ATE334700T1 - Refluxinhibitoren - Google Patents

Refluxinhibitoren

Info

Publication number
ATE334700T1
ATE334700T1 AT03013667T AT03013667T ATE334700T1 AT E334700 T1 ATE334700 T1 AT E334700T1 AT 03013667 T AT03013667 T AT 03013667T AT 03013667 T AT03013667 T AT 03013667T AT E334700 T1 ATE334700 T1 AT E334700T1
Authority
AT
Austria
Prior art keywords
reflux inhibitors
reflux
inhibitors
Prior art date
Application number
AT03013667T
Other languages
English (en)
Inventor
Anders Lehmann
Paul L R Andrews
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20403936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE334700(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE334700T1 publication Critical patent/ATE334700T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03013667T 1996-09-18 1997-09-15 Refluxinhibitoren ATE334700T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9603408A SE9603408D0 (sv) 1996-09-18 1996-09-18 Medical use

Publications (1)

Publication Number Publication Date
ATE334700T1 true ATE334700T1 (de) 2006-08-15

Family

ID=20403936

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03013667T ATE334700T1 (de) 1996-09-18 1997-09-15 Refluxinhibitoren
AT97942346T ATE249212T1 (de) 1996-09-18 1997-09-15 Refluxinhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97942346T ATE249212T1 (de) 1996-09-18 1997-09-15 Refluxinhibitoren

Country Status (35)

Country Link
US (2) US6117908A (de)
EP (2) EP0936906B1 (de)
JP (1) JP4098832B2 (de)
KR (2) KR100568659B1 (de)
CN (1) CN1117560C (de)
AR (1) AR007747A1 (de)
AT (2) ATE334700T1 (de)
AU (1) AU714370B2 (de)
BR (1) BR9711400A (de)
CA (1) CA2265615C (de)
CZ (1) CZ299997B6 (de)
DE (2) DE69724809T2 (de)
DK (2) DK1344524T3 (de)
EE (1) EE03952B1 (de)
ES (2) ES2268227T3 (de)
HK (2) HK1022100A1 (de)
HU (1) HU224968B1 (de)
ID (1) ID19621A (de)
IL (1) IL128961A (de)
IS (2) IS2329B (de)
MY (1) MY122020A (de)
NO (1) NO326837B1 (de)
NZ (2) NZ334495A (de)
PL (1) PL190028B1 (de)
PT (2) PT936906E (de)
RU (1) RU2199316C2 (de)
SA (1) SA97180522B1 (de)
SE (1) SE9603408D0 (de)
SI (2) SI1344524T1 (de)
SK (1) SK285744B6 (de)
TR (1) TR199900591T2 (de)
TW (1) TW548104B (de)
UA (1) UA61081C2 (de)
WO (1) WO1998011885A1 (de)
ZA (1) ZA977969B (de)

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KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
AU8668598A (en) * 1997-08-20 1999-03-08 University Of Oklahoma, The Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (de) * 1998-04-24 2000-12-13 Jouveinal Arzneimittel zur Vorbeugung und Behandlung von Magendarmschäden
US20080207755A1 (en) * 2000-05-31 2008-08-28 Pfizer Inc Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
US7164034B2 (en) * 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
TWI256314B (en) * 2000-02-09 2006-06-11 Mitsubishi Pharma Corp Preventive-therapeutical medicament for gastroesophageal reflux disease
MXPA03011096A (es) * 2001-05-29 2004-12-06 Depomed Dev Ltd Metodo para el tratamiento de la enfermedad de reflujo gastroesofagico y la saturacion acida nocturna.
SE0102058D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts II
SE0102057D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts I
SE0102055D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Compounds
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
GB0209481D0 (en) * 2002-04-24 2002-06-05 Novartis Ag Organic compounds
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201943D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New use
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
US7964609B2 (en) * 2002-06-20 2011-06-21 Astrazeneca Ab Use of mGluR5 antagonists for the treatment of gerd
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
NZ540591A (en) * 2002-12-13 2008-03-28 Warner Lambert Co Pregabalin derivatives for the treatment of fibromyalgia and other disorders
US7109239B2 (en) 2003-08-20 2006-09-19 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2354120A1 (de) 2003-08-20 2011-08-10 XenoPort, Inc. Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon
CN1849336A (zh) * 2003-09-12 2006-10-18 詹森药业有限公司 嵌合gabab受体
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
US20050220873A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist
US20050226927A1 (en) * 2004-04-02 2005-10-13 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist
US20050220863A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having controlled release properties that contain a GABAB receptor agonist
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
WO2006050471A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006071186A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Use of gabab receptor agonists
AU2006327314A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Pyrazoles for the treatment of GERD and IBS
WO2007073296A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Heterocyclic gaba-b modulators
JP2009521428A (ja) * 2005-12-23 2009-06-04 アストラゼネカ・アクチエボラーグ 胃腸疾患治療用のイミダゾール誘導体
AU2006327316A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Imidazoles as GABA-B receptor modulators
WO2007073300A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Gaba-b receptor modulators
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
PT2124884T (pt) * 2006-12-22 2019-09-17 Ironwood Pharmaceuticals Inc Composições compreendendo sequestradores de ácido biliar para tratar distúrbios esofágicos
US20080206332A1 (en) * 2007-01-11 2008-08-28 Kidney David J Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
BRPI0810019A2 (pt) * 2007-04-18 2014-10-14 Astrazeneca Ab Composto, composição farmacêutica, e, uso de um composto
WO2008157408A2 (en) * 2007-06-15 2008-12-24 Xenoport, Inc. Use of prodrugs of gaba analogs, antispasticity agents, and prodrugs of gaba b receptor agonists for treating spasticity
JP2010534239A (ja) * 2007-07-25 2010-11-04 アストラゼネカ・アクチエボラーグ Ｎｅｒｄの治療のための（３−アミノ−２−フルオロプロピル）ホスフィン酸の使用
TW200936123A (en) * 2007-11-06 2009-09-01 Xenoport Inc Use of prodrugs of GABAb agonists for treating neuropathic and musculoskeletal pain
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
WO2009094563A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
CA2706575C (en) * 2008-01-25 2015-07-14 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
US8993639B2 (en) * 2008-03-20 2015-03-31 Burt Shulman Compound and method for treatment of gastroesophageal reflux
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates
NZ594648A (en) * 2009-03-03 2013-12-20 Xenoport Inc Sustained release oral dosage forms of an r-baclofen prodrug
US8344028B2 (en) * 2009-04-17 2013-01-01 Xenoport, Inc. Gamma-amino-butyric acid derivatives as GABAB receptor ligands
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US8580850B2 (en) 2011-08-11 2013-11-12 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
CA2874737A1 (en) 2012-06-01 2013-12-05 Lynn Health Science Institute, Inc. Use of baclofen to treat insomnia
TW202412754A (zh) * 2022-06-07 2024-04-01 瑞士商意梭凱普公司 應用於食道黏膜的包含逆流抑制劑的藥物傳遞系統

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Also Published As

Publication number Publication date
DK1344524T3 (da) 2006-10-30
HUP9903825A3 (en) 2001-06-28
AU4406497A (en) 1998-04-14
SI1344524T1 (sl) 2006-12-31
CN1237105A (zh) 1999-12-01
JP2001501604A (ja) 2001-02-06
ZA977969B (en) 1998-03-18
NO991287L (no) 1999-03-17
IS5001A (is) 1999-03-15
PT936906E (pt) 2003-12-31
NO991287D0 (no) 1999-03-17
NZ334495A (en) 2000-09-29
EP1344524A1 (de) 2003-09-17
DE69724809T2 (de) 2004-07-15
AR007747A1 (es) 1999-11-10
CA2265615A1 (en) 1998-03-26
JP4098832B2 (ja) 2008-06-11
NZ504244A (en) 2000-09-29
US6664069B1 (en) 2003-12-16
EP0936906A1 (de) 1999-08-25
EE9900095A (et) 1999-10-15
AU714370B2 (en) 1999-12-23
RU2199316C2 (ru) 2003-02-27
TW548104B (en) 2003-08-21
UA61081C2 (uk) 2003-11-17
SE9603408D0 (sv) 1996-09-18
HU224968B1 (en) 2006-04-28
WO1998011885A1 (en) 1998-03-26
CN1117560C (zh) 2003-08-13
BR9711400A (pt) 1999-08-17
CA2265615C (en) 2007-01-30
SK285744B6 (sk) 2007-07-06
KR20000036185A (ko) 2000-06-26
DK0936906T3 (da) 2003-11-24
US6117908A (en) 2000-09-12
PT1344524E (pt) 2006-11-30
EE03952B1 (et) 2003-02-17
DE69724809D1 (de) 2003-10-16
IS8623A (is) 2007-03-19
MY122020A (en) 2006-03-31
DE69736445D1 (de) 2006-09-14
NO326837B1 (no) 2009-02-23
PL190028B1 (pl) 2005-10-31
DE69736445T2 (de) 2007-03-15
KR100553294B1 (ko) 2006-02-22
ES2268227T3 (es) 2007-03-16
KR20050101237A (ko) 2005-10-20
ID19621A (id) 1998-07-23
EP0936906B1 (de) 2003-09-10
KR100568659B1 (ko) 2006-04-07
HK1022100A1 (en) 2000-07-28
CZ93099A3 (cs) 1999-09-15
IS2538B (is) 2009-09-15
HUP9903825A2 (hu) 2001-05-28
EP1344524B1 (de) 2006-08-02
IL128961A (en) 2004-08-31
CZ299997B6 (cs) 2009-01-14
SK30599A3 (en) 2000-01-18
ES2206749T3 (es) 2004-05-16
SI0936906T1 (en) 2004-02-29
TR199900591T2 (xx) 1999-07-21
PL332497A1 (en) 1999-09-13
SA97180522B1 (ar) 2006-04-04
IS2329B (is) 2008-01-15
HK1057004A1 (en) 2004-03-12
IL128961A0 (en) 2000-02-17
ATE249212T1 (de) 2003-09-15

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