JP5788896B2 - 膀胱疾患の治療のための医薬組成物 - Google Patents
膀胱疾患の治療のための医薬組成物 Download PDFInfo
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- JP5788896B2 JP5788896B2 JP2012539417A JP2012539417A JP5788896B2 JP 5788896 B2 JP5788896 B2 JP 5788896B2 JP 2012539417 A JP2012539417 A JP 2012539417A JP 2012539417 A JP2012539417 A JP 2012539417A JP 5788896 B2 JP5788896 B2 JP 5788896B2
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- 239000004033 plastic Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000007363 regulatory process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229940100996 sodium bisulfate Drugs 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 229940001474 sodium thiosulfate Drugs 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000036318 urination frequency Effects 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Description
・ 間質性膀胱炎
・ 慢性再発性細菌性および非細菌性膀胱炎
・ 放射線性膀胱炎および化学物質性膀胱炎
実験の2つのシリーズは、膀胱壁の再生におけるヒアルロン酸亜鉛溶液の有効性を評価するために設計された。間質性膀胱炎において膀胱壁内に起こる変化のモデルとして、第1のシリーズの実験病理学的プロセスが提供される。実験の第2シリーズでは、膀胱の急性炎症プロセスがモデル化される。
実験は、20匹の雌のホワイトラットで行われた。間質性膀胱炎における膀胱壁内に起こるのと同様の実験病理学的プロセスがモデル化された。凍結破壊(cryodestruction)を、膀胱内に引き起こした。液体窒素を含浸させたタンポンは、膀胱に導入され20秒間保持されて、間質性膀胱炎を誘発した。
・ グループ1:ラットは凍結破壊後の48時間後に、一度だけ処理された。ヒアルロン酸亜鉛溶液(実施例1に従う)の1mlが膀胱内に導入され、30分間保持された。
・ グループ2:動物は、第一のグループの動物と同じ処理を受けたが、3回(3日間連続で)受けた。
・ グループ3:3匹の対照動物は凍結破壊後の処理を受けなかった。
実験は、16匹の雌のホワイトラットで行われた。大腸菌E.coli培養液(106CFU/ml)1.0mlの注射(圧力下)によって膀胱の急性炎症を引き起こさせた。
・ グループ1:ラットはE.coliの注射後48時間後に一度だけ処理された。ヒアルロン酸亜鉛溶液(実施例1に従う)の1mlが膀胱内に導入され、30分間保持された。
・ グループ2:動物は第一のグループの動物と同じ処理を受けたが、3回(3日間連続で)受けた。
・ グループ3:3匹の対照動物は凍結破壊後の処理を受けなかった。
・ 膀胱壁全層の顕著な浸潤
・ 微小循環系血管の血管拡張
・ 浮腫
・ 膀胱上皮およびその結合組織の局所的破壊
この研究のための試験対象患者基準は、以下を含む:
1. 女性
2. 年齢>18歳
3. 少なくとも6ヶ月間の尿意切迫および排尿回数の増加または骨盤痛
4. 少なくとも一日に7回の排尿または排尿刺激または骨盤痛(ビジュアルアナログスケールで測定)
5. 麻酔下、点状出血(glomerulation)および血液流出(bloody effluent)を伴う60〜80cmH2O圧力における水圧拡張術
6. 無菌尿培養
1. 尿の平均量が150ml以上である
2. 泌尿生殖器系の結核
3. 良性または悪性の膀胱腫瘍
4. 研究への登録30日以内に間質性膀胱炎の薬の投与または積極的な治療を受けている患者
5. 1週間以内に膀胱にも影響する薬を服用した患者
6. 妊娠、授乳
7. 卵巣癌、子宮癌および膣癌
8. 膣感染症
9. 3ヶ月以内に細菌性膀胱炎
10. 3ヶ月以内に活動性ヘルペス
11. 既往症のシクロフォスファミド(cyclophosamide)治療
12. 放射線膀胱炎
13. 神経因性膀胱機能障害
14. 3ヶ月以内の膀胱の炎症
15. 膀胱拡張または切除の手術
8人の患者を処置した。
ヒアルロン酸亜鉛の投与を膀胱のバルーン拡張術と併用した。処置後または処置前に患者は、上述の実施例に従って、何回か膀胱内にヒアルロン酸亜鉛溶液を受ける。膀胱カテーテルを膀胱内に挿入して膀胱の残尿を排出し、次いで、ヒアルロン酸亜鉛溶液(実施例1による)の20mlを膀胱内に導入する。その後、カテーテルを除去し、バルーンカテーテルを膀胱に挿入した。その後、バルーンは図1に示す装置を用いていっぱいにされた。
処置は、実施例5に記載したものと同じにした。悪性腫瘍のため膀胱切除手術を受けた2人の患者に処置をした。手術後、彼らは、膀胱内に細胞増殖抑制薬剤を受けた。細胞増殖抑制剤治療後の彼らの症状は間質性膀胱炎の症状と非常に類似していた。
Claims (9)
- 哺乳動物における泌尿生殖器系のグルコサミノグリカン(GAG)層の異常や欠損に関連する病気の治療および予防のためのヒアルロン酸亜鉛錯体を含む医薬組成物。
- 膀胱炎の治療のための請求項1に記載の医薬組成物。
- 間質性膀胱炎の治療のための請求項1ないし2のいずれかに記載の医薬組成物。
- 溶液の形態である請求項1ないし3のいずれかに記載の医薬組成物。
- 溶液の濃度が0.01〜5mg/mlである請求項4に記載の医薬組成物。
- 溶液の内圧が50〜80H2Ocmである請求項4ないし5のいずれかに記載の医薬組成物。
- 哺乳動物における泌尿生殖器系のグルコサミノグリカン(GAG)層の異常や欠損に関連する病気の治療および予防のための医薬の製造におけるヒアルロン酸亜鉛錯体の使用。
- 請求項1に記載の医薬組成物、膀胱内投与に適用可能なカテーテルおよび必要に応じて膀胱拡張術に適用可能なバルーンを含むキット。
- キットが膀胱拡張術に適用可能なバルーンを含むことを特徴とする請求項8に記載のキット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0900717A HUP0900717A3 (en) | 2009-11-18 | 2009-11-18 | Pharmaceutical composition for urological use containing zinc hyaluronate |
HUP0900717 | 2009-11-18 | ||
PCT/HU2010/000125 WO2011061554A2 (en) | 2009-11-18 | 2010-11-18 | Pharmaceutical composition for the treatment of bladder disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013511504A JP2013511504A (ja) | 2013-04-04 |
JP5788896B2 true JP5788896B2 (ja) | 2015-10-07 |
Family
ID=89989378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012539417A Active JP5788896B2 (ja) | 2009-11-18 | 2010-11-18 | 膀胱疾患の治療のための医薬組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20120245518A1 (ja) |
EP (1) | EP2501391A2 (ja) |
JP (1) | JP5788896B2 (ja) |
CN (1) | CN102665732A (ja) |
CA (1) | CA2779937C (ja) |
EA (1) | EA025141B1 (ja) |
HU (1) | HUP0900717A3 (ja) |
IL (1) | IL219050B (ja) |
MX (1) | MX2012005814A (ja) |
MY (1) | MY163107A (ja) |
WO (1) | WO2011061554A2 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103861091B (zh) * | 2014-03-20 | 2016-04-27 | 辽宁亿灵科创生物医药科技有限公司 | 治疗膀胱炎的药物组合物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU203372B (en) * | 1989-02-24 | 1991-07-29 | Richter Gedeon Vegyeszet | Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient |
US6458774B1 (en) * | 1989-02-24 | 2002-10-01 | Richter Gedeon Vegyeszeti Gyar Rt. | Compositions containing hyaluronic acid associates and a process for preparing same |
IT1273742B (it) * | 1994-08-01 | 1997-07-09 | Lifegroup Spa | Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose |
IN181358B (ja) * | 1995-02-14 | 1998-05-30 | Bioniche Inc | |
US5880108A (en) * | 1995-02-14 | 1999-03-09 | Bioniche, Inc. | Method for treating the internal urinary bladder and associated structures using hyaluronic acid |
HU225329B1 (en) * | 1996-09-12 | 2006-09-28 | Richter Gedeon Vegyeszet | Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity |
HU225991B1 (en) * | 1997-04-29 | 2008-02-28 | Richter Gedeon Nyrt | Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer |
US6548487B2 (en) * | 1996-12-27 | 2003-04-15 | Seikagaku Corporation | Agent for treatment of bladder troubles |
NZ511068A (en) * | 1998-10-22 | 2003-10-31 | Bioniche Life Sciences Inc | Use of hyaluronic acid for preventing, reducing, and treating radiation cystitis |
JP2003089647A (ja) | 1999-03-10 | 2003-03-28 | Takada Seiyaku Kk | 関節性疾患治療剤 |
CN100355790C (zh) * | 2005-11-04 | 2007-12-19 | 山东福瑞达生物化工有限公司 | 一种透明质酸锌的制备方法 |
-
2009
- 2009-11-18 HU HU0900717A patent/HUP0900717A3/hu not_active Application Discontinuation
-
2010
- 2010-11-18 JP JP2012539417A patent/JP5788896B2/ja active Active
- 2010-11-18 EA EA201200753A patent/EA025141B1/ru unknown
- 2010-11-18 MY MYPI2012001595A patent/MY163107A/en unknown
- 2010-11-18 EP EP10812988A patent/EP2501391A2/en active Pending
- 2010-11-18 MX MX2012005814A patent/MX2012005814A/es active IP Right Grant
- 2010-11-18 US US13/499,385 patent/US20120245518A1/en not_active Abandoned
- 2010-11-18 CN CN2010800521899A patent/CN102665732A/zh active Pending
- 2010-11-18 WO PCT/HU2010/000125 patent/WO2011061554A2/en active Application Filing
- 2010-11-18 CA CA2779937A patent/CA2779937C/en active Active
-
2012
- 2012-04-04 IL IL219050A patent/IL219050B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO2011061554A3 (en) | 2011-08-18 |
HUP0900717A3 (en) | 2012-02-28 |
US20120245518A1 (en) | 2012-09-27 |
EA201200753A1 (ru) | 2013-03-29 |
MY163107A (en) | 2017-08-15 |
CN102665732A (zh) | 2012-09-12 |
EA025141B1 (ru) | 2016-11-30 |
EP2501391A2 (en) | 2012-09-26 |
HU0900717D0 (en) | 2010-01-28 |
IL219050B (en) | 2019-02-28 |
CA2779937C (en) | 2017-11-07 |
CA2779937A1 (en) | 2011-05-26 |
WO2011061554A8 (en) | 2012-04-26 |
MX2012005814A (es) | 2012-06-19 |
WO2011061554A2 (en) | 2011-05-26 |
JP2013511504A (ja) | 2013-04-04 |
HUP0900717A2 (en) | 2011-06-28 |
IL219050A0 (en) | 2012-06-28 |
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