NO322978B1 - Kjemisk modifisert polypeptid, fremgangsmate for fremstilling derav, samt farmasoytisk preparat. - Google Patents
Kjemisk modifisert polypeptid, fremgangsmate for fremstilling derav, samt farmasoytisk preparat. Download PDFInfo
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- NO322978B1 NO322978B1 NO19990560A NO990560A NO322978B1 NO 322978 B1 NO322978 B1 NO 322978B1 NO 19990560 A NO19990560 A NO 19990560A NO 990560 A NO990560 A NO 990560A NO 322978 B1 NO322978 B1 NO 322978B1
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- Prior art keywords
- amino acid
- substituted
- acid sequence
- serine
- polypeptide
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- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000003607 modifier Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14934297 | 1997-06-06 | ||
| PCT/JP1998/002504 WO1998055500A1 (fr) | 1997-06-06 | 1998-06-05 | Polypeptides chimiquement modifies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO990560D0 NO990560D0 (no) | 1999-02-05 |
| NO990560L NO990560L (no) | 1999-03-26 |
| NO322978B1 true NO322978B1 (no) | 2006-12-18 |
Family
ID=15473025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19990560A NO322978B1 (no) | 1997-06-06 | 1999-02-05 | Kjemisk modifisert polypeptid, fremgangsmate for fremstilling derav, samt farmasoytisk preparat. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6583267B2 (fr) |
| EP (1) | EP0921131B1 (fr) |
| JP (1) | JP4011124B2 (fr) |
| KR (1) | KR100565022B1 (fr) |
| CN (1) | CN1250566C (fr) |
| AT (1) | ATE469166T1 (fr) |
| AU (1) | AU744085B2 (fr) |
| CA (1) | CA2263795C (fr) |
| DE (1) | DE69841682D1 (fr) |
| HK (1) | HK1022919A1 (fr) |
| HU (1) | HUP0001153A3 (fr) |
| NO (1) | NO322978B1 (fr) |
| NZ (1) | NZ334068A (fr) |
| RO (1) | RO121474B1 (fr) |
| WO (1) | WO1998055500A1 (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| DE69841682D1 (de) * | 1997-06-06 | 2010-07-08 | Kyowa Hakko Kirin Co Ltd | Chemisch modifizierte polypeptide |
| US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| HUP0203751A3 (en) | 2000-01-10 | 2005-01-28 | Maxygen Holdings Ltd Redwood C | G-csf conjugates |
| ATE428445T1 (de) | 2000-02-11 | 2009-05-15 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
| US20020065397A1 (en) * | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| RU2003128955A (ru) | 2001-02-27 | 2005-04-10 | Максиген Апс (Dk) | Новые интерферон бета-подобные молекулы |
| CA2452582C (fr) | 2001-07-11 | 2013-01-22 | Maxygen Holdings, Ltd. | Conjugues de g-csf |
| PT1517710E (pt) | 2002-06-21 | 2011-07-08 | Novo Nordisk Healthcare Ag | Glicoformas do factor vii peguilado |
| EP1673387B1 (fr) | 2003-10-10 | 2010-09-15 | Novo Nordisk A/S | Derives de il-21 |
| EP2641611A3 (fr) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Thérapie combinée |
| WO2005074546A2 (fr) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Polypeptides d'hormone de croissance humaine modifies et utilisations |
| KR101699142B1 (ko) | 2004-06-18 | 2017-01-23 | 암브룩스, 인코포레이티드 | 신규 항원-결합 폴리펩티드 및 이의 용도 |
| US7939496B2 (en) | 2004-12-22 | 2011-05-10 | Ambrx, Inc. | Modified human growth horomone polypeptides and their uses |
| JP5137821B2 (ja) | 2005-06-01 | 2013-02-06 | マキシジェン， インコーポレイテッド | Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法 |
| JP5335422B2 (ja) | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
| PT2339014E (pt) | 2005-11-16 | 2015-10-13 | Ambrx Inc | Métodos e composições compreendendo aminoácidos não-naturais |
| RU2008145084A (ru) | 2006-05-24 | 2010-06-27 | Ново Нордиск Хелс Кеа Аг (Ch) | Аналоги фактора ix, имеющие пролонгированное время полужизни in vivo |
| EP2061878B1 (fr) | 2006-09-08 | 2014-01-08 | Ambrx, Inc. | Arnt suppresseur hybride pour cellules de vertébrés |
| DK2615108T3 (en) | 2006-09-08 | 2017-01-30 | Ambrx Inc | Modified human plasma polypeptide or fc scaffolds and their applications |
| BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
| RS53404B (en) | 2007-08-27 | 2014-10-31 | Ratiopharm Gmbh | LIQUID FORMULATION OF G-CSF CONJUGATES |
| NZ584825A (en) | 2007-11-20 | 2013-03-28 | Ambrx Inc | Modified insulin polypeptides and their uses |
| EP3103880A1 (fr) | 2008-02-08 | 2016-12-14 | Ambrx, Inc. | Polypeptides d'insuline modifiés et utilisations de ceux-ci |
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| WO2015054658A1 (fr) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Acides aminés modifiés comprenant des groupes fonctionnels de tétrazine, procédés de préparation et procédés d'utilisation associés |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4732863A (en) * | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
| US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
| JPH0644927B2 (ja) * | 1987-03-14 | 1994-06-15 | 日本油脂株式会社 | 徐放性活性成分放出剤 |
| US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| CA1340810C (fr) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Derives de polypeptides actifs comme facteurs stimulant les colonies de granulocytes chez l'homme |
| JPH0796558B2 (ja) | 1988-03-31 | 1995-10-18 | 協和醗酵工業株式会社 | 修飾ポリペプチド |
| DK0400472T3 (da) | 1989-05-27 | 1996-05-13 | Sumitomo Pharma | Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein |
| US5342940A (en) * | 1989-05-27 | 1994-08-30 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, process for preparing the same |
| JP2931622B2 (ja) * | 1989-05-27 | 1999-08-09 | 住友製薬株式会社 | ポリエチレングリコール誘導体を得る製造方法 |
| JPH03236400A (ja) * | 1990-02-09 | 1991-10-22 | Kirin Brewery Co Ltd | 化学修飾ポリペプチド及びその用途 |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| JPH06319537A (ja) | 1993-05-18 | 1994-11-22 | Daikin Ind Ltd | 修飾ペプチドおよびその製造方法 |
| WO1995023165A1 (fr) | 1994-02-23 | 1995-08-31 | Kyowa Hakko Kogyo Co., Ltd. | Accelerateur de croissance des thrombocytes |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6884419B1 (en) * | 1996-12-23 | 2005-04-26 | Kyowa Hakko Kogyo, Co., Ltd. | hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same |
| DE69841682D1 (de) * | 1997-06-06 | 2010-07-08 | Kyowa Hakko Kirin Co Ltd | Chemisch modifizierte polypeptide |
| EP1075282B1 (fr) * | 1998-04-28 | 2005-06-15 | Applied Research Systems ARS Holding N.V. | Conjugues d'analogues de peg-lhrh |
-
1998
- 1998-06-05 DE DE69841682T patent/DE69841682D1/de not_active Expired - Fee Related
- 1998-06-05 KR KR1019997000988A patent/KR100565022B1/ko not_active IP Right Cessation
- 1998-06-05 HU HU0001153A patent/HUP0001153A3/hu unknown
- 1998-06-05 JP JP50207399A patent/JP4011124B2/ja not_active Expired - Fee Related
- 1998-06-05 CA CA002263795A patent/CA2263795C/fr not_active Expired - Fee Related
- 1998-06-05 RO RO99-00142A patent/RO121474B1/ro unknown
- 1998-06-05 US US09/230,733 patent/US6583267B2/en not_active Expired - Fee Related
- 1998-06-05 AT AT98923147T patent/ATE469166T1/de not_active IP Right Cessation
- 1998-06-05 CN CNB988010747A patent/CN1250566C/zh not_active Expired - Fee Related
- 1998-06-05 WO PCT/JP1998/002504 patent/WO1998055500A1/fr active IP Right Grant
- 1998-06-05 EP EP98923147A patent/EP0921131B1/fr not_active Expired - Lifetime
- 1998-06-05 AU AU75512/98A patent/AU744085B2/en not_active Ceased
- 1998-06-05 NZ NZ334068A patent/NZ334068A/xx unknown
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1999
- 1999-02-05 NO NO19990560A patent/NO322978B1/no not_active IP Right Cessation
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2000
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2003
- 2003-02-13 US US10/365,418 patent/US7547675B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO990560L (no) | 1999-03-26 |
| HK1022919A1 (en) | 2000-11-03 |
| NO990560D0 (no) | 1999-02-05 |
| CA2263795A1 (fr) | 1998-12-10 |
| EP0921131B1 (fr) | 2010-05-26 |
| JP4011124B2 (ja) | 2007-11-21 |
| HUP0001153A2 (hu) | 2000-10-28 |
| NZ334068A (en) | 2000-07-28 |
| KR100565022B1 (ko) | 2006-03-30 |
| EP0921131A4 (fr) | 2002-11-27 |
| US6583267B2 (en) | 2003-06-24 |
| KR20000068069A (ko) | 2000-11-25 |
| AU7551298A (en) | 1998-12-21 |
| WO1998055500A1 (fr) | 1998-12-10 |
| CN1250566C (zh) | 2006-04-12 |
| DE69841682D1 (de) | 2010-07-08 |
| CA2263795C (fr) | 2008-02-19 |
| EP0921131A1 (fr) | 1999-06-09 |
| ATE469166T1 (de) | 2010-06-15 |
| US20020028912A1 (en) | 2002-03-07 |
| HUP0001153A3 (en) | 2000-12-28 |
| US7547675B2 (en) | 2009-06-16 |
| AU744085B2 (en) | 2002-02-14 |
| RO121474B1 (ro) | 2007-06-29 |
| US20030195339A1 (en) | 2003-10-16 |
| CN1236370A (zh) | 1999-11-24 |
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