NO326837B1 - Anvendelse av GABAB-reseptoragonister for inhibering av transiente relaksjoner av nedre osofagfinkter - Google Patents
Anvendelse av GABAB-reseptoragonister for inhibering av transiente relaksjoner av nedre osofagfinkter Download PDFInfo
- Publication number
- NO326837B1 NO326837B1 NO19991287A NO991287A NO326837B1 NO 326837 B1 NO326837 B1 NO 326837B1 NO 19991287 A NO19991287 A NO 19991287A NO 991287 A NO991287 A NO 991287A NO 326837 B1 NO326837 B1 NO 326837B1
- Authority
- NO
- Norway
- Prior art keywords
- acid
- gabab receptor
- receptor agonist
- use according
- amino
- Prior art date
Links
- 239000000018 receptor agonist Substances 0.000 title claims description 30
- 229940044601 receptor agonist Drugs 0.000 title claims description 30
- 230000001052 transient effect Effects 0.000 title claims description 8
- 230000005764 inhibitory process Effects 0.000 title description 6
- 241000287227 Fringillidae Species 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 16
- 210000000111 lower esophageal sphincter Anatomy 0.000 claims description 16
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 11
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical group OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 229960000794 baclofen Drugs 0.000 claims description 8
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- -1 aminopropyl Chemical group 0.000 claims description 5
- 206010067171 Regurgitation Diseases 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- CJTIGOOCRLKWAP-UHFFFAOYSA-N (3-amino-2-oxopropyl)-methylphosphinic acid Chemical group CP(O)(=O)CC(=O)CN CJTIGOOCRLKWAP-UHFFFAOYSA-N 0.000 claims description 3
- GSZQTIFGANBTNF-UHFFFAOYSA-N (3-aminopropyl)phosphonic acid Chemical group NCCCP(O)(O)=O GSZQTIFGANBTNF-UHFFFAOYSA-N 0.000 claims description 3
- NRAKQMOQGMIXRK-UHFFFAOYSA-N 3-amino-2-(4-chlorophenyl)propane-1-sulfinic acid Chemical group OS(=O)CC(CN)C1=CC=C(Cl)C=C1 NRAKQMOQGMIXRK-UHFFFAOYSA-N 0.000 claims description 3
- TXAHGWWWANKBDA-UHFFFAOYSA-N 3-aminopropyl(difluoromethyl)phosphinic acid Chemical group NCCCP(O)(=O)C(F)F TXAHGWWWANKBDA-UHFFFAOYSA-N 0.000 claims description 3
- CDFQDLUHBLZCGL-UHFFFAOYSA-N 4-azaniumyl-3-(5-chlorothiophen-2-yl)butanoate Chemical group OC(=O)CC(CN)C1=CC=C(Cl)S1 CDFQDLUHBLZCGL-UHFFFAOYSA-N 0.000 claims description 3
- FUUPFUIGNBPCAY-UHFFFAOYSA-N (3-amino-2-hydroxypropyl)-methylphosphinic acid Chemical group CP(O)(=O)CC(O)CN FUUPFUIGNBPCAY-UHFFFAOYSA-N 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 2
- IWOKCMBOJXYDEE-UHFFFAOYSA-N sulfinylmethane Chemical group C=S=O IWOKCMBOJXYDEE-UHFFFAOYSA-N 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 description 24
- 108020003175 receptors Proteins 0.000 description 19
- 102000005962 receptors Human genes 0.000 description 18
- 241000282472 Canis lupus familiaris Species 0.000 description 10
- 238000010992 reflux Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000001270 agonistic effect Effects 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- BCDIWLCKOCHCIH-UHFFFAOYSA-N methylphosphinic acid Chemical compound CP(O)=O BCDIWLCKOCHCIH-UHFFFAOYSA-N 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 239000004031 partial agonist Substances 0.000 description 3
- NHVRIDDXGZPJTJ-UHFFFAOYSA-N skf-97,541 Chemical compound CP(O)(=O)CCCN NHVRIDDXGZPJTJ-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920000945 Amylopectin Polymers 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 102000027484 GABAA receptors Human genes 0.000 description 2
- 108091008681 GABAA receptors Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- FUUPFUIGNBPCAY-BYPYZUCNSA-N [(2s)-3-amino-2-hydroxypropyl]-methylphosphinic acid Chemical compound CP(O)(=O)C[C@@H](O)CN FUUPFUIGNBPCAY-BYPYZUCNSA-N 0.000 description 2
- BVNHDZGVZMMOQP-UHFFFAOYSA-N [3-amino-2-(4-chlorophenyl)-2-hydroxypropyl]phosphonic acid Chemical compound NCC(CP(O)(O)=O)(O)C1=CC=C(C=C1)Cl BVNHDZGVZMMOQP-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000027119 gastric acid secretion Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VHBRTSZUHRQZQW-UHFFFAOYSA-N (3-amino-1-hydroxypropyl)-methylphosphinic acid Chemical compound CP(O)(=O)C(O)CCN VHBRTSZUHRQZQW-UHFFFAOYSA-N 0.000 description 1
- QAMHBPFVHWMQCV-UHFFFAOYSA-N (3-amino-2-cyclohexylpropyl)phosphonic acid Chemical compound OP(=O)(O)CC(CN)C1CCCCC1 QAMHBPFVHWMQCV-UHFFFAOYSA-N 0.000 description 1
- QDCTWRNBNBELIJ-UHFFFAOYSA-N (3-amino-2-methylpropyl)phosphonic acid Chemical compound NCC(C)CP(O)(O)=O QDCTWRNBNBELIJ-UHFFFAOYSA-N 0.000 description 1
- PVJLBKJIIJSBDL-UHFFFAOYSA-N (3-amino-2-phenylpropyl)phosphonic acid Chemical compound OP(=O)(O)CC(CN)C1=CC=CC=C1 PVJLBKJIIJSBDL-UHFFFAOYSA-N 0.000 description 1
- OWOIXRFDMCACSM-UHFFFAOYSA-N (3-azaniumyl-2-hydroxypropyl)-hydroxyphosphinate Chemical compound NCC(O)CP(O)(O)=O OWOIXRFDMCACSM-UHFFFAOYSA-N 0.000 description 1
- XYRPBUKHKWHPDI-UHFFFAOYSA-N (4-amino-1,1,1-trifluorobutan-2-yl)-methylphosphinic acid Chemical compound CP(O)(=O)C(C(F)(F)F)CCN XYRPBUKHKWHPDI-UHFFFAOYSA-N 0.000 description 1
- CCGFQGUALPHBIC-UHFFFAOYSA-N 1-aminopentan-3-yl(methyl)phosphinic acid Chemical compound CCC(P(C)(O)=O)CCN CCGFQGUALPHBIC-UHFFFAOYSA-N 0.000 description 1
- UCHLASNXBCEDCG-UHFFFAOYSA-N 2-(4-chlorophenyl)-3-nitropropan-1-amine Chemical compound [O-][N+](=O)CC(CN)C1=CC=C(Cl)C=C1 UCHLASNXBCEDCG-UHFFFAOYSA-N 0.000 description 1
- BLJXXNIBTBFGMC-UHFFFAOYSA-N 2-[4-amino-5-(4-chlorophenyl)-5-hydroxycyclohexa-1,3-dien-1-yl]butanoic acid Chemical compound C1C(C(C(O)=O)CC)=CC=C(N)C1(O)C1=CC=C(Cl)C=C1 BLJXXNIBTBFGMC-UHFFFAOYSA-N 0.000 description 1
- WAMWUASNGUFIPI-UHFFFAOYSA-N 3-(4-chlorophenyl)-4-(diaminomethylideneamino)butanoic acid Chemical compound NC(=N)NCC(CC(O)=O)C1=CC=C(Cl)C=C1 WAMWUASNGUFIPI-UHFFFAOYSA-N 0.000 description 1
- MJINPOMKSVZKFL-UHFFFAOYSA-N 3-aminobutylphosphonic acid Chemical compound CC(N)CCP(O)(O)=O MJINPOMKSVZKFL-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- NPGXQDBNBFXJKB-UHFFFAOYSA-N 3-azaniumylpropane-1-sulfinate Chemical compound NCCCS(O)=O NPGXQDBNBFXJKB-UHFFFAOYSA-N 0.000 description 1
- HZRGLMRBARSCHX-UHFFFAOYSA-N 4-amino-3-(1h-imidazol-2-yl)butanoic acid Chemical compound OC(=O)CC(CN)C1=NC=CN1 HZRGLMRBARSCHX-UHFFFAOYSA-N 0.000 description 1
- AGSZIPFOQSAPON-UHFFFAOYSA-N 4-amino-3-(5-bromothiophen-2-yl)butanoic acid Chemical compound OC(=O)CC(CN)C1=CC=C(Br)S1 AGSZIPFOQSAPON-UHFFFAOYSA-N 0.000 description 1
- RPNWEWXYTFWDTR-UHFFFAOYSA-N 4-amino-3-(5-methylthiophen-2-yl)butanoic acid Chemical compound CC1=CC=C(C(CN)CC(O)=O)S1 RPNWEWXYTFWDTR-UHFFFAOYSA-N 0.000 description 1
- QDVRXIPQICAUFK-UHFFFAOYSA-N 4-amino-3-thiophen-2-ylbutanoic acid Chemical compound OC(=O)CC(CN)C1=CC=CS1 QDVRXIPQICAUFK-UHFFFAOYSA-N 0.000 description 1
- CLAMDXSFCRQZLE-UHFFFAOYSA-N 4-aminobutan-2-ylphosphonic acid Chemical compound OP(=O)(O)C(C)CCN CLAMDXSFCRQZLE-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 244000289527 Cordyline terminalis Species 0.000 description 1
- 235000009091 Cordyline terminalis Nutrition 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010015137 Eructation Diseases 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 102000005915 GABA Receptors Human genes 0.000 description 1
- 108010005551 GABA Receptors Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- QHFHPVZYQDALHT-HNQUOIGGSA-N [(E)-3-aminoprop-1-enyl]phosphonic acid Chemical compound NC\C=C\P(O)(O)=O QHFHPVZYQDALHT-HNQUOIGGSA-N 0.000 description 1
- CUBSNZQABONBRT-UHFFFAOYSA-N [3-amino-2-(4-fluorophenyl)propyl]phosphonic acid Chemical compound NCC(CP(O)(O)=O)C1=CC=C(C=C1)F CUBSNZQABONBRT-UHFFFAOYSA-N 0.000 description 1
- OSSQLDHLXVQWSP-UHFFFAOYSA-N [3-amino-2-(4-methoxyphenyl)propyl]phosphonic acid Chemical compound NCC(CP(O)(O)=O)C1=CC=C(C=C1)OC OSSQLDHLXVQWSP-UHFFFAOYSA-N 0.000 description 1
- QASTVKCDPUKUBQ-UHFFFAOYSA-N [3-amino-2-(4-methylphenyl)propyl]phosphonic acid Chemical compound NCC(CP(O)(O)=O)C1=CC=C(C=C1)C QASTVKCDPUKUBQ-UHFFFAOYSA-N 0.000 description 1
- LUNROKWYYHDDSP-UHFFFAOYSA-N [3-amino-2-[4-(trifluoromethyl)phenyl]propyl]phosphonic acid Chemical compound NCC(CP(O)(O)=O)C1=CC=C(C=C1)C(F)(F)F LUNROKWYYHDDSP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 239000003434 antitussive agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 208000027687 belching Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- YQGDEPYYFWUPGO-UHFFFAOYSA-N gamma-amino-beta-hydroxybutyric acid Chemical compound [NH3+]CC(O)CC([O-])=O YQGDEPYYFWUPGO-UHFFFAOYSA-N 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- SIGZYWRTSGWBNO-UHFFFAOYSA-N hydroxymethylphosphinic acid Chemical compound OCP(O)=O SIGZYWRTSGWBNO-UHFFFAOYSA-N 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 229940028435 intralipid Drugs 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- VSGNGLJPOGUDON-UHFFFAOYSA-N phaclofen Chemical compound OP(=O)(O)CC(CN)C1=CC=C(Cl)C=C1 VSGNGLJPOGUDON-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- DAFOCGYVTAOKAJ-UHFFFAOYSA-N phenibut Chemical compound OC(=O)CC(CN)C1=CC=CC=C1 DAFOCGYVTAOKAJ-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002325 prokinetic agent Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9603408A SE9603408D0 (sv) | 1996-09-18 | 1996-09-18 | Medical use |
| PCT/SE1997/001555 WO1998011885A1 (fr) | 1996-09-18 | 1997-09-15 | Inhibiteurs du reflux gastro-oesophagien |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO991287D0 NO991287D0 (no) | 1999-03-17 |
| NO991287L NO991287L (no) | 1999-03-17 |
| NO326837B1 true NO326837B1 (no) | 2009-02-23 |
Family
ID=20403936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19991287A NO326837B1 (no) | 1996-09-18 | 1999-03-17 | Anvendelse av GABAB-reseptoragonister for inhibering av transiente relaksjoner av nedre osofagfinkter |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6117908A (fr) |
| EP (2) | EP0936906B1 (fr) |
| JP (1) | JP4098832B2 (fr) |
| KR (2) | KR100553294B1 (fr) |
| CN (1) | CN1117560C (fr) |
| AR (1) | AR007747A1 (fr) |
| AT (2) | ATE249212T1 (fr) |
| AU (1) | AU714370B2 (fr) |
| BR (1) | BR9711400A (fr) |
| CA (1) | CA2265615C (fr) |
| CZ (1) | CZ299997B6 (fr) |
| DE (2) | DE69736445T2 (fr) |
| DK (2) | DK0936906T3 (fr) |
| EE (1) | EE03952B1 (fr) |
| ES (2) | ES2268227T3 (fr) |
| HK (2) | HK1022100A1 (fr) |
| HU (1) | HU224968B1 (fr) |
| ID (1) | ID19621A (fr) |
| IL (1) | IL128961A (fr) |
| IS (2) | IS2329B (fr) |
| MY (1) | MY122020A (fr) |
| NO (1) | NO326837B1 (fr) |
| NZ (2) | NZ334495A (fr) |
| PL (1) | PL190028B1 (fr) |
| PT (2) | PT1344524E (fr) |
| RU (1) | RU2199316C2 (fr) |
| SA (1) | SA97180522B1 (fr) |
| SE (1) | SE9603408D0 (fr) |
| SI (2) | SI1344524T1 (fr) |
| SK (1) | SK285744B6 (fr) |
| TR (1) | TR199900591T2 (fr) |
| TW (1) | TW548104B (fr) |
| UA (1) | UA61081C2 (fr) |
| WO (1) | WO1998011885A1 (fr) |
| ZA (1) | ZA977969B (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE41920E1 (en) | 1996-07-24 | 2010-11-09 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
| US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| WO1999008670A1 (fr) | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Analogues de gaba utilises pour prevenir et traiter des lesions gastro-intestinales |
| EP0974351A3 (fr) * | 1998-04-24 | 2000-12-13 | Jouveinal | Médicament pour la prévention et le traitement des dommages gastrointestinaux |
| US7164034B2 (en) * | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
| US20080207755A1 (en) * | 2000-05-31 | 2008-08-28 | Pfizer Inc | Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders |
| SE9904508D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| US7319095B2 (en) * | 1999-12-09 | 2008-01-15 | Astrazeneca Ab | Use of GABAB receptor agonists |
| SE9904507D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
| TWI256314B (en) * | 2000-02-09 | 2006-06-11 | Mitsubishi Pharma Corp | Preventive-therapeutical medicament for gastroesophageal reflux disease |
| US20030031711A1 (en) * | 2001-05-29 | 2003-02-13 | Fara John W. | Method of treating gastroesophageal reflux disease and nocturnal acid breakthrough |
| SE0102055D0 (sv) * | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Compounds |
| AR033779A1 (es) | 2001-06-08 | 2004-01-07 | Astrazeneca Ab | Compuestos utiles en la enfermedad de reflujo |
| SE0102057D0 (sv) * | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Salts I |
| SE0102058D0 (sv) * | 2001-06-08 | 2001-06-08 | Astrazeneca Ab | New Salts II |
| GB0209481D0 (en) * | 2002-04-24 | 2002-06-05 | Novartis Ag | Organic compounds |
| US7964609B2 (en) | 2002-06-20 | 2011-06-21 | Astrazeneca Ab | Use of mGluR5 antagonists for the treatment of gerd |
| SE0201939D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination |
| SE0201943D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New use |
| SE0201940D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New combination II |
| GB0226434D0 (en) * | 2002-11-13 | 2002-12-18 | Astrazeneca Ab | Combination product |
| CA2505788A1 (fr) * | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Derives de pregabalin pour le traitement de la fibromyalgie et d'autres troubles |
| KR20110097942A (ko) * | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| EP2354120A1 (fr) | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthèse de promédicaments a base de carbamate d'acyloxyalkyle et leurs intermédiaires |
| KR20060120612A (ko) * | 2003-09-12 | 2006-11-27 | 얀센 파마슈티카 엔.브이. | 키메라 ｇａｂａｂ 수용체 |
| US20050220873A1 (en) * | 2004-04-02 | 2005-10-06 | Chien-Hsuan Han | Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist |
| US8007827B2 (en) * | 2004-04-02 | 2011-08-30 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties |
| US20050220863A1 (en) * | 2004-04-02 | 2005-10-06 | Chien-Hsuan Han | Pharmaceutical dosage forms having controlled release properties that contain a GABAB receptor agonist |
| US20050226927A1 (en) * | 2004-04-02 | 2005-10-13 | Impax Laboratories, Inc. | Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist |
| SE0401653D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
| US7494985B2 (en) * | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| US7566738B2 (en) * | 2004-11-03 | 2009-07-28 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| WO2006071186A1 (fr) * | 2004-12-27 | 2006-07-06 | Astrazeneca Ab | Utilisation d'agonistes du recepteur gabab |
| BRPI0620373A2 (pt) * | 2005-12-23 | 2011-11-08 | Astrazeneca Ab | composto e sais farmaceuticamente e farmacologicamente aceitáveis dos mesmos, e enantiÈmeros do composto e sais dos mesmos, uso dos mesmos, opcionalmente em combinação com um agonista do receptor de gabab,e , composição farmaceutica |
| AU2006327317B2 (en) * | 2005-12-23 | 2010-11-25 | Astrazeneca Ab | GABA-B receptor modulators |
| BRPI0620345A2 (pt) * | 2005-12-23 | 2017-11-21 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, métodod para o tratamento de uma doença |
| US20090062365A1 (en) * | 2005-12-23 | 2009-03-05 | Udo Bauer | Pyrazoles for the Treatment of GERD and IBS |
| CN101341130A (zh) * | 2005-12-23 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 用于治疗胃肠障碍的咪唑衍生物 |
| WO2008033572A1 (fr) * | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Promédicaments à base de carbamate d'acyloxyalkyle, procédés de synthèse et utilisation |
| RU2491075C2 (ru) * | 2006-12-22 | 2013-08-27 | Айронвуд Фармасьютикалз, Инк. | Способы и композиции для лечения расстройств пищевода |
| ATE511392T1 (de) * | 2007-01-11 | 2011-06-15 | Xenoport Inc | Verzögert freigesetzte orale dosierungsformen eines prodrugs von r-baclofen und behandlungsverfahren damit |
| WO2008130314A1 (fr) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | Composés de xanthine ayant un effet modulateur allostérique positif du récepteur gaba b |
| WO2008157408A2 (fr) * | 2007-06-15 | 2008-12-24 | Xenoport, Inc. | Utilisation de promédicaments d'analogues de gaba, agents antispasticité et promédicaments d'agonistes de récepteur de gaba b pour traiter la spasticité |
| WO2009014491A1 (fr) * | 2007-07-25 | 2009-01-29 | Astrazeneca Ab | Utilisation d'acide phosphonique (3-amino-2-fluoropropyl) pour le traitement du nerd |
| WO2009061934A1 (fr) * | 2007-11-06 | 2009-05-14 | Xenoport, Inc. | Utilisation de promédicaments d'agonistes de gaba b pour le traitement de douleur neuropathique et musculo-squelettique |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| EP2250148B1 (fr) * | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Forme cristalline de sels de calcium d'acide (3s)-aminomethyl-5-methyl-hexanoique et ses procedes d'utilisation |
| CA2706575C (fr) * | 2008-01-25 | 2015-07-14 | Xenoport, Inc. | Resolution des enantiomeres de thiocarbonates d'acyloxyalkyle utilises dans la synthese de precurseurs de carbamates d'acyloxyalkyle |
| US20100137442A2 (en) * | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
| WO2009117160A2 (fr) * | 2008-03-20 | 2009-09-24 | General Mills, Inc. | Composé et procédé pour le traitement du reflux gastro-œsophagien |
| WO2010017504A1 (fr) * | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Procédés de synthèse de promédicaments de 1-(acyloxy)-alkylcarbamate |
| WO2010017498A1 (fr) | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Procédés de synthèse de carbonates de n-hydroxysuccinimidyle |
| NZ594648A (en) * | 2009-03-03 | 2013-12-20 | Xenoport Inc | Sustained release oral dosage forms of an r-baclofen prodrug |
| WO2010120370A2 (fr) * | 2009-04-17 | 2010-10-21 | Xenoport, Inc. | Dérivés d'acide gamma-aminobutyrique comme ligands des récepteurs gabab |
| WO2011113904A1 (fr) | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Médicaments pour la prévention et le traitement d'une maladie associée à la dégénérescence des cellules ganglionnaires rétiniennes |
| WO2013023155A1 (fr) | 2011-08-11 | 2013-02-14 | Xenoport, Inc. | Formes cristallines anhydres et hémihydratées d'un promédicament (r)-baclofène, procédés de synthèse et procédés d'utilisation |
| CA2874737A1 (fr) | 2012-06-01 | 2013-12-05 | Lynn Health Science Institute, Inc. | Utilisation de baclofene pour traiter l'insomnie |
| WO2023237426A1 (fr) * | 2022-06-07 | 2023-12-14 | Esocap Ag | Système d'administration de médicament comprenant un inhibiteur de reflux pour l'application à des membranes muqueuses oesophagiennes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0250572A1 (fr) * | 1986-01-03 | 1988-01-07 | The University Of Melbourne | Composition contre les reflux gastro-oesophagiens |
| NO882881L (no) * | 1988-06-29 | 1990-01-02 | Trond Nilsen | Anordning for lengdekorrugering av metallplater. |
| WO1990009096A2 (fr) * | 1989-02-03 | 1990-08-23 | Cambridge Neuroscience Research, Inc. | Procede de tirage et de classification de composes |
| GB9117716D0 (en) * | 1991-08-16 | 1991-10-02 | Lynxvale Ltd | Gaba derivatives and their therapeutic application |
| DE69331783T2 (de) * | 1992-01-22 | 2002-11-21 | Glaxo Group Ltd | Medizinische Verwendung von atypischen Beta-adrenoceptor Agonisten |
| GB9408064D0 (en) * | 1994-04-22 | 1994-06-15 | Merck Sharp & Dohme | Nucleic acids |
| US5491134A (en) * | 1994-09-16 | 1996-02-13 | Bristol-Myers Squibb Company | Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives |
| US5656730A (en) * | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
-
1996
- 1996-09-18 SE SE9603408A patent/SE9603408D0/xx unknown
-
1997
- 1997-09-04 AR ARP970104051A patent/AR007747A1/es unknown
- 1997-09-04 ZA ZA9707969A patent/ZA977969B/xx unknown
- 1997-09-12 TW TW086113275A patent/TW548104B/zh not_active IP Right Cessation
- 1997-09-12 ID IDP973172A patent/ID19621A/id unknown
- 1997-09-15 CN CN97199600A patent/CN1117560C/zh not_active Expired - Fee Related
- 1997-09-15 SK SK305-99A patent/SK285744B6/sk not_active IP Right Cessation
- 1997-09-15 KR KR1019997002239A patent/KR100553294B1/ko not_active IP Right Cessation
- 1997-09-15 ES ES03013667T patent/ES2268227T3/es not_active Expired - Lifetime
- 1997-09-15 PL PL97332497A patent/PL190028B1/pl not_active IP Right Cessation
- 1997-09-15 US US08/952,400 patent/US6117908A/en not_active Expired - Lifetime
- 1997-09-15 TR TR1999/00591T patent/TR199900591T2/xx unknown
- 1997-09-15 CZ CZ0093099A patent/CZ299997B6/cs not_active IP Right Cessation
- 1997-09-15 SI SI9730749T patent/SI1344524T1/sl unknown
- 1997-09-15 RU RU99107969/14A patent/RU2199316C2/ru not_active IP Right Cessation
- 1997-09-15 DE DE69736445T patent/DE69736445T2/de not_active Expired - Lifetime
- 1997-09-15 WO PCT/SE1997/001555 patent/WO1998011885A1/fr active Application Filing
- 1997-09-15 UA UA99031298A patent/UA61081C2/uk unknown
- 1997-09-15 NZ NZ334495A patent/NZ334495A/xx not_active IP Right Cessation
- 1997-09-15 DE DE69724809T patent/DE69724809T2/de not_active Expired - Lifetime
- 1997-09-15 DK DK97942346T patent/DK0936906T3/da active
- 1997-09-15 HU HU9903825A patent/HU224968B1/hu not_active IP Right Cessation
- 1997-09-15 ES ES97942346T patent/ES2206749T3/es not_active Expired - Lifetime
- 1997-09-15 DK DK03013667T patent/DK1344524T3/da active
- 1997-09-15 AU AU44064/97A patent/AU714370B2/en not_active Ceased
- 1997-09-15 SI SI9730594T patent/SI0936906T1/xx unknown
- 1997-09-15 EP EP97942346A patent/EP0936906B1/fr not_active Expired - Lifetime
- 1997-09-15 EP EP03013667A patent/EP1344524B1/fr not_active Expired - Lifetime
- 1997-09-15 JP JP51458198A patent/JP4098832B2/ja not_active Expired - Fee Related
- 1997-09-15 AT AT97942346T patent/ATE249212T1/de active
- 1997-09-15 AT AT03013667T patent/ATE334700T1/de active
- 1997-09-15 BR BR9711400A patent/BR9711400A/pt not_active Application Discontinuation
- 1997-09-15 NZ NZ504244A patent/NZ504244A/xx not_active IP Right Cessation
- 1997-09-15 IL IL12896197A patent/IL128961A/en not_active IP Right Cessation
- 1997-09-15 CA CA002265615A patent/CA2265615C/fr not_active Expired - Fee Related
- 1997-09-15 KR KR1020057018539A patent/KR100568659B1/ko not_active IP Right Cessation
- 1997-09-15 PT PT03013667T patent/PT1344524E/pt unknown
- 1997-09-15 EE EEP199900095A patent/EE03952B1/xx not_active IP Right Cessation
- 1997-09-15 PT PT97942346T patent/PT936906E/pt unknown
- 1997-09-16 MY MYPI97004296A patent/MY122020A/en unknown
- 1997-10-27 SA SA97180522A patent/SA97180522B1/ar unknown
-
1999
- 1999-03-15 IS IS5001A patent/IS2329B/is unknown
- 1999-03-17 NO NO19991287A patent/NO326837B1/no not_active IP Right Cessation
-
2000
- 2000-02-24 HK HK00101114A patent/HK1022100A1/xx not_active IP Right Cessation
- 2000-09-08 US US09/658,242 patent/US6664069B1/en not_active Expired - Fee Related
-
2003
- 2003-12-23 HK HK03109347A patent/HK1057004A1/xx not_active IP Right Cessation
-
2007
- 2007-03-19 IS IS8623A patent/IS2538B/is unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO326837B1 (no) | Anvendelse av GABAB-reseptoragonister for inhibering av transiente relaksjoner av nedre osofagfinkter | |
| US9925156B2 (en) | Enterically coated cysteamine, cystamine and derivatives thereof | |
| RU2498795C2 (ru) | Способы лечения неалкогольного стеатогепатита (nash) с применением цистеаминовых продуктов | |
| US20080090878A1 (en) | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders | |
| Pennathur et al. | Erythromycin strengthens the defective lower esophageal sphincter in patients with gastroesophageal reflux disease | |
| Konturek et al. | CCK receptor antagonism by loxiglumide and gall bladder contractions in response to cholecystokinin, sham feeding and ordinary feeding in man. | |
| US20060172979A1 (en) | New use of GABAB receptor agonists | |
| WO2004000855A1 (fr) | Combinaison d'un agent inhibiteur de secretion acide et inhibiteur de reflux pour le traitement du reflux gastro-oesophagien | |
| Aizawa et al. | L-NAME-sensitive and-insensitive nonadrenergic noncholinergic relaxation of cat airway in vivo and in vitro | |
| JP2002220345A (ja) | 脂肪肝改善剤 | |
| AU2016204132B2 (en) | Enterically coated cysteamine, cystamine and derivatives thereof | |
| WO2006071185A1 (fr) | Nouvelle utilisation des agonistes du recepteur gabab | |
| Merritt | The Equine Stomach: A Personal Perspective (1963-2003)(21-Nov-2003) | |
| WO2006071186A1 (fr) | Utilisation d'agonistes du recepteur gabab |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |