NO327259B1 - Substituerte 2-benzylamino-2-fenyl-acetamid-forbindelser, farmasoytisk sammensetning som inneholder slike, samt anvendelse derav - Google Patents
Substituerte 2-benzylamino-2-fenyl-acetamid-forbindelser, farmasoytisk sammensetning som inneholder slike, samt anvendelse derav Download PDFInfo
- Publication number
- NO327259B1 NO327259B1 NO20003398A NO20003398A NO327259B1 NO 327259 B1 NO327259 B1 NO 327259B1 NO 20003398 A NO20003398 A NO 20003398A NO 20003398 A NO20003398 A NO 20003398A NO 327259 B1 NO327259 B1 NO 327259B1
- Authority
- NO
- Norway
- Prior art keywords
- benzylamino
- compound
- phenylacetamide
- hydrogen
- acetamide
- Prior art date
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- 239000008194 pharmaceutical composition Chemical class 0.000 title claims description 6
- PYVTTZQYAVUMNV-UHFFFAOYSA-N 2-(benzylamino)-2-phenylacetamide Chemical class C=1C=CC=CC=1C(C(=O)N)NCC1=CC=CC=C1 PYVTTZQYAVUMNV-UHFFFAOYSA-N 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 61
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 208000002193 Pain Diseases 0.000 claims abstract description 13
- 208000004296 neuralgia Diseases 0.000 claims abstract description 12
- 208000021722 neuropathic pain Diseases 0.000 claims abstract description 9
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 8
- 150000002367 halogens Chemical class 0.000 claims abstract description 8
- 208000000094 Chronic Pain Diseases 0.000 claims abstract description 7
- 230000001684 chronic effect Effects 0.000 claims abstract description 6
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 3
- SUAPKJRANCSCBZ-UHFFFAOYSA-N 2-(2-fluorophenyl)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC=C(F)C=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 SUAPKJRANCSCBZ-UHFFFAOYSA-N 0.000 claims description 2
- RBPLIQLNWOKJFW-UHFFFAOYSA-N 2-(3-fluorophenyl)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC(F)=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 RBPLIQLNWOKJFW-UHFFFAOYSA-N 0.000 claims description 2
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- 239000004006 olive oil Substances 0.000 description 1
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- 150000007524 organic acids Chemical class 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9727521.8A GB9727521D0 (en) | 1997-12-31 | 1997-12-31 | Substituted 2-benzylamino-2-phenyl-acetamide compounds |
| PCT/EP1998/008158 WO1999035123A1 (en) | 1997-12-31 | 1998-12-12 | Substituted 2-benzylamino-2-phenyl-acetamide compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003398D0 NO20003398D0 (no) | 2000-06-29 |
| NO20003398L NO20003398L (no) | 2000-08-02 |
| NO327259B1 true NO327259B1 (no) | 2009-05-25 |
Family
ID=10824340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003398A NO327259B1 (no) | 1997-12-31 | 2000-06-29 | Substituerte 2-benzylamino-2-fenyl-acetamid-forbindelser, farmasoytisk sammensetning som inneholder slike, samt anvendelse derav |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6303819B1 (de) |
| EP (1) | EP1044186B9 (de) |
| JP (1) | JP3839665B2 (de) |
| KR (1) | KR100629628B1 (de) |
| AT (1) | ATE319680T1 (de) |
| BG (1) | BG64700B1 (de) |
| CA (1) | CA2316082C (de) |
| CZ (1) | CZ296722B6 (de) |
| DE (1) | DE69833797T2 (de) |
| EA (1) | EA003097B1 (de) |
| ES (1) | ES2256976T3 (de) |
| GB (1) | GB9727521D0 (de) |
| HK (1) | HK1028021A1 (de) |
| HR (1) | HRP20000508B9 (de) |
| HU (1) | HUP0100184A3 (de) |
| ID (1) | ID26622A (de) |
| IL (1) | IL136735A0 (de) |
| NO (1) | NO327259B1 (de) |
| NZ (1) | NZ505441A (de) |
| PL (1) | PL194745B1 (de) |
| PT (1) | PT1044186E (de) |
| TR (1) | TR200001950T2 (de) |
| WO (1) | WO1999035123A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9727523D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| WO2002048114A1 (en) * | 2000-11-27 | 2002-06-20 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| AU2002333374B2 (en) | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
| US6667327B2 (en) | 2002-02-04 | 2003-12-23 | Hoffmann-La Roche Inc. | Pyridine amido derivatives |
| EP1438956A1 (de) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind |
| WO2004087125A1 (en) * | 2003-04-02 | 2004-10-14 | Ionix Pharmaceuticals Limited | Amino acid derivatives as inhibitors of mammalian sodium channels |
| EP1524267A1 (de) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Substituierte Benzylaminoalkylen-Heterozyklen |
| EP1680127B1 (de) | 2003-10-23 | 2008-10-15 | F. Hoffmann-La Roche Ag | Benzazepin-derivate als mao-b-hemmer |
| EP1533302A1 (de) * | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Histidinderivate |
| EP1533298A1 (de) | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | 3-aminopyrrolidonederivate |
| EP1535908A1 (de) * | 2003-11-24 | 2005-06-01 | Newron Pharmaceuticals S.p.A. | N-Acyl-N'-Beznylalyklendiamin Derivate |
| EP1588704A1 (de) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamidderivate zur Behandlung des Restless-Leg-Syndroms und der Suchterkrankungen |
| SI1809271T1 (sl) * | 2004-09-10 | 2010-10-29 | Newron Pharm Spa | Uporaba (R)-(halobenziloksi) benzilamino propanamidov kot selektivnih modulatorjev natrijevih in/ali kalcijevih kanalov |
| RS54522B1 (en) * | 2005-12-22 | 2016-06-30 | Newron Pharmaceuticals S.P.A. | 2-Phenylethylamino Derivatives as Modulators of Calcium and (or Sodium) Channels |
| EP1870097A1 (de) | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamidederivate zur Behandlung von kognitiven Störungen |
| AU2008223916A1 (en) * | 2007-03-05 | 2008-09-12 | F. Hoffmann-La Roche Ag | Aminoamides as orexin antagonists |
| US11111208B2 (en) * | 2019-06-17 | 2021-09-07 | RK Pharma Solutions LLC | Process for the preparation of safinamide mesylate intermediate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541204A (en) * | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| KR0147963B1 (ko) * | 1995-01-10 | 1998-08-17 | 강박광 | 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법 |
| US5688830A (en) | 1996-01-25 | 1997-11-18 | Syntex (U.S.A.) Inc. | Treatment of neuropathic pain |
-
1997
- 1997-12-31 GB GBGB9727521.8A patent/GB9727521D0/en not_active Ceased
-
1998
- 1998-12-12 EP EP98964511A patent/EP1044186B9/de not_active Expired - Lifetime
- 1998-12-12 US US09/581,254 patent/US6303819B1/en not_active Expired - Fee Related
- 1998-12-12 HU HU0100184A patent/HUP0100184A3/hu unknown
- 1998-12-12 PT PT98964511T patent/PT1044186E/pt unknown
- 1998-12-12 ID IDW20001444A patent/ID26622A/id unknown
- 1998-12-12 CA CA002316082A patent/CA2316082C/en not_active Expired - Fee Related
- 1998-12-12 KR KR1020007007306A patent/KR100629628B1/ko not_active IP Right Cessation
- 1998-12-12 NZ NZ505441A patent/NZ505441A/en unknown
- 1998-12-12 DE DE69833797T patent/DE69833797T2/de not_active Expired - Fee Related
- 1998-12-12 AT AT98964511T patent/ATE319680T1/de not_active IP Right Cessation
- 1998-12-12 PL PL98341514A patent/PL194745B1/pl not_active IP Right Cessation
- 1998-12-12 JP JP2000527525A patent/JP3839665B2/ja not_active Expired - Fee Related
- 1998-12-12 EA EA200000728A patent/EA003097B1/ru not_active IP Right Cessation
- 1998-12-12 ES ES98964511T patent/ES2256976T3/es not_active Expired - Lifetime
- 1998-12-12 TR TR2000/01950T patent/TR200001950T2/xx unknown
- 1998-12-12 IL IL13673598A patent/IL136735A0/xx not_active IP Right Cessation
- 1998-12-12 WO PCT/EP1998/008158 patent/WO1999035123A1/en active IP Right Grant
- 1998-12-12 CZ CZ20002496A patent/CZ296722B6/cs not_active IP Right Cessation
-
2000
- 2000-06-28 BG BG104569A patent/BG64700B1/bg unknown
- 2000-06-29 NO NO20003398A patent/NO327259B1/no not_active IP Right Cessation
- 2000-07-27 HR HR20000508A patent/HRP20000508B9/xx not_active IP Right Cessation
- 2000-11-20 HK HK00107399A patent/HK1028021A1/xx not_active IP Right Cessation
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