NO329639B1 - Anilin-avledete ligander for thyroid-reseptoren - Google Patents
Anilin-avledete ligander for thyroid-reseptoren Download PDFInfo
- Publication number
- NO329639B1 NO329639B1 NO20023895A NO20023895A NO329639B1 NO 329639 B1 NO329639 B1 NO 329639B1 NO 20023895 A NO20023895 A NO 20023895A NO 20023895 A NO20023895 A NO 20023895A NO 329639 B1 NO329639 B1 NO 329639B1
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- compound according
- alkyl
- mmol
- compound
- Prior art date
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- 108090000721 thyroid hormone receptors Proteins 0.000 title description 15
- 102000004217 thyroid hormone receptors Human genes 0.000 title description 15
- 239000003446 ligand Substances 0.000 title description 11
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 79
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- 239000003472 antidiabetic agent Substances 0.000 claims description 14
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- 229910052736 halogen Inorganic materials 0.000 claims description 14
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- 229940125708 antidiabetic agent Drugs 0.000 claims description 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 208000017520 skin disease Diseases 0.000 claims description 9
- 125000005907 alkyl ester group Chemical group 0.000 claims description 8
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- 229940078581 Bone resorption inhibitor Drugs 0.000 claims description 7
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
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- 201000010099 disease Diseases 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
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- 102000007330 LDL Lipoproteins Human genes 0.000 description 6
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- C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Endocrinology (AREA)
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- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US18322300P | 2000-02-17 | 2000-02-17 | |
| PCT/US2001/001204 WO2001060784A1 (en) | 2000-02-17 | 2001-01-12 | Aniline-derived ligands for the thyroid receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023895D0 NO20023895D0 (no) | 2002-08-16 |
| NO20023895L NO20023895L (no) | 2002-10-16 |
| NO329639B1 true NO329639B1 (no) | 2010-11-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023895A NO329639B1 (no) | 2000-02-17 | 2002-08-16 | Anilin-avledete ligander for thyroid-reseptoren |
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| JP (1) | JP4629294B2 (hu) |
| KR (1) | KR100740383B1 (hu) |
| CN (1) | CN1216857C (hu) |
| AR (1) | AR031094A1 (hu) |
| AT (1) | ATE295348T1 (hu) |
| AU (2) | AU2001230929B2 (hu) |
| BR (1) | BR0108134A (hu) |
| CA (1) | CA2400486C (hu) |
| CO (1) | CO5271672A1 (hu) |
| CZ (1) | CZ20022771A3 (hu) |
| DE (1) | DE60110753T2 (hu) |
| DK (1) | DK1257526T3 (hu) |
| EG (1) | EG25009A (hu) |
| ES (1) | ES2242723T3 (hu) |
| HK (1) | HK1047925B (hu) |
| HU (1) | HUP0301777A3 (hu) |
| IL (2) | IL150449A0 (hu) |
| MX (1) | MXPA02007929A (hu) |
| MY (1) | MY124534A (hu) |
| NO (1) | NO329639B1 (hu) |
| NZ (1) | NZ520023A (hu) |
| PE (1) | PE20020767A1 (hu) |
| PL (1) | PL201790B1 (hu) |
| PT (1) | PT1257526E (hu) |
| RU (1) | RU2260586C2 (hu) |
| UY (1) | UY26581A1 (hu) |
| WO (1) | WO2001060784A1 (hu) |
| ZA (1) | ZA200206072B (hu) |
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| US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| DE10131462A1 (de) * | 2001-06-29 | 2003-01-09 | Bayer Ag | Phenol-Derivate |
| US6806381B2 (en) | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
| EP1448512A1 (en) * | 2001-11-17 | 2004-08-25 | NeuroSearch A/S | Prodrugs of antidepressants and their use for treating depressions |
| GB0208384D0 (en) * | 2002-04-11 | 2002-05-22 | Karobio Ab | Novel compounds |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| JP2006516620A (ja) * | 2003-01-24 | 2006-07-06 | ブリストル−マイヤーズ スクイブ カンパニー | 甲状腺受容体におけるシクロアルキル含有アニリドリガンド |
| CN103664802B (zh) * | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
| US7501427B2 (en) * | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| GB0406378D0 (en) * | 2004-03-22 | 2004-04-21 | Karobio Ab | Novel pharmaceutical compositions |
| US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
| GB0606212D0 (en) * | 2006-03-28 | 2006-05-10 | Karobio Ab | Pharmaceutical compositions |
| GB0606201D0 (en) * | 2006-03-28 | 2006-05-10 | Karobio Ab | Improved crytalline material |
| US20070238770A1 (en) * | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
| GB0724478D0 (en) * | 2007-12-14 | 2008-01-30 | Karobio Ab | Pharmaceutical compositions |
| US20090197947A1 (en) * | 2008-02-01 | 2009-08-06 | The Research Foundation Of State University Of New York | Medicaments and methods for lowering plasma lipid levels and screening drugs |
| US8922530B2 (en) * | 2010-01-06 | 2014-12-30 | Apple Inc. | Communicating stylus |
| EP2609910A1 (en) | 2011-12-30 | 2013-07-03 | Deva Holding Anonim Sirketi | Formulations of eprotirome |
| PL2695611T3 (pl) | 2012-08-06 | 2015-03-31 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Eprotirom do stosowania w profilaktyce i/lub leczeniu zaburzeń włosów oraz jego kompozycje |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| JP6982004B2 (ja) * | 2016-05-18 | 2021-12-17 | オレゴン ヘルス アンド サイエンス ユニバーシティ | ソベチロム誘導体 |
| KR20190104524A (ko) | 2016-11-21 | 2019-09-10 | 바이킹 테라퓨틱스 인코포레이티드 | 당원축적질환의 치료 방법 |
| EP3634426A4 (en) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS |
| EA202091979A1 (ru) | 2018-03-22 | 2021-06-22 | Вайкинг Терапьютикс, Инк. | Кристаллические формы и способы получения кристаллических форм соединения |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| AU2019397067A1 (en) * | 2018-12-12 | 2021-07-22 | Autobahn Therapeutics, Inc. | Novel thyromimetics |
| JP7445996B2 (ja) | 2019-02-21 | 2024-03-08 | ナンジン・ルイジェ・ファーマ・カンパニー・リミテッド | 新規化合物及び甲状腺ホルモン受容体アゴニストとしてのそれらの使用 |
| US11667606B2 (en) | 2019-03-01 | 2023-06-06 | Autobahn Therapeutics, Inc. | Thyromimetics |
| AU2021283577A1 (en) | 2020-06-02 | 2023-01-19 | Chengdu Kanghong Pharmaceutical Co., Ltd. | Novel thyroid hormone β receptor agonist |
| WO2023177667A1 (en) * | 2022-03-16 | 2023-09-21 | Brii Biosciences, Inc. | Thyroid hormone receptor agonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1078582B (de) * | 1958-10-29 | 1960-03-31 | Hoechst Ag | Verfahren zur Herstellung substituierter Thyropropionsaeuren |
| JPS6061747A (ja) * | 1983-09-16 | 1985-04-09 | Konishiroku Photo Ind Co Ltd | 熱現像感光材料 |
| ES2108855T3 (es) | 1992-07-21 | 1998-01-01 | Ciba Geigy Ag | Derivados de acido oxamico como agentes hipocolesteremicos. |
| GB9713739D0 (en) * | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
| ATE272609T1 (de) | 1999-03-01 | 2004-08-15 | Pfizer Prod Inc | Oxamsäure und deren derivate als liganden der thyroid-rezeptoren |
| PT1033364E (pt) | 1999-03-01 | 2005-07-29 | Pfizer Prod Inc | Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide |
| CO5160290A1 (es) | 1999-03-29 | 2002-05-30 | Novartis Ag | Derivados de acido fenoxifeniloxamico sustituido . |
| DK1088819T3 (da) | 1999-09-30 | 2005-09-12 | Pfizer Prod Inc | 6-azauracilderivater som thyroidreceptorligander |
| US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| AP2002002634A0 (en) * | 2000-03-31 | 2002-09-30 | Pfizer Prod Inc | Malonamic Acids And Derivatives Thereof As Thyroid Receptor Ligands. |
| AU4884701A (en) * | 2000-05-12 | 2001-11-20 | Kissei Pharmaceutical Co. Ltd. | Malonanilic acid derivatives, medicinal compositions containing the same and usethereof |
| JP4225791B2 (ja) * | 2001-05-18 | 2009-02-18 | キッセイ薬品工業株式会社 | 肝癌の予防または再発抑制剤 |
| TW200504021A (en) * | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
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2001
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- 2001-01-12 MX MXPA02007929A patent/MXPA02007929A/es active IP Right Grant
- 2001-01-12 HU HU0301777A patent/HUP0301777A3/hu unknown
- 2001-01-12 RU RU2002123349/04A patent/RU2260586C2/ru not_active IP Right Cessation
- 2001-01-12 NZ NZ520023A patent/NZ520023A/en not_active IP Right Cessation
- 2001-01-12 CA CA2400486A patent/CA2400486C/en not_active Expired - Fee Related
- 2001-01-12 ES ES01903064T patent/ES2242723T3/es not_active Expired - Lifetime
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- 2001-01-12 IL IL15044901A patent/IL150449A0/xx active IP Right Grant
- 2001-01-12 AU AU2001230929A patent/AU2001230929B2/en not_active Ceased
- 2001-01-12 JP JP2001559838A patent/JP4629294B2/ja not_active Expired - Fee Related
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- 2001-01-12 AU AU3092901A patent/AU3092901A/xx active Pending
- 2001-01-12 KR KR1020027010684A patent/KR100740383B1/ko not_active IP Right Cessation
- 2001-01-12 PT PT01903064T patent/PT1257526E/pt unknown
- 2001-01-12 EP EP01903064A patent/EP1257526B1/en not_active Expired - Lifetime
- 2001-01-12 DE DE60110753T patent/DE60110753T2/de not_active Expired - Lifetime
- 2001-01-12 DK DK01903064T patent/DK1257526T3/da active
- 2001-01-12 WO PCT/US2001/001204 patent/WO2001060784A1/en active IP Right Grant
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- 2001-01-16 US US09/761,050 patent/US6800605B1/en not_active Expired - Lifetime
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- 2001-02-14 EG EG20010132A patent/EG25009A/xx active
- 2001-02-15 CO CO01012101A patent/CO5271672A1/es not_active Application Discontinuation
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2002
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- 2002-07-30 ZA ZA200206072A patent/ZA200206072B/en unknown
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2003
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2004
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