NO321028B1 - Tiazolinsyrederivater, anvendelse av disse for fremstilling av medikamenter, samt anvendelse av disse for forebygging eller behandling av en patologisk tilstand mottagelig for chelatering eller sekvesttrasjon av trivalente metaller. - Google Patents
Tiazolinsyrederivater, anvendelse av disse for fremstilling av medikamenter, samt anvendelse av disse for forebygging eller behandling av en patologisk tilstand mottagelig for chelatering eller sekvesttrasjon av trivalente metaller. Download PDFInfo
- Publication number
- NO321028B1 NO321028B1 NO20011003A NO20011003A NO321028B1 NO 321028 B1 NO321028 B1 NO 321028B1 NO 20011003 A NO20011003 A NO 20011003A NO 20011003 A NO20011003 A NO 20011003A NO 321028 B1 NO321028 B1 NO 321028B1
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- Norway
- Prior art keywords
- pharmaceutically acceptable
- compound according
- alkyl
- salts
- carbon atoms
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Game Rules And Presentations Of Slot Machines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/144,103 US6083966A (en) | 1998-08-31 | 1998-08-31 | Thiazoline acid derivatives |
PCT/US1999/019691 WO2000012493A1 (en) | 1998-08-31 | 1999-08-31 | Thiazoline acid derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20011003L NO20011003L (no) | 2001-02-27 |
NO20011003D0 NO20011003D0 (no) | 2001-02-27 |
NO321028B1 true NO321028B1 (no) | 2006-02-27 |
Family
ID=22507049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20011003A NO321028B1 (no) | 1998-08-31 | 2001-02-27 | Tiazolinsyrederivater, anvendelse av disse for fremstilling av medikamenter, samt anvendelse av disse for forebygging eller behandling av en patologisk tilstand mottagelig for chelatering eller sekvesttrasjon av trivalente metaller. |
Country Status (24)
Country | Link |
---|---|
US (9) | US6083966A (zh) |
EP (1) | EP1109795B1 (zh) |
JP (3) | JP4817498B2 (zh) |
KR (1) | KR20010074907A (zh) |
CN (1) | CN100455574C (zh) |
AT (1) | ATE317392T1 (zh) |
AU (1) | AU759851B2 (zh) |
BR (1) | BR9913441B1 (zh) |
CA (1) | CA2342210C (zh) |
CZ (1) | CZ2001711A3 (zh) |
DE (1) | DE69929807T2 (zh) |
EA (1) | EA200100261A1 (zh) |
ES (1) | ES2260933T3 (zh) |
HK (1) | HK1035720A1 (zh) |
HU (1) | HUP0103165A3 (zh) |
IL (2) | IL141611A0 (zh) |
NO (1) | NO321028B1 (zh) |
NZ (1) | NZ509899A (zh) |
PL (1) | PL346852A1 (zh) |
PT (1) | PT1109795E (zh) |
TR (1) | TR200100541T2 (zh) |
UA (1) | UA57161C2 (zh) |
WO (1) | WO2000012493A1 (zh) |
YU (1) | YU21801A (zh) |
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US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
NZ526880A (en) * | 1998-09-21 | 2005-05-27 | Univ Florida | Antimalarial agents |
EP1488791A3 (en) * | 1998-09-21 | 2005-04-06 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
CA2387767A1 (en) | 1999-10-15 | 2001-04-26 | Henricus P. C. Hogenkamp | Cobalamin conjugates useful as imaging and therapeutic agents |
US6689788B1 (en) * | 2000-08-25 | 2004-02-10 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
WO2002055530A2 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
AU2003247374A1 (en) * | 2002-05-15 | 2003-12-02 | Genzyme Corporation | Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof |
US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
AU2003263948A1 (en) * | 2002-08-22 | 2004-03-11 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US20060069134A1 (en) * | 2002-10-01 | 2006-03-30 | Kaneka Corporation | Process for producing optically active alpha-substituted cysteine or salt thereof, intermediate therefor, and process for producing the same |
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DE602004014949D1 (de) * | 2003-09-09 | 2008-08-21 | Univ Florida | Polyamin-metallchelatbildner-konjugate |
AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
US20120095058A1 (en) * | 2003-12-03 | 2012-04-19 | Hanauske-Abel H M | Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses |
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CN101189216B (zh) * | 2005-04-04 | 2011-10-19 | 佛罗里达大学研究基金会 | Desferrithiocin聚醚类似物 |
US7365371B2 (en) | 2005-08-04 | 2008-04-29 | Cree, Inc. | Packages for semiconductor light emitting devices utilizing dispensed encapsulants |
AU2007351826A1 (en) * | 2006-12-12 | 2008-10-30 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogue actinide decorporation agents |
AU2008229472B2 (en) * | 2007-03-15 | 2013-03-14 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
US8063227B2 (en) * | 2008-07-14 | 2011-11-22 | Ferrokin Biosciences, Inc. | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
US20130053387A1 (en) | 2010-05-04 | 2013-02-28 | FerroKin BioScience, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
CN103562379A (zh) * | 2011-05-19 | 2014-02-05 | 国立大学法人德岛大学 | 细胞分化诱导剂以及分化诱导方法 |
KR102111176B1 (ko) | 2011-12-16 | 2020-05-15 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 4'-데스페리티오신 유사체의 용도 |
JP6353751B2 (ja) * | 2013-09-25 | 2018-07-04 | 国立大学法人電気通信大学 | 新規複素環式化合物及びその塩、並びに、発光基質組成物 |
EP3071201A4 (en) * | 2013-11-22 | 2017-04-26 | University of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
AU2016255770A1 (en) | 2015-04-27 | 2017-11-16 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
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-
1998
- 1998-08-31 US US09/144,103 patent/US6083966A/en not_active Ceased
-
1999
- 1999-08-31 JP JP2000567521A patent/JP4817498B2/ja not_active Expired - Fee Related
- 1999-08-31 PL PL99346852A patent/PL346852A1/xx not_active Application Discontinuation
- 1999-08-31 EP EP99945267A patent/EP1109795B1/en not_active Expired - Lifetime
- 1999-08-31 DE DE69929807T patent/DE69929807T2/de not_active Expired - Lifetime
- 1999-08-31 EA EA200100261A patent/EA200100261A1/ru unknown
- 1999-08-31 CZ CZ2001711A patent/CZ2001711A3/cs unknown
- 1999-08-31 ES ES99945267T patent/ES2260933T3/es not_active Expired - Lifetime
- 1999-08-31 YU YU21801A patent/YU21801A/sh unknown
- 1999-08-31 BR BRPI9913441-1B1A patent/BR9913441B1/pt not_active IP Right Cessation
- 1999-08-31 CN CNB998099899A patent/CN100455574C/zh not_active Expired - Fee Related
- 1999-08-31 PT PT99945267T patent/PT1109795E/pt unknown
- 1999-08-31 HU HU0103165A patent/HUP0103165A3/hu unknown
- 1999-08-31 CA CA002342210A patent/CA2342210C/en not_active Expired - Fee Related
- 1999-08-31 TR TR2001/00541T patent/TR200100541T2/xx unknown
- 1999-08-31 AT AT99945267T patent/ATE317392T1/de not_active IP Right Cessation
- 1999-08-31 IL IL14161199A patent/IL141611A0/xx active IP Right Grant
- 1999-08-31 NZ NZ509899A patent/NZ509899A/en not_active IP Right Cessation
- 1999-08-31 WO PCT/US1999/019691 patent/WO2000012493A1/en not_active Application Discontinuation
- 1999-08-31 KR KR1020017002702A patent/KR20010074907A/ko not_active Application Discontinuation
- 1999-08-31 UA UA2001032117A patent/UA57161C2/uk unknown
- 1999-08-31 AU AU57897/99A patent/AU759851B2/en not_active Ceased
-
2000
- 2000-03-20 US US09/531,755 patent/US6525080B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,753 patent/US6559315B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,754 patent/US6521652B1/en not_active Expired - Lifetime
-
2001
- 2001-02-22 IL IL141611A patent/IL141611A/en not_active IP Right Cessation
- 2001-02-27 NO NO20011003A patent/NO321028B1/no not_active IP Right Cessation
- 2001-09-04 HK HK01106220A patent/HK1035720A1/xx not_active IP Right Cessation
- 2001-10-17 US US09/981,586 patent/USRE39132E1/en not_active Expired - Lifetime
-
2002
- 2002-11-20 US US10/300,071 patent/US20030236417A1/en not_active Abandoned
-
2004
- 2004-09-17 US US10/944,150 patent/US7126004B2/en not_active Expired - Fee Related
-
2006
- 2006-09-15 US US11/522,299 patent/US7531563B2/en not_active Expired - Fee Related
-
2009
- 2009-03-27 US US12/383,854 patent/US8008502B2/en not_active Expired - Fee Related
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2011
- 2011-04-22 JP JP2011095879A patent/JP5520875B2/ja not_active Expired - Fee Related
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2013
- 2013-12-12 JP JP2013257270A patent/JP2014065730A/ja active Pending
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