NO315693B1 - Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen - Google Patents

Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen Download PDF

Info

Publication number
NO315693B1
NO315693B1 NO19995906A NO995906A NO315693B1 NO 315693 B1 NO315693 B1 NO 315693B1 NO 19995906 A NO19995906 A NO 19995906A NO 995906 A NO995906 A NO 995906A NO 315693 B1 NO315693 B1 NO 315693B1
Authority
NO
Norway
Prior art keywords
mixture
povidone
peptide
mci
radioactively labeled
Prior art date
Application number
NO19995906A
Other languages
English (en)
Norwegian (no)
Other versions
NO995906D0 (no
NO995906L (no
Inventor
Dan Shochat
Albert S K Chan
Michael J Buckley
David Colcher
Original Assignee
Coulter Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Pharm Inc filed Critical Coulter Pharm Inc
Publication of NO995906D0 publication Critical patent/NO995906D0/no
Publication of NO995906L publication Critical patent/NO995906L/no
Publication of NO315693B1 publication Critical patent/NO315693B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO19995906A 1997-06-03 1999-12-02 Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen NO315693B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4838797P 1997-06-03 1997-06-03
US08/918,525 US5961955A (en) 1997-06-03 1997-08-21 Radioprotectant for peptides labeled with radioisotope
PCT/US1998/011428 WO1998055154A1 (en) 1997-06-03 1998-06-03 Radioprotectant for peptides labeled with radioisotope

Publications (3)

Publication Number Publication Date
NO995906D0 NO995906D0 (no) 1999-12-02
NO995906L NO995906L (no) 1999-12-03
NO315693B1 true NO315693B1 (no) 2003-10-13

Family

ID=26726075

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995906A NO315693B1 (no) 1997-06-03 1999-12-02 Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen

Country Status (14)

Country Link
US (2) US5961955A (enExample)
EP (1) EP1003560B1 (enExample)
JP (1) JP4291417B2 (enExample)
AT (1) ATE249845T1 (enExample)
AU (1) AU743823B2 (enExample)
CA (1) CA2290987A1 (enExample)
DE (1) DE69818272T2 (enExample)
DK (1) DK1003560T3 (enExample)
ES (1) ES2212304T3 (enExample)
IL (1) IL133271A (enExample)
NO (1) NO315693B1 (enExample)
NZ (1) NZ502029A (enExample)
PT (1) PT1003560E (enExample)
WO (1) WO1998055154A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
CA2334146C (en) 1998-06-02 2008-11-18 The Dow Chemical Company Radioiodinated phenols for brachytherapy
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
KR100330733B1 (ko) * 1999-11-30 2002-04-03 노광 폴리에틸렌글리콜포스페이트, 그의 합성방법 및 그를방사능보호제로 사용하는 방법
CA2422291C (en) * 2000-09-15 2011-03-08 Sloan-Kettering Institute For Cancer Research Targeted alpha particle therapy using actinium-225 conjugates
BR0207315A (pt) * 2001-02-26 2004-02-10 Bristol Myers Squibb Pharma Co Análogos de ácido ascórbico para metalorradiofármacos
US6972324B2 (en) * 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
US7238338B1 (en) * 2001-06-22 2007-07-03 Triumf System and method for the large scale labeling of compounds with radiohalogens
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
WO2003105762A2 (en) * 2002-06-14 2003-12-24 Actinium Pharmaceuticals Ltd. Treating disease using radium-225
US7018614B2 (en) * 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
MXPA05005558A (es) 2002-11-26 2005-07-26 Protein Design Labs Inc Anticuerpos quimericos y humanizados para integrina ( 5 ( 1 que modulan la angiogenesis.
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
JP5230865B2 (ja) 2004-07-15 2013-07-10 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ結合性化合物
EA012810B1 (ru) 2005-02-25 2009-12-30 Тетралоджик Фармасеутикалс Димерные ингибиторы ингибиторов белков апоптоза (iap)
CA2617642A1 (en) * 2005-08-09 2007-02-22 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
WO2008014240A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
MX2009000824A (es) * 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
US20100143499A1 (en) * 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
CN101621997B (zh) 2007-01-26 2013-05-08 株式会社宝丽制药 医药组合物
WO2008116347A1 (en) 2007-03-26 2008-10-02 General Regeneratives Limited Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies
KR101616139B1 (ko) 2008-02-29 2016-04-27 랜티우스 메디컬 이메징, 인크. 관류 영상화를 포함하는 용도를 위한 조영제
KR20110097772A (ko) * 2008-11-17 2011-08-31 제넨테크, 인크. 생리적 조건하에 거대분자의 응집을 감소시키는 방법 및 제제
CN102458396B (zh) 2009-04-15 2017-05-10 兰休斯医疗成像公司 使用抗坏血酸稳定化放射性药物组合物
US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CA2901231C (en) * 2013-02-15 2020-06-23 Thomas Jefferson University Kit comprising lyophilized compositions for tumor imaging
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
EP3094391B1 (en) * 2014-01-17 2024-11-20 Repligen Corporation Sterilizing chromatography columns
IL237852A0 (en) 2015-03-19 2016-03-24 Yeda Res & Dev Antibodies against amphigoline, medical preparations containing them and their use
TWI799366B (zh) * 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
CA3016901C (en) * 2016-03-07 2023-06-13 Actinium Pharmaceuticals, Inc. Stabilized radiolabeled anti-cd45 immunoglobulin compositions
US11339221B2 (en) 2017-11-01 2022-05-24 Tufts Medical Center, Inc. Bispecific antibody constructs and methods of use
CN113660927A (zh) 2019-04-23 2021-11-16 安进公司 使用低分子量聚乙烯吡咯烷酮（pvp）降低高浓度蛋白质配制品的黏度
WO2022265912A1 (en) 2021-06-16 2022-12-22 Gundersen Lutheran Medical Foundation, Inc. Antibodies targeting an amphiregulin-derived cell surface neo-epitope
WO2024259346A1 (en) 2023-06-16 2024-12-19 Progenics Pharmaceuticals, Inc Improved synthesis of the prostate specific membrane antigen (psma) radiolabeled inhibitor [18f]dcfpyl

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE933885C (de) * 1952-06-22 1955-10-06 Helmut Richard Dr Kanitz Verfahren zur Herstellung kolloidaler Loesungen radioaktiver Metalle wie radioaktiver Goldisotope
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
US4427631A (en) * 1982-05-27 1984-01-24 Euroceltique, S.A. Povidone irradiation
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
EP0111414A3 (en) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
US4676979A (en) * 1984-12-31 1987-06-30 Eastern Virginia Medical Authority/Med. Ctr. Hosp. Method of protecting animals against ionizing radiation
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
RO103925B1 (ro) * 1989-02-27 1992-04-26 Institutul De Chimie Macromoleculara "P.Poni" Derivat de polivinilpirolidona si procedeu de preparare
CA2066779A1 (en) * 1989-09-22 1991-03-23 Jean-Luc Vanderheyden Stable therapeutic radionuclide compositions and methods for preparation thereof
US5011676A (en) * 1990-03-27 1991-04-30 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
AU2541592A (en) * 1991-08-01 1993-03-02 Hybritech Incorporated Improvements in or relating to modified haptens useful as imaging and therapeutic agents
DE69231469T2 (de) * 1991-08-29 2001-01-25 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
WO1993022260A1 (en) * 1992-04-30 1993-11-11 Amersham International Plc Radiolabelled compound formulations
EP0622082A4 (en) * 1992-07-28 1996-12-04 Toray Industries IMMUNE COMPLEX.
US5595721A (en) * 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope

Also Published As

Publication number Publication date
ES2212304T3 (es) 2004-07-16
AU743823B2 (en) 2002-02-07
NO995906D0 (no) 1999-12-02
DE69818272T2 (de) 2004-07-01
US5961955A (en) 1999-10-05
NZ502029A (en) 2001-12-21
CA2290987A1 (en) 1998-12-10
JP4291417B2 (ja) 2009-07-08
IL133271A (en) 2004-06-01
IL133271A0 (en) 2001-04-30
AU8057098A (en) 1998-12-21
ATE249845T1 (de) 2003-10-15
PT1003560E (pt) 2004-02-27
DE69818272D1 (de) 2003-10-23
WO1998055154A9 (en) 1999-04-08
EP1003560B1 (en) 2003-09-17
JP2002516612A (ja) 2002-06-04
NO995906L (no) 1999-12-03
EP1003560A1 (en) 2000-05-31
WO1998055154A1 (en) 1998-12-10
US6338835B1 (en) 2002-01-15
DK1003560T3 (da) 2003-12-01

Similar Documents

Publication Publication Date Title
EP1003560B1 (en) Radioprotectant for peptides labeled with radioisotope
EP3426305B1 (en) Stabilized radiolabeled anti-cd45 immunoglobulin compositions
Behr et al. Reduction of renal uptake of monoclonal antibody fragments by amino acid infusion
RU2704802C2 (ru) Способы получения радиоиммуноконъюгатов
Lahorte et al. Biodistribution and dosimetry study of 123I-rh-annexin V in mice and humans
JP2023026708A (ja) 骨髄関連疾患の治療に使用するための放射性免疫複合体
US20100047167A1 (en) Combination therapy in the treatment of cancer
JP2008520707A (ja) 放射線量測定法及び遮断抗体並びに癌を治療する際の該方法及び使用
Ballantyne et al. Experience with a commercial preparation of 125I-labelled human albumin for study of albumin metabolism
CN121729243A (zh) 治疗骨关节炎的方法
Reynolds et al. Radiohalogenation of monoclonal antibodies: Experiences with radioiodination of monoclonal antibodies for radioimmunotherapy
CN116322768A (zh) 激活素a抗体调配物和其使用方法
Broer et al. 89Zr-brentuximab development for whole-body PET imaging of patients with CD30 positive lymphoma, eligible for brentuximab-vedotin therapy
HK40002997A (en) Stabilized radiolabeled anti-cd45 immunoglobulin compositions
HK40002997B (en) Stabilized radiolabeled anti-cd45 immunoglobulin compositions

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees