EE03952B1 - Tagasivoolu inhibiitorid - Google Patents

Tagasivoolu inhibiitorid

Info

Publication number
EE03952B1
EE03952B1 EEP199900095A EE9900095A EE03952B1 EE 03952 B1 EE03952 B1 EE 03952B1 EE P199900095 A EEP199900095 A EE P199900095A EE 9900095 A EE9900095 A EE 9900095A EE 03952 B1 EE03952 B1 EE 03952B1
Authority
EE
Estonia
Prior art keywords
reflux inhibitors
reflux
inhibitors
Prior art date
Application number
EEP199900095A
Other languages
English (en)
Other versions
EE9900095A (et
Inventor
L. R. Andrews Paul
Lehmann Anders
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20403936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03952(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9900095A publication Critical patent/EE9900095A/et
Publication of EE03952B1 publication Critical patent/EE03952B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9426—GABA, i.e. gamma-amino-butyrate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EEP199900095A 1996-09-18 1997-09-15 Tagasivoolu inhibiitorid EE03952B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9603408A SE9603408D0 (sv) 1996-09-18 1996-09-18 Medical use
PCT/SE1997/001555 WO1998011885A1 (en) 1996-09-18 1997-09-15 Reflux inhibitors

Publications (2)

Publication Number Publication Date
EE9900095A EE9900095A (et) 1999-10-15
EE03952B1 true EE03952B1 (et) 2003-02-17

Family

ID=20403936

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900095A EE03952B1 (et) 1996-09-18 1997-09-15 Tagasivoolu inhibiitorid

Country Status (35)

Country Link
US (2) US6117908A (et)
EP (2) EP0936906B1 (et)
JP (1) JP4098832B2 (et)
KR (2) KR100568659B1 (et)
CN (1) CN1117560C (et)
AR (1) AR007747A1 (et)
AT (2) ATE334700T1 (et)
AU (1) AU714370B2 (et)
BR (1) BR9711400A (et)
CA (1) CA2265615C (et)
CZ (1) CZ299997B6 (et)
DE (2) DE69736445T2 (et)
DK (2) DK0936906T3 (et)
EE (1) EE03952B1 (et)
ES (2) ES2268227T3 (et)
HK (2) HK1022100A1 (et)
HU (1) HU224968B1 (et)
ID (1) ID19621A (et)
IL (1) IL128961A (et)
IS (2) IS2329B (et)
MY (1) MY122020A (et)
NO (1) NO326837B1 (et)
NZ (2) NZ504244A (et)
PL (1) PL190028B1 (et)
PT (2) PT1344524E (et)
RU (1) RU2199316C2 (et)
SA (1) SA97180522B1 (et)
SE (1) SE9603408D0 (et)
SI (2) SI1344524T1 (et)
SK (1) SK285744B6 (et)
TR (1) TR199900591T2 (et)
TW (1) TW548104B (et)
UA (1) UA61081C2 (et)
WO (1) WO1998011885A1 (et)
ZA (1) ZA977969B (et)

Families Citing this family (58)

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PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
WO1999008670A1 (en) 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (en) * 1998-04-24 2000-12-13 Jouveinal Medicament for preventing and treating gastrointestinal damage
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US20080207755A1 (en) * 2000-05-31 2008-08-28 Pfizer Inc Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
TWI256314B (en) * 2000-02-09 2006-06-11 Mitsubishi Pharma Corp Preventive-therapeutical medicament for gastroesophageal reflux disease
EP1401423A4 (en) * 2001-05-29 2006-08-16 Depomed Dev Ltd METHOD FOR THE TREATMENT OF GASTROÖSOPHAGEAL REFLUX DISEASE AND NURSING ACID BREAKDOWN
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0102055D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Compounds
SE0102057D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts I
SE0102058D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Salts II
GB0209481D0 (en) * 2002-04-24 2002-06-05 Novartis Ag Organic compounds
US7964609B2 (en) * 2002-06-20 2011-06-21 Astrazeneca Ab Use of mGluR5 antagonists for the treatment of gerd
SE0201943D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New use
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
GB0226434D0 (en) * 2002-11-13 2002-12-18 Astrazeneca Ab Combination product
PL377520A1 (pl) * 2002-12-13 2006-02-06 Warner-Lambert Company Llc Pochodne pregabaliny przeznaczone do leczenia fibromialgii i innych zaburzeń
PT1660440E (pt) * 2003-08-20 2012-05-15 Xenoport Inc Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
AU2004272302A1 (en) * 2003-09-12 2005-03-24 Janssen Pharmaceutica N.V. Chimeric GABAb receptor
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
US20050226927A1 (en) * 2004-04-02 2005-10-13 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist
US20050220873A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist
US20050220863A1 (en) * 2004-04-02 2005-10-06 Chien-Hsuan Han Pharmaceutical dosage forms having controlled release properties that contain a GABAB receptor agonist
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7494985B2 (en) * 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
WO2006071186A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Use of gabab receptor agonists
JP2009521428A (ja) * 2005-12-23 2009-06-04 アストラゼネカ・アクチエボラーグ 胃腸疾患治療用のイミダゾール誘導体
EP1968946A4 (en) * 2005-12-23 2010-05-05 Astrazeneca Ab IMIDAZOLE AS MODULATORS OF THE GABA B RECEPTOR
EP1966176A4 (en) * 2005-12-23 2011-08-10 Astrazeneca Ab HETEROCYCLIC GABA B MODULATORS
BRPI0620415A2 (pt) * 2005-12-23 2011-11-08 Astrazeneca Ab composto e sais farmaceuticamente e farmacologicamente aceitáveis do mesmo, e enantiÈmeros do composto e sais do mesmo, composição farmaceutica, e, uso de um composto opcionalmente em combinação com um agonista do receptor de gabab, e, métodos para o tratamento de doença, de um distúrbio, e de sìndrome
KR20080087852A (ko) 2005-12-23 2008-10-01 아스트라제네카 아베 Ｇａｂａ-ｂ 수용체 조절제
WO2008033572A1 (en) * 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP2010514702A (ja) * 2006-12-22 2010-05-06 アイロンウッド ファーマシューティカルズ，インコーポレーテッド 食道障害の治療方法および治療用組成物
WO2008086492A1 (en) * 2007-01-11 2008-07-17 Xenoport, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
EP2146996A4 (en) * 2007-04-18 2011-08-03 Astrazeneca Ab XANTHIN COMPOUNDS WITH A POSITIVE ALLOSTERIC GABAB RECEPTOR MODULATORE EFFECT
WO2008157408A2 (en) * 2007-06-15 2008-12-24 Xenoport, Inc. Use of prodrugs of gaba analogs, antispasticity agents, and prodrugs of gaba b receptor agonists for treating spasticity
JP2010534239A (ja) * 2007-07-25 2010-11-04 アストラゼネカ・アクチエボラーグ Ｎｅｒｄの治療のための（３−アミノ−２−フルオロプロピル）ホスフィン酸の使用
WO2009061934A1 (en) * 2007-11-06 2009-05-14 Xenoport, Inc. Use of prodrugs of gaba b agonists for treating neuropathic and musculoskeletal pain
TWI380812B (zh) * 2008-01-25 2013-01-01 Xenoport Inc （３ｓ）-胺甲基-５-甲基己酸前藥之晶形及使用方法
EP2250148B1 (en) 2008-01-25 2016-08-17 XenoPort, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use
WO2009094577A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
WO2009117160A2 (en) * 2008-03-20 2009-09-24 General Mills, Inc. Compound and method for treatment of gastroesophageal reflux
US8299291B2 (en) * 2008-08-07 2012-10-30 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
WO2010017498A1 (en) 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing n-hydroxysuccinimidyl carbonates
EP2403486A1 (en) 2009-03-03 2012-01-11 XenoPort, Inc. Sustained release oral dosage forms of an r-baclofen prodrug
EP2419401A2 (en) * 2009-04-17 2012-02-22 XenoPort, Inc. GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
WO2013023155A1 (en) 2011-08-11 2013-02-14 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use
CA2874737A1 (en) 2012-06-01 2013-12-05 Lynn Health Science Institute, Inc. Use of baclofen to treat insomnia
TW202412754A (zh) * 2022-06-07 2024-04-01 瑞士商意梭凱普公司 應用於食道黏膜的包含逆流抑制劑的藥物傳遞系統

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US5656730A (en) * 1995-04-07 1997-08-12 Enzon, Inc. Stabilized monomeric protein compositions

Also Published As

Publication number Publication date
SI0936906T1 (en) 2004-02-29
CZ93099A3 (cs) 1999-09-15
DK0936906T3 (da) 2003-11-24
KR20050101237A (ko) 2005-10-20
TR199900591T2 (xx) 1999-07-21
IL128961A (en) 2004-08-31
US6117908A (en) 2000-09-12
AR007747A1 (es) 1999-11-10
TW548104B (en) 2003-08-21
UA61081C2 (uk) 2003-11-17
DE69724809T2 (de) 2004-07-15
SI1344524T1 (sl) 2006-12-31
WO1998011885A1 (en) 1998-03-26
SK30599A3 (en) 2000-01-18
EP0936906A1 (en) 1999-08-25
HK1057004A1 (en) 2004-03-12
ES2268227T3 (es) 2007-03-16
AU4406497A (en) 1998-04-14
KR100568659B1 (ko) 2006-04-07
JP2001501604A (ja) 2001-02-06
IL128961A0 (en) 2000-02-17
ID19621A (id) 1998-07-23
ES2206749T3 (es) 2004-05-16
ZA977969B (en) 1998-03-18
DK1344524T3 (da) 2006-10-30
DE69736445T2 (de) 2007-03-15
EP1344524A1 (en) 2003-09-17
PT1344524E (pt) 2006-11-30
HUP9903825A2 (hu) 2001-05-28
NZ334495A (en) 2000-09-29
IS2538B (is) 2009-09-15
BR9711400A (pt) 1999-08-17
KR100553294B1 (ko) 2006-02-22
EE9900095A (et) 1999-10-15
CN1117560C (zh) 2003-08-13
NZ504244A (en) 2000-09-29
SE9603408D0 (sv) 1996-09-18
US6664069B1 (en) 2003-12-16
HU224968B1 (en) 2006-04-28
CZ299997B6 (cs) 2009-01-14
PL332497A1 (en) 1999-09-13
IS8623A (is) 2007-03-19
CN1237105A (zh) 1999-12-01
SK285744B6 (sk) 2007-07-06
NO991287D0 (no) 1999-03-17
DE69724809D1 (de) 2003-10-16
ATE249212T1 (de) 2003-09-15
PL190028B1 (pl) 2005-10-31
JP4098832B2 (ja) 2008-06-11
RU2199316C2 (ru) 2003-02-27
SA97180522B1 (ar) 2006-04-04
IS5001A (is) 1999-03-15
HK1022100A1 (en) 2000-07-28
HUP9903825A3 (en) 2001-06-28
EP0936906B1 (en) 2003-09-10
EP1344524B1 (en) 2006-08-02
CA2265615C (en) 2007-01-30
KR20000036185A (ko) 2000-06-26
IS2329B (is) 2008-01-15
ATE334700T1 (de) 2006-08-15
DE69736445D1 (de) 2006-09-14
PT936906E (pt) 2003-12-31
MY122020A (en) 2006-03-31
AU714370B2 (en) 1999-12-23
NO326837B1 (no) 2009-02-23
CA2265615A1 (en) 1998-03-26
NO991287L (no) 1999-03-17

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