NO325245B1 - Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse - Google Patents
Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse Download PDFInfo
- Publication number
- NO325245B1 NO325245B1 NO20033618A NO20033618A NO325245B1 NO 325245 B1 NO325245 B1 NO 325245B1 NO 20033618 A NO20033618 A NO 20033618A NO 20033618 A NO20033618 A NO 20033618A NO 325245 B1 NO325245 B1 NO 325245B1
- Authority
- NO
- Norway
- Prior art keywords
- salts
- tetrahydro
- piperidin
- compounds
- solvates
- Prior art date
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- 239000003814 drug Substances 0.000 title claims description 17
- 229940079593 drug Drugs 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 97
- -1 pyridin-4-yl-carbonyl Chemical group 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 57
- 150000004677 hydrates Chemical class 0.000 claims description 28
- 239000012453 solvate Substances 0.000 claims description 28
- 238000011282 treatment Methods 0.000 claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 8
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 8
- 208000010668 atopic eczema Diseases 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 3
- VBKPPDYGFUZOAJ-UHFFFAOYSA-N 5-oxopentanoic acid Chemical compound OC(=O)CCCC=O VBKPPDYGFUZOAJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 3
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 3
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 3
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 3
- NHVCANZLYPMKSR-LEWJYISDSA-N (4as,8ar)-2-(1-acetylpiperidin-4-yl)-4-(3,4-diethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(C)=O)CC1 NHVCANZLYPMKSR-LEWJYISDSA-N 0.000 claims description 2
- PMSDQTJDMYHMRP-VQTJNVASSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-(1-methylsulfonylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(C)(=O)=O)CC1 PMSDQTJDMYHMRP-VQTJNVASSA-N 0.000 claims description 2
- IRQAORMVIRUVSL-IZZNHLLZSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(=O)(=O)C=2C=CC(C)=CC=2)CC1 IRQAORMVIRUVSL-IZZNHLLZSA-N 0.000 claims description 2
- IDSNOSDXUZNXFS-RRPNLBNLSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-[5-(dimethylamino)naphthalen-1-yl]sulfonylpiperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(S(=O)(=O)C=2C3=CC=CC(=C3C=CC=2)N(C)C)CC1 IDSNOSDXUZNXFS-RRPNLBNLSA-N 0.000 claims description 2
- MFSYFDUUARWTFQ-CJRXIRLBSA-N 2-[4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]piperidin-1-yl]acetamide;hydrochloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC(N)=O)CC1 MFSYFDUUARWTFQ-CJRXIRLBSA-N 0.000 claims description 2
- OBLQGGDVCNLUBG-VQTJNVASSA-N 4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]-n-tert-butylpiperidine-1-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)NC(C)(C)C)CC1 OBLQGGDVCNLUBG-VQTJNVASSA-N 0.000 claims description 2
- HPAKPHNDMHWESA-FCHUYYIVSA-N 5-[4-[(4as,8ar)-4-(3,4-diethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2-yl]piperidin-1-yl]-5-oxopentanoic acid Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)CCCC(O)=O)CC1 HPAKPHNDMHWESA-FCHUYYIVSA-N 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
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- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
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- 239000012876 carrier material Substances 0.000 claims description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- DZUJGZGLPQEEDQ-LEWJYISDSA-N (4as,8ar)-2-[1-[2-(4-amino-3,5-dichlorophenyl)-2-oxoethyl]piperidin-4-yl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC(=O)C=2C=C(Cl)C(N)=C(Cl)C=2)CC1 DZUJGZGLPQEEDQ-LEWJYISDSA-N 0.000 claims 1
- LSOGXQFCQOSGNV-BJKOFHAPSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(2-morpholin-4-ylacetyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)CN2CCOCC2)CC1 LSOGXQFCQOSGNV-BJKOFHAPSA-N 0.000 claims 1
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- RLBQZJLGPGGCRU-BJKOFHAPSA-N (4as,8ar)-4-(3,4-diethoxyphenyl)-2-[1-(pyridine-4-carbonyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OCC)C(OCC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C(=O)C=2C=CN=CC=2)CC1 RLBQZJLGPGGCRU-BJKOFHAPSA-N 0.000 claims 1
- YWHBSFAATHJDAA-VQTJNVASSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-(1-pyrimidin-2-ylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2N=CC=CN=2)CC1 YWHBSFAATHJDAA-VQTJNVASSA-N 0.000 claims 1
- ZLSJEILNOWSWRS-VQTJNVASSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-(1-thieno[2,3-d]pyrimidin-4-ylpiperidin-4-yl)-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2C=3C=CSC=3N=CN=2)CC1 ZLSJEILNOWSWRS-VQTJNVASSA-N 0.000 claims 1
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- AMRVEJYMDSINDP-XZOQPEGZSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-(4-nitrophenyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(C=2C=CC(=CC=2)[N+]([O-])=O)CC1 AMRVEJYMDSINDP-XZOQPEGZSA-N 0.000 claims 1
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- LWTZEJDQHWUMON-XZOQPEGZSA-N (4as,8ar)-4-(3,4-dimethoxyphenyl)-2-[1-(pyridin-4-ylmethyl)piperidin-4-yl]-4a,5,8,8a-tetrahydrophthalazin-1-one Chemical compound C1=C(OC)C(OC)=CC=C1C([C@H]1CC=CC[C@H]1C1=O)=NN1C1CCN(CC=2C=CN=CC=2)CC1 LWTZEJDQHWUMON-XZOQPEGZSA-N 0.000 claims 1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Hospice & Palliative Care (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01103496 | 2001-02-15 | ||
| PCT/EP2002/001547 WO2002064584A1 (en) | 2001-02-15 | 2002-02-14 | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20033618D0 NO20033618D0 (no) | 2003-08-14 |
| NO20033618L NO20033618L (no) | 2003-10-15 |
| NO325245B1 true NO325245B1 (no) | 2008-03-10 |
Family
ID=8176497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20033618A NO325245B1 (no) | 2001-02-15 | 2003-08-14 | Ftalayinon-piperidinderivater, legemidler inneholdende disse og deres anvendelse |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6953853B2 (hu) |
| EP (1) | EP1362044A1 (hu) |
| JP (1) | JP4301812B2 (hu) |
| KR (1) | KR20030074817A (hu) |
| CN (1) | CN1524080A (hu) |
| AU (1) | AU2002234634B2 (hu) |
| BG (1) | BG108124A (hu) |
| BR (1) | BR0207278A (hu) |
| CA (1) | CA2438520C (hu) |
| CZ (1) | CZ20032491A3 (hu) |
| EA (1) | EA200300836A1 (hu) |
| EE (1) | EE05386B1 (hu) |
| HR (1) | HRP20030636B1 (hu) |
| HU (1) | HUP0303193A3 (hu) |
| IL (1) | IL156812A0 (hu) |
| MX (1) | MXPA03007310A (hu) |
| NO (1) | NO325245B1 (hu) |
| NZ (1) | NZ527424A (hu) |
| PL (1) | PL363391A1 (hu) |
| SK (1) | SK11382003A3 (hu) |
| WO (1) | WO2002064584A1 (hu) |
| ZA (1) | ZA200306815B (hu) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030074817A (ko) | 2001-02-15 | 2003-09-19 | 알타나 파마 아게 | Ｐｄｅ4 억제제로서의 프탈라지논-피페리디노-유도체 |
| DK1429807T3 (da) * | 2001-09-19 | 2007-06-18 | Altana Pharma Ag | Kombination af et NSAID og en PDE4-inhibitor |
| PL373146A1 (en) * | 2002-08-10 | 2005-08-22 | Altana Pharma Ag | Pyridazinone-derivatives as pde4 inhibitors |
| AU2003255376A1 (en) * | 2002-08-10 | 2004-03-11 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| EP1542987A1 (en) * | 2002-08-10 | 2005-06-22 | ALTANA Pharma AG | Piperidine-n-oxide-derivatives |
| EP1537100B1 (en) * | 2002-08-10 | 2007-04-25 | ALTANA Pharma AG | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| EP1587512A2 (en) * | 2003-01-14 | 2005-10-26 | ALTANA Pharma AG | Pde4 inhibitors for the treatment of neoplasms of lymphoid cells |
| WO2004098605A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Pharmaceutical composition comprising a pde4 inhibitor and il-1 trap |
| WO2004098578A2 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517 |
| WO2004098606A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and shuil-1r ii |
| WO2004098633A1 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde-4 inhibitor and a tnf alpha antagonist |
| JP2006528229A (ja) * | 2003-05-22 | 2006-12-14 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４阻害剤及びｐｄｅ５阻害剤を含有する組成物 |
| MXPA06002521A (es) * | 2003-09-05 | 2006-06-20 | Altana Pharma Ag | Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus. |
| JP4778449B2 (ja) * | 2004-02-04 | 2011-09-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体 |
| EP1720854A1 (en) * | 2004-02-04 | 2006-11-15 | Altana Pharma AG | Phthalzinone derivatives as pde4 inhibitors |
| EP1716123A1 (en) * | 2004-02-04 | 2006-11-02 | Altana Pharma AG | Pyridazinone derivatives and their use as pde4 inhibitors |
| BRPI0609371A2 (pt) | 2005-03-08 | 2010-03-30 | Nycomed Gmbh | usos de roflumilast na produção de composições farmacêuticas para o tratamento de diabetes mellitus |
| EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| JP2009523805A (ja) * | 2006-01-17 | 2009-06-25 | シグナル ファーマシューティカルズ，エルエルシー | ＴＮＦα、ＰＤＥ４及びＢ−ＲＡＦの阻害剤、それらの組成物及びそれらの使用法 |
| PL2363130T3 (pl) | 2006-07-05 | 2014-09-30 | Astrazeneca Ab | Kombinacja inhibitorów reduktazy HMG-CoA atorwastatyny i symwastatyny z inhibitorem fosfodiesterazy, takim jak roflumilast do leczenia zapalnych chorób płuc |
| DE602007005167D1 (de) * | 2006-12-20 | 2010-04-15 | Glaxo Group Ltd | 4-benzyl-1(2h)-phthalazinone als h1-rezeptor-antagonisten |
| MY154498A (en) * | 2007-05-16 | 2015-06-30 | Takeda Gmbh | Pyrazolone derivatives as pde4 inhibitors |
| AR074318A1 (es) | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| US8885991B2 (en) * | 2009-12-21 | 2014-11-11 | Hewlett-Packard Development Company, L.P. | Circuit switched optical interconnection fabric |
| BR112013031791A2 (pt) | 2011-06-17 | 2017-01-31 | Takeda Gmbh | derivados de ftalazinona-pirrolopirimidinacarboxamida |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| JP6820717B2 (ja) | 2016-10-28 | 2021-01-27 | 株式会社日立ハイテク | プラズマ処理装置 |
| CN113121417A (zh) * | 2019-12-30 | 2021-07-16 | 苏州盛迪亚生物医药有限公司 | 一种新型哌啶衍生物及其药物用途 |
| WO2021192210A1 (ja) | 2020-03-27 | 2021-09-30 | 株式会社日立ハイテク | 半導体製造方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT66969A (en) * | 1991-10-09 | 1995-01-30 | Syntex Inc | Benzo- and pyrido-pyridazinone- and pyridazin-thion derivatives, pharmaceutical compositions containing the same and process for the production of thereof |
| JP3100984B2 (ja) | 1992-12-02 | 2000-10-23 | ファイザー・インク． | 選択的ｐｄｅ▲下ｉ▼▲下ｖ▼阻害物質としてのカテコールジエーテル類 |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| PT971901E (pt) | 1997-01-15 | 2003-07-31 | Altana Pharma Ag | Ftalazinonas |
| AU1760399A (en) * | 1997-12-15 | 1999-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| US6380196B1 (en) * | 1997-12-15 | 2002-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurans |
| EP0934933A1 (en) | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
| DE69918422T2 (de) * | 1998-03-14 | 2005-08-11 | Altana Pharma Ag | Phthalazinone als PDE3/4 Inhibitoren |
| AU7654200A (en) | 1999-09-14 | 2001-04-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| EA005856B1 (ru) | 1999-10-25 | 2005-06-30 | Алтана Фарма Аг | Тетрагидротиопиранфталазиноновые производные в качестве ингибиторов pde4 |
| CA2388121A1 (en) * | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pde 4 inhibitors |
| WO2001094319A1 (en) | 2000-06-05 | 2001-12-13 | Altana Pharma Ag | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
| KR20030074817A (ko) * | 2001-02-15 | 2003-09-19 | 알타나 파마 아게 | Ｐｄｅ4 억제제로서의 프탈라지논-피페리디노-유도체 |
| NZ529221A (en) | 2001-04-25 | 2005-04-29 | Altana Pharma Ag | Phthalazinones with PDE-inhibiting properties for treatment of airway disorders and other inflammatory conditions |
| KR20030089723A (ko) | 2001-04-25 | 2003-11-22 | 알타나 파마 아게 | 피페라지노-유도체 및 이것의 ｐｄｅ4 억제제로서의 용도 |
| EP1542987A1 (en) | 2002-08-10 | 2005-06-22 | ALTANA Pharma AG | Piperidine-n-oxide-derivatives |
| EP1537100B1 (en) | 2002-08-10 | 2007-04-25 | ALTANA Pharma AG | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| PL373146A1 (en) | 2002-08-10 | 2005-08-22 | Altana Pharma Ag | Pyridazinone-derivatives as pde4 inhibitors |
-
2002
- 2002-02-14 KR KR10-2003-7010552A patent/KR20030074817A/ko not_active Application Discontinuation
- 2002-02-14 US US10/467,832 patent/US6953853B2/en not_active Expired - Fee Related
- 2002-02-14 WO PCT/EP2002/001547 patent/WO2002064584A1/en active IP Right Grant
- 2002-02-14 AU AU2002234634A patent/AU2002234634B2/en not_active Ceased
- 2002-02-14 HU HU0303193A patent/HUP0303193A3/hu unknown
- 2002-02-14 SK SK1138-2003A patent/SK11382003A3/sk unknown
- 2002-02-14 EA EA200300836A patent/EA200300836A1/ru unknown
- 2002-02-14 PL PL02363391A patent/PL363391A1/xx unknown
- 2002-02-14 MX MXPA03007310A patent/MXPA03007310A/es active IP Right Grant
- 2002-02-14 IL IL15681202A patent/IL156812A0/xx unknown
- 2002-02-14 CN CNA02805038XA patent/CN1524080A/zh active Pending
- 2002-02-14 EP EP02701277A patent/EP1362044A1/en not_active Withdrawn
- 2002-02-14 NZ NZ527424A patent/NZ527424A/en not_active IP Right Cessation
- 2002-02-14 JP JP2002564515A patent/JP4301812B2/ja not_active Expired - Fee Related
- 2002-02-14 CA CA2438520A patent/CA2438520C/en not_active Expired - Fee Related
- 2002-02-14 BR BR0207278-5A patent/BR0207278A/pt not_active IP Right Cessation
- 2002-02-14 CZ CZ20032491A patent/CZ20032491A3/cs unknown
- 2002-02-14 EE EEP200300311A patent/EE05386B1/xx not_active IP Right Cessation
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2003
- 2003-08-11 HR HRP20030636AA patent/HRP20030636B1/xx not_active IP Right Cessation
- 2003-08-14 NO NO20033618A patent/NO325245B1/no not_active IP Right Cessation
- 2003-08-21 BG BG108124A patent/BG108124A/bg unknown
- 2003-09-01 ZA ZA200306815A patent/ZA200306815B/en unknown
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2005
- 2005-06-03 US US11/143,721 patent/US7179810B2/en not_active Expired - Fee Related
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2006
- 2006-12-29 US US11/647,191 patent/US7531540B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030074817A (ko) | 2003-09-19 |
| US7179810B2 (en) | 2007-02-20 |
| HUP0303193A3 (en) | 2007-08-28 |
| NO20033618L (no) | 2003-10-15 |
| HRP20030636A2 (en) | 2005-06-30 |
| IL156812A0 (en) | 2004-02-08 |
| US6953853B2 (en) | 2005-10-11 |
| MXPA03007310A (es) | 2003-12-04 |
| EE05386B1 (et) | 2011-02-15 |
| US7531540B2 (en) | 2009-05-12 |
| EE200300311A (et) | 2003-10-15 |
| PL363391A1 (en) | 2004-11-15 |
| US20070129373A1 (en) | 2007-06-07 |
| US20050234062A1 (en) | 2005-10-20 |
| EP1362044A1 (en) | 2003-11-19 |
| HUP0303193A2 (hu) | 2003-12-29 |
| US20040067946A1 (en) | 2004-04-08 |
| CA2438520C (en) | 2011-10-04 |
| BR0207278A (pt) | 2004-02-10 |
| JP2004518727A (ja) | 2004-06-24 |
| NZ527424A (en) | 2005-02-25 |
| HRP20030636B1 (en) | 2012-05-31 |
| EA200300836A1 (ru) | 2004-02-26 |
| CZ20032491A3 (cs) | 2004-01-14 |
| NO20033618D0 (no) | 2003-08-14 |
| CA2438520A1 (en) | 2002-08-22 |
| AU2002234634B2 (en) | 2007-07-26 |
| JP4301812B2 (ja) | 2009-07-22 |
| SK11382003A3 (sk) | 2004-01-08 |
| CN1524080A (zh) | 2004-08-25 |
| ZA200306815B (en) | 2004-06-17 |
| WO2002064584A1 (en) | 2002-08-22 |
| BG108124A (bg) | 2004-08-31 |
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Owner name: TAKEDA GMBH, DE |
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