FI118083B - Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi - Google Patents
Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi Download PDFInfo
- Publication number
- FI118083B FI118083B FI970229A FI970229A FI118083B FI 118083 B FI118083 B FI 118083B FI 970229 A FI970229 A FI 970229A FI 970229 A FI970229 A FI 970229A FI 118083 B FI118083 B FI 118083B
- Authority
- FI
- Finland
- Prior art keywords
- tgf
- leu
- concentration
- cys
- ser
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94810438 | 1994-07-25 | ||
EP94810438 | 1994-07-25 | ||
EP9502718 | 1995-07-12 | ||
PCT/EP1995/002718 WO1996003432A1 (en) | 1994-07-25 | 1995-07-12 | Novel process for the production of biologically active dimeric protein |
Publications (3)
Publication Number | Publication Date |
---|---|
FI970229A FI970229A (fi) | 1997-01-20 |
FI970229A0 FI970229A0 (fi) | 1997-01-20 |
FI118083B true FI118083B (fi) | 2007-06-29 |
Family
ID=8218292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI970229A FI118083B (fi) | 1994-07-25 | 1997-01-20 | Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi |
Country Status (19)
Country | Link |
---|---|
US (1) | US6057430A (ja) |
EP (1) | EP0775159B1 (ja) |
JP (2) | JP3923516B2 (ja) |
KR (1) | KR100432839B1 (ja) |
AT (1) | ATE207933T1 (ja) |
AU (1) | AU690311B2 (ja) |
CA (1) | CA2194582C (ja) |
DE (1) | DE69523605T2 (ja) |
DK (1) | DK0775159T3 (ja) |
ES (1) | ES2166401T3 (ja) |
FI (1) | FI118083B (ja) |
HU (1) | HU222830B1 (ja) |
IL (1) | IL114701A (ja) |
NO (1) | NO316926B1 (ja) |
NZ (1) | NZ290373A (ja) |
PT (1) | PT775159E (ja) |
TW (1) | TW440566B (ja) |
WO (1) | WO1996003432A1 (ja) |
ZA (1) | ZA956138B (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW517059B (en) * | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
US6084076A (en) * | 1995-12-21 | 2000-07-04 | Ajinomoto Co., Inc. | Method of refolding human activin A |
DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
AU2001244647A1 (en) * | 2000-03-30 | 2001-10-15 | Takeda Chemical Industries Ltd. | Process for producing recombinant protein |
WO2001072331A1 (en) * | 2000-03-31 | 2001-10-04 | Vaccine Chip Technology Aps | Immunostimulating properties of a fragment of tgf-beta |
US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
US8075934B2 (en) * | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
GB0514262D0 (en) * | 2005-07-12 | 2005-08-17 | Renovo Ltd | Promotion of epithelial regeneration |
GB0604938D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
GB0617816D0 (en) * | 2006-09-11 | 2006-10-18 | Renovo Ltd | Nucleic acids and methods of protein expression |
US8986769B2 (en) * | 2008-10-24 | 2015-03-24 | Mead Johnson Nutrition Company | Methods for preserving endogenous TGF-β |
CA3048735A1 (en) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides, compositions, and methods thereof |
KR20210080370A (ko) * | 2018-09-17 | 2021-06-30 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 뼈 손상 치료용 조성물 및 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4731440A (en) * | 1985-02-22 | 1988-03-15 | Monsanto Company | Method of somatotropin solubilization using dimethylsulfone and naturation |
JPH0759598B2 (ja) * | 1986-02-14 | 1995-06-28 | 藤沢薬品工業株式会社 | ヒトインスリン様成長因子▲i▼の製造法 |
EP0293785A3 (en) * | 1987-05-29 | 1990-05-02 | Oncogen Limited Partnership | Cloning and expression of simian transforming growth factor-ss1 |
US5061786A (en) * | 1989-05-25 | 1991-10-29 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
US5144006A (en) * | 1991-06-13 | 1992-09-01 | The Rockefeller University | Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides |
AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
-
1995
- 1995-07-11 TW TW084107188A patent/TW440566B/zh not_active IP Right Cessation
- 1995-07-12 EP EP95926857A patent/EP0775159B1/en not_active Expired - Lifetime
- 1995-07-12 DK DK95926857T patent/DK0775159T3/da active
- 1995-07-12 PT PT95926857T patent/PT775159E/pt unknown
- 1995-07-12 ES ES95926857T patent/ES2166401T3/es not_active Expired - Lifetime
- 1995-07-12 KR KR1019970700476A patent/KR100432839B1/ko not_active IP Right Cessation
- 1995-07-12 NZ NZ290373A patent/NZ290373A/en not_active IP Right Cessation
- 1995-07-12 CA CA002194582A patent/CA2194582C/en not_active Expired - Fee Related
- 1995-07-12 WO PCT/EP1995/002718 patent/WO1996003432A1/en active IP Right Grant
- 1995-07-12 DE DE69523605T patent/DE69523605T2/de not_active Expired - Lifetime
- 1995-07-12 AT AT95926857T patent/ATE207933T1/de not_active IP Right Cessation
- 1995-07-12 HU HU9700210A patent/HU222830B1/hu not_active IP Right Cessation
- 1995-07-12 JP JP50540096A patent/JP3923516B2/ja not_active Expired - Fee Related
- 1995-07-12 AU AU31095/95A patent/AU690311B2/en not_active Ceased
- 1995-07-24 ZA ZA956138A patent/ZA956138B/xx unknown
- 1995-07-24 IL IL11470195A patent/IL114701A/xx not_active IP Right Cessation
-
1997
- 1997-01-20 FI FI970229A patent/FI118083B/fi active IP Right Grant
- 1997-01-24 NO NO19970325A patent/NO316926B1/no not_active IP Right Cessation
-
1998
- 1998-07-28 US US09/123,233 patent/US6057430A/en not_active Expired - Fee Related
-
2006
- 2006-11-09 JP JP2006304295A patent/JP2007031453A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PT775159E (pt) | 2002-04-29 |
ES2166401T3 (es) | 2002-04-16 |
ZA956138B (en) | 1996-03-07 |
ATE207933T1 (de) | 2001-11-15 |
HU222830B1 (hu) | 2003-11-28 |
NZ290373A (en) | 1998-04-27 |
JP2007031453A (ja) | 2007-02-08 |
KR100432839B1 (ko) | 2004-08-30 |
IL114701A0 (en) | 1995-11-27 |
NO970325L (no) | 1997-03-06 |
NO316926B1 (no) | 2004-06-28 |
DK0775159T3 (da) | 2002-02-11 |
JP3923516B2 (ja) | 2007-06-06 |
US6057430A (en) | 2000-05-02 |
HUT76668A (en) | 1997-10-28 |
EP0775159A1 (en) | 1997-05-28 |
IL114701A (en) | 2005-11-20 |
NO970325D0 (no) | 1997-01-24 |
EP0775159B1 (en) | 2001-10-31 |
FI970229A (fi) | 1997-01-20 |
CA2194582C (en) | 2008-09-02 |
FI970229A0 (fi) | 1997-01-20 |
WO1996003432A1 (en) | 1996-02-08 |
JPH11505506A (ja) | 1999-05-21 |
TW440566B (en) | 2001-06-16 |
DE69523605T2 (de) | 2002-07-11 |
AU690311B2 (en) | 1998-04-23 |
AU3109595A (en) | 1996-02-22 |
DE69523605D1 (de) | 2001-12-06 |
CA2194582A1 (en) | 1996-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4354980B2 (ja) | 生物学的に活性なタンパク質の製造のための新規の方法 | |
KR100203230B1 (ko) | 생물학적 활성 이량체 형태의 생장 변환 인자 b 또는 골 형태발생 단백질을 제조하는 방법 | |
JP2007031453A (ja) | 生物学的に活性な二量体型タンパク質の製造のための新規の方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or assigment of application |
Owner name: NOVARTIS AG |
|
FG | Patent granted |
Ref document number: 118083 Country of ref document: FI |