NO326409B1 - 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse - Google Patents

1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse Download PDF

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Publication number
NO326409B1
NO326409B1 NO20024134A NO20024134A NO326409B1 NO 326409 B1 NO326409 B1 NO 326409B1 NO 20024134 A NO20024134 A NO 20024134A NO 20024134 A NO20024134 A NO 20024134A NO 326409 B1 NO326409 B1 NO 326409B1
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Norway
Prior art keywords
pyrimidin
pyrimido
difluorophenyl
dihydro
fluoro
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NO20024134A
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English (en)
Norwegian (no)
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NO20024134L (no
NO20024134D0 (no
Inventor
Jeffrey Charles Boehm
Ralph Floyd Hall
Jerry L Adams
John J Taggart
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Smithkline Beecham Corp
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Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20024134D0 publication Critical patent/NO20024134D0/no
Publication of NO20024134L publication Critical patent/NO20024134L/no
Publication of NO326409B1 publication Critical patent/NO326409B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
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    • A61P17/00Drugs for dermatological disorders
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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NO20024134A 2000-03-02 2002-08-30 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse NO326409B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18641900P 2000-03-02 2000-03-02
PCT/US2001/006688 WO2001064679A1 (en) 2000-03-02 2001-03-02 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases

Publications (3)

Publication Number Publication Date
NO20024134D0 NO20024134D0 (no) 2002-08-30
NO20024134L NO20024134L (no) 2002-10-24
NO326409B1 true NO326409B1 (no) 2008-12-01

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NO20024134A NO326409B1 (no) 2000-03-02 2002-08-30 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse

Country Status (26)

Country Link
EP (1) EP1265900B1 (hu)
JP (1) JP2003525295A (hu)
KR (1) KR100806978B1 (hu)
CN (1) CN100482664C (hu)
AR (2) AR030053A1 (hu)
AT (1) ATE362473T1 (hu)
AU (2) AU2001239992B2 (hu)
BR (1) BR0108715A (hu)
CA (1) CA2402092C (hu)
CY (1) CY1106816T1 (hu)
CZ (1) CZ20022933A3 (hu)
DE (1) DE60128457T2 (hu)
DK (1) DK1265900T3 (hu)
ES (1) ES2287107T3 (hu)
HK (1) HK1052932A1 (hu)
HU (1) HUP0204431A3 (hu)
IL (3) IL151426A0 (hu)
MX (1) MXPA02008588A (hu)
MY (1) MY141144A (hu)
NO (1) NO326409B1 (hu)
NZ (1) NZ520914A (hu)
PL (1) PL358280A1 (hu)
PT (1) PT1265900E (hu)
TW (1) TWI290926B (hu)
WO (1) WO2001064679A1 (hu)
ZA (1) ZA200207017B (hu)

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ES2310039T3 (es) 1998-05-26 2008-12-16 Warner-Lambert Company Llc Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular.
MXPA03003612A (es) * 2000-10-23 2003-06-19 Smithkline Beecham Corp Compuestos novedosos.
AU2002246677B2 (en) * 2000-12-20 2006-11-16 Merck Sharp & Dohme Corp. (Halo-Benzo Carbonyl)Heterocyclo Fused Phenyl p38 Kinase Inhibiting Agents
GB0124848D0 (en) 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
US7125898B2 (en) 2002-02-12 2006-10-24 Smithkline Beecham Corporation Nicotinamide derivatives useful as p38 inhibitors.
PL371678A1 (en) * 2002-02-13 2005-06-27 F.Hoffmann-La Roche Ag Novel pyridin- and pyrimidin-derivatives
CN1646131A (zh) * 2002-04-19 2005-07-27 史密丝克莱恩比彻姆公司 新化合物
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
CA2497240A1 (en) 2002-08-29 2004-03-11 Andrew Asher Protter Methods of promoting osteogenesis
US7129351B2 (en) 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
WO2004043367A2 (en) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Fused heterocyclic compounds and use thereof
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
WO2004089955A1 (en) 2003-04-10 2004-10-21 F.Hoffmann-La Roche Ag Pyrimido compounds
US7244441B2 (en) 2003-09-25 2007-07-17 Scios, Inc. Stents and intra-luminal prostheses containing map kinase inhibitors
ES2339670T3 (es) * 2003-12-23 2010-05-24 Novartis Ag Inhibidores heterociclicos biciclicos de la quinasa p-38.
AU2005316668B2 (en) * 2004-12-13 2012-09-06 Millennium Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
EP1676574A3 (en) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Methods for promoting survival of transplanted tissues and cells
JP5201817B2 (ja) * 2005-10-28 2013-06-05 大塚製薬株式会社 医薬組成物
JP2009542818A (ja) * 2006-06-16 2009-12-03 グラクソ グループ リミテッド 新規化合物
WO2007147104A2 (en) * 2006-06-16 2007-12-21 Glaxo Group Limited Novel compounds
KR101040394B1 (ko) * 2010-05-18 2011-06-09 (주)이성산업 역화 방지 기능을 갖는 야외용 가스 히터
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
KR102350704B1 (ko) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 헤테로아릴 화합물 및 이의 용도
TWI647220B (zh) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 雜芳基化合物及其用途
PE20151776A1 (es) 2013-03-15 2015-12-11 Celgene Avilomics Res Inc Compuestos de heteroarilo y sus usos
CA2926596C (en) * 2013-10-16 2020-07-14 Shanghai Yingli Pharmaceutical Co., Ltd Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
WO2019071144A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2023066283A1 (en) 2021-10-20 2023-04-27 Insilico Medicine Ip Limited Methionine adenosyltransferase 2a (mat2a) inhibitors and uses thereof

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JPS60226882A (ja) * 1984-04-24 1985-11-12 Nippon Zoki Pharmaceut Co Ltd 新規ピリミドピリミジン誘導体
DK0920429T3 (da) * 1996-08-06 2003-05-12 Pfizer Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
ES2310039T3 (es) * 1998-05-26 2008-12-16 Warner-Lambert Company Llc Pirimidinas biciclicas y 3,4-dihidropirimidinas biciclicas como inhibidores de la proliferacion celular.
AU4429799A (en) * 1998-06-12 1999-12-30 Vertex Pharmaceuticals Incorporated Inhibitors of p38
ID28276A (id) * 1998-10-23 2001-05-10 Hoffmann La Roche Heterolingkar nitrogen bisiklik

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Publication number Publication date
NZ520914A (en) 2004-03-26
CA2402092C (en) 2012-01-24
HUP0204431A1 (hu) 2003-04-28
EP1265900A1 (en) 2002-12-18
DE60128457D1 (de) 2007-06-28
KR20020082858A (ko) 2002-10-31
CN1422273A (zh) 2003-06-04
NO20024134L (no) 2002-10-24
ZA200207017B (en) 2004-02-26
KR100806978B1 (ko) 2008-02-25
AR030053A1 (es) 2003-08-13
AR040075A2 (es) 2005-03-16
CY1106816T1 (el) 2012-01-25
NO20024134D0 (no) 2002-08-30
AU3999201A (en) 2001-09-12
MY141144A (en) 2010-03-15
MXPA02008588A (es) 2003-02-24
ATE362473T1 (de) 2007-06-15
JP2003525295A (ja) 2003-08-26
CZ20022933A3 (cs) 2003-02-12
IL151426A0 (en) 2003-04-10
ES2287107T3 (es) 2007-12-16
PL358280A1 (en) 2004-08-09
CA2402092A1 (en) 2001-09-07
IL189865A0 (en) 2008-08-07
DE60128457T2 (de) 2008-01-17
CN100482664C (zh) 2009-04-29
IL151426A (en) 2011-01-31
HK1052932A1 (en) 2003-10-03
BR0108715A (pt) 2004-04-27
WO2001064679A1 (en) 2001-09-07
TWI290926B (en) 2007-12-11
HUP0204431A3 (en) 2006-01-30
EP1265900B1 (en) 2007-05-16
PT1265900E (pt) 2007-08-22
DK1265900T3 (da) 2007-09-24
AU2001239992B2 (en) 2005-09-01
EP1265900A4 (en) 2004-11-10

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