NO318143B1 - Substituerte cyklobutylamin-derivater samt farmasoytisk preparat - Google Patents
Substituerte cyklobutylamin-derivater samt farmasoytisk preparat Download PDFInfo
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- NO318143B1 NO318143B1 NO19995839A NO995839A NO318143B1 NO 318143 B1 NO318143 B1 NO 318143B1 NO 19995839 A NO19995839 A NO 19995839A NO 995839 A NO995839 A NO 995839A NO 318143 B1 NO318143 B1 NO 318143B1
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- Prior art keywords
- compound
- salt
- fluoro
- hydrates
- group
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- 239000000825 pharmaceutical preparation Chemical class 0.000 title claims description 6
- KZZKOVLJUKWSKX-UHFFFAOYSA-N cyclobutanamine Chemical class NC1CCC1 KZZKOVLJUKWSKX-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 132
- 150000003839 salts Chemical class 0.000 claims description 44
- -1 5-amino-3-carboxy-6-fluoro-1-[2-(S)-fluoro-1-(R)-cyclopropyl]-1,4-dihydro-8 -methyl-4-oxoquinolin-7-yl group Chemical group 0.000 claims description 39
- 150000004677 hydrates Chemical class 0.000 claims description 34
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 125000005843 halogen group Chemical group 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 17
- 229910052731 fluorine Inorganic materials 0.000 claims description 15
- 125000001153 fluoro group Chemical group F* 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 125000003277 amino group Chemical group 0.000 claims description 7
- 125000006165 cyclic alkyl group Chemical group 0.000 claims description 3
- MENSSOHGBIRROR-HEVMSJOKSA-N 5-amino-7-[3-(1-amino-3,3-difluorocyclobutyl)pyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical group FC1=C(N)C(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N(C1)CCC1C1(N)CC(F)(F)C1 MENSSOHGBIRROR-HEVMSJOKSA-N 0.000 claims description 2
- GEBGQJFHSUAVMX-JFNZQFHQSA-N 5-amino-7-[3-(1-amino-3-fluorocyclobutyl)pyrrolidin-1-yl]-6,8-difluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid Chemical group FC=1C=2N([C@H]3[C@H](C3)F)C=C(C(O)=O)C(=O)C=2C(N)=C(F)C=1N(C1)CCC1C1(N)CC(F)C1 GEBGQJFHSUAVMX-JFNZQFHQSA-N 0.000 claims description 2
- GTLFEFKIVGAPDH-GOYITYAMSA-N 5-amino-7-[3-(1-amino-3-fluorocyclobutyl)pyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methyl-4-oxoquinoline-3-carboxylic acid Chemical group FC1=C(N)C(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(C)=C1N(C1)CCC1C1(N)CC(F)C1 GTLFEFKIVGAPDH-GOYITYAMSA-N 0.000 claims description 2
- PWUNIVDYHDVCHN-RVFBMXNDSA-N 7-[3-(1-amino-3-fluorocyclobutyl)pyrrolidin-1-yl]-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical group FC1=CC(C(C(C(O)=O)=CN2[C@H]3[C@H](C3)F)=O)=C2C(OC)=C1N(C1)CCC1C1(N)CC(F)C1 PWUNIVDYHDVCHN-RVFBMXNDSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 13
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- 201000005113 shigellosis Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- UDYFLDICVHJSOY-UHFFFAOYSA-N sulfur trioxide-pyridine complex Substances O=S(=O)=O.C1=CC=NC=C1 UDYFLDICVHJSOY-UHFFFAOYSA-N 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- OQGKMYIBMJVCAB-UHFFFAOYSA-N tert-butyl n-[1-(1-benzyl-5-oxopyrrolidin-3-yl)-3-phenylmethoxycyclobutyl]carbamate Chemical compound C1C(NC(=O)OC(C)(C)C)(C2CC(=O)N(CC=3C=CC=CC=3)C2)CC1OCC1=CC=CC=C1 OQGKMYIBMJVCAB-UHFFFAOYSA-N 0.000 description 1
- LGAGWUJGOMXMSU-UHFFFAOYSA-N tert-butyl n-[1-(5-oxopyrrolidin-3-yl)-3-phenylmethoxycyclobutyl]carbamate Chemical compound C1C(NC(=O)OC(C)(C)C)(C2CC(=O)NC2)CC1OCC1=CC=CC=C1 LGAGWUJGOMXMSU-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14139897 | 1997-05-30 | ||
| PCT/JP1998/002359 WO1998054169A1 (fr) | 1997-05-30 | 1998-05-28 | Derives substitues de la cyclobutylamine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995839D0 NO995839D0 (no) | 1999-11-29 |
| NO995839L NO995839L (no) | 2000-01-28 |
| NO318143B1 true NO318143B1 (no) | 2005-02-07 |
Family
ID=15291079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995839A NO318143B1 (no) | 1997-05-30 | 1999-11-29 | Substituerte cyklobutylamin-derivater samt farmasoytisk preparat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6448266B1 (xx) |
| EP (1) | EP0990654B1 (xx) |
| JP (1) | JP4357598B2 (xx) |
| KR (1) | KR100551462B1 (xx) |
| CN (1) | CN1191245C (xx) |
| AR (1) | AR012883A1 (xx) |
| AT (1) | ATE378327T1 (xx) |
| AU (1) | AU732175B2 (xx) |
| BR (1) | BR9809702A (xx) |
| CA (1) | CA2292580A1 (xx) |
| DE (1) | DE69838716T2 (xx) |
| DK (1) | DK0990654T3 (xx) |
| ES (1) | ES2297885T3 (xx) |
| ID (1) | ID23696A (xx) |
| IL (1) | IL133123A (xx) |
| MY (1) | MY119816A (xx) |
| NO (1) | NO318143B1 (xx) |
| RU (1) | RU2205829C2 (xx) |
| WO (1) | WO1998054169A1 (xx) |
| ZA (1) | ZA984527B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK286420B6 (sk) | 1997-09-15 | 2008-09-05 | The Procter & Gamble Company | Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie |
| KR100768034B1 (ko) | 1999-03-17 | 2007-10-17 | 다이이찌 세이야꾸 가부시기가이샤 | 의약 조성물 |
| US20040063754A1 (en) * | 2000-11-20 | 2004-04-01 | Hisashi Takahashi | Dehalogeno compounds |
| AU3089102A (en) | 2000-12-14 | 2002-06-24 | Procter & Gamble | Antimicrobial quinolones |
| WO2002048143A2 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Antimicrobial 2-pyridones, their compositions and uses |
| ES2402420T3 (es) * | 2003-09-29 | 2013-05-03 | Daiichi Sankyo Company, Limited | Derivado del ácido 8-cianoquinolonacarboxílico |
| US7456279B2 (en) | 2006-03-28 | 2008-11-25 | The Procter & Gamble Company | Coupling process for preparing quinolone intermediates |
| AU2007230630B2 (en) | 2006-03-28 | 2012-12-20 | Taigen Biotechnology Co., Ltd | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207420B1 (en) * | 1985-06-26 | 1992-05-06 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives |
| JPH0827728A (ja) * | 1990-02-13 | 1996-01-30 | Sf Marina System Ab | ポンツーンの昇降案内装置 |
| JP3745433B2 (ja) | 1995-02-02 | 2006-02-15 | 第一製薬株式会社 | 複素環式化合物 |
| DE69627985T2 (de) * | 1995-02-02 | 2004-02-19 | Daiichi Pharmaceutical Co., Ltd. | Heterozyklische verbindungen |
| ATE317393T1 (de) * | 1995-11-22 | 2006-02-15 | Daiichi Seiyaku Co | Substituierte aminocycloalkylpyrrolidinderivate |
-
1998
- 1998-05-27 MY MYPI98002358A patent/MY119816A/en unknown
- 1998-05-27 ZA ZA984527A patent/ZA984527B/xx unknown
- 1998-05-28 RU RU99125325/04A patent/RU2205829C2/ru not_active IP Right Cessation
- 1998-05-28 KR KR1019997011191A patent/KR100551462B1/ko not_active IP Right Cessation
- 1998-05-28 EP EP98921863A patent/EP0990654B1/en not_active Expired - Lifetime
- 1998-05-28 IL IL13312398A patent/IL133123A/en not_active IP Right Cessation
- 1998-05-28 CN CNB988078066A patent/CN1191245C/zh not_active Expired - Fee Related
- 1998-05-28 DE DE69838716T patent/DE69838716T2/de not_active Expired - Fee Related
- 1998-05-28 DK DK98921863T patent/DK0990654T3/da active
- 1998-05-28 ID IDW991489A patent/ID23696A/id unknown
- 1998-05-28 ES ES98921863T patent/ES2297885T3/es not_active Expired - Lifetime
- 1998-05-28 AT AT98921863T patent/ATE378327T1/de not_active IP Right Cessation
- 1998-05-28 CA CA002292580A patent/CA2292580A1/en not_active Abandoned
- 1998-05-28 BR BR9809702-4A patent/BR9809702A/pt not_active Application Discontinuation
- 1998-05-28 AU AU74539/98A patent/AU732175B2/en not_active Ceased
- 1998-05-28 WO PCT/JP1998/002359 patent/WO1998054169A1/ja active IP Right Grant
- 1998-05-28 JP JP50048599A patent/JP4357598B2/ja not_active Expired - Fee Related
- 1998-05-28 US US09/424,780 patent/US6448266B1/en not_active Expired - Fee Related
- 1998-05-29 AR ARP980102496A patent/AR012883A1/es active IP Right Grant
-
1999
- 1999-11-29 NO NO19995839A patent/NO318143B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1265659A (zh) | 2000-09-06 |
| US6448266B1 (en) | 2002-09-10 |
| ES2297885T3 (es) | 2008-05-01 |
| AU7453998A (en) | 1998-12-30 |
| ZA984527B (en) | 1998-12-03 |
| KR20010013204A (ko) | 2001-02-26 |
| ID23696A (id) | 2000-05-11 |
| IL133123A (en) | 2005-12-18 |
| IL133123A0 (en) | 2001-03-19 |
| EP0990654A4 (en) | 2004-09-15 |
| ATE378327T1 (de) | 2007-11-15 |
| DK0990654T3 (da) | 2008-01-21 |
| DE69838716T2 (de) | 2008-10-30 |
| NO995839D0 (no) | 1999-11-29 |
| MY119816A (en) | 2005-07-29 |
| CA2292580A1 (en) | 1998-12-03 |
| KR100551462B1 (ko) | 2006-02-14 |
| CN1191245C (zh) | 2005-03-02 |
| BR9809702A (pt) | 2001-12-11 |
| AR012883A1 (es) | 2000-11-22 |
| WO1998054169A1 (fr) | 1998-12-03 |
| EP0990654B1 (en) | 2007-11-14 |
| AU732175B2 (en) | 2001-04-12 |
| DE69838716D1 (de) | 2007-12-27 |
| JP4357598B2 (ja) | 2009-11-04 |
| RU2205829C2 (ru) | 2003-06-10 |
| EP0990654A1 (en) | 2000-04-05 |
| NO995839L (no) | 2000-01-28 |
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