FI118083B - Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi - Google Patents

Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi Download PDF

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Publication number
FI118083B
FI118083B FI970229A FI970229A FI118083B FI 118083 B FI118083 B FI 118083B FI 970229 A FI970229 A FI 970229A FI 970229 A FI970229 A FI 970229A FI 118083 B FI118083 B FI 118083B
Authority
FI
Finland
Prior art keywords
tgf
leu
concentration
cys
ser
Prior art date
Application number
FI970229A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970229A (fi
FI970229A0 (fi
Inventor
Nico Cerletti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI970229A publication Critical patent/FI970229A/fi
Publication of FI970229A0 publication Critical patent/FI970229A0/fi
Application granted granted Critical
Publication of FI118083B publication Critical patent/FI118083B/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/495Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI970229A 1994-07-25 1997-01-20 Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi FI118083B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94810438 1994-07-25
EP94810438 1994-07-25
EP9502718 1995-07-12
PCT/EP1995/002718 WO1996003432A1 (en) 1994-07-25 1995-07-12 Novel process for the production of biologically active dimeric protein

Publications (3)

Publication Number Publication Date
FI970229A FI970229A (fi) 1997-01-20
FI970229A0 FI970229A0 (fi) 1997-01-20
FI118083B true FI118083B (fi) 2007-06-29

Family

ID=8218292

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970229A FI118083B (fi) 1994-07-25 1997-01-20 Uusi menetelmä biologisesti aktiivisen dimeerisen proteiinin valmistamiseksi

Country Status (19)

Country Link
US (1) US6057430A (ja)
EP (1) EP0775159B1 (ja)
JP (2) JP3923516B2 (ja)
KR (1) KR100432839B1 (ja)
AT (1) ATE207933T1 (ja)
AU (1) AU690311B2 (ja)
CA (1) CA2194582C (ja)
DE (1) DE69523605T2 (ja)
DK (1) DK0775159T3 (ja)
ES (1) ES2166401T3 (ja)
FI (1) FI118083B (ja)
HU (1) HU222830B1 (ja)
IL (1) IL114701A (ja)
NO (1) NO316926B1 (ja)
NZ (1) NZ290373A (ja)
PT (1) PT775159E (ja)
TW (1) TW440566B (ja)
WO (1) WO1996003432A1 (ja)
ZA (1) ZA956138B (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW517059B (en) * 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
US6084076A (en) * 1995-12-21 2000-07-04 Ajinomoto Co., Inc. Method of refolding human activin A
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
AU2001244647A1 (en) * 2000-03-30 2001-10-15 Takeda Chemical Industries Ltd. Process for producing recombinant protein
WO2001072331A1 (en) * 2000-03-31 2001-10-04 Vaccine Chip Technology Aps Immunostimulating properties of a fragment of tgf-beta
US7572474B2 (en) 2005-06-01 2009-08-11 Mead Johnson Nutrition Company Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) * 2008-10-24 2011-12-13 Mead Johnson Nutrition Company Nutritional composition with improved digestibility
GB0514262D0 (en) * 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
GB0604938D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
US8986769B2 (en) * 2008-10-24 2015-03-24 Mead Johnson Nutrition Company Methods for preserving endogenous TGF-β
CA3048735A1 (en) 2016-12-30 2018-07-05 Biogend Therapeutics Co., Ltd. Recombinant polypeptides, compositions, and methods thereof
KR20210080370A (ko) * 2018-09-17 2021-06-30 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 뼈 손상 치료용 조성물 및 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731440A (en) * 1985-02-22 1988-03-15 Monsanto Company Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (ja) * 1986-02-14 1995-06-28 藤沢薬品工業株式会社 ヒトインスリン様成長因子▲i▼の製造法
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
US5061786A (en) * 1989-05-25 1991-10-29 Genentech, Inc. Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5144006A (en) * 1991-06-13 1992-09-01 The Rockefeller University Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors

Also Published As

Publication number Publication date
PT775159E (pt) 2002-04-29
ES2166401T3 (es) 2002-04-16
ZA956138B (en) 1996-03-07
ATE207933T1 (de) 2001-11-15
HU222830B1 (hu) 2003-11-28
NZ290373A (en) 1998-04-27
JP2007031453A (ja) 2007-02-08
KR100432839B1 (ko) 2004-08-30
IL114701A0 (en) 1995-11-27
NO970325L (no) 1997-03-06
NO316926B1 (no) 2004-06-28
DK0775159T3 (da) 2002-02-11
JP3923516B2 (ja) 2007-06-06
US6057430A (en) 2000-05-02
HUT76668A (en) 1997-10-28
EP0775159A1 (en) 1997-05-28
IL114701A (en) 2005-11-20
NO970325D0 (no) 1997-01-24
EP0775159B1 (en) 2001-10-31
FI970229A (fi) 1997-01-20
CA2194582C (en) 2008-09-02
FI970229A0 (fi) 1997-01-20
WO1996003432A1 (en) 1996-02-08
JPH11505506A (ja) 1999-05-21
TW440566B (en) 2001-06-16
DE69523605T2 (de) 2002-07-11
AU690311B2 (en) 1998-04-23
AU3109595A (en) 1996-02-22
DE69523605D1 (de) 2001-12-06
CA2194582A1 (en) 1996-02-08

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