NO315693B1 - Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen - Google Patents
Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen Download PDFInfo
- Publication number
- NO315693B1 NO315693B1 NO19995906A NO995906A NO315693B1 NO 315693 B1 NO315693 B1 NO 315693B1 NO 19995906 A NO19995906 A NO 19995906A NO 995906 A NO995906 A NO 995906A NO 315693 B1 NO315693 B1 NO 315693B1
- Authority
- NO
- Norway
- Prior art keywords
- mixture
- povidone
- peptide
- mci
- radioactively labeled
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4838797P | 1997-06-03 | 1997-06-03 | |
| US08/918,525 US5961955A (en) | 1997-06-03 | 1997-08-21 | Radioprotectant for peptides labeled with radioisotope |
| PCT/US1998/011428 WO1998055154A1 (en) | 1997-06-03 | 1998-06-03 | Radioprotectant for peptides labeled with radioisotope |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995906D0 NO995906D0 (no) | 1999-12-02 |
| NO995906L NO995906L (no) | 1999-12-03 |
| NO315693B1 true NO315693B1 (no) | 2003-10-13 |
Family
ID=26726075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995906A NO315693B1 (no) | 1997-06-03 | 1999-12-02 | Stabil peptid radioisotop-blanding, samt fremgangsmåte for fremstilling derav, og fremgangsmåte for å minske radioaktiv nedbrytning avblandingen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5961955A (enExample) |
| EP (1) | EP1003560B1 (enExample) |
| JP (1) | JP4291417B2 (enExample) |
| AT (1) | ATE249845T1 (enExample) |
| AU (1) | AU743823B2 (enExample) |
| CA (1) | CA2290987A1 (enExample) |
| DE (1) | DE69818272T2 (enExample) |
| DK (1) | DK1003560T3 (enExample) |
| ES (1) | ES2212304T3 (enExample) |
| IL (1) | IL133271A (enExample) |
| NO (1) | NO315693B1 (enExample) |
| NZ (1) | NZ502029A (enExample) |
| PT (1) | PT1003560E (enExample) |
| WO (1) | WO1998055154A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
| JP2002516883A (ja) * | 1998-06-02 | 2002-06-11 | ザ ダウ ケミカル カンパニー | 近接照射療法のための放射性ヨウ素化フェノール |
| US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| KR100330733B1 (ko) * | 1999-11-30 | 2002-04-03 | 노광 | 폴리에틸렌글리콜포스페이트, 그의 합성방법 및 그를방사능보호제로 사용하는 방법 |
| WO2002022000A2 (en) * | 2000-09-15 | 2002-03-21 | Sloan Kettering Institute For Cancer Research | Targeted alpha particle therapy using actinium-225 conjugates |
| HUP0304083A2 (hu) * | 2001-02-26 | 2004-03-29 | Bristol-Myers Squibb Pharma Company | Radiofarmakon kompozíciók, előállításuk és eljárás radiofarmakonok pufferolására |
| US6972324B2 (en) * | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
| US7238338B1 (en) * | 2001-06-22 | 2007-07-03 | Triumf | System and method for the large scale labeling of compounds with radiohalogens |
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| WO2003105762A2 (en) * | 2002-06-14 | 2003-12-24 | Actinium Pharmaceuticals Ltd. | Treating disease using radium-225 |
| US7018614B2 (en) * | 2002-11-05 | 2006-03-28 | Eastern Isotopes, Inc. | Stabilization of radiopharmaceuticals labeled with 18-F |
| MXPA05005558A (es) | 2002-11-26 | 2005-07-26 | Protein Design Labs Inc | Anticuerpos quimericos y humanizados para integrina ( 5 ( 1 que modulan la angiogenesis. |
| EP1444990A1 (en) * | 2003-02-07 | 2004-08-11 | Amersham plc | Improved Radiometal Complex Compositions |
| US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| JP5230865B2 (ja) | 2004-07-15 | 2013-07-10 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ結合性化合物 |
| DK1851200T3 (da) | 2005-02-25 | 2014-04-14 | Tetralogic Pharm Corp | Dimere iap-inhibitorer |
| US20100256046A1 (en) * | 2009-04-03 | 2010-10-07 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| AU2006279929A1 (en) * | 2005-08-09 | 2007-02-22 | Tetralogic Pharmaceuticals Corporation | Treatment of proliferative disorders |
| EP2049563B1 (en) * | 2006-07-24 | 2014-03-12 | Tetralogic Pharmaceuticals Corporation | Dimeric iap antagonists |
| JP5452223B2 (ja) * | 2006-07-24 | 2014-03-26 | テトラロジック ファーマシューティカルズ コーポレーション | Ｉａｐ阻害剤 |
| US20100056495A1 (en) * | 2006-07-24 | 2010-03-04 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014238A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100113326A1 (en) * | 2006-07-24 | 2010-05-06 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| EP2116241B1 (en) | 2007-01-26 | 2016-04-27 | Pola Pharma Inc. | Pharmaceutical composition |
| EP2136832B1 (en) | 2007-03-26 | 2015-09-02 | General Regeneratives Limited | Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies |
| AU2009220244B2 (en) | 2008-02-29 | 2014-10-09 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| TW201021831A (en) * | 2008-11-17 | 2010-06-16 | Genentech Inc | Method and formulation for reducing aggregation of a macromolecule under physiological conditions |
| CN102458396B (zh) | 2009-04-15 | 2017-05-10 | 兰休斯医疗成像公司 | 使用抗坏血酸稳定化放射性药物组合物 |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| EP3323810B1 (en) | 2010-02-08 | 2022-01-05 | Lantheus Medical Imaging, Inc. | Automated reaction system, cassette and apparatus for synthesizing imaging agents |
| GB201013808D0 (en) * | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| AU2014216515A1 (en) * | 2013-02-15 | 2015-10-08 | Thomas Jefferson University | Kit for tumor imaging |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| EP3094391B1 (en) * | 2014-01-17 | 2024-11-20 | Repligen Corporation | Sterilizing chromatography columns |
| IL237852A0 (en) | 2015-03-19 | 2016-03-24 | Yeda Res & Dev | Antibodies against amphigoline, medical preparations containing them and their use |
| TWI799366B (zh) * | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| WO2017155937A1 (en) * | 2016-03-07 | 2017-09-14 | Actinium Pharmaceuticals, Inc. | Stabilized radiolabeled anti-cd45 immunoglobulin compositions |
| US11339221B2 (en) | 2017-11-01 | 2022-05-24 | Tufts Medical Center, Inc. | Bispecific antibody constructs and methods of use |
| WO2020219550A1 (en) * | 2019-04-23 | 2020-10-29 | Amgen Inc. | The use of low molecular weight polyvinylpyrrolidone (pvp) to reduce viscosity of high concentration protein formulations |
| US12043671B2 (en) | 2021-06-16 | 2024-07-23 | Gundersen Lutheran Medical Foundation, Inc. | Antibodies targeting an amphiregulin-derived cell surface neo-epitope |
| US20250019350A1 (en) | 2023-06-16 | 2025-01-16 | Progenics Pharmaceuticals, Inc | Synthesis of the prostate specific membrane antigen (psma) radiolabeled inhibitor [18f]dcfpyl |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE933885C (de) * | 1952-06-22 | 1955-10-06 | Helmut Richard Dr Kanitz | Verfahren zur Herstellung kolloidaler Loesungen radioaktiver Metalle wie radioaktiver Goldisotope |
| US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
| US4427631A (en) * | 1982-05-27 | 1984-01-24 | Euroceltique, S.A. | Povidone irradiation |
| US4411881A (en) * | 1982-07-12 | 1983-10-25 | New England Nuclear Corporation | Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines |
| EP0111414A3 (en) * | 1982-12-08 | 1985-05-02 | Mallinckrodt, Inc. (a Delaware corporation) | Radiographic imaging agents |
| US4676979A (en) * | 1984-12-31 | 1987-06-30 | Eastern Virginia Medical Authority/Med. Ctr. Hosp. | Method of protecting animals against ionizing radiation |
| US5393512A (en) * | 1985-01-14 | 1995-02-28 | Vanderheyden; Jean-Luc | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| RO103925B1 (ro) * | 1989-02-27 | 1992-04-26 | Institutul De Chimie Macromoleculara "P.Poni" | Derivat de polivinilpirolidona si procedeu de preparare |
| CA2066779A1 (en) * | 1989-09-22 | 1991-03-23 | Jean-Luc Vanderheyden | Stable therapeutic radionuclide compositions and methods for preparation thereof |
| US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
| AU2541592A (en) * | 1991-08-01 | 1993-03-02 | Hybritech Incorporated | Improvements in or relating to modified haptens useful as imaging and therapeutic agents |
| AU2462592A (en) * | 1991-08-29 | 1993-04-05 | Mallinckrodt Medical, Inc. | Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins |
| ES2081717T5 (es) * | 1992-04-30 | 2000-02-16 | Amersham Int Plc | Formulaciones de compuestos radiomarcados. |
| WO1994002174A1 (fr) * | 1992-07-28 | 1994-02-03 | Toray Industries, Inc. | Immunocomplexe |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US5961955A (en) * | 1997-06-03 | 1999-10-05 | Coulter Pharmaceutical, Inc. | Radioprotectant for peptides labeled with radioisotope |
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1997
- 1997-08-21 US US08/918,525 patent/US5961955A/en not_active Expired - Lifetime
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1998
- 1998-06-03 IL IL13327198A patent/IL133271A/en not_active IP Right Cessation
- 1998-06-03 AT AT98928875T patent/ATE249845T1/de active
- 1998-06-03 NZ NZ502029A patent/NZ502029A/en not_active IP Right Cessation
- 1998-06-03 DE DE69818272T patent/DE69818272T2/de not_active Expired - Lifetime
- 1998-06-03 WO PCT/US1998/011428 patent/WO1998055154A1/en not_active Ceased
- 1998-06-03 JP JP50281899A patent/JP4291417B2/ja not_active Expired - Fee Related
- 1998-06-03 CA CA002290987A patent/CA2290987A1/en not_active Abandoned
- 1998-06-03 ES ES98928875T patent/ES2212304T3/es not_active Expired - Lifetime
- 1998-06-03 AU AU80570/98A patent/AU743823B2/en not_active Ceased
- 1998-06-03 PT PT98928875T patent/PT1003560E/pt unknown
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- 1998-06-03 EP EP98928875A patent/EP1003560B1/en not_active Expired - Lifetime
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1999
- 1999-12-02 NO NO19995906A patent/NO315693B1/no not_active IP Right Cessation
- 1999-12-02 US US09/453,985 patent/US6338835B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO995906L (no) | 1999-12-03 |
| JP2002516612A (ja) | 2002-06-04 |
| JP4291417B2 (ja) | 2009-07-08 |
| DE69818272T2 (de) | 2004-07-01 |
| WO1998055154A1 (en) | 1998-12-10 |
| US6338835B1 (en) | 2002-01-15 |
| DE69818272D1 (de) | 2003-10-23 |
| IL133271A (en) | 2004-06-01 |
| IL133271A0 (en) | 2001-04-30 |
| DK1003560T3 (da) | 2003-12-01 |
| EP1003560A1 (en) | 2000-05-31 |
| ES2212304T3 (es) | 2004-07-16 |
| AU743823B2 (en) | 2002-02-07 |
| WO1998055154A9 (en) | 1999-04-08 |
| CA2290987A1 (en) | 1998-12-10 |
| US5961955A (en) | 1999-10-05 |
| NO995906D0 (no) | 1999-12-02 |
| AU8057098A (en) | 1998-12-21 |
| ATE249845T1 (de) | 2003-10-15 |
| EP1003560B1 (en) | 2003-09-17 |
| PT1003560E (pt) | 2004-02-27 |
| NZ502029A (en) | 2001-12-21 |
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