NO329756B1 - Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor - Google Patents
Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor Download PDFInfo
- Publication number
- NO329756B1 NO329756B1 NO20043567A NO20043567A NO329756B1 NO 329756 B1 NO329756 B1 NO 329756B1 NO 20043567 A NO20043567 A NO 20043567A NO 20043567 A NO20043567 A NO 20043567A NO 329756 B1 NO329756 B1 NO 329756B1
- Authority
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- Norway
- Prior art keywords
- pyrimidin
- imidazo
- group
- ethyl
- stated
- Prior art date
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- 229940079593 drug Drugs 0.000 title claims description 22
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- 108010061506 tau-protein kinase Proteins 0.000 description 1
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- 238000010798 ubiquitination Methods 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290487A EP1340759A1 (en) | 2002-02-28 | 2002-02-28 | 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives |
| PCT/EP2003/002652 WO2003072580A1 (en) | 2002-02-28 | 2003-02-26 | 1-[ALKYL], 1-[HETEROARYL)ALKYL] AND 1-[ARYL)ALKYL]-7-(PYRIMIDIN-4-YL)-IMADAZO[1,2-a]PYRIMIDIN-5(1H)-ONE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20043567L NO20043567L (no) | 2004-11-26 |
| NO329756B1 true NO329756B1 (no) | 2010-12-13 |
Family
ID=27675771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043567A NO329756B1 (no) | 2002-02-28 | 2004-08-26 | Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7429663B2 (xx) |
| EP (2) | EP1340759A1 (xx) |
| JP (1) | JP4484524B2 (xx) |
| KR (1) | KR100935262B1 (xx) |
| CN (1) | CN100441581C (xx) |
| AR (1) | AR038620A1 (xx) |
| AT (1) | ATE309246T1 (xx) |
| AU (1) | AU2003214127C1 (xx) |
| BR (1) | BR0308106A (xx) |
| CA (1) | CA2474875C (xx) |
| DE (1) | DE60302220T2 (xx) |
| DK (1) | DK1480981T3 (xx) |
| EA (1) | EA007459B1 (xx) |
| ES (1) | ES2250876T3 (xx) |
| IL (1) | IL163288A (xx) |
| MX (1) | MXPA04008365A (xx) |
| NO (1) | NO329756B1 (xx) |
| NZ (1) | NZ534467A (xx) |
| PL (1) | PL372664A1 (xx) |
| SI (1) | SI1480981T1 (xx) |
| TW (1) | TWI305534B (xx) |
| WO (1) | WO2003072580A1 (xx) |
| ZA (1) | ZA200406154B (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004008098T8 (de) * | 2003-10-10 | 2008-04-17 | Pfizer Products Inc., Groton | Substituierte 2h-[1,2,4]triazolo[4,3-a]pyrazine als gsk-3-inhibitoren |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| AU2009260526A1 (en) * | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted indoles |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2448939B1 (fr) * | 2009-07-02 | 2017-03-01 | Sanofi | Derives de 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique |
| CN106459059B (zh) | 2014-05-13 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 氘化杂环化合物和其作为成像剂的用途 |
| CN112574219A (zh) * | 2021-01-31 | 2021-03-30 | 湖北大学 | 一种苯并咪唑并嘧啶酮衍生物的合成方法 |
| CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0184384B1 (en) * | 1984-12-06 | 1989-08-02 | Pfizer Inc. | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them |
| AU733877C (en) * | 1996-12-05 | 2003-05-08 | Amgen, Inc. | Substituted pyrimidine compounds and their use |
| TWI241298B (en) * | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
| EP1184384A1 (en) * | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 1-(Alkyl), 1-((heteroaryl)alkyl) and 1-((aryl)alkyl)-7-pyridin-4-ylimidazo(1,2a)pyrimidin-5(1H)-one derivatives |
| EP1295884A1 (en) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives |
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2002
- 2002-02-28 EP EP02290487A patent/EP1340759A1/en not_active Withdrawn
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2003
- 2003-02-26 BR BR0308106-0A patent/BR0308106A/pt active Search and Examination
- 2003-02-26 DE DE60302220T patent/DE60302220T2/de not_active Expired - Lifetime
- 2003-02-26 EP EP03709786A patent/EP1480981B1/en not_active Expired - Lifetime
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- 2003-02-26 KR KR1020047013439A patent/KR100935262B1/ko not_active IP Right Cessation
- 2003-02-26 AU AU2003214127A patent/AU2003214127C1/en not_active Ceased
- 2003-02-26 AT AT03709786T patent/ATE309246T1/de active
- 2003-02-26 NZ NZ534467A patent/NZ534467A/en not_active IP Right Cessation
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- 2003-02-26 SI SI200330137T patent/SI1480981T1/sl unknown
- 2003-02-26 ES ES03709786T patent/ES2250876T3/es not_active Expired - Lifetime
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- 2003-02-27 TW TW092104221A patent/TWI305534B/zh not_active IP Right Cessation
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2004
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2008
- 2008-08-20 US US12/194,899 patent/US20080318980A1/en not_active Abandoned
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