NO327294B1 - Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. - Google Patents
Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. Download PDFInfo
- Publication number
- NO327294B1 NO327294B1 NO19985699A NO985699A NO327294B1 NO 327294 B1 NO327294 B1 NO 327294B1 NO 19985699 A NO19985699 A NO 19985699A NO 985699 A NO985699 A NO 985699A NO 327294 B1 NO327294 B1 NO 327294B1
- Authority
- NO
- Norway
- Prior art keywords
- oral preparation
- enteric coating
- alginic acid
- composition
- coating
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 238000009505 enteric coating Methods 0.000 title claims abstract description 27
- 239000002702 enteric coating Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 40
- 238000000034 method Methods 0.000 title claims description 6
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 27
- 229920000615 alginic acid Polymers 0.000 claims abstract description 27
- 239000000783 alginic acid Substances 0.000 claims abstract description 26
- 229960001126 alginic acid Drugs 0.000 claims abstract description 26
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 26
- 239000002245 particle Substances 0.000 claims abstract description 19
- 239000002775 capsule Substances 0.000 claims abstract description 17
- 239000011230 binding agent Substances 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 239000008188 pellet Substances 0.000 claims abstract description 6
- 239000003826 tablet Substances 0.000 claims abstract description 6
- 235000021120 animal protein Nutrition 0.000 claims abstract description 3
- 239000007864 aqueous solution Substances 0.000 claims abstract description 3
- 229920000159 gelatin Polymers 0.000 claims abstract description 3
- 235000019322 gelatine Nutrition 0.000 claims abstract description 3
- 239000000416 hydrocolloid Substances 0.000 claims abstract description 3
- 235000013311 vegetables Nutrition 0.000 claims abstract description 3
- 239000008199 coating composition Substances 0.000 claims description 13
- 241000894006 Bacteria Species 0.000 claims description 12
- 238000000576 coating method Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 8
- 239000007903 gelatin capsule Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 235000015872 dietary supplement Nutrition 0.000 claims description 5
- 229920000161 Locust bean gum Polymers 0.000 claims description 4
- 235000010420 locust bean gum Nutrition 0.000 claims description 4
- 239000000711 locust bean gum Substances 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000003232 water-soluble binding agent Substances 0.000 claims description 2
- 235000013912 Ceratonia siliqua Nutrition 0.000 abstract 1
- 240000008886 Ceratonia siliqua Species 0.000 abstract 1
- 239000001828 Gelatine Substances 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 239000013543 active substance Substances 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000004006 olive oil Substances 0.000 description 4
- 235000008390 olive oil Nutrition 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- -1 carboxymethylethyl Chemical group 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK63696 | 1996-06-06 | ||
| PCT/DK1997/000252 WO1997046224A1 (en) | 1996-06-06 | 1997-06-06 | Enteric coating, comprising alginic acid, for an oral preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985699D0 NO985699D0 (no) | 1998-12-04 |
| NO985699L NO985699L (no) | 1999-02-08 |
| NO327294B1 true NO327294B1 (no) | 2009-06-02 |
Family
ID=8095832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985699A NO327294B1 (no) | 1996-06-06 | 1998-12-04 | Sammensetning for dannelse av et enterisk belegg pa et oralt preparat, preparatet forsynt med et enterisk belegg og fremgangsmate for fremstilling av et slikt preparat. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6455052B1 (de) |
| EP (1) | EP0952824B1 (de) |
| JP (1) | JP2000514406A (de) |
| KR (1) | KR20000016331A (de) |
| CN (1) | CN1147291C (de) |
| AT (1) | ATE277605T1 (de) |
| AU (1) | AU717817B2 (de) |
| BR (1) | BR9709535A (de) |
| CA (1) | CA2257378C (de) |
| DE (1) | DE69730991T2 (de) |
| IL (1) | IL127378A (de) |
| NO (1) | NO327294B1 (de) |
| NZ (1) | NZ333182A (de) |
| WO (1) | WO1997046224A1 (de) |
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| JP3142821B2 (ja) * | 1998-08-27 | 2001-03-07 | 株式会社エヌ・ティ・ティ・ドコモ | 情報通信ネットワークの課金方法 |
| JP3142820B2 (ja) | 1998-08-27 | 2001-03-07 | 株式会社エヌ・ティ・ティ・ドコモ | プッシュ型情報配信方法およびその中継装置 |
| BR0114552A (pt) * | 2000-10-20 | 2003-07-01 | Biovitrum Ab | N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia |
| NL1018991C2 (nl) * | 2001-09-20 | 2003-03-21 | Tno | Vochtwerende eetbare bekledingslaag voor voedingsmiddelen. |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| KR100491647B1 (ko) * | 2002-11-21 | 2005-05-27 | 한국화학연구원 | 알긴산 나트륨 피복층을 포함하는 벤즈 이미다졸 유도체의경구체제 및 그의 제조방법 |
| US7122370B2 (en) * | 2003-01-14 | 2006-10-17 | Randolph Stanley Porubcan | Formulations to increase in vivo survival of probiotic bacteria and extend their shelf-life |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| GB0320522D0 (en) | 2003-09-02 | 2003-10-01 | Glaxo Group Ltd | Formulation |
| ES2300546T3 (es) * | 2003-09-05 | 2008-06-16 | Myung-Jun Chung | Polvo de bacterias del acido lactico doblemente recubiertas usando proteina y polisacarido y metodo de preparacion del mismo y forma farmaceutica del mismo. |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| US20080126195A1 (en) | 2004-07-22 | 2008-05-29 | Ritter Andrew J | Methods and Compositions for Treating Lactose Intolerance |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| ATE515198T1 (de) | 2005-05-18 | 2011-07-15 | Dsm Ip Assets Bv | Zusammensetzung für die enterale verabreichung von mikroorganismen |
| US8519120B2 (en) | 2006-08-08 | 2013-08-27 | Shin-Etsu Chemical Co., Ltd. | Methods for producing a low-substituted hydroxypropylcellulose powder |
| US8343547B2 (en) | 2006-08-08 | 2013-01-01 | Shin-Etsu Chemical Co., Ltd. | Solid dosage form comprising solid dispersion |
| US8343548B2 (en) * | 2006-08-08 | 2013-01-01 | Shin-Etsu Chemical Co., Ltd. | Solid dosage form comprising solid dispersion |
| BRPI0912811B1 (pt) * | 2008-09-17 | 2021-08-03 | Hunter Immunology Pty Limited | Vacina monobacteriana |
| GB2480042B (en) | 2009-02-24 | 2014-03-12 | Ritter Pharmaceuticals Inc | Solid oral unit-dosage prebiotic forms and methods of use |
| ES2534908T3 (es) | 2009-07-22 | 2015-04-30 | Grünenthal GmbH | Forma de dosificación de liberación controlada extruida por fusión en caliente |
| BR112012001244A2 (pt) | 2009-07-22 | 2020-12-08 | Gruünenthal Gmbh | Forma de dosagem resitente à adulteração, seu processo de produção, e embalagem contendo tal forma |
| EP2563372A4 (de) | 2010-04-28 | 2013-10-02 | Ritter Pharmaceuticals Inc | Präbiotische formulierungen und verwendungsverfahren dafür |
| US8940858B2 (en) * | 2010-05-17 | 2015-01-27 | Northwestern University | Fibrous microcapsules and methods of assembly and use thereof |
| JP5925779B2 (ja) | 2010-09-02 | 2016-05-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 無機塩を含む不正使用抵抗性剤形 |
| JP6063462B2 (ja) | 2011-07-29 | 2017-01-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| BR112015026549A2 (pt) | 2013-05-29 | 2017-07-25 | Gruenenthal Gmbh | forma de dosagem à prova de violação contendo uma ou mais partículas |
| CN105682643B (zh) | 2013-07-12 | 2019-12-13 | 格吕伦塔尔有限公司 | 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型 |
| CA2931553C (en) | 2013-11-26 | 2022-01-18 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| WO2015153841A1 (en) | 2014-04-04 | 2015-10-08 | Ritter Pharmaceuticals, Inc. | Methods and compositions for microbiome alteration |
| CA2947786A1 (en) | 2014-05-12 | 2015-11-19 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising tapentadol |
| KR102392313B1 (ko) * | 2014-09-03 | 2022-05-02 | 라이온 가부시키가이샤 | 코팅 제제 및 그 제조 방법 |
| ITUB20152290A1 (it) * | 2015-07-17 | 2017-01-17 | Laboratori Baldacci Spa | Prodotto a base di ferro bisglicinato chelato e acido alginico e/o suoi sali idrosolubili, sue formulazioni ed suoi usi farmaceutici |
| US11865099B2 (en) | 2015-07-17 | 2024-01-09 | Laboratori Baldacci S.P.A. | Product based on iron bis-glycinate chelate and alginic acid and/or water-soluble salts thereof, formulations thereof, and pharmaceutical uses thereof |
| EP3346991A1 (de) | 2015-09-10 | 2018-07-18 | Grünenthal GmbH | Schutz vor oraler überdosierung mit missbrauchssicheren formulierungen mit sofortiger freisetzung |
| CN115252650A (zh) | 2015-11-03 | 2022-11-01 | 布里格姆及妇女医院股份有限公司 | 用于治疗和/或预防食物变态反应的治疗性微生物群 |
| US20170296476A1 (en) * | 2016-04-15 | 2017-10-19 | Grünenthal GmbH | Modified release abuse deterrent dosage forms |
| US10618042B1 (en) | 2017-05-31 | 2020-04-14 | University Of South Florida | Mixed metal oxide extrudate catalyst |
| EP3723775A4 (de) | 2017-12-15 | 2022-04-13 | Solarea Bio, Inc. | Mikrobielle zusammensetzungen und verfahren zur behandlung von typ-2-diabetes, fettleibigkeit und stoffwechselsyndrom |
| FR3083545A1 (fr) | 2018-07-04 | 2020-01-10 | Institut National De La Recherche Agronomique | Utilisation d'une souche de roseburia intestinalis pour la prevention et le traitement de l'inflammation de l'intestin |
| WO2020051379A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| EP3646857A1 (de) | 2018-11-01 | 2020-05-06 | Evonik Operations GmbH | System zur abgabe von mikroorganismen im dickdarm |
| AU2019377423B2 (en) | 2018-11-05 | 2023-09-21 | MarvelBiome, Inc. | Microbial compositions comprising ellagitannin and methods of use |
| WO2020257722A2 (en) | 2019-06-19 | 2020-12-24 | Solarea Bio, Inc. | Microbial compositions and methods for producing upgraded probiotic assemblages |
| CN117794518A (zh) * | 2021-07-29 | 2024-03-29 | 营养与生物科学美国1有限责任公司 | 控释包衣剂 |
| WO2023092150A1 (en) | 2021-11-22 | 2023-05-25 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE338976B (de) * | 1970-01-29 | 1971-09-27 | Foerenade Superfosfatfab Ab | |
| GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
| CN1033441A (zh) * | 1987-12-11 | 1989-06-21 | 福建省水产研究所 | 用褐藻胶制肠溶片剂的方法 |
| CN1034489A (zh) * | 1987-12-11 | 1989-08-09 | 福建省水产研究所 | 一种制作肠溶胶囊的方法 |
| US5733575A (en) * | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
| US5674495A (en) * | 1995-02-27 | 1997-10-07 | Purdue Research Foundation | Alginate-based vaccine compositions |
| WO1997000674A1 (en) * | 1995-06-20 | 1997-01-09 | Pharma-Vinci A/S | A method of preparing an oral preparation provided on the outer side with an enteric coating, as well as an oral preparation obtained by the method |
-
1997
- 1997-06-06 NZ NZ333182A patent/NZ333182A/xx not_active IP Right Cessation
- 1997-06-06 DE DE69730991T patent/DE69730991T2/de not_active Expired - Lifetime
- 1997-06-06 US US09/194,922 patent/US6455052B1/en not_active Expired - Lifetime
- 1997-06-06 IL IL12737897A patent/IL127378A/xx not_active IP Right Cessation
- 1997-06-06 WO PCT/DK1997/000252 patent/WO1997046224A1/en active IP Right Grant
- 1997-06-06 CA CA002257378A patent/CA2257378C/en not_active Expired - Lifetime
- 1997-06-06 CN CNB971959986A patent/CN1147291C/zh not_active Expired - Lifetime
- 1997-06-06 EP EP97924938A patent/EP0952824B1/de not_active Expired - Lifetime
- 1997-06-06 KR KR1019980709904A patent/KR20000016331A/ko not_active Application Discontinuation
- 1997-06-06 AT AT97924938T patent/ATE277605T1/de not_active IP Right Cessation
- 1997-06-06 BR BR9709535-4A patent/BR9709535A/pt not_active IP Right Cessation
- 1997-06-06 JP JP10500114A patent/JP2000514406A/ja active Pending
- 1997-06-06 AU AU30263/97A patent/AU717817B2/en not_active Expired
-
1998
- 1998-12-04 NO NO19985699A patent/NO327294B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ333182A (en) | 2000-03-27 |
| CN1223573A (zh) | 1999-07-21 |
| IL127378A (en) | 2003-07-31 |
| DE69730991T2 (de) | 2006-02-23 |
| EP0952824A1 (de) | 1999-11-03 |
| NO985699D0 (no) | 1998-12-04 |
| EP0952824B1 (de) | 2004-09-29 |
| CA2257378A1 (en) | 1997-12-11 |
| US6455052B1 (en) | 2002-09-24 |
| AU3026397A (en) | 1998-01-05 |
| NO985699L (no) | 1999-02-08 |
| JP2000514406A (ja) | 2000-10-31 |
| WO1997046224A1 (en) | 1997-12-11 |
| IL127378A0 (en) | 1999-10-28 |
| BR9709535A (pt) | 2000-01-11 |
| AU717817B2 (en) | 2000-04-06 |
| CA2257378C (en) | 2009-04-07 |
| KR20000016331A (ko) | 2000-03-25 |
| CN1147291C (zh) | 2004-04-28 |
| ATE277605T1 (de) | 2004-10-15 |
| DE69730991D1 (de) | 2004-11-04 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |