NO315842B1 - Anvendelse av hyaluronsyre for fremstilling av en farmasöytisk blanding - Google Patents
Anvendelse av hyaluronsyre for fremstilling av en farmasöytisk blanding Download PDFInfo
- Publication number
- NO315842B1 NO315842B1 NO19973732A NO973732A NO315842B1 NO 315842 B1 NO315842 B1 NO 315842B1 NO 19973732 A NO19973732 A NO 19973732A NO 973732 A NO973732 A NO 973732A NO 315842 B1 NO315842 B1 NO 315842B1
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- dalton
- molecular weight
- interstitial cystitis
- urinary bladder
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/388,038 US5591724A (en) | 1995-02-14 | 1995-02-14 | Method for treating the urinary bladder and associated structures using hyaluronic acid |
| US59101596A | 1996-02-08 | 1996-02-08 | |
| PCT/CA1996/000094 WO1996025168A1 (en) | 1995-02-14 | 1996-02-14 | Use of hyaluronic acid for the treatment of interstitial cystitis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO973732D0 NO973732D0 (no) | 1997-08-13 |
| NO973732L NO973732L (no) | 1997-10-10 |
| NO315842B1 true NO315842B1 (no) | 2003-11-03 |
Family
ID=27012116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19973732A NO315842B1 (no) | 1995-02-14 | 1997-08-13 | Anvendelse av hyaluronsyre for fremstilling av en farmasöytisk blanding |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5888986A (ja) |
| EP (1) | EP0813417B1 (ja) |
| JP (1) | JP4354528B2 (ja) |
| KR (1) | KR100268660B1 (ja) |
| CN (1) | CN1181016A (ja) |
| AT (1) | ATE247476T1 (ja) |
| AU (1) | AU705289B2 (ja) |
| BR (1) | BR9607601A (ja) |
| CA (1) | CA2203621C (ja) |
| CZ (1) | CZ288218B6 (ja) |
| DE (1) | DE69629553T2 (ja) |
| DK (1) | DK0813417T3 (ja) |
| ES (1) | ES2205013T3 (ja) |
| HU (1) | HUP9800467A3 (ja) |
| IN (1) | IN181358B (ja) |
| NO (1) | NO315842B1 (ja) |
| NZ (1) | NZ300903A (ja) |
| PT (1) | PT813417E (ja) |
| TR (1) | TR199700782T1 (ja) |
| WO (1) | WO1996025168A1 (ja) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2268476A1 (en) | 1991-07-03 | 1998-04-30 | Hyal Pharmaceutical Corporation | Use of hyaluronan in gene therapy |
| US6548487B2 (en) | 1996-12-27 | 2003-04-15 | Seikagaku Corporation | Agent for treatment of bladder troubles |
| CA2247389C (en) * | 1996-12-27 | 2009-11-24 | Seikagaku Corporation | Agent for treatment of bladder troubles |
| DE69916643T2 (de) * | 1998-10-22 | 2005-04-28 | Bioniche Life Sciences Inc., London | Verwendung von hyaluronsäure zur behandlung der bestrahlungs-blasenentzündung |
| US6083933A (en) * | 1999-04-19 | 2000-07-04 | Stellar International Inc. | Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution |
| MXPA02005842A (es) * | 1999-12-13 | 2003-10-14 | Bioniche Life Sciences Inc | Oligonucleotidos sinteticos terapeuticamente utiles. |
| JP4215429B2 (ja) * | 1999-12-28 | 2009-01-28 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | 癌治療におけるヒアルロン酸 |
| US7504387B2 (en) * | 2002-10-16 | 2009-03-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis |
| US20040161476A1 (en) | 2003-02-19 | 2004-08-19 | Hahn Sungtack Samuel | Cystitis treatment with high dose chondroitin sulfate |
| EP3556360A1 (en) * | 2005-01-14 | 2019-10-23 | Urigen, Inc. | Compositions for treating lower urinary tract disorders |
| DE102006060953A1 (de) | 2006-12-12 | 2008-08-07 | Farco-Pharma Gmbh | Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes |
| US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
| TWI516269B (zh) | 2009-08-14 | 2016-01-11 | 禾伸堂生技股份有限公司 | 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物 |
| TWI383796B (zh) | 2009-08-14 | 2013-02-01 | Holy Stone Healthcare Co Ltd | Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer |
| HUP0900717A3 (en) * | 2009-11-18 | 2012-02-28 | Richter Gedeon Nyrt | Pharmaceutical composition for urological use containing zinc hyaluronate |
| US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
| US20110166098A1 (en) * | 2010-01-04 | 2011-07-07 | Wu Tsung-Chung | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
| US8575130B2 (en) * | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
| US8449512B2 (en) | 2010-04-09 | 2013-05-28 | Davinci Biomedical Research Products Inc. | Stoma stabilitating device and method |
| US9029347B2 (en) | 2010-08-05 | 2015-05-12 | Holy Stone Healthcare Co., Ltd. | Method and mixture for treating and preventing inflammatory bowel disease |
| EP2545925B1 (en) | 2011-07-12 | 2018-02-14 | Holy Stone Healthcare Co.,Ltd. | Compositions comprising hyaluronic acid for treating and preventing mucosa related diseases |
| ITMI20111732A1 (it) * | 2011-09-27 | 2013-03-28 | Bsdpharma Srl | Formulazioni farmaceutiche per la riduzione della sensibilizzazione crociata tra colon-retto ed il distretto urogenitale con mezzi non-farmacologici. |
| RU2519010C1 (ru) * | 2013-03-20 | 2014-06-10 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Композиция для лечения цистита |
| WO2015018461A1 (fr) | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
| CN103655601B (zh) * | 2013-12-31 | 2019-10-25 | 上海建华精细生物制品有限公司 | 一种用于膀胱灌洗的组合物 |
| CN103861091B (zh) * | 2014-03-20 | 2016-04-27 | 辽宁亿灵科创生物医药科技有限公司 | 治疗膀胱炎的药物组合物 |
| WO2015154007A1 (en) * | 2014-04-03 | 2015-10-08 | Lipella Pharmaceuticals, Inc. | Systems and methods of detecting interstitial cystitis |
| RU2557949C1 (ru) * | 2014-08-14 | 2015-07-27 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Способ лечения лучевого и интерстициального цистита |
| EP3400951B1 (de) * | 2017-05-12 | 2019-12-11 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4296104A (en) * | 1979-08-30 | 1981-10-20 | Herschler R J | Therapeutic dimethyl sulfoxide composition and methods of use |
| US4302577A (en) * | 1979-10-05 | 1981-11-24 | Biomed Research Inc. | Process for preparing CSA or CSC |
| US5180715A (en) * | 1980-11-17 | 1993-01-19 | The Regents Of The University Of California | Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate |
| DE3118588C2 (de) * | 1981-05-11 | 1983-07-07 | Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
| US4640912A (en) * | 1983-06-09 | 1987-02-03 | Hausman Marvin S | Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans |
| US4711780A (en) * | 1984-06-11 | 1987-12-08 | Fahim Mostafa S | Composition and process for promoting epithelial regeneration |
| US4966890A (en) * | 1986-04-04 | 1990-10-30 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US4820693A (en) * | 1986-05-22 | 1989-04-11 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| US5037810A (en) * | 1987-03-17 | 1991-08-06 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| ES2150427T3 (es) * | 1992-06-02 | 2000-12-01 | Bard Inc C R | Procedimiento y dispositivo de implante para el suministro de farmacos a largo plazo. |
| JP2995090B2 (ja) * | 1993-03-19 | 1999-12-27 | キユー・メド・アクチエボラーグ | 組織増大のための組成物および方法 |
-
1996
- 1996-02-13 IN IN262CA1996 patent/IN181358B/en unknown
- 1996-02-14 KR KR1019970705648A patent/KR100268660B1/ko not_active IP Right Cessation
- 1996-02-14 EP EP96901681A patent/EP0813417B1/en not_active Expired - Lifetime
- 1996-02-14 TR TR97/00782T patent/TR199700782T1/xx unknown
- 1996-02-14 DE DE69629553T patent/DE69629553T2/de not_active Expired - Lifetime
- 1996-02-14 WO PCT/CA1996/000094 patent/WO1996025168A1/en active IP Right Grant
- 1996-02-14 CN CN96192529A patent/CN1181016A/zh active Pending
- 1996-02-14 CZ CZ19972574A patent/CZ288218B6/cs not_active IP Right Cessation
- 1996-02-14 AT AT96901681T patent/ATE247476T1/de active
- 1996-02-14 ES ES96901681T patent/ES2205013T3/es not_active Expired - Lifetime
- 1996-02-14 PT PT96901681T patent/PT813417E/pt unknown
- 1996-02-14 DK DK96901681T patent/DK0813417T3/da active
- 1996-02-14 JP JP52454596A patent/JP4354528B2/ja not_active Expired - Lifetime
- 1996-02-14 NZ NZ300903A patent/NZ300903A/xx not_active IP Right Cessation
- 1996-02-14 CA CA002203621A patent/CA2203621C/en not_active Expired - Lifetime
- 1996-02-14 HU HU9800467A patent/HUP9800467A3/hu unknown
- 1996-02-14 BR BR9607601-1A patent/BR9607601A/pt not_active Application Discontinuation
- 1996-02-14 AU AU46179/96A patent/AU705289B2/en not_active Expired
- 1996-05-13 US US08/644,438 patent/US5888986A/en not_active Expired - Lifetime
-
1997
- 1997-08-13 NO NO19973732A patent/NO315842B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10513476A (ja) | 1998-12-22 |
| JP4354528B2 (ja) | 2009-10-28 |
| DE69629553D1 (de) | 2003-09-25 |
| CZ288218B6 (en) | 2001-05-16 |
| US5888986A (en) | 1999-03-30 |
| CA2203621C (en) | 1998-04-28 |
| NZ300903A (en) | 1999-07-29 |
| HUP9800467A3 (en) | 1999-01-28 |
| WO1996025168A1 (en) | 1996-08-22 |
| CN1181016A (zh) | 1998-05-06 |
| PT813417E (pt) | 2003-12-31 |
| AU705289B2 (en) | 1999-05-20 |
| MX9706182A (es) | 1998-07-31 |
| ATE247476T1 (de) | 2003-09-15 |
| KR100268660B1 (ko) | 2000-10-16 |
| HUP9800467A2 (hu) | 1998-06-29 |
| NO973732L (no) | 1997-10-10 |
| CZ257497A3 (cs) | 1998-01-14 |
| TR199700782T1 (xx) | 1998-03-21 |
| AU4617996A (en) | 1996-09-04 |
| EP0813417A1 (en) | 1997-12-29 |
| KR19980702251A (ko) | 1998-07-15 |
| DE69629553T2 (de) | 2004-06-17 |
| DK0813417T3 (da) | 2003-11-03 |
| EP0813417B1 (en) | 2003-08-20 |
| BR9607601A (pt) | 1999-09-14 |
| IN181358B (ja) | 1998-05-30 |
| CA2203621A1 (en) | 1996-08-22 |
| ES2205013T3 (es) | 2004-05-01 |
| NO973732D0 (no) | 1997-08-13 |
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| MK1K | Patent expired |