PT1003560E - Radioprotector para peptidos marcados com radioisotopos - Google Patents

Radioprotector para peptidos marcados com radioisotopos

Info

Publication number
PT1003560E
PT1003560E PT98928875T PT98928875T PT1003560E PT 1003560 E PT1003560 E PT 1003560E PT 98928875 T PT98928875 T PT 98928875T PT 98928875 T PT98928875 T PT 98928875T PT 1003560 E PT1003560 E PT 1003560E
Authority
PT
Portugal
Prior art keywords
radioprotector
radioisotopes
radiolabeled
composition
radioprotectant
Prior art date
Application number
PT98928875T
Other languages
English (en)
Inventor
Dan Shochat
Albert S K Chan
Michael J Buckley
David Colcher
Original Assignee
Coulter Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Pharm Inc filed Critical Coulter Pharm Inc
Publication of PT1003560E publication Critical patent/PT1003560E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT98928875T 1997-06-03 1998-06-03 Radioprotector para peptidos marcados com radioisotopos PT1003560E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4838797P 1997-06-03 1997-06-03
US08/918,525 US5961955A (en) 1997-06-03 1997-08-21 Radioprotectant for peptides labeled with radioisotope

Publications (1)

Publication Number Publication Date
PT1003560E true PT1003560E (pt) 2004-02-27

Family

ID=26726075

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98928875T PT1003560E (pt) 1997-06-03 1998-06-03 Radioprotector para peptidos marcados com radioisotopos

Country Status (14)

Country Link
US (2) US5961955A (pt)
EP (1) EP1003560B1 (pt)
JP (1) JP4291417B2 (pt)
AT (1) ATE249845T1 (pt)
AU (1) AU743823B2 (pt)
CA (1) CA2290987A1 (pt)
DE (1) DE69818272T2 (pt)
DK (1) DK1003560T3 (pt)
ES (1) ES2212304T3 (pt)
IL (1) IL133271A (pt)
NO (1) NO315693B1 (pt)
NZ (1) NZ502029A (pt)
PT (1) PT1003560E (pt)
WO (1) WO1998055154A1 (pt)

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US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
KR100589568B1 (ko) * 1998-06-02 2006-06-14 더 다우 케미칼 캄파니 근접조사요법용 방사성 요오드화 페놀류
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
KR100330733B1 (ko) * 1999-11-30 2002-04-03 노광 폴리에틸렌글리콜포스페이트, 그의 합성방법 및 그를방사능보호제로 사용하는 방법
WO2002022000A2 (en) * 2000-09-15 2002-03-21 Sloan Kettering Institute For Cancer Research Targeted alpha particle therapy using actinium-225 conjugates
IL157359A0 (en) * 2001-02-26 2004-02-19 Bristol Myers Squibb Pharma Co A radiopharmaceutical composition containing an ascorbic acid analog
US6972324B2 (en) * 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
US7238338B1 (en) * 2001-06-22 2007-07-03 Triumf System and method for the large scale labeling of compounds with radiohalogens
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
WO2003105762A2 (en) * 2002-06-14 2003-12-24 Actinium Pharmaceuticals Ltd. Treating disease using radium-225
US7018614B2 (en) * 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
JP4741242B2 (ja) 2002-11-26 2011-08-03 アボット バイオセラピューティクス コーポレイション 新脈管形成を調節するα５β１インテグリンへのキメラ及びヒト化抗体
EP1444990A1 (en) * 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
ES2475207T3 (es) 2004-07-15 2014-07-10 Tetralogic Pharmaceuticals Corporation Compuestos de unión a IAP
BRPI0607988A2 (pt) 2005-02-25 2009-10-27 Tetralogic Pharmaceuticals composto, composição farmacêutica, e método para induzir apoptose em uma célula
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
EP1913398A2 (en) * 2005-08-09 2008-04-23 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
US20100143499A1 (en) * 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014263A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap antagonists
WO2008014240A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
CL2007002166A1 (es) * 2006-07-24 2008-01-25 Tetralogic Pharm Corp Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer.
EP2116241B1 (en) 2007-01-26 2016-04-27 Pola Pharma Inc. Pharmaceutical composition
EP2136832B1 (en) 2007-03-26 2015-09-02 General Regeneratives Limited Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies
CA2967254C (en) 2008-02-29 2019-03-26 Lantheus Medical Imaging, Inc. Contrast agents for applications including imaging cancer
AR074196A1 (es) * 2008-11-17 2010-12-29 Genentech Inc Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas
DK2419096T3 (da) 2009-04-15 2020-02-03 Lantheus Medical Imaging Inc Stabilisering af radiofarmaceutiske sammensætninger under anvendelse af ascorbinsyre
US8283372B2 (en) * 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
CN113058046A (zh) 2010-02-08 2021-07-02 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
EP2956157A4 (en) * 2013-02-15 2017-03-01 Thomas Jefferson University Kit for tumor imaging
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
WO2015109246A1 (en) * 2014-01-17 2015-07-23 Repligen Corporation Sterilizing chromatography columns
IL237852A0 (en) 2015-03-19 2016-03-24 Yeda Res & Dev Antibodies against amphigoline, medical preparations containing them and their use
EP3426305A4 (en) * 2016-03-07 2020-01-08 Actinium Pharmaceuticals, Inc. STABILIZED RADIOACTIVELY MARKED ANTI-CD45 IMMUNOGLOBULIN COMPOSITIONS
WO2019089544A1 (en) 2017-11-01 2019-05-09 Tufts Medical Center, Inc. Bispecific antibody constructs and methods of use

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DE933885C (de) * 1952-06-22 1955-10-06 Helmut Richard Dr Kanitz Verfahren zur Herstellung kolloidaler Loesungen radioaktiver Metalle wie radioaktiver Goldisotope
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
US4427631A (en) * 1982-05-27 1984-01-24 Euroceltique, S.A. Povidone irradiation
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
EP0111414A3 (en) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
US4676979A (en) * 1984-12-31 1987-06-30 Eastern Virginia Medical Authority/Med. Ctr. Hosp. Method of protecting animals against ionizing radiation
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
RO103925B1 (ro) * 1989-02-27 1992-04-26 Institutul De Chimie Macromoleculara "P.Poni" Derivat de polivinilpirolidona si procedeu de preparare
CA2066779A1 (en) * 1989-09-22 1991-03-23 Jean-Luc Vanderheyden Stable therapeutic radionuclide compositions and methods for preparation thereof
US5011676A (en) * 1990-03-27 1991-04-30 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
AU2541592A (en) * 1991-08-01 1993-03-02 Hybritech Incorporated Improvements in or relating to modified haptens useful as imaging and therapeutic agents
DE69231469T2 (de) * 1991-08-29 2001-01-25 Mallinckrodt Medical Inc Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
EP0594837B2 (en) * 1992-04-30 1999-12-08 AMERSHAM INTERNATIONAL plc Radiolabelled compound formulations
CA2120023A1 (en) * 1992-07-28 1994-02-03 Noriaki Uenishi Immunoconjugate
US5595721A (en) * 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope

Also Published As

Publication number Publication date
JP2002516612A (ja) 2002-06-04
US5961955A (en) 1999-10-05
WO1998055154A9 (en) 1999-04-08
ES2212304T3 (es) 2004-07-16
CA2290987A1 (en) 1998-12-10
DE69818272T2 (de) 2004-07-01
NZ502029A (en) 2001-12-21
IL133271A0 (en) 2001-04-30
US6338835B1 (en) 2002-01-15
EP1003560B1 (en) 2003-09-17
NO315693B1 (no) 2003-10-13
JP4291417B2 (ja) 2009-07-08
AU8057098A (en) 1998-12-21
IL133271A (en) 2004-06-01
NO995906D0 (no) 1999-12-02
DK1003560T3 (da) 2003-12-01
ATE249845T1 (de) 2003-10-15
DE69818272D1 (de) 2003-10-23
EP1003560A1 (en) 2000-05-31
NO995906L (no) 1999-12-03
WO1998055154A1 (en) 1998-12-10
AU743823B2 (en) 2002-02-07

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