NO317103B1 - Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi - Google Patents
Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi Download PDFInfo
- Publication number
- NO317103B1 NO317103B1 NO20004141A NO20004141A NO317103B1 NO 317103 B1 NO317103 B1 NO 317103B1 NO 20004141 A NO20004141 A NO 20004141A NO 20004141 A NO20004141 A NO 20004141A NO 317103 B1 NO317103 B1 NO 317103B1
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- Prior art keywords
- hydrogen
- mmol
- compound
- alkyl
- mixture
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- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title abstract description 20
- 238000011282 treatment Methods 0.000 title abstract description 17
- 150000001875 compounds Chemical class 0.000 claims abstract description 76
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
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- 239000001257 hydrogen Substances 0.000 claims description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 150000002431 hydrogen Chemical class 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 239000001301 oxygen Substances 0.000 claims description 11
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- 238000000746 purification Methods 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000003653 radioligand binding assay Methods 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 239000003087 receptor blocking agent Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7532198P | 1998-02-20 | 1998-02-20 | |
| PCT/US1999/003608 WO1999042448A1 (fr) | 1998-02-20 | 1999-02-19 | Pyridino arylpiperazines substituees utiles pour le traitement de l'adenome prostatique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004141D0 NO20004141D0 (no) | 2000-08-18 |
| NO20004141L NO20004141L (no) | 2000-10-19 |
| NO317103B1 true NO317103B1 (no) | 2004-08-09 |
Family
ID=22124955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004141A NO317103B1 (no) | 1998-02-20 | 2000-08-18 | Nye substituerte pyridino arylpiperaziner er anvendelige ved behandling av benign prostata hyperplasi |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6218396B1 (fr) |
| EP (1) | EP1054868B1 (fr) |
| JP (1) | JP2002503724A (fr) |
| KR (1) | KR100591028B1 (fr) |
| CN (1) | CN1121390C (fr) |
| AR (1) | AR014626A1 (fr) |
| AT (1) | ATE250580T1 (fr) |
| AU (1) | AU766398B2 (fr) |
| BR (1) | BR9909647A (fr) |
| CZ (1) | CZ294136B6 (fr) |
| DE (1) | DE69911582T2 (fr) |
| DK (1) | DK1054868T3 (fr) |
| ES (1) | ES2209468T3 (fr) |
| HK (1) | HK1030776A1 (fr) |
| HU (1) | HUP0100781A3 (fr) |
| IL (2) | IL137954A0 (fr) |
| NO (1) | NO317103B1 (fr) |
| NZ (1) | NZ506462A (fr) |
| PL (1) | PL342339A1 (fr) |
| PT (1) | PT1054868E (fr) |
| TR (1) | TR200003220T2 (fr) |
| TW (1) | TW565555B (fr) |
| WO (1) | WO1999042448A1 (fr) |
| ZA (1) | ZA991315B (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0100048A3 (en) * | 1997-05-12 | 2002-12-28 | Ortho Mcneil Pharm Inc | Arylsubstituted piperazine-derivatives, useful in the treatement of benign prostatic hyperlasia use of them for producing pharmaceutical compositions and pharmaceutical compositions containing them |
| AU2001281121B2 (en) | 2000-08-08 | 2007-08-23 | Ortho-Mcneil Pharmaceutical, Inc. | Non-imidazole aryloxypiperidines as H3 receptor ligands |
| BR0215389A (pt) * | 2001-12-28 | 2004-10-26 | Takeda Chemical Industries Ltd | Agente preventivo ou terapêutico para distúrbio urinário, método para prevenir ou tratar distúrbio urinário, uso de um composto, composto, pró-droga, processo para preparar o composto, medicamento, e, método para triar um composto |
| EP2077262A4 (fr) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | Dérivé de l'iminopyridine et son utilisation |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| ES2478823T3 (es) * | 2008-04-23 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Derivados de iminopiridina y uso de los mismos |
| CN103980195A (zh) * | 2014-04-28 | 2014-08-13 | 广州医科大学 | 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用 |
| CN108530391B (zh) * | 2018-05-17 | 2022-05-17 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| US5403847A (en) | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| WO1999003833A1 (fr) * | 1997-07-15 | 1999-01-28 | Sankyo Company, Limited | Derives de piperazine |
-
1999
- 1999-02-18 US US09/252,313 patent/US6218396B1/en not_active Expired - Lifetime
- 1999-02-18 ZA ZA9901315A patent/ZA991315B/xx unknown
- 1999-02-19 DK DK99934281T patent/DK1054868T3/da active
- 1999-02-19 ES ES99934281T patent/ES2209468T3/es not_active Expired - Lifetime
- 1999-02-19 PL PL99342339A patent/PL342339A1/xx unknown
- 1999-02-19 DE DE69911582T patent/DE69911582T2/de not_active Expired - Fee Related
- 1999-02-19 JP JP2000532400A patent/JP2002503724A/ja active Pending
- 1999-02-19 IL IL13795499A patent/IL137954A0/xx active IP Right Grant
- 1999-02-19 CN CN99803027A patent/CN1121390C/zh not_active Expired - Fee Related
- 1999-02-19 AU AU33025/99A patent/AU766398B2/en not_active Ceased
- 1999-02-19 CZ CZ20003044A patent/CZ294136B6/cs not_active IP Right Cessation
- 1999-02-19 WO PCT/US1999/003608 patent/WO1999042448A1/fr active IP Right Grant
- 1999-02-19 KR KR1020007009156A patent/KR100591028B1/ko not_active IP Right Cessation
- 1999-02-19 EP EP99934281A patent/EP1054868B1/fr not_active Expired - Lifetime
- 1999-02-19 BR BR9909647-1A patent/BR9909647A/pt not_active Application Discontinuation
- 1999-02-19 PT PT99934281T patent/PT1054868E/pt unknown
- 1999-02-19 AT AT99934281T patent/ATE250580T1/de not_active IP Right Cessation
- 1999-02-19 NZ NZ506462A patent/NZ506462A/en unknown
- 1999-02-19 HU HU0100781A patent/HUP0100781A3/hu unknown
- 1999-02-19 TR TR2000/03220T patent/TR200003220T2/xx unknown
- 1999-02-23 AR ARP990100675A patent/AR014626A1/es active IP Right Grant
- 1999-04-02 TW TW088102511A patent/TW565555B/zh not_active IP Right Cessation
-
2000
- 2000-08-18 NO NO20004141A patent/NO317103B1/no not_active IP Right Cessation
- 2000-08-18 IL IL137954A patent/IL137954A/en not_active IP Right Cessation
-
2001
- 2001-03-08 HK HK01101679A patent/HK1030776A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9909647A (pt) | 2000-11-21 |
| IL137954A (en) | 2007-06-03 |
| ATE250580T1 (de) | 2003-10-15 |
| ZA991315B (en) | 2000-11-20 |
| AR014626A1 (es) | 2001-03-28 |
| CZ294136B6 (cs) | 2004-10-13 |
| TR200003220T2 (tr) | 2001-04-20 |
| HK1030776A1 (en) | 2001-05-18 |
| DK1054868T3 (da) | 2003-12-22 |
| HUP0100781A3 (en) | 2002-12-28 |
| TW565555B (en) | 2003-12-11 |
| EP1054868B1 (fr) | 2003-09-24 |
| CN1291188A (zh) | 2001-04-11 |
| WO1999042448A1 (fr) | 1999-08-26 |
| CN1121390C (zh) | 2003-09-17 |
| NO20004141L (no) | 2000-10-19 |
| JP2002503724A (ja) | 2002-02-05 |
| EP1054868A1 (fr) | 2000-11-29 |
| NZ506462A (en) | 2003-07-25 |
| AU766398B2 (en) | 2003-10-16 |
| CZ20003044A3 (cs) | 2001-04-11 |
| HUP0100781A2 (hu) | 2001-08-28 |
| IL137954A0 (en) | 2001-10-31 |
| AU3302599A (en) | 1999-09-06 |
| PT1054868E (pt) | 2004-01-30 |
| KR100591028B1 (ko) | 2006-06-22 |
| PL342339A1 (en) | 2001-06-04 |
| DE69911582D1 (de) | 2003-10-30 |
| ES2209468T3 (es) | 2004-06-16 |
| US6218396B1 (en) | 2001-04-17 |
| DE69911582T2 (de) | 2005-09-15 |
| NO20004141D0 (no) | 2000-08-18 |
| KR20010041115A (ko) | 2001-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |