/15A patent/RU2311928C2/ru active
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- 2001-07-09 AU AU2001273269A patent/AU2001273269B2/en not_active Expired
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- 2001-07-13 TW TW090117220A patent/TWI287998B/zh not_active IP Right Cessation
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- 2002-08-28 IL IL151530A patent/IL151530A/en unknown
- 2002-09-04 NO NO20024221A patent/NO333367B1/no not_active IP Right Cessation
- 2002-09-06 US US10/236,566 patent/US6641834B2/en not_active Expired - Lifetime
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