NO318081B1 - Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav - Google Patents

Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav Download PDF

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Publication number
NO318081B1
NO318081B1 NO20005671A NO20005671A NO318081B1 NO 318081 B1 NO318081 B1 NO 318081B1 NO 20005671 A NO20005671 A NO 20005671A NO 20005671 A NO20005671 A NO 20005671A NO 318081 B1 NO318081 B1 NO 318081B1
Authority
NO
Norway
Prior art keywords
etm
metabolites
ecteinascidin
compounds
spectrum
Prior art date
Application number
NO20005671A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005671L (no
NO20005671D0 (no
Inventor
Kenneth Lloyd Rinehart
Jose J Morales
Joel Reid
Isabel Reymundo
Pablo Floriano
Lola Garcia Gravalos
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of NO20005671D0 publication Critical patent/NO20005671D0/no
Publication of NO20005671L publication Critical patent/NO20005671L/no
Publication of NO318081B1 publication Critical patent/NO318081B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10Quaternary compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO20005671A 1998-05-11 2000-11-10 Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav NO318081B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8502498P 1998-05-11 1998-05-11
PCT/US1999/010233 WO1999058125A1 (en) 1998-05-11 1999-05-11 Metabolites of ecteinascidin 743

Publications (3)

Publication Number Publication Date
NO20005671D0 NO20005671D0 (no) 2000-11-10
NO20005671L NO20005671L (no) 2001-01-10
NO318081B1 true NO318081B1 (no) 2005-01-31

Family

ID=22188976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005671A NO318081B1 (no) 1998-05-11 2000-11-10 Metabolitter av ecteinascidin 743, farmasoytiske preparater inneholdende dem, samt metode for bestemmelse av matabolitter derav

Country Status (22)

Country Link
US (3) US6316214B1 (ja)
EP (1) EP1077698B1 (ja)
JP (2) JP4583598B2 (ja)
KR (1) KR100643092B1 (ja)
CN (3) CN100548988C (ja)
AT (1) ATE289810T1 (ja)
AU (1) AU759281B2 (ja)
BG (1) BG65235B1 (ja)
BR (1) BR9910419A (ja)
CA (1) CA2331593C (ja)
CZ (1) CZ302168B6 (ja)
DE (1) DE69923965T2 (ja)
ES (1) ES2239442T3 (ja)
HU (1) HUP0101960A3 (ja)
IL (2) IL139607A0 (ja)
NO (1) NO318081B1 (ja)
NZ (1) NZ508585A (ja)
PL (1) PL192409B1 (ja)
RU (1) RU2225864C2 (ja)
SK (1) SK285069B6 (ja)
TR (1) TR200003470T2 (ja)
WO (1) WO1999058125A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4583598B2 (ja) 1998-05-11 2010-11-17 ファルマ・マール・ソシエダード・アノニマ エクテイナシジン743の代謝産物
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
BRPI0110024B8 (pt) * 2000-04-12 2021-05-25 Pharma Mar Sa derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US6809099B2 (en) 2000-11-03 2004-10-26 President And Fellows Of Harvard College Saframycins, analogues and uses thereof
IL155781A0 (en) * 2000-11-06 2003-12-23 Pharma Mar Sa Effective antitumor treatments
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
US7407327B2 (en) * 2003-03-21 2008-08-05 Seagate Technology Llc Method and system for withstanding shock in a spindle motor bearing
WO2005049031A1 (en) 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Combination
NZ554761A (en) 2004-10-29 2010-01-29 Pharma Mar Sa Formulations comprising ecteinascidin and a disaccharide
WO2006094012A2 (en) * 2005-03-02 2006-09-08 The Trustees Of Columbia University In The City Of New York Pentacyclic alkaloid compounds and methods of use thereof
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
US20090012157A1 (en) 2006-02-06 2009-01-08 Sears Barry D Sesamol Derivatives as Novel Inhibitors of Arachidonic Acid Formation
KR20170096224A (ko) 2010-11-12 2017-08-23 파르마 마르 에스.에이. 항종양 알칼로이드를 이용한 병용요법
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
WO1987007610A2 (en) 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
ATE158293T1 (de) 1992-06-19 1997-10-15 Hoechst Ag Polycyclische 31668p- und 31668u-verbindungen, verfahren zu ihrer herstellung und ihre verwendung als antibiotische oder antitumorale arzneistoffe
US5426108A (en) 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5809563A (en) * 1996-11-12 1998-09-15 Institute For The Development Of Emerging Architectures, Llc Method and apparatus utilizing a region based page table walk bit
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
WO1999051238A1 (en) * 1998-04-06 1999-10-14 The Board Of Trustees Of The University Of Illinois Semi-synthetic ecteinascidins
JP4583598B2 (ja) 1998-05-11 2010-11-17 ファルマ・マール・ソシエダード・アノニマ エクテイナシジン743の代謝産物
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
US6686470B2 (en) * 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
BRPI0110024B8 (pt) 2000-04-12 2021-05-25 Pharma Mar Sa derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
DE69923965T2 (de) 2006-04-06
JP2010215656A (ja) 2010-09-30
JP2002514597A (ja) 2002-05-21
CN1683299A (zh) 2005-10-19
PL192409B1 (pl) 2006-10-31
IL139607A (en) 2006-12-10
NO20005671L (no) 2001-01-10
EP1077698B1 (en) 2005-03-02
SK285069B6 (sk) 2006-05-04
AU4073799A (en) 1999-11-29
RU2225864C2 (ru) 2004-03-20
CN1371279A (zh) 2002-09-25
EP1077698A1 (en) 2001-02-28
TR200003470T2 (tr) 2001-06-21
NZ508585A (en) 2002-11-26
ATE289810T1 (de) 2005-03-15
AU759281B2 (en) 2003-04-10
US20020032326A1 (en) 2002-03-14
DE69923965D1 (de) 2005-04-07
ES2239442T3 (es) 2005-09-16
IL139607A0 (en) 2002-02-10
US6867334B2 (en) 2005-03-15
US7115743B2 (en) 2006-10-03
WO1999058125A1 (en) 1999-11-18
KR20010071237A (ko) 2001-07-28
BG105023A (en) 2001-08-31
CN1195514C (zh) 2005-04-06
CZ20004183A3 (en) 2001-06-13
CN100339375C (zh) 2007-09-26
CZ302168B6 (cs) 2010-11-24
BG65235B1 (bg) 2007-09-28
US6316214B1 (en) 2001-11-13
JP4583598B2 (ja) 2010-11-17
CA2331593C (en) 2008-08-05
US20050261326A1 (en) 2005-11-24
HUP0101960A3 (en) 2003-03-28
NO20005671D0 (no) 2000-11-10
PL344183A1 (en) 2001-10-08
HUP0101960A2 (hu) 2001-11-28
CN100548988C (zh) 2009-10-14
EP1077698A4 (en) 2002-05-08
SK17152000A3 (sk) 2001-07-10
CN1896064A (zh) 2007-01-17
BR9910419A (pt) 2001-01-09
CA2331593A1 (en) 1999-11-18
KR100643092B1 (ko) 2006-11-10

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