NO318585B1 - Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer. - Google Patents
Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer. Download PDFInfo
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- NO318585B1 NO318585B1 NO19970141A NO970141A NO318585B1 NO 318585 B1 NO318585 B1 NO 318585B1 NO 19970141 A NO19970141 A NO 19970141A NO 970141 A NO970141 A NO 970141A NO 318585 B1 NO318585 B1 NO 318585B1
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- oligonucleotide
- oligonucleotides
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- ester
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CLUMXSRGYWVAAK-UHFFFAOYSA-N tert-butyl n-[2-[[2-(methanesulfonamido)-3-(4-phenylmethoxyphenyl)propanoyl]amino]ethyl]carbamate Chemical compound C1=CC(CC(C(=O)NCCNC(=O)OC(C)(C)C)NS(C)(=O)=O)=CC=C1OCC1=CC=CC=C1 CLUMXSRGYWVAAK-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229950006389 thiodiglycol Drugs 0.000 description 1
- ATGUDZODTABURZ-UHFFFAOYSA-N thiolan-2-ylideneazanium;chloride Chemical compound Cl.N=C1CCCS1 ATGUDZODTABURZ-UHFFFAOYSA-N 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- PXFLCAQHOZXYED-UHFFFAOYSA-N tripyrrolidin-1-ylphosphane Chemical compound C1CCCN1P(N1CCCC1)N1CCCC1 PXFLCAQHOZXYED-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4424922A DE4424922A1 (de) | 1994-07-14 | 1994-07-14 | Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden |
| DE19944445078 DE4445078A1 (de) | 1994-12-05 | 1994-12-05 | Konjugate aus Metallkomplexen und Oligonucleotiden, diese enthaltende Mittel, deren Verwendung in der Radiodiagnostik sowie Verfahren zu deren Herstellung |
| PCT/EP1995/002539 WO1996002274A1 (en) | 1994-07-14 | 1995-06-30 | Conjugates made of metal complexes and oligonucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970141D0 NO970141D0 (no) | 1997-01-13 |
| NO970141L NO970141L (no) | 1997-03-14 |
| NO318585B1 true NO318585B1 (no) | 2005-04-11 |
Family
ID=25938359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970141A NO318585B1 (no) | 1994-07-14 | 1997-01-13 | Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0777498B1 (cs) |
| JP (2) | JPH10503182A (cs) |
| KR (1) | KR100366525B1 (cs) |
| CN (1) | CN1219551C (cs) |
| AT (1) | ATE265229T1 (cs) |
| AU (1) | AU2979195A (cs) |
| CA (1) | CA2194558A1 (cs) |
| CZ (1) | CZ295930B6 (cs) |
| DE (1) | DE69532958T2 (cs) |
| DK (1) | DK0777498T3 (cs) |
| ES (1) | ES2220933T3 (cs) |
| HU (1) | HU220859B1 (cs) |
| IL (1) | IL114237A (cs) |
| MX (1) | MX9606443A (cs) |
| NO (1) | NO318585B1 (cs) |
| NZ (1) | NZ289831A (cs) |
| PL (1) | PL318147A1 (cs) |
| PT (1) | PT777498E (cs) |
| RU (1) | RU2165771C2 (cs) |
| SK (1) | SK284598B6 (cs) |
| TW (1) | TW502040B (cs) |
| UA (1) | UA48140C2 (cs) |
| WO (1) | WO1996002274A1 (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2259493A1 (en) * | 1996-07-03 | 1998-01-08 | President And Fellows Of Harvard College | Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides |
| US6335437B1 (en) * | 1998-09-07 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Methods for the preparation of conjugated oligomers |
| JP2009535383A (ja) * | 2006-05-03 | 2009-10-01 | バルティック テクロノジー デヴェロプメント，リミテッド | 強く結合した塩基で修飾されたオリゴヌクレオチドと人工ヌクレアーゼを組み合わせたアンチセンス作用物質 |
| GB201012418D0 (en) * | 2010-07-23 | 2010-09-08 | Santaris Pharma As | Process |
| KR101948404B1 (ko) | 2014-05-13 | 2019-02-14 | 폴 슈레 앙스띠뛰 | 양전자 방출 단층촬영에 사용하기 위한 43sc 방사성핵종 및 그의 방사성제약의 제조 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013831A (en) * | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
| JP2785025B2 (ja) * | 1985-03-19 | 1998-08-13 | ランデル・エル・ミルズ | 診断と選択的組織壊死を与える装置 |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| WO1989000062A1 (en) * | 1987-07-07 | 1989-01-12 | The Cancer Institute Board | Radiotherapy |
| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| EP1493825A3 (en) * | 1990-06-11 | 2005-02-09 | Gilead Sciences, Inc. | Method for producing nucleic acid ligands |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| IE914220A1 (en) * | 1990-12-10 | 1992-06-17 | Akzo Nv | Labelled, modified oligonucleotides |
| EP0588229A3 (en) * | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
-
1995
- 1995-06-20 IL IL11423795A patent/IL114237A/xx not_active IP Right Cessation
- 1995-06-30 DK DK95925792T patent/DK0777498T3/da active
- 1995-06-30 CZ CZ1997114A patent/CZ295930B6/cs not_active IP Right Cessation
- 1995-06-30 SK SK28-97A patent/SK284598B6/sk not_active IP Right Cessation
- 1995-06-30 RU RU97102039/14A patent/RU2165771C2/ru not_active IP Right Cessation
- 1995-06-30 KR KR1019970700223A patent/KR100366525B1/ko not_active IP Right Cessation
- 1995-06-30 ES ES95925792T patent/ES2220933T3/es not_active Expired - Lifetime
- 1995-06-30 CA CA002194558A patent/CA2194558A1/en not_active Abandoned
- 1995-06-30 WO PCT/EP1995/002539 patent/WO1996002274A1/en active IP Right Grant
- 1995-06-30 NZ NZ289831A patent/NZ289831A/xx not_active IP Right Cessation
- 1995-06-30 PL PL95318147A patent/PL318147A1/xx unknown
- 1995-06-30 DE DE69532958T patent/DE69532958T2/de not_active Expired - Fee Related
- 1995-06-30 PT PT95925792T patent/PT777498E/pt unknown
- 1995-06-30 UA UA97020642A patent/UA48140C2/uk unknown
- 1995-06-30 MX MX9606443A patent/MX9606443A/es not_active IP Right Cessation
- 1995-06-30 EP EP95925792A patent/EP0777498B1/en not_active Expired - Lifetime
- 1995-06-30 CN CNB951940007A patent/CN1219551C/zh not_active Expired - Fee Related
- 1995-06-30 AT AT95925792T patent/ATE265229T1/de not_active IP Right Cessation
- 1995-06-30 AU AU29791/95A patent/AU2979195A/en not_active Abandoned
- 1995-06-30 HU HU9700100A patent/HU220859B1/hu not_active IP Right Cessation
- 1995-06-30 JP JP8504630A patent/JPH10503182A/ja not_active Withdrawn
- 1995-10-14 TW TW084110812A patent/TW502040B/zh not_active IP Right Cessation
-
1997
- 1997-01-13 NO NO19970141A patent/NO318585B1/no not_active IP Right Cessation
-
2009
- 2009-06-04 JP JP2009134684A patent/JP2009197024A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69532958T2 (de) | 2009-04-09 |
| PT777498E (pt) | 2004-09-30 |
| EP0777498A1 (en) | 1997-06-11 |
| KR970704471A (ko) | 1997-09-06 |
| JPH10503182A (ja) | 1998-03-24 |
| RU2165771C2 (ru) | 2001-04-27 |
| DK0777498T3 (da) | 2004-08-16 |
| TW502040B (en) | 2002-09-11 |
| NO970141D0 (no) | 1997-01-13 |
| CZ11497A3 (cs) | 1998-08-12 |
| UA48140C2 (uk) | 2002-08-15 |
| ATE265229T1 (de) | 2004-05-15 |
| HU9700100D0 (en) | 1997-02-28 |
| JP2009197024A (ja) | 2009-09-03 |
| IL114237A0 (en) | 1995-10-31 |
| IL114237A (en) | 2000-08-31 |
| CZ295930B6 (cs) | 2005-12-14 |
| MX9606443A (es) | 1997-12-31 |
| KR100366525B1 (ko) | 2003-03-15 |
| CN1152879A (zh) | 1997-06-25 |
| SK284598B6 (sk) | 2005-07-01 |
| EP0777498B1 (en) | 2004-04-28 |
| NO970141L (no) | 1997-03-14 |
| HU220859B1 (en) | 2002-06-29 |
| PL318147A1 (en) | 1997-05-12 |
| NZ289831A (en) | 1999-01-28 |
| CN1219551C (zh) | 2005-09-21 |
| WO1996002274A1 (en) | 1996-02-01 |
| ES2220933T3 (es) | 2004-12-16 |
| SK2897A3 (en) | 1997-09-10 |
| DE69532958D1 (de) | 2004-06-03 |
| AU2979195A (en) | 1996-02-16 |
| CA2194558A1 (en) | 1996-02-01 |
| HUT76329A (en) | 1997-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |