NO331780B1 - Prodrug av eksitasjonsaminosyre, farmasoytisk preparat samt anvendelser derav - Google Patents
Prodrug av eksitasjonsaminosyre, farmasoytisk preparat samt anvendelser derav Download PDFInfo
- Publication number
- NO331780B1 NO331780B1 NO20050122A NO20050122A NO331780B1 NO 331780 B1 NO331780 B1 NO 331780B1 NO 20050122 A NO20050122 A NO 20050122A NO 20050122 A NO20050122 A NO 20050122A NO 331780 B1 NO331780 B1 NO 331780B1
- Authority
- NO
- Norway
- Prior art keywords
- mmol
- dicarboxylic acid
- hexane
- tert
- amino
- Prior art date
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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EP02380120 | 2002-06-11 | ||
EP02380121 | 2002-06-11 | ||
US41593602P | 2002-10-03 | 2002-10-03 | |
US41593702P | 2002-10-03 | 2002-10-03 | |
PCT/US2003/015405 WO2003104217A2 (en) | 2002-06-01 | 2003-06-06 | Prodrugs of excitatory amino acids |
Publications (2)
Publication Number | Publication Date |
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NO20050122L NO20050122L (no) | 2005-01-10 |
NO331780B1 true NO331780B1 (no) | 2012-03-26 |
Family
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Application Number | Title | Priority Date | Filing Date |
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NO20050122A NO331780B1 (no) | 2002-06-11 | 2005-01-10 | Prodrug av eksitasjonsaminosyre, farmasoytisk preparat samt anvendelser derav |
NO20080765A NO20080765L (no) | 2002-06-11 | 2008-02-12 | Prodrug av eksitasjonsaminosyrer |
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Application Number | Title | Priority Date | Filing Date |
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NO20080765A NO20080765L (no) | 2002-06-11 | 2008-02-12 | Prodrug av eksitasjonsaminosyrer |
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US (5) | US7371872B2 (pt) |
EP (2) | EP1517915B1 (pt) |
JP (2) | JP4342437B2 (pt) |
KR (1) | KR20080058509A (pt) |
AR (1) | AR040257A1 (pt) |
AT (1) | ATE421526T1 (pt) |
AU (1) | AU2003232146B2 (pt) |
BR (1) | BR0311558A (pt) |
CA (1) | CA2488167C (pt) |
CO (1) | CO5631438A2 (pt) |
CR (2) | CR7616A (pt) |
CY (1) | CY1108976T1 (pt) |
DE (1) | DE60325968D1 (pt) |
DK (1) | DK1517915T3 (pt) |
EA (2) | EA014979B1 (pt) |
EC (1) | ECSP085481A (pt) |
ES (1) | ES2319116T3 (pt) |
HK (1) | HK1075259A1 (pt) |
HR (2) | HRP20041179B1 (pt) |
IL (2) | IL165100A0 (pt) |
MX (1) | MXPA04012518A (pt) |
MY (1) | MY146238A (pt) |
NO (2) | NO331780B1 (pt) |
NZ (3) | NZ536459A (pt) |
PE (1) | PE20040555A1 (pt) |
PL (1) | PL221489B1 (pt) |
PT (1) | PT1517915E (pt) |
SI (1) | SI1517915T1 (pt) |
WO (1) | WO2003104217A2 (pt) |
ZA (1) | ZA200409553B (pt) |
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CA2488167C (en) * | 2002-06-11 | 2012-07-24 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
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TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
JP5656848B2 (ja) | 2008-10-16 | 2015-01-21 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体 |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
WO2010111080A2 (en) | 2009-03-27 | 2010-09-30 | Eli Lilly And Company | Optimized treatment of schizophrenia |
MX2011011962A (es) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostericos positivos de receptores de glutamato metabotropico (mglur2). |
ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2449083B9 (en) * | 2009-06-29 | 2018-04-25 | Inolex Investment Corporation | Non-petrochemically derived cationic emulsifiers that are neutralized amino acid esters and related compositions and methods |
AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
ES2682959T3 (es) * | 2010-11-18 | 2018-09-24 | Eli Lilly And Company | Compuestos de 3-benciloxi-biciclo[3.1.0]hexano 4-sustituidos como antagonistas de mGLuR 2/3 |
AR083845A1 (es) * | 2010-11-18 | 2013-03-27 | Lilly Co Eli | COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR2/3 |
AU2012271024B2 (en) | 2011-06-17 | 2015-07-09 | Eli Lilly And Company | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mGlu2 receptor agonist |
AR089718A1 (es) * | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
JP5979230B2 (ja) | 2012-06-01 | 2016-08-24 | 大正製薬株式会社 | 含フッ素アミノ酸のプロドラッグ |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
PL3096790T3 (pl) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
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CA2488167C (en) * | 2002-06-11 | 2012-07-24 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
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- 2003-06-06 BR BRPI0311558-5A patent/BR0311558A/pt not_active Application Discontinuation
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- 2003-06-06 PL PL374381A patent/PL221489B1/pl unknown
- 2003-06-06 EP EP07122014A patent/EP1897550A3/en not_active Withdrawn
- 2003-06-06 WO PCT/US2003/015405 patent/WO2003104217A2/en active Application Filing
- 2003-06-06 KR KR1020087013701A patent/KR20080058509A/ko not_active Application Discontinuation
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- 2003-06-10 AR ARP030102065A patent/AR040257A1/es active IP Right Grant
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- 2004-12-07 CO CO04122695A patent/CO5631438A2/es not_active Application Discontinuation
- 2004-12-09 CR CR7616A patent/CR7616A/es unknown
- 2004-12-10 HR HRP20041179AA patent/HRP20041179B1/hr not_active IP Right Cessation
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2005
- 2005-01-10 NO NO20050122A patent/NO331780B1/no not_active IP Right Cessation
- 2005-08-31 HK HK05107648.6A patent/HK1075259A1/xx not_active IP Right Cessation
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2008
- 2008-02-07 IL IL189355A patent/IL189355A/en not_active IP Right Cessation
- 2008-02-12 NO NO20080765A patent/NO20080765L/no not_active Application Discontinuation
- 2008-02-13 JP JP2008031490A patent/JP2008201779A/ja active Pending
- 2008-03-31 US US12/059,112 patent/US7671082B2/en not_active Expired - Lifetime
- 2008-04-03 EC EC2008005481A patent/ECSP085481A/es unknown
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2009
- 2009-01-30 HR HR20090058A patent/HRP20090058A2/xx not_active Application Discontinuation
- 2009-04-07 CY CY20091100411T patent/CY1108976T1/el unknown
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2010
- 2010-01-15 US US12/688,074 patent/US7964632B2/en not_active Expired - Lifetime
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