NO326122B1 - Farmasoytisk preparat inneholdende "Lactobacillus casei rhamnosus" - Google Patents
Farmasoytisk preparat inneholdende "Lactobacillus casei rhamnosus" Download PDFInfo
- Publication number
- NO326122B1 NO326122B1 NO19995794A NO995794A NO326122B1 NO 326122 B1 NO326122 B1 NO 326122B1 NO 19995794 A NO19995794 A NO 19995794A NO 995794 A NO995794 A NO 995794A NO 326122 B1 NO326122 B1 NO 326122B1
- Authority
- NO
- Norway
- Prior art keywords
- strain
- lactobacillus casei
- pharmaceutical material
- accordance
- lactobacillus
- Prior art date
Links
- 241000218588 Lactobacillus rhamnosus Species 0.000 title claims abstract description 77
- 229940004311 lactobacillus casei rhamnosus Drugs 0.000 title claims abstract description 65
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 claims abstract description 26
- 244000005700 microbiome Species 0.000 claims abstract description 19
- 208000018522 Gastrointestinal disease Diseases 0.000 claims abstract description 13
- 241001465754 Metazoa Species 0.000 claims abstract description 13
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- 239000003937 drug carrier Substances 0.000 claims abstract description 9
- 230000035899 viability Effects 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 47
- 241000186660 Lactobacillus Species 0.000 claims description 33
- 210000003608 fece Anatomy 0.000 claims description 26
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- 229940039696 lactobacillus Drugs 0.000 claims description 22
- 230000000968 intestinal effect Effects 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 12
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical group O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 2
- WLDRFJDGKMTPPV-UHFFFAOYSA-N 1,2-dimethylhydrazine dihydrochloride Chemical compound Cl.Cl.CNNC WLDRFJDGKMTPPV-UHFFFAOYSA-N 0.000 description 1
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- 229940056367 penicillin v Drugs 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/245—Lactobacillus casei
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702083A SE511524C2 (sv) | 1997-06-02 | 1997-06-02 | Lactobacillus casei rhamnosus-stam samt farmaceutisk beredning för bekämpning av patogena tarmbakterier |
PCT/SE1998/001041 WO1998055131A1 (en) | 1997-06-02 | 1998-06-02 | Pharmaceutical preparation comprising lactobacillus casei rhamnosus |
Publications (3)
Publication Number | Publication Date |
---|---|
NO995794D0 NO995794D0 (no) | 1999-11-26 |
NO995794L NO995794L (no) | 2000-01-31 |
NO326122B1 true NO326122B1 (no) | 2008-09-29 |
Family
ID=20407203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19995794A NO326122B1 (no) | 1997-06-02 | 1999-11-26 | Farmasoytisk preparat inneholdende "Lactobacillus casei rhamnosus" |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1005353B1 (es) |
JP (1) | JP4350170B2 (es) |
CN (1) | CN1153575C (es) |
AT (1) | ATE304366T1 (es) |
AU (1) | AU726217B2 (es) |
CA (1) | CA2291623A1 (es) |
DE (1) | DE69831578T2 (es) |
DK (1) | DK1005353T3 (es) |
ES (1) | ES2245801T3 (es) |
NO (1) | NO326122B1 (es) |
SE (1) | SE511524C2 (es) |
WO (1) | WO1998055131A1 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1034787A1 (en) * | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
EP1251747B1 (en) * | 2000-01-18 | 2012-01-25 | Société des Produits Nestlé S.A. | Pet food composition for treating helicobacter species in pets |
FR2808689B1 (fr) | 2000-05-11 | 2004-09-03 | Agronomique Inst Nat Rech | Utilisation de souches acetogenes hydrogenotrophes pour la prevention ou le traitement de troubles digestifs |
US20030180260A1 (en) * | 2000-06-19 | 2003-09-25 | Clancy Robert Llewellyn | Immunotherapy or treating bacterial or viral infection at mucosal surfaces with probiotics, and compositions therefor |
BR0006628A (pt) * | 2000-12-07 | 2004-06-22 | Sanab Saneamento Ambiental E B | Sistema anaeróbico de tratamento de lixo urbano, resìduos agro-industrias e biomassa |
KR100424790B1 (ko) * | 2000-12-08 | 2004-03-30 | (주) 피엘바이오 | 헬리코박터 필로리의 활성을 억제하는 유산균 |
WO2002045727A1 (en) * | 2000-12-08 | 2002-06-13 | Plbio Co., Ltd. | Lactic acid bacteria inhibiting adhesion of helicobacter pylori to gastric mucosa |
AU7675601A (en) * | 2000-12-08 | 2002-06-18 | Pl Bio Co Ltd | Lactic acid bacteria with inhibiting activities on (helicobacter pylori) |
KR100449597B1 (ko) * | 2000-12-08 | 2004-09-18 | (주) 피엘바이오 | 헬리코박터 필로리의 활성을 억제하는 유산균 |
BR0116349A (pt) * | 2000-12-18 | 2003-12-23 | Probiohealth Llc | Compostos probióticos derivados da cepa ke01 de lactobacillus casei |
US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
SG97174A1 (en) * | 2000-12-19 | 2003-07-18 | Cell Biotechnology Food Co Ltd | Lactobacillus rhamnosus strain and uses thereof |
WO2002055092A1 (fr) * | 2001-01-16 | 2002-07-18 | Amato Pharmaceutical Products,Ltd. | Traitements preventifs et/ou remedes contre les maladies digestives |
ES2288630T3 (es) * | 2002-12-02 | 2008-01-16 | Basf Aktiengesellschaft | Sistema de expresion, que puede ser inducido por medio de la l-ramnosa. |
US7125963B2 (en) | 2004-03-03 | 2006-10-24 | En N Tech Inc | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions |
WO2007108763A1 (en) * | 2006-03-17 | 2007-09-27 | Probac Ab | Use of lactobacillus strains for promoting immunotolerance in autoimmune disease |
HUE033028T2 (hu) * | 2006-03-17 | 2017-11-28 | Probi Ab | Termostabil lactobacillus törzsek |
CN101173228B (zh) * | 2006-11-01 | 2011-08-17 | 信谊药厂 | 新的乳酸杆菌菌株、药物组合物及其用途、以及制造方法 |
FR2928935B1 (fr) * | 2008-03-19 | 2011-05-20 | Gervais Danone Sa | Souche de lactobacillus rhamnosus. |
WO2010056198A1 (en) | 2008-11-17 | 2010-05-20 | Essum Ab | Pharmaceutical preparation comprising a combination of streptococcus strains and lactobacillus strains |
US20110223137A1 (en) * | 2008-12-05 | 2011-09-15 | Nestec S.A. | Compositions for use in low-birth weight infants |
GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
EP2604123A1 (en) | 2011-12-15 | 2013-06-19 | Friesland Brands B.V. | Method and nutritional compositions for the treatment of diarrhea. |
US20130344042A1 (en) * | 2012-06-20 | 2013-12-26 | Gretchen Tanbonliong | Dietary management of celiac disease and food allergy |
WO2014077365A1 (ja) | 2012-11-16 | 2014-05-22 | カルピス株式会社 | 特定のラクトバチルス・ガセリ株又はその処理物を含有するストレス性腸障害の軽減剤 |
GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
ME02997B (me) | 2014-12-23 | 2018-10-20 | 4D Pharma Res Ltd | Soj bacteroides thetaiotaomicron i njegova upotreba u smanjenju inflamacije |
WO2016102951A1 (en) | 2014-12-23 | 2016-06-30 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
CN115364122A (zh) | 2015-06-15 | 2022-11-22 | 4D制药研究有限公司 | 包含细菌菌株的组合物 |
MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
PL3206700T3 (pl) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Kompozycje zawierające szczepy bakteryjne |
MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
MD3307288T2 (ro) | 2015-06-15 | 2019-12-31 | 4D Pharma Res Ltd | Compoziții care conțin tulpini bacteriene |
EA034677B1 (ru) | 2015-11-20 | 2020-03-05 | 4Д Фарма Рисёрч Лимитед | Композиции для лечения или профилактики рака, содержащие штамм enterococcus gallinarum |
GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
DK3313423T3 (da) | 2016-03-04 | 2019-05-20 | 4D Pharma Plc | Sammensætninger omfattende bakterielle blautia-stammer til behandling af visceral hypersensitivitet |
GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
LT3630136T (lt) | 2017-05-22 | 2021-06-10 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterines padermes |
WO2018215782A1 (en) | 2017-05-24 | 2018-11-29 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
EP3638271B1 (en) | 2017-06-14 | 2020-10-14 | 4D Pharma Research Limited | Compositions comprising bacterial strains |
HUE052258T2 (hu) | 2017-06-14 | 2021-04-28 | 4D Pharma Res Ltd | Megasphaera nemzetségbe tartozó baktériumtörzset tartalmazó készítmény, és alkalmazása |
IL283973B (en) | 2017-06-14 | 2022-08-01 | 4D Pharma Res Ltd | Preparations containing bacterial strains |
CN109182166B (zh) * | 2018-08-27 | 2021-08-20 | 南昌大学 | 一株具有缓解便秘功效的鼠李糖乳杆菌及其应用 |
CN110295130A (zh) * | 2019-07-29 | 2019-10-01 | 诺佰克(武汉)生物科技有限公司 | 一株鼠李糖乳杆菌及其应用 |
CN113088470A (zh) * | 2021-04-14 | 2021-07-09 | 广东医科大学 | 一株鼠李糖乳杆菌L.rB16及其应用 |
Family Cites Families (3)
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DE2421066A1 (de) * | 1974-05-02 | 1976-03-25 | Solco Basel Ag | Bifidobakterien enthaltendes praeparat |
AU624067B2 (en) * | 1986-12-12 | 1992-06-04 | Biorem C.C. | Preparation suitable for use in the treatment of enteric disorders |
SE469875C (sv) * | 1991-07-25 | 1997-04-14 | Probi Ab | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
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1997
- 1997-06-02 SE SE9702083A patent/SE511524C2/sv not_active IP Right Cessation
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1998
- 1998-06-02 CA CA002291623A patent/CA2291623A1/en not_active Abandoned
- 1998-06-02 AU AU80460/98A patent/AU726217B2/en not_active Expired
- 1998-06-02 DE DE69831578T patent/DE69831578T2/de not_active Expired - Lifetime
- 1998-06-02 JP JP50225399A patent/JP4350170B2/ja not_active Expired - Lifetime
- 1998-06-02 ES ES98928734T patent/ES2245801T3/es not_active Expired - Lifetime
- 1998-06-02 EP EP98928734A patent/EP1005353B1/en not_active Expired - Lifetime
- 1998-06-02 DK DK98928734T patent/DK1005353T3/da active
- 1998-06-02 CN CNB988070170A patent/CN1153575C/zh not_active Expired - Fee Related
- 1998-06-02 WO PCT/SE1998/001041 patent/WO1998055131A1/en active IP Right Grant
- 1998-06-02 AT AT98928734T patent/ATE304366T1/de not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
WO1998055131A1 (en) | 1998-12-10 |
JP2002507200A (ja) | 2002-03-05 |
EP1005353A1 (en) | 2000-06-07 |
SE9702083D0 (sv) | 1997-06-02 |
NO995794L (no) | 2000-01-31 |
DE69831578D1 (de) | 2005-10-20 |
NO995794D0 (no) | 1999-11-26 |
AU8046098A (en) | 1998-12-21 |
JP4350170B2 (ja) | 2009-10-21 |
ES2245801T3 (es) | 2006-01-16 |
EP1005353B1 (en) | 2005-09-14 |
DE69831578T2 (de) | 2006-04-27 |
DK1005353T3 (da) | 2005-10-03 |
CN1272791A (zh) | 2000-11-08 |
CN1153575C (zh) | 2004-06-16 |
SE9702083L (sv) | 1998-12-03 |
CA2291623A1 (en) | 1998-12-10 |
AU726217B2 (en) | 2000-11-02 |
SE511524C2 (sv) | 1999-10-11 |
ATE304366T1 (de) | 2005-09-15 |
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