NO326409B1 - 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse - Google Patents

1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse Download PDF

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Publication number
NO326409B1
NO326409B1 NO20024134A NO20024134A NO326409B1 NO 326409 B1 NO326409 B1 NO 326409B1 NO 20024134 A NO20024134 A NO 20024134A NO 20024134 A NO20024134 A NO 20024134A NO 326409 B1 NO326409 B1 NO 326409B1
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Norway
Prior art keywords
pyrimidin
pyrimido
difluorophenyl
dihydro
fluoro
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NO20024134A
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English (en)
Norwegian (no)
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NO20024134L (no
NO20024134D0 (no
Inventor
Jeffrey Charles Boehm
Ralph Floyd Hall
Jerry L Adams
John J Taggart
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Smithkline Beecham Corp
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Publication of NO20024134D0 publication Critical patent/NO20024134D0/no
Publication of NO20024134L publication Critical patent/NO20024134L/no
Publication of NO326409B1 publication Critical patent/NO326409B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/06—Antipsoriatics
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P33/00—Antiparasitic agents
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NO20024134A 2000-03-02 2002-08-30 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse NO326409B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18641900P 2000-03-02 2000-03-02
PCT/US2001/006688 WO2001064679A1 (en) 2000-03-02 2001-03-02 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases

Publications (3)

Publication Number Publication Date
NO20024134D0 NO20024134D0 (no) 2002-08-30
NO20024134L NO20024134L (no) 2002-10-24
NO326409B1 true NO326409B1 (no) 2008-12-01

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NO20024134A NO326409B1 (no) 2000-03-02 2002-08-30 1,5-disubstituerte 3,4-dihydro-1H-pyrimido[4,5-D]-pyrimidin-2-onforbindelser og deres anvendelse samt farmasoytisk preparat inneholdende en slik forbindelse

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EP (1) EP1265900B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003525295A (cg-RX-API-DMAC10.html)
KR (1) KR100806978B1 (cg-RX-API-DMAC10.html)
CN (1) CN100482664C (cg-RX-API-DMAC10.html)
AR (2) AR030053A1 (cg-RX-API-DMAC10.html)
AT (1) ATE362473T1 (cg-RX-API-DMAC10.html)
AU (2) AU3999201A (cg-RX-API-DMAC10.html)
BR (1) BR0108715A (cg-RX-API-DMAC10.html)
CA (1) CA2402092C (cg-RX-API-DMAC10.html)
CY (1) CY1106816T1 (cg-RX-API-DMAC10.html)
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MX (1) MXPA02008588A (cg-RX-API-DMAC10.html)
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DE60015599T2 (de) 1999-11-23 2005-11-03 Smithkline Beecham Corp. 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN
EP1233950B1 (en) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
AU2002246855B2 (en) * 2000-10-23 2005-12-22 Smithkline Beecham Corporation Novel compounds
JP2004521892A (ja) * 2000-12-20 2004-07-22 メルク　エンド　カムパニー　インコーポレーテッド （ハロ−ベンゾカルボニル）複素環縮合フェニル系ｐ３８キナーゼ阻害剤
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KR101058292B1 (ko) 2002-02-12 2011-08-22 글락소스미스클라인 엘엘씨 Ｐ38 억제제로 유용한 니코틴아미드 유도체
KR100608414B1 (ko) * 2002-02-13 2006-08-02 에프. 호프만-라 로슈 아게 신규한 피리딘- 및 피리미딘-유도체
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JP2006508051A (ja) 2002-08-29 2006-03-09 サイオス インク． 骨形成を促進する方法
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ES2339670T3 (es) * 2003-12-23 2010-05-24 Novartis Ag Inhibidores heterociclicos biciclicos de la quinasa p-38.
CA2590294A1 (en) 2004-12-13 2006-06-22 Sunesis Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
EP1676574A3 (en) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Methods for promoting survival of transplanted tissues and cells
JP5201817B2 (ja) * 2005-10-28 2013-06-05 大塚製薬株式会社 医薬組成物
US20090318424A1 (en) * 2006-06-16 2009-12-24 Mauro Corsi Novel compounds
US20100069409A1 (en) * 2006-06-16 2010-03-18 Glaxo Group Limited "novel compounds"
KR101040394B1 (ko) * 2010-05-18 2011-06-09 (주)이성산업 역화 방지 기능을 갖는 야외용 가스 히터
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
KR102350704B1 (ko) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 헤테로아릴 화합물 및 이의 용도
CN111793068A (zh) 2013-03-15 2020-10-20 西建卡尔有限责任公司 杂芳基化合物和其用途
TWI647220B (zh) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 雜芳基化合物及其用途
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WO2001064679A1 (en) 2001-09-07
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IL189865A0 (en) 2008-08-07
EP1265900A1 (en) 2002-12-18
ZA200207017B (en) 2004-02-26
IL151426A0 (en) 2003-04-10
EP1265900A4 (en) 2004-11-10
CA2402092C (en) 2012-01-24
NO20024134L (no) 2002-10-24
PL358280A1 (en) 2004-08-09
AU3999201A (en) 2001-09-12
EP1265900B1 (en) 2007-05-16
JP2003525295A (ja) 2003-08-26
MY141144A (en) 2010-03-15
HUP0204431A1 (hu) 2003-04-28
HUP0204431A3 (en) 2006-01-30
NZ520914A (en) 2004-03-26
CA2402092A1 (en) 2001-09-07
PT1265900E (cg-RX-API-DMAC10.html) 2007-08-22
KR20020082858A (ko) 2002-10-31
CN1422273A (zh) 2003-06-04
AU2001239992B2 (en) 2005-09-01
NO20024134D0 (no) 2002-08-30
DK1265900T3 (da) 2007-09-24
AR030053A1 (es) 2003-08-13
CY1106816T1 (el) 2012-01-25
CZ20022933A3 (cs) 2003-02-12
HK1052932A1 (en) 2003-10-03
DE60128457D1 (de) 2007-06-28
BR0108715A (pt) 2004-04-27
CN100482664C (zh) 2009-04-29
MXPA02008588A (es) 2003-02-24
DE60128457T2 (de) 2008-01-17
IL151426A (en) 2011-01-31
TWI290926B (en) 2007-12-11
AR040075A2 (es) 2005-03-16

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