NO316926B1 - Fremgangsmate for fremstilling av et dimerisk biologisk aktivt TGF-<beta>-protein - Google Patents

Fremgangsmate for fremstilling av et dimerisk biologisk aktivt TGF-<beta>-protein Download PDF

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Publication number
NO316926B1
NO316926B1 NO19970325A NO970325A NO316926B1 NO 316926 B1 NO316926 B1 NO 316926B1 NO 19970325 A NO19970325 A NO 19970325A NO 970325 A NO970325 A NO 970325A NO 316926 B1 NO316926 B1 NO 316926B1
Authority
NO
Norway
Prior art keywords
tgf
concentration
protein
approximately
buffer
Prior art date
Application number
NO19970325A
Other languages
English (en)
Norwegian (no)
Other versions
NO970325D0 (no
NO970325L (no
Inventor
Nico Cerletti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO970325D0 publication Critical patent/NO970325D0/no
Publication of NO970325L publication Critical patent/NO970325L/no
Publication of NO316926B1 publication Critical patent/NO316926B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
NO19970325A 1994-07-25 1997-01-24 Fremgangsmate for fremstilling av et dimerisk biologisk aktivt TGF-<beta>-protein NO316926B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94810438 1994-07-25
PCT/EP1995/002718 WO1996003432A1 (en) 1994-07-25 1995-07-12 Novel process for the production of biologically active dimeric protein

Publications (3)

Publication Number Publication Date
NO970325D0 NO970325D0 (no) 1997-01-24
NO970325L NO970325L (no) 1997-03-06
NO316926B1 true NO316926B1 (no) 2004-06-28

Family

ID=8218292

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19970325A NO316926B1 (no) 1994-07-25 1997-01-24 Fremgangsmate for fremstilling av et dimerisk biologisk aktivt TGF-<beta>-protein

Country Status (19)

Country Link
US (1) US6057430A (ja)
EP (1) EP0775159B1 (ja)
JP (2) JP3923516B2 (ja)
KR (1) KR100432839B1 (ja)
AT (1) ATE207933T1 (ja)
AU (1) AU690311B2 (ja)
CA (1) CA2194582C (ja)
DE (1) DE69523605T2 (ja)
DK (1) DK0775159T3 (ja)
ES (1) ES2166401T3 (ja)
FI (1) FI118083B (ja)
HU (1) HU222830B1 (ja)
IL (1) IL114701A (ja)
NO (1) NO316926B1 (ja)
NZ (1) NZ290373A (ja)
PT (1) PT775159E (ja)
TW (1) TW440566B (ja)
WO (1) WO1996003432A1 (ja)
ZA (1) ZA956138B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517059B (en) * 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
DE69636739T2 (de) * 1995-12-21 2007-10-18 Ajinomoto Co., Inc. Verfahren zur rückfaltung von menschlichem activin a
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
WO2001075095A1 (fr) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Procede de production de proteine de recombinaison
EP1292330A1 (en) * 2000-03-31 2003-03-19 Vaccine Chip Technology APS Immunostimulating properties of a fragment of tgf- beta
US7572474B2 (en) 2005-06-01 2009-08-11 Mead Johnson Nutrition Company Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) * 2008-10-24 2011-12-13 Mead Johnson Nutrition Company Nutritional composition with improved digestibility
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
US8986769B2 (en) * 2008-10-24 2015-03-24 Mead Johnson Nutrition Company Methods for preserving endogenous TGF-β
EP3562839A4 (en) 2016-12-30 2020-09-02 Biogend Therapeutics Co., Ltd. RECOMBINANT POLYPEPTIDES, ASSOCIATED COMPOSITIONS AND PROCESSES
WO2020061067A2 (en) * 2018-09-17 2020-03-26 Board Of Regents, The University Of Texas System Texas System Compositions and methods for treating bone injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731440A (en) * 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (ja) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 ヒトインスリン様成長因子▲i▼の製造法
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
US5061786A (en) * 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5144006A (en) * 1991-06-13 1992-09-01 The Rockefeller University Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors

Also Published As

Publication number Publication date
PT775159E (pt) 2002-04-29
IL114701A0 (en) 1995-11-27
CA2194582C (en) 2008-09-02
ES2166401T3 (es) 2002-04-16
TW440566B (en) 2001-06-16
AU3109595A (en) 1996-02-22
JP3923516B2 (ja) 2007-06-06
HU222830B1 (hu) 2003-11-28
HUT76668A (en) 1997-10-28
NZ290373A (en) 1998-04-27
US6057430A (en) 2000-05-02
JPH11505506A (ja) 1999-05-21
NO970325D0 (no) 1997-01-24
CA2194582A1 (en) 1996-02-08
JP2007031453A (ja) 2007-02-08
FI118083B (fi) 2007-06-29
AU690311B2 (en) 1998-04-23
EP0775159B1 (en) 2001-10-31
EP0775159A1 (en) 1997-05-28
DK0775159T3 (da) 2002-02-11
NO970325L (no) 1997-03-06
WO1996003432A1 (en) 1996-02-08
FI970229A (fi) 1997-01-20
ATE207933T1 (de) 2001-11-15
DE69523605T2 (de) 2002-07-11
FI970229A0 (fi) 1997-01-20
IL114701A (en) 2005-11-20
ZA956138B (en) 1996-03-07
DE69523605D1 (de) 2001-12-06
KR100432839B1 (ko) 2004-08-30

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