NO970141L - Konjugater av metallkomplekser og oligonukleotider, midler inneholdende konjugatene, deres anvendelse ved radiodiagnose samt fremgangsmåte for deres fremstilling - Google Patents

Konjugater av metallkomplekser og oligonukleotider, midler inneholdende konjugatene, deres anvendelse ved radiodiagnose samt fremgangsmåte for deres fremstilling

Info

Publication number
NO970141L
NO970141L NO970141A NO970141A NO970141L NO 970141 L NO970141 L NO 970141L NO 970141 A NO970141 A NO 970141A NO 970141 A NO970141 A NO 970141A NO 970141 L NO970141 L NO 970141L
Authority
NO
Norway
Prior art keywords
conjugates
oligonucleotides
radiodiagnosis
preparation
metal complexes
Prior art date
Application number
NO970141A
Other languages
English (en)
Other versions
NO318585B1 (no
NO970141D0 (no
Inventor
Ludger Dinkelborg
Christoph-Stephan Hilger
Ulrich Niedballa
Johannes Platzek
Bernd Raduechel
Ulrich Speck
Larry Gold
Wolfgang Pieken
Original Assignee
Schering Ag
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25938359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO970141(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4424922A external-priority patent/DE4424922A1/de
Priority claimed from DE19944445078 external-priority patent/DE4445078A1/de
Application filed by Schering Ag, Nexstar Pharmaceuticals Inc filed Critical Schering Ag
Publication of NO970141D0 publication Critical patent/NO970141D0/no
Publication of NO970141L publication Critical patent/NO970141L/no
Publication of NO318585B1 publication Critical patent/NO318585B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Kjemisk modifiserte oligo-nukleotidkonjugater som inneholder et kompleksdannende middel eller et kompleks som er bundet ved hjelp av en bindingskomponent til oligonukleo-tidene. I dette tilfelle er oligo-nukleotidene modifisert på en måte som forhindrer, eller i det minste betydelig inhiberer, nedbrytningen av naturlig forekommende nukleaser. Oligo-nukleotidradikalet kan bindes spesifikt, og med høy bindings-affinitet, til målstrukturer, og kan således produsere en spesifikk terapeutisk eller diagnostisk virkning av det bundne kompleksdannende middel eller kompleks.
NO19970141A 1994-07-14 1997-01-13 Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer. NO318585B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4424922A DE4424922A1 (de) 1994-07-14 1994-07-14 Konjugate aus Metallkomplexen und Oligonucleotiden, die spezifisch an bestimmte Zielstrukturen binden
DE19944445078 DE4445078A1 (de) 1994-12-05 1994-12-05 Konjugate aus Metallkomplexen und Oligonucleotiden, diese enthaltende Mittel, deren Verwendung in der Radiodiagnostik sowie Verfahren zu deren Herstellung
PCT/EP1995/002539 WO1996002274A1 (en) 1994-07-14 1995-06-30 Conjugates made of metal complexes and oligonucleotides

Publications (3)

Publication Number Publication Date
NO970141D0 NO970141D0 (no) 1997-01-13
NO970141L true NO970141L (no) 1997-03-14
NO318585B1 NO318585B1 (no) 2005-04-11

Family

ID=25938359

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19970141A NO318585B1 (no) 1994-07-14 1997-01-13 Oligonukleotider bestaende av et oligonukleotidradikal og substituenter, fremgangsmate for pavisning av malstrukturer ved hjelp av dem, anvendelse av dem til produksjon av medikamenter og diagnosesett inneholdende dem for pavisning av malstrukturer.

Country Status (23)

Country Link
EP (1) EP0777498B1 (no)
JP (2) JPH10503182A (no)
KR (1) KR100366525B1 (no)
CN (1) CN1219551C (no)
AT (1) ATE265229T1 (no)
AU (1) AU2979195A (no)
CA (1) CA2194558A1 (no)
CZ (1) CZ295930B6 (no)
DE (1) DE69532958T2 (no)
DK (1) DK0777498T3 (no)
ES (1) ES2220933T3 (no)
HU (1) HU220859B1 (no)
IL (1) IL114237A (no)
MX (1) MX9606443A (no)
NO (1) NO318585B1 (no)
NZ (1) NZ289831A (no)
PL (1) PL318147A1 (no)
PT (1) PT777498E (no)
RU (1) RU2165771C2 (no)
SK (1) SK284598B6 (no)
TW (1) TW502040B (no)
UA (1) UA48140C2 (no)
WO (1) WO1996002274A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU739391B2 (en) * 1996-07-03 2001-10-11 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
US6335437B1 (en) * 1998-09-07 2002-01-01 Isis Pharmaceuticals, Inc. Methods for the preparation of conjugated oligomers
EP2013344B1 (en) * 2006-05-03 2012-08-29 Baltic Technology Development, Ltd. Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
GB201012418D0 (en) * 2010-07-23 2010-09-08 Santaris Pharma As Process
JP6429899B2 (ja) * 2014-05-13 2018-11-28 パウル・シェラー・インスティトゥート 陽電子放出断層撮影法で使用するための４３Ｓｃ放射性核種およびその放射性医薬品の製造

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013831A (en) * 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
ATE132350T1 (de) * 1985-03-19 1996-01-15 Randell L Mills Verfahren und system zur erzielung einer lokalen mössbauer-absorption in einem organischen medium
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
WO1989000062A1 (en) * 1987-07-07 1989-01-12 The Cancer Institute Board Radiotherapy
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5270163A (en) * 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
DK0786469T3 (da) * 1990-06-11 2006-07-10 Gilead Sciences Inc Nukleinsyreligander
IE914220A1 (en) * 1990-12-10 1992-06-17 Akzo Nv Labelled, modified oligonucleotides
EP0588229A3 (en) * 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes

Also Published As

Publication number Publication date
MX9606443A (es) 1997-12-31
AU2979195A (en) 1996-02-16
DE69532958T2 (de) 2009-04-09
CN1152879A (zh) 1997-06-25
IL114237A0 (en) 1995-10-31
HU220859B1 (en) 2002-06-29
PL318147A1 (en) 1997-05-12
WO1996002274A1 (en) 1996-02-01
CZ11497A3 (cs) 1998-08-12
RU2165771C2 (ru) 2001-04-27
CN1219551C (zh) 2005-09-21
NO318585B1 (no) 2005-04-11
UA48140C2 (uk) 2002-08-15
ES2220933T3 (es) 2004-12-16
ATE265229T1 (de) 2004-05-15
PT777498E (pt) 2004-09-30
NZ289831A (en) 1999-01-28
KR100366525B1 (ko) 2003-03-15
KR970704471A (ko) 1997-09-06
SK2897A3 (en) 1997-09-10
DE69532958D1 (de) 2004-06-03
DK0777498T3 (da) 2004-08-16
CA2194558A1 (en) 1996-02-01
EP0777498B1 (en) 2004-04-28
JP2009197024A (ja) 2009-09-03
HU9700100D0 (en) 1997-02-28
SK284598B6 (sk) 2005-07-01
JPH10503182A (ja) 1998-03-24
NO970141D0 (no) 1997-01-13
TW502040B (en) 2002-09-11
HUT76329A (en) 1997-08-28
EP0777498A1 (en) 1997-06-11
IL114237A (en) 2000-08-31
CZ295930B6 (cs) 2005-12-14

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