NO331712B1 - Fremgangsmate for rensing av IL-18 BP samt anvendelse av et vandig tofasesystem for rensing eller innfanging av IL-18BP - Google Patents
Fremgangsmate for rensing av IL-18 BP samt anvendelse av et vandig tofasesystem for rensing eller innfanging av IL-18BP Download PDFInfo
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- NO331712B1 NO331712B1 NO20070483A NO20070483A NO331712B1 NO 331712 B1 NO331712 B1 NO 331712B1 NO 20070483 A NO20070483 A NO 20070483A NO 20070483 A NO20070483 A NO 20070483A NO 331712 B1 NO331712 B1 NO 331712B1
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229960001388 interferon-beta Drugs 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 239000008180 pharmaceutical surfactant Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000013587 production medium Substances 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04103047 | 2004-06-29 | ||
US58729604P | 2004-07-12 | 2004-07-12 | |
PCT/EP2005/053010 WO2006003134A1 (en) | 2004-06-29 | 2005-06-27 | Process for the purification of il-18 binding protein |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20070483L NO20070483L (no) | 2007-03-14 |
NO331712B1 true NO331712B1 (no) | 2012-03-05 |
Family
ID=39124614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070483A NO331712B1 (no) | 2004-06-29 | 2007-01-25 | Fremgangsmate for rensing av IL-18 BP samt anvendelse av et vandig tofasesystem for rensing eller innfanging av IL-18BP |
Country Status (11)
Country | Link |
---|---|
US (2) | US7439336B2 (de) |
EP (1) | EP1761552B1 (de) |
JP (1) | JP5043654B2 (de) |
AT (1) | ATE408616T1 (de) |
AU (1) | AU2005259269B2 (de) |
CA (1) | CA2569795C (de) |
DE (1) | DE602005009827D1 (de) |
ES (1) | ES2313367T3 (de) |
IL (1) | IL179997A (de) |
NO (1) | NO331712B1 (de) |
WO (1) | WO2006003134A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI335336B (de) * | 2000-02-10 | 2011-01-01 | Abbott Gmbh & Co Kg | |
RS50488B (sr) | 2003-03-11 | 2010-03-02 | Laboratoires Serono Sa. | Vektori ekspresije koji sadrže mcmv ie2 promotor |
SI1622939T1 (sl) * | 2003-05-13 | 2012-06-29 | Merck Serono Sa | Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega |
PL1675956T3 (pl) * | 2003-10-21 | 2011-06-30 | Merck Serono Sa | Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek |
SI1689777T1 (sl) | 2003-11-05 | 2007-08-31 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
RS50531B (sr) * | 2004-03-01 | 2010-05-07 | Ares Trading S.A. | Upotreba podloge za ćelijsku kulturu bez sadržaja seruma za produkciju il-18bp u ćelijama sisara |
DE602005009827D1 (de) * | 2004-06-29 | 2008-10-30 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
DK1885753T3 (da) | 2005-06-03 | 2011-10-03 | Ares Trading Sa | Fremstilling af rekombinant II-18-proteiner |
DK1891088T3 (da) | 2005-06-10 | 2012-01-30 | Ares Trading Sa | Fremgangsmåde til rensning af et IL-18-bindende protein |
BRPI0812721A2 (pt) * | 2007-06-19 | 2014-12-30 | Ge Healthcare Bio Sciences Ab | Processo para isolar um ou mais compostos alvo de um líquido aquoso, processo de multietapas para isolar um ou mais compostos alvo, e, método para isolar pelo menos um anticorpo de um líquido |
US9176105B2 (en) | 2010-08-20 | 2015-11-03 | President And Fellows Of Harvard College | Density-based separation of biological analytes using multiphase systems |
CN101962635B (zh) * | 2010-10-20 | 2012-02-15 | 山东农业大学 | 生姜蛋白酶的三步双水相萃取方法 |
CN111363024A (zh) * | 2018-12-26 | 2020-07-03 | 深圳翰宇药业股份有限公司 | 多肽的纯化方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4508825A (en) * | 1983-03-30 | 1985-04-02 | Miles Laboratories, Inc. | Method for the separation of extracellular amylase and protease produced during the fermentation of enzyme producing microorganisms |
SE8302483L (sv) * | 1983-05-02 | 1984-11-03 | Pharmacia Ind | Forfarande vid rening av biologiskt aktiva substanser |
FR2545501B1 (fr) * | 1983-05-06 | 1985-08-02 | Elf Bio Rech | Procede de purification de la dextrane-saccharase |
US4743550A (en) * | 1985-04-29 | 1988-05-10 | Union Carbide Corporation | Method for improving the partition coefficient in enzyme-containing systems having at least two phases |
US4728613A (en) * | 1985-09-04 | 1988-03-01 | Miles Laboratories, Inc. | Method for the recovery of extracellular enzymes from whole fermentation beer |
US4684723A (en) * | 1985-09-11 | 1987-08-04 | Miles Laboratories, Inc. | Method of separating proteins from aqueous solutions |
ATE126531T1 (de) | 1989-06-13 | 1995-09-15 | Genencor Int | Verfahren zur gewinnung von natürlich hergestelltem chymosin. |
US5139943A (en) * | 1989-06-13 | 1992-08-18 | Genencor International, Inc. | Processes for the recovery of microbially produced chymosin |
US5093254A (en) * | 1990-01-23 | 1992-03-03 | The United States Of America, As Represented By The Secretary Of Commerce | Aqueous two-phase protein extraction |
US5328841A (en) * | 1990-10-05 | 1994-07-12 | Genencor International, Inc. | Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol |
SE9003534D0 (sv) | 1990-11-06 | 1990-11-06 | Kabigen Ab | A method for isolating and purifying peptides and proteins |
US5407579A (en) * | 1993-07-02 | 1995-04-18 | National Science Council | Hemoglobin purification |
US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
WO1996023061A2 (en) | 1995-01-27 | 1996-08-01 | Genencor International, Inc. | Surfactant-based enzyme extraction process |
US5907035A (en) * | 1996-05-23 | 1999-05-25 | Baxter Biotech Technology Sarl | Aqueous two-phase metal affinity partitioning protein purification system |
SE9603303D0 (sv) * | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
ZA986162B (en) * | 1997-07-11 | 1999-01-28 | Euresys Sa | Image acquisition and processing method and apparatus |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
KR100537558B1 (ko) * | 1998-09-01 | 2005-12-19 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 인터류킨-18 결합 단백질 |
JP4216950B2 (ja) * | 1998-09-01 | 2009-01-28 | 株式会社林原生物化学研究所 | インターロイキン−18結合蛋白質 |
AU777203B2 (en) * | 1998-12-30 | 2004-10-07 | Hans Olof Johansson | Separation method utilizing liquid-liquid partition |
US6437101B1 (en) | 1999-05-07 | 2002-08-20 | Akzo Nobel N.V. | Methods for protein purification using aqueous two-phase extraction |
RS50488B (sr) * | 2003-03-11 | 2010-03-02 | Laboratoires Serono Sa. | Vektori ekspresije koji sadrže mcmv ie2 promotor |
SI1622939T1 (sl) * | 2003-05-13 | 2012-06-29 | Merck Serono Sa | Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega |
PL1675956T3 (pl) | 2003-10-21 | 2011-06-30 | Merck Serono Sa | Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek |
SI1689777T1 (sl) | 2003-11-05 | 2007-08-31 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
RS50531B (sr) * | 2004-03-01 | 2010-05-07 | Ares Trading S.A. | Upotreba podloge za ćelijsku kulturu bez sadržaja seruma za produkciju il-18bp u ćelijama sisara |
DE602005009827D1 (de) * | 2004-06-29 | 2008-10-30 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
DK1885753T3 (da) | 2005-06-03 | 2011-10-03 | Ares Trading Sa | Fremstilling af rekombinant II-18-proteiner |
DK1891088T3 (da) | 2005-06-10 | 2012-01-30 | Ares Trading Sa | Fremgangsmåde til rensning af et IL-18-bindende protein |
-
2005
- 2005-06-27 DE DE602005009827T patent/DE602005009827D1/de active Active
- 2005-06-27 CA CA2569795A patent/CA2569795C/en active Active
- 2005-06-27 ES ES05756895T patent/ES2313367T3/es active Active
- 2005-06-27 US US11/630,845 patent/US7439336B2/en active Active
- 2005-06-27 AT AT05756895T patent/ATE408616T1/de not_active IP Right Cessation
- 2005-06-27 EP EP05756895A patent/EP1761552B1/de active Active
- 2005-06-27 JP JP2007518598A patent/JP5043654B2/ja active Active
- 2005-06-27 AU AU2005259269A patent/AU2005259269B2/en active Active
- 2005-06-27 WO PCT/EP2005/053010 patent/WO2006003134A1/en active IP Right Grant
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2006
- 2006-12-12 IL IL179997A patent/IL179997A/en active IP Right Grant
-
2007
- 2007-01-25 NO NO20070483A patent/NO331712B1/no unknown
-
2008
- 2008-10-13 US US12/250,075 patent/US7943746B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2006003134A1 (en) | 2006-01-12 |
US7943746B2 (en) | 2011-05-17 |
ATE408616T1 (de) | 2008-10-15 |
IL179997A0 (en) | 2007-05-15 |
CA2569795C (en) | 2013-08-13 |
US20090054627A1 (en) | 2009-02-26 |
US20070293658A1 (en) | 2007-12-20 |
NO20070483L (no) | 2007-03-14 |
AU2005259269B2 (en) | 2010-12-09 |
US7439336B2 (en) | 2008-10-21 |
CA2569795A1 (en) | 2006-01-12 |
ES2313367T3 (es) | 2009-03-01 |
DE602005009827D1 (de) | 2008-10-30 |
EP1761552B1 (de) | 2008-09-17 |
JP5043654B2 (ja) | 2012-10-10 |
IL179997A (en) | 2015-10-29 |
AU2005259269A1 (en) | 2006-01-12 |
JP2008504346A (ja) | 2008-02-14 |
EP1761552A1 (de) | 2007-03-14 |
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